Efficacy and Safety of Upadacitinib Monotherapy in Methotrexate‐Naive Patients With Moderately‐to‐Severely Active Rheumatoid Arthritis (SELECT‐EARLY): A Multicenter, Multi‐Country, Randomized, Double‐Blind, Active Comparator–Controlled Trial
Vollenhoven, Ronald, Takeuchi, Tsutomu, Pangan, Aileen L., Friedman, Alan, Mohamed, Mohamed‐Eslam F., Chen, Su, Rischmueller, Maureen, Blanco, Ricardo, Xavier, Ricardo M., Strand, Vibeke
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.10.2020)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.10.2020)
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Pharmacokinetics of Upadacitinib in Healthy Subjects and Subjects With Rheumatoid Arthritis, Crohn's Disease, Ulcerative Colitis, or Atopic Dermatitis: Population Analyses of Phase 1 and 2 Clinical Trials
Nader, Ahmed, Stodtmann, Sven, Friedel, Anna, Mohamed, Mohamed-Eslam F, Othman, Ahmed A
Published in Journal of clinical pharmacology (01.04.2020)
Published in Journal of clinical pharmacology (01.04.2020)
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Preferential Inhibition of JAK1 Relative to JAK3 by Upadacitinib: Exposure‐Response Analyses of Ex Vivo Data From 2 Phase 1 Clinical Trials and Comparison to Tofacitinib
Mohamed, Mohamed‐Eslam F., Beck, Denise, Camp, Heidi S., Othman, Ahmed A.
Published in Journal of clinical pharmacology (01.02.2020)
Published in Journal of clinical pharmacology (01.02.2020)
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Safety and efficacy of upadacitinib in patients with active rheumatoid arthritis refractory to biologic disease-modifying anti-rheumatic drugs (SELECT-BEYOND): a double-blind, randomised controlled phase 3 trial
Genovese, Mark C, Fleischmann, Roy, Combe, Bernard, Hall, Stephen, Rubbert-Roth, Andrea, Zhang, Ying, Zhou, Yijie, Mohamed, Mohamed-Eslam F, Meerwein, Sebastian, Pangan, Aileen L
Published in The Lancet (British edition) (23.06.2018)
Published in The Lancet (British edition) (23.06.2018)
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Use of Clinical Trial Simulations to Compare the Performance of Different Approaches for Population Analyses of Pediatric Pharmacokinetic Data
Temrikar, Zaid, Muensterman, Elena, Engelhardt, Benjamin, Mohamed, Mohamed-Eslam F
Published in Journal of clinical pharmacology (01.07.2023)
Published in Journal of clinical pharmacology (01.07.2023)
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The JAK1 Inhibitor Upadacitinib Has No Effect on the Pharmacokinetics of Levonorgestrel and Ethinylestradiol: A Study in Healthy Female Subjects
Mohamed, Mohamed‐Eslam F., Trueman, Sheryl, Feng, Tian, Friedman, Alan, Othman, Ahmed A.
Published in Journal of clinical pharmacology (01.04.2019)
Published in Journal of clinical pharmacology (01.04.2019)
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Assessment of effect of CYP3A inhibition, CYP induction, OATP1B inhibition, and high‐fat meal on pharmacokinetics of the JAK1 inhibitor upadacitinib
Mohamed, Mohamed‐Eslam F., Jungerwirth, Steven, Asatryan, Armen, Jiang, Ping, Othman, Ahmed A.
Published in British journal of clinical pharmacology (01.10.2017)
Published in British journal of clinical pharmacology (01.10.2017)
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Effects of Upadacitinib Coadministration on the Pharmacokinetics of Sensitive Cytochrome P450 Probe Substrates: A Study With the Modified Cooperstown 5+1 Cocktail
Mohamed, Mohamed‐Eslam F., Feng, Tian, Enejosa, Jeffrey V., Fisniku, Ogert, Othman, Ahmed A.
Published in Journal of clinical pharmacology (01.01.2020)
Published in Journal of clinical pharmacology (01.01.2020)
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Upadacitinib in adults with moderate to severe atopic dermatitis: 16-week results from a randomized, placebo-controlled trial
Guttman-Yassky, Emma, Thaçi, Diamant, Pangan, Aileen L., Hong, H. Chih-ho, Papp, Kim A., Reich, Kristian, Beck, Lisa A., Mohamed, Mohamed-Eslam F., Othman, Ahmed A., Anderson, Jaclyn K., Gu, Yihua, Teixeira, Henrique D., Silverberg, Jonathan I.
