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The Platform Vector Gene Therapies Project: Increasing the Efficiency of Adeno-Associated Virus Gene Therapy Clinical Trial Startup
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Published in Human gene therapy (01.10.2020)
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Enhanced clearance of Aβ in brain by sustaining the plasmin proteolysis cascade
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Published in Proceedings of the National Academy of Sciences - PNAS (24.06.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (24.06.2008)
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Tool support for implementing a methodology in magnet development projects at CERN
Kaeske, Jens, Wagner, Erik, Albers, Albert, Russenschuck, Stephan
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Regional oral absorption, hepatic first-pass effect, and non-linear disposition of salmon calcitonin in beagle dogs
Hee Lee, Yong, Leesman, Glen D, Makhey, Vijaya, Yu, Hongshi, Hu, Peidi, Perry, Barbara, Sutyak, John P, Wagner, Erik J, Falzone, Lisa M, Stern, William, Sinko, Patrick J
Published in European journal of pharmaceutics and biopharmaceutics (01.09.2000)
Published in European journal of pharmaceutics and biopharmaceutics (01.09.2000)
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Design and Synthesis of 5,5′-Disubstituted Aminohydantoins as Potent and Selective Human β-Secretase (BACE1) Inhibitors
Malamas, Michael S, Erdei, Jim, Gunawan, Iwan, Turner, Jim, Hu, Yun, Wagner, Erik, Fan, Kristi, Chopra, Rajiv, Olland, Andrea, Bard, Jonathan, Jacobsen, Steve, Magolda, Ronald L, Pangalos, Menelas, Robichaud, Albert J
Published in Journal of medicinal chemistry (11.02.2010)
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Successfully Navigating Food and Drug Administration Orphan Drug and Rare Pediatric Disease Designations for AAV9-hPCCA Gene Therapy: The National Institutes of Health Platform Vector Gene Therapy Experience
Lomash, Richa Madan, Shchelochkov, Oleg, Chandler, Randy J, Venditti, Charles P, Pariser, Anne R, Ottinger, Elizabeth A
Published in Human gene therapy (01.03.2023)
Published in Human gene therapy (01.03.2023)
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Aminoimidazoles as Potent and Selective Human β-Secretase (BACE1) Inhibitors
Malamas, Michael S, Erdei, Jim, Gunawan, Iwan, Barnes, Keith, Johnson, Matthew, Hui, Yu, Turner, Jim, Hu, Yun, Wagner, Erik, Fan, Kristi, Olland, Andrea, Bard, Jonathan, Robichaud, Albert J
Published in Journal of medicinal chemistry (22.10.2009)
Published in Journal of medicinal chemistry (22.10.2009)
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Utility of pharmacodynamic measures for assessing the oral bioavailability of peptides. 1. Administration of recombinant salmon calcitonin in rats
Sinko, P J, Smith, C L, McWhorter, L T, Stern, W, Wagner, E, Gilligan, J P
Published in Journal of pharmaceutical sciences (01.11.1995)
Published in Journal of pharmaceutical sciences (01.11.1995)
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Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease
Martone, Robert L, Zhou, Hua, Atchison, Kevin, Comery, Thomas, Xu, Jane Z, Huang, Xinyi, Gong, Xioahai, Jin, Mei, Kreft, Anthony, Harrison, Boyd, Mayer, Scott C, Aschmies, Suzan, Gonzales, Cathleen, Zaleska, Margaret M, Riddell, David R, Wagner, Erik, Lu, Peimin, Sun, Shaiu-Ching, Sonnenberg-Reines, June, Oganesian, Aram, Adkins, Karissa, Leach, Michael W, Clarke, David W, Huryn, Donna, Abou-Gharbia, Magid, Magolda, Ronald, Bard, Jonathan, Frick, Glen, Raje, Sangeeta, Forlow, S Bradley, Balliet, Carrie, Burczynski, Michael E, Reinhart, Peter H, Wan, Hong I, Pangalos, Menelas N, Jacobsen, J Steven
Published in The Journal of pharmacology and experimental therapeutics (01.11.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2009)
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Design and synthesis of aminohydantoins as potent and selective human β-secretase (BACE1) inhibitors with enhanced brain permeability
Malamas, Michael S., Robichaud, Albert, Erdei, Jim, Quagliato, Dominick, Solvibile, William, Zhou, Ping, Morris, Koi, Turner, Jim, Wagner, Erik, Fan, Kristi, Olland, Andrea, Jacobsen, Steve, Reinhart, Peter, Riddell, David, Pangalos, Menelas
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
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Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease
Mayer, Scott C, Kreft, Anthony F, Harrison, Boyd, Abou-Gharbia, Magid, Antane, Madelene, Aschmies, Suzan, Atchison, Kevin, Chlenov, Michael, Cole, Derek C, Comery, Thomas, Diamantidis, George, Ellingboe, John, Fan, Kristi, Galante, Rocco, Gonzales, Cathleen, Ho, Douglas M, Hoke, Molly E, Hu, Yun, Huryn, Donna, Jain, Uday, Jin, Mei, Kremer, Kenneth, Kubrak, Dennis, Lin, Melissa, Lu, Peimin, Magolda, Ron, Martone, Robert, Moore, William, Oganesian, Aram, Pangalos, Menelas N, Porte, Alex, Reinhart, Peter, Resnick, Lynn, Riddell, David R, Sonnenberg-Reines, June, Stock, Joseph R, Sun, Shaiu-Ching, Wagner, Erik, Wang, Ting, Woller, Kevin, Xu, Zheng, Zaleska, Margaret M, Zeldis, Joseph, Zhang, Minsheng, Zhou, Hua, Jacobsen, J. Steven
Published in Journal of medicinal chemistry (11.12.2008)
Published in Journal of medicinal chemistry (11.12.2008)
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Di-substituted pyridinyl aminohydantoins as potent and highly selective human β-secretase (BACE1) inhibitors
Malamas, Michael S., Barnes, Keith, Johnson, Matthew, Hui, Yu, Zhou, Ping, Turner, Jim, Hu, Yun, Wagner, Erik, Fan, Kristi, Chopra, Rajiv, Olland, Andrea, Bard, Jonathan, Pangalos, Menelas, Reinhart, Peter, Robichaud, Albert J.
Published in Bioorganic & medicinal chemistry (15.01.2010)
Published in Bioorganic & medicinal chemistry (15.01.2010)
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Acylguanidines as Small-Molecule β-Secretase Inhibitors
Cole, Derek C, Manas, Eric S, Stock, Joseph R, Condon, Jeffrey S, Jennings, Lee D, Aulabaugh, Ann, Chopra, Rajiv, Cowling, Rebecca, Ellingboe, John W, Fan, Kristi Y, Harrison, Boyd L, Hu, Yun, Jacobsen, Steve, Jin, Guixan, Lin, Laura, Lovering, Frank E, Malamas, Michael S, Stahl, Mark L, Strand, James, Sukhdeo, Mohani N, Svenson, Kristine, Turner, M. James, Wagner, Erik, Wu, Junjun, Zhou, Ping, Bard, Jonathan
Published in Journal of medicinal chemistry (19.10.2006)
Published in Journal of medicinal chemistry (19.10.2006)
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Thiophene substituted acylguanidines as BACE1 inhibitors
Fobare, William F., Solvibile, William R., Robichaud, Albert J., Malamas, Michael S., Manas, Eric, Turner, Jim, Hu, Yun, Wagner, Erik, Chopra, Rajiv, Cowling, Rebecca, Jin, Guixan, Bard, Jonathan
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
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