Discovery and initial optimization of 5,5′-disubstituted aminohydantoins as potent β-secretase (BACE1) inhibitors
Nowak, Pawel, Cole, Derek C., Aulabaugh, Ann, Bard, Jonathan, Chopra, Rajiv, Cowling, Rebecca, Fan, Kristi Y., Hu, Baihua, Jacobsen, Steve, Jani, Minakshi, Jin, Guixan, Lo, Mei-Chu, Malamas, Michael S., Manas, Eric S., Narasimhan, Rani, Reinhart, Peter, Robichaud, Albert J., Stock, Joseph R., Subrath, Joan, Svenson, Kristine, Turner, Jim, Wagner, Erik, Zhou, Ping, Ellingboe, John W.
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Get full text
Journal Article
Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the S 1 ′ substrate binding pocket
Jennings, Lee D., Cole, Derek C., Stock, Joseph R., Sukhdeo, Mohani N., Ellingboe, John W., Cowling, Rebecca, Jin, Guixian, Manas, Eric S., Fan, Kristi Y., Malamas, Michael S., Harrison, Boyd L., Jacobsen, Steve, Chopra, Rajiv, Lohse, Peter A., Moore, William J., O’Donnell, Mary-Margaret, Hu, Yun, Robichaud, Albert J., Turner, M. James, Wagner, Erik, Bard, Jonathan
Published in Bioorganic & medicinal chemistry letters (15.01.2008)
Published in Bioorganic & medicinal chemistry letters (15.01.2008)
Get full text
Journal Article
Acylguanidine inhibitors of β-secretase : Optimization of the pyrrole ring substituents extending into the S'1 substrate binding pocket
JENNINGS, Lee D, COLE, Derek C, HARRISON, Boyd L, JACOBSEN, Steve, CHOPRA, Rajiv, LOHSE, Peter A, MOORE, William J, O'DONNELL, Mary-Margaret, YUN HU, ROBICHAUD, Albert J, TURNER, M. James, WAGNER, Erik, STOCK, Joseph R, BARD, Jonathan, SUKHDEO, Mohani N, ELLINGBOE, John W, COWLING, Rebecca, GUIXIAN JIN, MANAS, Eric S, FAN, Kristi Y, MALAMAS, Michael S
Published in Bioorganic & medicinal chemistry letters (15.01.2008)
Published in Bioorganic & medicinal chemistry letters (15.01.2008)
Get full text
Journal Article
Corrections to Aminoimidazoles as Potent and Selective Human β-Secretase (BACE1) Inhibitors
Malamas, Michael S, Erdei, Jim, Gunawan, Iwan, Barnes, Keith, Johnson, Matthew, Hui, Yu, Turner, Jim, Hu, Yun, Wagner, Erik, Fan, Kristi, Olland, Andrea, Bard, Jonathan, Robichaud, Albert J
Published in Journal of medicinal chemistry (25.02.2010)
Published in Journal of medicinal chemistry (25.02.2010)
Get full text
Journal Article
Discovery of a novel series of Notch-sparing γ-secretase inhibitors
Kreft, Anthony, Harrison, Boyd, Aschmies, Suzan, Atchison, Kevin, Casebier, David, Cole, Derek C., Diamantidis, George, Ellingboe, John, Hauze, Diane, Hu, Yun, Huryn, Donna, Jin, Mei, Kubrak, Dennis, Lu, Peimin, Lundquist, Joseph, Mann, Charles, Martone, Robert, Moore, William, Oganesian, Aram, Porte, Alex, Riddell, Dave R., Sonnenberg-Reines, June, Stock, Joseph R., Sun, Shaiu-Ching, Wagner, Erik, Woller, Kevin, Xu, Zheng, Zhou, Hua, Steven Jacobsen, J.
