Search Results - "Ernest J. Mceachern" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Discovery of MK-8719, a Potent O‑GlcNAcase Inhibitor as a Potential Treatment for Tauopathies

Discovery of MK-8719, a Potent O‑GlcNAcase Inhibitor as a Potential Treatment for Tauopathies

by Selnick, Harold G, Hess, J. Fred, Tang, Cuyue, Liu, Kun, Schachter, Joel B, Ballard, Jeanine E, Marcus, Jacob, Klein, Daniel J, Wang, Xiaohai, Pearson, Michelle, Savage, Mary J, Kaul, Ramesh, Li, Tong-Shuang, Vocadlo, David J, Zhou, Yuanxi, Zhu, Yongbao, Mu, Changwei, Wang, Yaode, Wei, Zhongyong, Bai, Chang, Duffy, Joseph L, McEachern, Ernest J
Published in Journal of medicinal chemistry (27.11.2019)

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Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

by Hastings, Nicholas B, Wang, Xiaohai, Song, Lixin, Butts, Brent D, Grotz, Diane, Hargreaves, Richard, Fred Hess, J, Hong, Kwok-Lam Karen, Huang, Cathy Ruey-Ruey, Hyde, Lynn, Laverty, Maureen, Lee, Julie, Levitan, Diane, Lu, Sherry X, Maguire, Maureen, Mahadomrongkul, Veeravan, McEachern, Ernest J, Ouyang, Xuesong, Rosahl, Thomas W, Selnick, Harold, Stanton, Michaela, Terracina, Giuseppe, Vocadlo, David J, Wang, Ganfeng, Duffy, Joseph L, Parker, Eric M, Zhang, Lili
Published in Molecular neurodegeneration (18.05.2017)

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A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

by Vocadlo, David J, Yuzwa, Scott A, Macauley, Matthew S, Heinonen, Julia E, Shan, Xiaoyang, Dennis, Rebecca J, He, Yuan, Whitworth, Garrett E, Stubbs, Keith A, McEachern, Ernest J, Davies, Gideon J
Published in Nature chemical biology (01.08.2008)

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Asymmetric Synthesis of Oxygen Heterocycles via Pd-Catalyzed Dynamic Kinetic Asymmetric Transformations: Application to Nucleosides

Asymmetric Synthesis of Oxygen Heterocycles via Pd-Catalyzed Dynamic Kinetic Asymmetric Transformations: Application to Nucleosides

by Trost, Barry M., Brown, Brian S., McEachern, Ernest J., Kuhn, Oliver
Published in Chemistry : a European journal (22.09.2003)

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MK-8719, a Novel and Selective O -GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy

MK-8719, a Novel and Selective O -GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy

by Wang, Xiaohai, Li, Wenping, Marcus, Jacob, Pearson, Michelle, Song, Lixin, Smith, Karen, Terracina, Giuseppe, Lee, Julie, Hong, Kwok-Lam Karen, Lu, Sherry X., Hyde, Lynn, Chen, Shu-Cheng, Kinsley, David, Melchor, Jerry P., Rubins, Daniel J., Meng, Xiangjun, Hostetler, Eric, Sur, Cyrille, Zhang, Lili, Schachter, Joel B., Hess, J. Fred, Selnick, Harold G., Vocadlo, David J., McEachern, Ernest J., Uslaner, Jason M., Duffy, Joseph L., Smith, Sean M.
Published in The Journal of pharmacology and experimental therapeutics (01.08.2020)

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Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms

Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms

by Kolappan, Subramaniapillai, Shen, David L., Mosi, Renee, Sun, Jianyu, McEachern, Ernest J., Vocadlo, David J., Craig, Lisa
Published in Acta crystallographica. Section D, Biological crystallography. (01.02.2015)

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Enzymatic Resolution of Bicyclic 1-Heteroarylamines Using Candida antarctica Lipase B

Enzymatic Resolution of Bicyclic 1-Heteroarylamines Using Candida antarctica Lipase B

by Skupinska, Krystyna A., McEachern, Ernest J., Baird, Ian R., Skerlj, Renato T., Bridger, Gary J.
Published in Journal of organic chemistry (02.05.2003)

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Inorganic Carbonates as Nucleophiles for the Asymmetric Synthesis of Vinylglycidols

Inorganic Carbonates as Nucleophiles for the Asymmetric Synthesis of Vinylglycidols

by Trost, Barry M, McEachern, Ernest J
Published in Journal of the American Chemical Society (22.09.1999)

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Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice

Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice

by Yuzwa, Scott A, Shan, Xiaoyang, Jones, Bryan A, Zhao, Gang, Woodward, Melissa L, Li, Xiaojing, Zhu, Yanping, McEachern, Ernest J, Silverman, Michael A, Watson, Neil V, Gong, Cheng-Xin, Vocadlo, David J
Published in Molecular neurodegeneration (26.10.2014)

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Discovery of Novel Small Molecule Orally Bioavailable C−X−C Chemokine Receptor 4 Antagonists That Are Potent Inhibitors of T-Tropic (X4) HIV-1 Replication

