Search Results - "Ericson, Mark D" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

The melanocortin pathway and energy homeostasis: From discovery to obesity therapy

The melanocortin pathway and energy homeostasis: From discovery to obesity therapy

by Yeo, Giles S.H., Chao, Daniela Herrera Moro, Siegert, Anna-Maria, Koerperich, Zoe M., Ericson, Mark D., Simonds, Stephanie E., Larson, Courtney M., Luquet, Serge, Clarke, Iain, Sharma, Shubh, Clément, Karine, Cowley, Michael A., Haskell-Luevano, Carrie, Van Der Ploeg, Lex, Adan, Roger A.H.
Published in Molecular metabolism (Germany) (01.06.2021)

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The Parallel Structure-Activity Relationship Screening of Three Compounds Identifies the Common Agonist Pharmacophore of Pyrrolidine Bis-Cyclic Guanidine Melanocortin-3 Receptor (MC3R) Small-Molecule Ligands

The Parallel Structure-Activity Relationship Screening of Three Compounds Identifies the Common Agonist Pharmacophore of Pyrrolidine Bis-Cyclic Guanidine Melanocortin-3 Receptor (MC3R) Small-Molecule Ligands

by Ericson, Mark D, Freeman, Katie T, LaVoi, Travis M, Donow, Haley M, Santos, Radleigh G, Giulianotti, Marc A, Pinilla, Clemencia, Houghten, Richard A, Haskell-Luevano, Carrie
Published in International journal of molecular sciences (14.06.2023)

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PEG length and chemical linkage controls polyacridine peptide DNA polyplex pharmacokinetics, biodistribution, metabolic stability and in vivo gene expression

PEG length and chemical linkage controls polyacridine peptide DNA polyplex pharmacokinetics, biodistribution, metabolic stability and in vivo gene expression

by Khargharia, Sanjib, Kizzire, Koby, Ericson, Mark D., Baumhover, Nicholas J., Rice, Kevin G.
Published in Journal of controlled release (28.09.2013)

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Structure–Activity Relationships of the Tetrapeptide Ac-His-Arg-(pI)DPhe-Tic-NH2 at the Mouse Melanocortin Receptors: Modification at the (pI)DPhe Position Leads to mMC3R Versus mMC4R Selective Ligands

Structure–Activity Relationships of the Tetrapeptide Ac-His-Arg-(pI)DPhe-Tic-NH2 at the Mouse Melanocortin Receptors: Modification at the (pI)DPhe Position Leads to mMC3R Versus mMC4R Selective Ligands

by Schlasner, Katherine N., Ericson, Mark D., Doering, Skye R., Freeman, Katie T., Weinrich, Mary, Haskell-Luevano, Carrie
Published in Molecules (Basel, Switzerland) (13.04.2019)

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Bench-top to clinical therapies: A review of melanocortin ligands from 1954 to 2016

Bench-top to clinical therapies: A review of melanocortin ligands from 1954 to 2016

by Ericson, Mark D., Lensing, Cody J., Fleming, Katlyn A., Schlasner, Katherine N., Doering, Skye R., Haskell-Luevano, Carrie
Published in Biochimica et biophysica acta (01.10.2017)

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A Review of Single-Nucleotide Polymorphisms in Orexigenic Neuropeptides Targeting G Protein-Coupled Receptors

A Review of Single-Nucleotide Polymorphisms in Orexigenic Neuropeptides Targeting G Protein-Coupled Receptors

by Ericson, Mark D, Haskell-Luevano, Carrie
Published in ACS chemical neuroscience (20.06.2018)

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Synthesis and Pharmacological Characterization of Adrenocorticotropic Hormone (ACTH 1–24) and C-Terminal Truncated Analogues Identifies the Minimal ACTH N-Terminal Fragment Required for Melanocorton-2 Receptor Activation

Synthesis and Pharmacological Characterization of Adrenocorticotropic Hormone (ACTH 1–24) and C-Terminal Truncated Analogues Identifies the Minimal ACTH N-Terminal Fragment Required for Melanocorton-2 Receptor Activation

by Todorovic, Aleksandar, Ericson, Mark D., Gridley, Kelly, Sorenson, Nicholas B., Haskell-Luevano, Carrie
Published in International journal of peptide research and therapeutics (30.10.2024)

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Discovery of a β‑Hairpin Octapeptide, c[Pro-Arg-Phe-Phe-Dap-Ala-Phe-DPro], Mimetic of Agouti-Related Protein(87–132) [AGRP(87–132)] with Equipotent Mouse Melanocortin‑4 Receptor (mMC4R) Antagonist Pharmacology

Discovery of a β‑Hairpin Octapeptide, c[Pro-Arg-Phe-Phe-Dap-Ala-Phe-DPro], Mimetic of Agouti-Related Protein(87–132) [AGRP(87–132)] with Equipotent Mouse Melanocortin‑4 Receptor (mMC4R) Antagonist Pharmacology

by Ericson, Mark D, Wilczynski, Andrzej, Sorensen, Nicholas B, Xiang, Zhimin, Haskell-Luevano, Carrie
Published in Journal of medicinal chemistry (11.06.2015)

