A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors
Pérez-Areales, F. Javier, Turcu, Andreea L., Barniol-Xicota, Marta, Pont, Caterina, Pivetta, Deborah, Espargaró, Alba, Bartolini, Manuela, De Simone, Angela, Andrisano, Vincenza, Pérez, Belén, Sabate, Raimon, Sureda, Francesc X., Vázquez, Santiago, Muñoz-Torrero, Diego
Published in European journal of medicinal chemistry (15.10.2019)
Published in European journal of medicinal chemistry (15.10.2019)
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Journal Article
Dual Effect of Prussian Blue Nanoparticles on Aβ40 Aggregation: β‑Sheet Fibril Reduction and Copper Dyshomeostasis Regulation
Kowalczyk, Joanna, Grapsi, Ettore, Espargaró, Alba, Caballero, Ana B, Juárez-Jiménez, Jordi, Busquets, Maria A, Gamez, Patrick, Sabate, Raimon, Estelrich, Joan
Published in Biomacromolecules (08.02.2021)
Published in Biomacromolecules (08.02.2021)
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Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies
Di Pietro, Ornella, Pérez-Areales, F. Javier, Juárez-Jiménez, Jordi, Espargaró, Alba, Clos, M. Victòria, Pérez, Belén, Lavilla, Rodolfo, Sabaté, Raimon, Luque, F. Javier, Muñoz-Torrero, Diego
Published in European journal of medicinal chemistry (12.09.2014)
Published in European journal of medicinal chemistry (12.09.2014)
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Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease
Purgatorio, Rosa, Gambacorta, Nicola, Catto, Marco, de Candia, Modesto, Pisani, Leonardo, Espargaró, Alba, Sabaté, Raimon, Cellamare, Saverio, Nicolotti, Orazio, Altomare, Cosimo D
Published in Molecules (Basel, Switzerland) (07.12.2020)
Published in Molecules (Basel, Switzerland) (07.12.2020)
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Journal Article
Shogaol–huprine hybrids: Dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties
Pérez-Areales, F. Javier, Di Pietro, Ornella, Espargaró, Alba, Vallverdú-Queralt, Anna, Galdeano, Carles, Ragusa, Ilaria M., Viayna, Elisabet, Guillou, Catherine, Clos, M. Victòria, Pérez, Belén, Sabaté, Raimon, Lamuela-Raventós, Rosa M., Luque, F. Javier, Muñoz-Torrero, Diego
Published in Bioorganic & medicinal chemistry (01.10.2014)
Published in Bioorganic & medicinal chemistry (01.10.2014)
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Journal Article
On the Binding of Congo Red to Amyloid Fibrils
Espargaró, Alba, Llabrés, Salomé, Saupe, Sven J., Curutchet, Carles, Luque, F. Javier, Sabaté, Raimon
Published in Angewandte Chemie International Edition (18.05.2020)
Published in Angewandte Chemie International Edition (18.05.2020)
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Dual Inhibitors of Amyloid‑β and Tau Aggregation with Amyloid‑β Disaggregating Properties: Extended In Cellulo, In Silico, and Kinetic Studies of Multifunctional Anti-Alzheimer’s Agents
Pasieka, Anna, Panek, Dawid, Szałaj, Natalia, Espargaró, Alba, Więckowska, Anna, Malawska, Barbara, Sabaté, Raimon, Bajda, Marek
Published in ACS chemical neuroscience (02.06.2021)
Published in ACS chemical neuroscience (02.06.2021)
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Combined in Vitro Cell-Based/in Silico Screening of Naturally Occurring Flavonoids and Phenolic Compounds as Potential Anti-Alzheimer Drugs
Espargaró, Alba, Ginex, Tiziana, Vadell, Maria del Mar, Busquets, Maria A, Estelrich, Joan, Muñoz-Torrero, Diego, Luque, F. Javier, Sabate, Raimon
Published in Journal of natural products (Washington, D.C.) (24.02.2017)
Published in Journal of natural products (Washington, D.C.) (24.02.2017)
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Journal Article
Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR‑6
Pérez-Areales, F. Javier, Garrido, María, Aso, Ester, Bartolini, Manuela, De Simone, Angela, Espargaró, Alba, Ginex, Tiziana, Sabate, Raimon, Pérez, Belén, Andrisano, Vincenza, Puigoriol-Illamola, Dolors, Pallàs, Mercè, Luque, F. Javier, Loza, María Isabel, Brea, José, Ferrer, Isidro, Ciruela, Francisco, Messeguer, Angel, Muñoz-Torrero, Diego