Published in Journal of allergy and clinical immunology (01.03.2020)
Published in Journal of allergy and clinical immunology (01.03.2020)
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Upadacitinib: Mechanism of action, clinical, and translational science
Mohamed, Mohamed‐Eslam F., Bhatnagar, Sumit, Parmentier, Julie M., Nakasato, Priscila, Wung, Peter
Published in Clinical and translational science (01.01.2024)
Published in Clinical and translational science (01.01.2024)
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Exposure‐Response Analyses for Upadacitinib Efficacy in Subjects With Atopic Dermatitis—Analyses of Phase 2b Study to Support Selection of Phase 3 Doses
Mohamed, Mohamed‐Eslam F., Gopalakrishnan, Sathej, Teixeira, Henrique D., Othman, Ahmed A.
Published in Journal of clinical pharmacology (01.05.2021)
Published in Journal of clinical pharmacology (01.05.2021)
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Upadacitinib pharmacokinetics and exposure‐response analyses of efficacy and safety in psoriatic arthritis patients – Analyses of phase III clinical trials
Muensterman, Elena, Engelhardt, Benjamin, Gopalakrishnan, Sathej, Anderson, Jaclyn K., Mohamed, Mohamed‐Eslam F.
Published in Clinical and translational science (01.01.2022)
Published in Clinical and translational science (01.01.2022)
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Impact of COVID‐19 on the Conduct and Design of Clinical Trials: IQ Consortium Perspective
Mohamed, Mohamed‐Eslam F., Girish, Sandhya, Humeniuk, Rita, Nuthalapati, Silpa, Desai, Amit, Datta‐Mannan, Amita, Gheyas, Ferdous, Kanodia, Jitendra, Cheeti, Sravanthi, Zhu, Tong
Published in Clinical pharmacology and therapeutics (01.07.2024)
Published in Clinical pharmacology and therapeutics (01.07.2024)
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Efficacy and Safety of Upadacitinib in a Randomized Trial of Patients With Crohn’s Disease
Sandborn, William J., Feagan, Brian G., Loftus, Edward V., Peyrin-Biroulet, Laurent, Van Assche, Gert, D’Haens, Geert, Schreiber, Stefan, Colombel, Jean-Frederic, Lewis, James D., Ghosh, Subrata, Armuzzi, Alessandro, Scherl, Ellen, Herfarth, Hans, Vitale, Lauren, Mohamed, Mohamed-Eslam F., Othman, Ahmed A., Zhou, Qian, Huang, Bidan, Thakkar, Roopal B., Pangan, Aileen L., Lacerda, Ana P., Panes, Julian
Published in Gastroenterology (New York, N.Y. 1943) (01.06.2020)
Published in Gastroenterology (New York, N.Y. 1943) (01.06.2020)
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Upadacitinib Induction and Maintenance Therapy for Crohn’s Disease
Loftus, Edward V., Panés, Julian, Lacerda, Ana P., Peyrin-Biroulet, Laurent, D’Haens, Geert, Panaccione, Remo, Reinisch, Walter, Louis, Edouard, Chen, Minhu, Nakase, Hiroshi, Begun, Jakob, Boland, Brigid S., Phillips, Charles, Mohamed, Mohamed-Eslam F., Liu, Jianzhong, Geng, Ziqian, Feng, Tian, Dubcenco, Elena, Colombel, Jean-Frederic
Published in The New England journal of medicine (25.05.2023)
Published in The New England journal of medicine (25.05.2023)
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Therapeutic Protein Drug Interaction Potential in Subjects With Psoriasis: An Assessment Based on Population Pharmacokinetic Analyses of Sensitive Cytochrome P450 Probe Substrates
Sathe, Abhishek G, Othman, Ahmed A, Mohamed, Mohamed-Eslam F
Published in Journal of clinical pharmacology (01.03.2021)
Published in Journal of clinical pharmacology (01.03.2021)
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Exposure–Response Analyses of Upadacitinib Efficacy and Safety in Phase II and III Studies to Support Benefit–Risk Assessment in Rheumatoid Arthritis
Nader, Ahmed, Mohamed, Mohamed‐Eslam F., Winzenborg, Insa, Doelger, Eva, Noertersheuser, Peter, Pangan, Aileen L., Othman, Ahmed A.
Published in Clinical pharmacology and therapeutics (01.04.2020)
Published in Clinical pharmacology and therapeutics (01.04.2020)
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