Discovery of Novel Small Molecule Orally Bioavailable C−X−C Chemokine Receptor 4 Antagonists That Are Potent Inhibitors of T-Tropic (X4) HIV-1 Replication

by Skerlj, Renato T, Bridger, Gary J, Kaller, Al, McEachern, Ernest J, Crawford, Jason B, Zhou, Yuanxi, Atsma, Bem, Langille, Jonathon, Nan, Susan, Veale, Duane, Wilson, Trevor, Harwig, Curtis, Hatse, Sigrid, Princen, Katrien, De Clercq, Erik, Schols, Dominique
Published in Journal of medicinal chemistry (22.04.2010)

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A Two-Component Catalyst System for Asymmetric Allylic Alkylations with Alcohol Pronucleophiles

A Two-Component Catalyst System for Asymmetric Allylic Alkylations with Alcohol Pronucleophiles

by Trost, Barry M, McEachern, Ernest J, Toste, F. Dean
Published in Journal of the American Chemical Society (09.12.1998)

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Copper Chloride-Catalyzed and Hydrochloric Acid-Mediated Chemoselective Protiodestannylations of Alkyl (Z)- or (E)-2,3-Bis(trimethylstannyl)-2-alkenoates. Stereoselective Preparation of Alkyl (E)- and (Z)-3-Trimethylstannyl-2-alkenoates

Copper Chloride-Catalyzed and Hydrochloric Acid-Mediated Chemoselective Protiodestannylations of Alkyl (Z)- or (E)-2,3-Bis(trimethylstannyl)-2-alkenoates. Stereoselective Preparation of Alkyl (E)- and (Z)-3-Trimethylstannyl-2-alkenoates

by Piers, Edward, McEachern, Ernest J, Romero, Miguel A
Published in Journal of organic chemistry (22.08.1997)

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Intramolecular Michael Additions: Copper(I) Chloride-Mediated Conjugate Addition of Vinyltrimethylstannane Functions to .alpha.,.beta.-Unsaturated Ketones

Intramolecular Michael Additions: Copper(I) Chloride-Mediated Conjugate Addition of Vinyltrimethylstannane Functions to .alpha.,.beta.-Unsaturated Ketones

by Piers, Edward, McEachern, Ernest J, Burns, Patricia A
Published in Journal of organic chemistry (01.04.1995)

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Concise Preparation of Amino-5,6,7,8-tetrahydroquinolines and Amino-5,6,7,8-tetrahydroisoquinolines via Catalytic Hydrogenation of Acetamidoquinolines and Acetamidoisoquinolines

Concise Preparation of Amino-5,6,7,8-tetrahydroquinolines and Amino-5,6,7,8-tetrahydroisoquinolines via Catalytic Hydrogenation of Acetamidoquinolines and Acetamidoisoquinolines

by Skupinska, Krystyna A, McEachern, Ernest J, Skerlj, Renato T, Bridger, Gary J
Published in Journal of organic chemistry (01.11.2002)

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GLYCOSIDASE INHIBITORS AND USES THEREOF

GLYCOSIDASE INHIBITORS AND USES THEREOF

by RAMESH KAUL, DANG QUN, ZHOU YUANXI, DAVID J VOCADLO, ERNEST J MCEACHERN, SELNICK HAROLD G
Year of Publication 08.11.2018

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Patent

Facile preparation of substituted benzimidazole-2-carboxylates

Facile preparation of substituted benzimidazole-2-carboxylates

by Zhu, YB, Skupinska, KA, McEachern, EJ
Published in Heterocycles (01.02.2006)

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Intermolecular copper(I) chloride-mediated coupling of alkenyltrialkylstannane functions: A convenient synthesis of conjugated diene systems

Intermolecular copper(I) chloride-mediated coupling of alkenyltrialkylstannane functions: A convenient synthesis of conjugated diene systems

by Piers, Edward, McEachern, Ernest J, Romero, Miguel A
Published in Tetrahedron letters (19.02.1996)

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SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF

SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF

by RAMESH KAUL, MU CHANGWEI, WEI ZHONGYONG, WANG YAODE, ZHOU YUANXI, DAVID J VOCADLO, ERNEST J MCEACHERN, ZHU YONGBAO, SELNICK HAROLD G
Year of Publication 10.03.2016

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Patent

Copper(I) chloride-mediated oxidative coupling of alkenyltrialkylstannyl functions: efficient stereocontrolled syntheses of uniquely functionalized conjugated diene systems

Copper(I) chloride-mediated oxidative coupling of alkenyltrialkylstannyl functions: efficient stereocontrolled syntheses of uniquely functionalized conjugated diene systems

by Piers, Edward, McEachern, Ernest J, Romero, Miguel A, Gladstone, Patricia L
Published in Canadian journal of chemistry (01.06.1997)

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Journal Article

Chemokine receptor binding heterocyclic compounds with enhanced efficacy

Chemokine receptor binding heterocyclic compounds with enhanced efficacy

by BRIDGER GARY J.,MCEACHERN ERNEST J.,SKERLJ RENATO,SCHOLS DOMINIQUE,BAIRD IAN,KALLER AI,HARWIG CURTIS,ZHU YONGBAO,CHEN GANG,SKUPINSKA KRYSTYNA,METZ MARKUS
Year of Publication 24.05.2006

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