The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling
Abdel-Nour, Mena, Carneiro, Leticia A M, Downey, Jeffrey, Tsalikis, Jessica, Outlioua, Ahmed, Prescott, Dave, Da Costa, Leandro Silva, Hovingh, Elise S, Farahvash, Armin, Gaudet, Ryan G, Molinaro, Raphael, van Dalen, Rob, Lau, Charles C Y, Azimi, Farshad C, Escalante, Nichole K, Trotman-Grant, Aaron, Lee, Jeffrey E, Gray-Owen, Scott D, Divangahi, Maziar, Chen, Jane-Jane, Philpott, Dana J, Arnoult, Damien, Girardin, Stephen E
Published in Science (American Association for the Advancement of Science) (05.07.2019)
Published in Science (American Association for the Advancement of Science) (05.07.2019)
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Journal Article
Lymph node colonization induces tumor-immune tolerance to promote distant metastasis
Reticker-Flynn, Nathan E., Zhang, Weiruo, Belk, Julia A., Basto, Pamela A., Escalante, Nichole K., Pilarowski, Genay O.W., Bejnood, Alborz, Martins, Maria M., Kenkel, Justin A., Linde, Ian L., Bagchi, Sreya, Yuan, Robert, Chang, Serena, Spitzer, Matthew H., Carmi, Yaron, Cheng, Jiahan, Tolentino, Lorna L., Choi, Okmi, Wu, Nancy, Kong, Christina S., Gentles, Andrew J., Sunwoo, John B., Satpathy, Ansuman T., Plevritis, Sylvia K., Engleman, Edgar G.
Published in Cell (26.05.2022)
Published in Cell (26.05.2022)
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Journal Article
Structure of the IFNγ receptor complex guides design of biased agonists
Mendoza, Juan L., Escalante, Nichole K., Jude, Kevin M., Sotolongo Bellon, Junel, Su, Leon, Horton, Tim M., Tsutsumi, Naotaka, Berardinelli, Steven J., Haltiwanger, Robert S., Piehler, Jacob, Engleman, Edgar G., Garcia, K. Christopher
Published in Nature (London) (07.03.2019)
Published in Nature (London) (07.03.2019)
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Journal Article
NKT Cell-Deficient Mice Harbor an Altered Microbiota That Fuels Intestinal Inflammation during Chemically Induced Colitis
Selvanantham, Thirumahal, Lin, Qiaochu, Guo, Cynthia Xinyi, Surendra, Anuradha, Fieve, Stephanie, Escalante, Nichole K, Guttman, David S, Streutker, Catherine J, Robertson, Susan J, Philpott, Dana J, Mallevaey, Thierry
Published in The Journal of immunology (1950) (01.12.2016)
Published in The Journal of immunology (1950) (01.12.2016)
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Journal Article
The common mouse protozoa Tritrichomonas muris alters mucosal T cell homeostasis and colitis susceptibility
Escalante, Nichole K, Lemire, Paul, Cruz Tleugabulova, Mayra, Prescott, David, Mortha, Arthur, Streutker, Catherine J, Girardin, Stephen E, Philpott, Dana J, Mallevaey, Thierry
Published in The Journal of experimental medicine (12.12.2016)
Published in The Journal of experimental medicine (12.12.2016)
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Journal Article
Circulating NOD1 Activators and Hematopoietic NOD1 Contribute to Metabolic Inflammation and Insulin Resistance
Chan, Kenny L., Tam, Theresa H., Boroumand, Parastoo, Prescott, David, Costford, Sheila R., Escalante, Nichole K., Fine, Noah, Tu, YuShan, Robertson, Susan J., Prabaharan, Dilshaayee, Liu, Zhi, Bilan, Philip J., Salter, Michael W., Glogauer, Michael, Girardin, Stephen E., Philpott, Dana J., Klip, Amira
Published in Cell reports (Cambridge) (07.03.2017)
Published in Cell reports (Cambridge) (07.03.2017)
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Journal Article
Discrete TCR Binding Kinetics Control Invariant NKT Cell Selection and Central Priming
Cruz Tleugabulova, Mayra, Escalante, Nichole K, Deng, Shenglou, Fieve, Stephanie, Ereño-Orbea, June, Savage, Paul B, Julien, Jean-Philippe, Mallevaey, Thierry
Published in The Journal of immunology (1950) (15.11.2016)
Published in The Journal of immunology (1950) (15.11.2016)
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Journal Article
Nod1 and Nod2 enhance TLR-mediated invariant NKT cell activation during bacterial infection
Selvanantham, Thirumahal, Escalante, Nichole K, Cruz Tleugabulova, Mayra, Fiévé, Stephanie, Girardin, Stephen E, Philpott, Dana J, Mallevaey, Thierry
Published in The Journal of immunology (1950) (01.12.2013)
Published in The Journal of immunology (1950) (01.12.2013)
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Journal Article
1372 TriTCE Co-Stim: a novel trispecific T cell engager platform, with integrated CD28 costimulation, engineered to widen the therapeutic window for treatment of poorly infiltrated tumors
Newhook, Lisa, Bhojane, Purva, Repenning, Peter, Lau, Desmond, Escalante, Nichole, Escanda, Diego Perez, Shao, Polly, Poffenberger, Maya, Robinson, Alec, Patel, Kesha, Livernois, Alexandra, Piscitelli, Chayne L, Afacan, Nicole, Kreudenstein, Thomas Spreter von, Weisser, Nina