Published in Bioorganic & medicinal chemistry (15.07.2008)
Published in Bioorganic & medicinal chemistry (15.07.2008)
Get full text
Journal Article
( S) -N-(5-Chlorothiophene-2-sulfonyl)-β,β-diethylalaninol a Notch-1-sparing γ-secretase inhibitor
Cole, Derek C., Stock, Joseph R., Kreft, Anthony F., Antane, Madelene, Aschmies, Suzan H., Atchison, Kevin P., Casebier, David S., Comery, Thomas A., Diamantidis, George, Ellingboe, John W., Harrison, Boyd L., Hu, Yun, Jin, Mei, Kubrak, Dennis M., Lu, Peimin, Mann, Charles W., Martone, Robert L., Moore, William J., Oganesian, Aram, Riddell, David R., Sonnenberg-Reines, June, Sun, Shaiu-Ching, Wagner, Erik, Wang, Zheng, Woller, Kevin R., Xu, Zheng, Zhou, Hua, Jacobsen, J. Steven
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
Get full text
Journal Article
Synthesis and structure–activity relationship of a novel series of heterocyclic sulfonamide γ-secretase inhibitors
Pu, Jun, Kreft, Anthony F., Aschmies, Suzan H., Atchison, Kevin P., Berkowitz, Joshua, Caggiano, Thomas J., Chlenov, Micheal, Diamantidis, George, Harrison, Boyd L., Hu, Yun, Huryn, Donna, Steven Jacobsen, J., Jin, Mei, Lipinski, Kerri, Lu, Peimin, Martone, Robert L., Morris, Koi, Sonnenberg-Reines, June, Riddell, Dave R., Sabalski, Joan, Sun, Shaiu-Ching, Wagner, Erik, Wang, Yiqun, Xu, Zheng, Zhou, Hua, Resnick, Lynn
Published in Bioorganic & medicinal chemistry (01.07.2009)
Published in Bioorganic & medicinal chemistry (01.07.2009)
Get full text
Journal Article
Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent b-secretase (BACE1) inhibitors
Nowak, Pawel, Cole, Derek C, Aulabaugh, Ann, Bard, Jonathan, Chopra, Rajiv, Cowling, Rebecca, Fan, Kristi Y, Hu, Baihua, Jacobsen, Steve, Jani, Minakshi, Jin, Guixan, Lo, Mei-Chu, Malamas, Michael S, Manas, Eric S, Narasimhan, Rani, Reinhart, Peter, Robichaud, Albert J, Stock, Joseph R, Subrath, Joan, Svenson, Kristine, Turner, Jim, Wagner, Erik, Zhou, Ping, Ellingboe, John W
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Get full text
Journal Article
Begacestat (GSI-953): A Novel, Selective Thiophene Sulfonamide Inhibitor of Amyloid Precursor Protein γ-Secretase for the Treatment of Alzheimer's Disease
Robert L. Martone, Hua Zhou, Kevin Atchison, Thomas Comery, Jane Z. Xu, Xinyi Huang, Xioahai Gong, Mei Jin, Anthony Kreft, Boyd Harrison, Scott C. Mayer, Suzan Aschmies, Cathleen Gonzales, Margaret M. Zaleska, David R. Riddell, Erik Wagner, Peimin Lu, Shaiu-Ching Sun, June Sonnenberg-Reines, Aram Oganesian, Karissa Adkins, Michael W. Leach, David W. Clarke, Donna Huryn, Magid Abou-Gharbia, Ronald Magolda, Jonathan Bard, Glen Frick, Sangeeta Raje, S. Bradley Forlow, Carrie Balliet, Michael E. Burczynski, Peter H. Reinhart, Hong I. Wan, Menelas N. Pangalos, J. Steven Jacobsen
Published in The Journal of pharmacology and experimental therapeutics (01.11.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2009)
Get full text
Journal Article
Enhanced clearance of A[beta] in brain by sustaining the plasmin proteolysis cascade
Jacobsen, J Steven, Comery, Thomas A, Martone, Robert L, Elokdah, Hassan, Crandall, David L, Oganesian, Aram, Aschmies, Suzan, Kirksey, Yolanda, Gonzales, Cathleen, Xu, Jane, Zhou, Hua, Atchison, Kevin, Wagner, Erik, Zaleska, Margaret M, Das, Indranil, Arias, Robert L, Bard, Jonathan, Riddell, David, Gardell, Stephen J, Abou-Gharbia, Magid, Robichaud, Albert, Magolda, Ronald, Vlasuk, George P, Bjornsson, Thorir, Reinhart, Peter H, Pangalos, Menelas N
Published in Proceedings of the National Academy of Sciences - PNAS (24.06.2008)
Get full text
Published in Proceedings of the National Academy of Sciences - PNAS (24.06.2008)
Journal Article
SIMPLIFIED MESSAGE GROUPING AND DISPLAY
Wu, William, Murray, Michael Brian, Wagner, Erik, Samaranayake, Chamal
Year of Publication 28.04.2022
Get full text
Year of Publication 28.04.2022
Patent