Published in Journal of medicinal chemistry (10.09.2020)
Published in Journal of medicinal chemistry (10.09.2020)
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Journal Article
New Pyrimidine and Pyridine Derivatives as Multitarget Cholinesterase Inhibitors: Design, Synthesis, and In Vitro and In Cellulo Evaluation
Bortolami, Martina, Pandolfi, Fabiana, Tudino, Valeria, Messore, Antonella, Madia, Valentina Noemi, De Vita, Daniela, Di Santo, Roberto, Costi, Roberta, Romeo, Isabella, Alcaro, Stefano, Colone, Marisa, Stringaro, Annarita, Espargaró, Alba, Sabatè, Raimon, Scipione, Luigi
Published in ACS chemical neuroscience (03.11.2021)
Published in ACS chemical neuroscience (03.11.2021)
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Journal Article
Novel Levetiracetam Derivatives That Are Effective against the Alzheimer-like Phenotype in Mice: Synthesis, in Vitro, ex Vivo, and in Vivo Efficacy Studies
Sola, Irene, Aso, Ester, Frattini, Daniela, López-González, Irene, Espargaró, Alba, Sabaté, Raimon, Di Pietro, Ornella, Luque, F. Javier, Clos, M. Victòria, Ferrer, Isidro, Muñoz-Torrero, Diego
Published in Journal of medicinal chemistry (13.08.2015)
Published in Journal of medicinal chemistry (13.08.2015)
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Journal Article
Ultra rapid in vivo screening for anti-Alzheimer anti-amyloid drugs
Espargaró, Alba, Medina, Aina, Di Pietro, Ornella, Muñoz-Torrero, Diego, Sabate, Raimon
Published in Scientific reports (22.03.2016)
Published in Scientific reports (22.03.2016)
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Journal Article
Novel drug-like fluorenyl derivatives as selective butyrylcholinesterase and β-amyloid inhibitors for the treatment of Alzheimer’s disease
Pasieka, Anna, Panek, Dawid, Zaręba, Paula, Sługocka, Emilia, Gucwa, Natalia, Espargaró, Alba, Latacz, Gniewomir, Khan, Nadia, Bucki, Adam, Sabaté, Raimon, Więckowska, Anna, Malawska, Barbara
Published in Bioorganic & medicinal chemistry (06.06.2023)
Published in Bioorganic & medicinal chemistry (06.06.2023)
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Journal Article
In Vivo Assays for Amyloid-Related Diseases
Espargaró, Alba, Álvarez-Berbel, Irene, Busquets, Maria Antònia, Sabate, Raimon
Published in Annual review of analytical chemistry (Palo Alto, Calif.) (01.01.2024)
Published in Annual review of analytical chemistry (Palo Alto, Calif.) (01.01.2024)
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New cyclopentaquinoline and 3,5-dichlorobenzoic acid hybrids with neuroprotection against oxidative stress for the treatment of Alzheimer's disease
Czarnecka, Kamila, Girek, Małgorzata, Kręcisz, Paweł, Skibiński, Robert, Łątka, Kamil, Jończyk, Jakub, Bajda, Marek, Szymczyk, Piotr, Galita, Grzegorz, Kabziński, Jacek, Majsterek, Ireneusz, Espargaró, Alba, Sabate, Raimon, Szymański, Paweł
Published in Journal of enzyme inhibition and medicinal chemistry (01.12.2023)
Published in Journal of enzyme inhibition and medicinal chemistry (01.12.2023)
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Journal Article
A versatile luminescent probe for sensing and monitoring amyloid proteins
Vázquez, Guillem, Espargaró, Alba, Caballero, Ana B., Di Pede-Mattatelli, Ania, Busquets, M. Antònia, Nawrot, Daria, Sabaté, Raimon, Nicolás, Ernesto, Juárez-Jiménez, Jordi, Gamez, Patrick
Published in Dyes and pigments (01.12.2024)
Published in Dyes and pigments (01.12.2024)
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Amyloid Pan-inhibitors: One Family of Compounds To Cope with All Conformational Diseases
Espargaró, Alba, Pont, Caterina, Gamez, Patrick, Muñoz-Torrero, Diego, Sabate, Raimon
Published in ACS chemical neuroscience (20.03.2019)
Published in ACS chemical neuroscience (20.03.2019)
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