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
1396 TriTCE CPI: a novel trispecifc T cell engager platform with integrated PD-1/PD-L1 checkpoint inhibition engineered for the treatment of immunosuppressed tumors
Verstraete, Meghan M, Poffenberger, Maya, Zago, Matteo, Luu, Veronica, Ma, Brenda, Escalante, Nichole, Li, Janessa, Escanda, Diego Perez, Cao, Siran, Meier, Edward, Arrafi, Sifa, Peng, Yun, Rossum, Anna Von, Desjardins, Genevieve, Weisser, Nina, Kreudenstein, Thomas Spreter von
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
Structure of the IFN[gamma] receptor complex guides design of biased agonists
Mendoza, Juan L, Escalante, Nichole K, Jude, Kevin M, Sotolongo Bellon, Junel, Su, Leon, Horton, Tim M, Tsutsumi, Naotaka
Published in Nature (London) (01.03.2019)
Published in Nature (London) (01.03.2019)
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Journal Article
Abstract 2633: Zanidatamab zovodotin (ZW49) induces hallmarks of immunogenic cell death and is active in patient-derived xenograft models of gastric cancer
Barnscher, Stuart D., Rojas, Andrea Hernández, Hamblett, Kevin J., Escalante, Nichole
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Abstract 6716: DLL3 TriTCE Co-Stim: A next generation trispecific T cell engager with integrated CD28 costimulation for the treatment of DLL3-expressing cancers
Repenning, Peter, Lau, Desmond, Hernaez, Diana C., Robinson, Alec, Escanda, Diego P., Rocha, Mariana, Moreno, Begonia S., Zhang, John, Shao, Polly, Escalante, Nichole, Newhook, Lisa, Bhojane, Purva, Piscitelli, Chayne L., Moore, Paul A., Von Kreudenstein, Thomas Spreter, Weisser, Nina E.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract 6719: TriTCE Co-Stim: A next generation trispecific T cell engager platform with integrated CD28 costimulation, engineered to improve responses in the treatment of solid tumors
Newhook, Lisa, Bhojane, Purva, Stahl, Kurt, Escalante, Nichole E., Repenning, Peter, Escanda, Diego Perez, Shao, Polly, Poffenberger, Maya C., Robinson, Alec, Patel, Kesha, Livernois, Alexandra, Piscitelli, Chayne L., Afacan, Nicole, Moore, Paul A., Weisser, Nina E., von Kreudenstein, Thomas Spreter
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Inflammatory Cytokines Determine the Susceptibility of Human CD8 T Cells to Fas-mediated Activation-induced Cell Death through Modulation of FasL and c-FLIPS Expression
von Rossum, Anna, Krall, Randall, Escalante, Nichole K., Choy, Jonathan C.
Published in The Journal of biological chemistry (17.06.2011)
Published in The Journal of biological chemistry (17.06.2011)
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Journal Article
Abstract 5121: TriTCE Co-stim, next generation costimulatory trispecific T cell engagers for the treatment of solid tumors
Newhook, Lisa, Bhojane, Purva P., Repenning, Peter W., Escanda, Diego Perez, Escalante, Nichole K., Zwierzchowski, Patricia, Robinson, Alec, Clifford, Lauren, Pratap, Harsh, Douda, David N., Piscitelli, Chayne L., Afacan, Nicole J., von Kreudenstein, Thomas Spreter, Weisser, Nina E.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Abstract 2926: PROTECTTM, a novel trispecific antibody masking platform with integrated immune modulation displays unique activity and differentiated modes of action
von Rossum, Anna, Desjardins, Genevieve, Escalante, Nichole, Wong, Wingkie, Harbourne, Bryant, Li, Janessa, Moreno, Begonia Silva, Raghunatha, Prajwal, Kunze, Richard, Fung, Madeline, Heinkel, Florian, Pratap, Harsh, Haworth, Kevin, Escobar-Cabrera, Eric, Clavette, Brandon, Dixit, Surjit, Weisser, Nina, von Kreudenstein, Thomas Spreter
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Inflammatory cytokines determine the susceptibility of human CD8 T cells to Fas-mediated activation-induced cell death through modulation of FasL and c-FLIP expression (46.4)
von Rossum, Anna, Krall, Randall, Escalante, Nichole, Choy, Jonathan
Published in The Journal of immunology (1950) (01.04.2011)
Published in The Journal of immunology (1950) (01.04.2011)
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Journal Article
Abstract 2935: ZW270, a conditionally masked IL-12 cytokine fusion protein displaying potent anti-tumor activity absent systemic toxicity
Poffenberger, Maya C., Bishop, Jennifer L., Blackler, Ryan J., Haworth, Kevin G., Booth, Steven, Hanson, Shalla, Proctor, Jeff R., Shao, I-Ting, Escalante, Nichole K., Siddappa, Dayananda, Smith, Joel, Anmole, Gursev, Konomura, Saki, Dawson, Nicholas A., Arrafi, Sifa, Lau, Desmond, Rowse, Gerry, Davies, Rupert H., von Kreudenstein, Thomas Spreter
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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