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Discovery of a Pan-Melanocortin Receptor Antagonist [Ac-DPhe(pI)-Arg-Nal(2′)-Orn-NH2] at the MC1R, MC3R, MC4R, and MC5R that Mediates an Increased Feeding Response in Mice and a 40-Fold Selective MC1R Antagonist [Ac-DPhe(pI)-DArg-Nal(2′)-Arg-NH2]

Discovery of a Pan-Melanocortin Receptor Antagonist [Ac-DPhe(pI)-Arg-Nal(2′)-Orn-NH2] at the MC1R, MC3R, MC4R, and MC5R that Mediates an Increased Feeding Response in Mice and a 40-Fold Selective MC1R Antagonist [Ac-DPhe(pI)-DArg-Nal(2′)-Arg-NH2]

by Ericson, Mark D., Tran, Linh T., Mathre, Sarah S., Freeman, Katie T., Holdaway, Kelsey, John, Kristen, Lunzer, Mary M., Bouchard, Jacob L., Haskell-Luevano, Carrie
Published in Journal of medicinal chemistry (22.06.2023)

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Synergistic Multiresidue Substitutions of a Macrocyclic c[Pro-Arg-Phe-Phe-Asn-Ala-Phe‑dPro] Agouti-Related Protein (AGRP) Scaffold Yield Potent and >600-Fold MC4R versus MC3R Selective Melanocortin Receptor Antagonists

Synergistic Multiresidue Substitutions of a Macrocyclic c[Pro-Arg-Phe-Phe-Asn-Ala-Phe‑dPro] Agouti-Related Protein (AGRP) Scaffold Yield Potent and >600-Fold MC4R versus MC3R Selective Melanocortin Receptor Antagonists

by Fleming, Katlyn A, Freeman, Katie T, Ericson, Mark D, Haskell-Luevano, Carrie
Published in Journal of medicinal chemistry (13.09.2018)

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Correction to “Discovery of Nanomolar Melanocortin‑3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High Throughput ‘Unbiased’ Screening Campaign”

Correction to “Discovery of Nanomolar Melanocortin‑3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High Throughput ‘Unbiased’ Screening Campaign”

by Doering, Skye R., Freeman, Katie, Debevec, Ginamarie, Geer, Phaedra, Santos, Radleigh G., Lavoi, Travis M., Giulianotti, Marc A., Pinilla, Clemencia, Appel, Jon R., Houghten, Richard A., Ericson, Mark D., Haskell-Luevano, Carrie
Published in Journal of medicinal chemistry (25.05.2023)

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Structure–Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin‑4 Receptor Antagonist Potency and Result in Inverse Agonist Pharmacology at the Melanocortin‑5 Receptor

Structure–Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin‑4 Receptor Antagonist Potency and Result in Inverse Agonist Pharmacology at the Melanocortin‑5 Receptor

by Ericson, Mark D, Freeman, Katie T, Schnell, Sathya M, Fleming, Katlyn A, Haskell-Luevano, Carrie
Published in Journal of medicinal chemistry (12.10.2017)

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A fragment of the Escherichia coli ClpB heat-shock protein is a micromolar melanocortin 1 receptor agonist

A fragment of the Escherichia coli ClpB heat-shock protein is a micromolar melanocortin 1 receptor agonist

by Ericson, Mark D., Schnell, Sathya M., Freeman, Katie T., Haskell-Luevano, Carrie
Published in Bioorganic & medicinal chemistry letters (15.11.2015)

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Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AgRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe‑dPro] Decreases Melanocortin‑4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin‑5 Receptor Antagonists

Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AgRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe‑dPro] Decreases Melanocortin‑4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin‑5 Receptor Antagonists

by Koerperich, Zoe M, Ericson, Mark D, Freeman, Katie T, Speth, Robert C, Pogozheva, Irina D, Mosberg, Henry I, Haskell-Luevano, Carrie
Published in Journal of medicinal chemistry (12.03.2020)

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Peptoid NPhe4 in AGRP-Based c[Pro1‑Arg2‑Phe3‑Phe4‑Xxx5‑Ala6‑Phe7‑DPro8] Scaffolds Maintain Mouse MC4R Antagonist Potency

Peptoid NPhe4 in AGRP-Based c[Pro1‑Arg2‑Phe3‑Phe4‑Xxx5‑Ala6‑Phe7‑DPro8] Scaffolds Maintain Mouse MC4R Antagonist Potency

by Ericson, Mark D, Freeman, Katie T, Haskell-Luevano, Carrie
Published in ACS medicinal chemistry letters (08.10.2020)

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Discovery of Nanomolar Melanocortin‑3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput “Unbiased” Screening Campaign

Discovery of Nanomolar Melanocortin‑3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput “Unbiased” Screening Campaign

by Doering, Skye R, Freeman, Katie, Debevec, Ginamarie, Geer, Phaedra, Santos, Radleigh G, Lavoi, Travis M, Giulianotti, Marc A, Pinilla, Clemencia, Appel, Jon R, Houghten, Richard A, Ericson, Mark D, Haskell-Luevano, Carrie
Published in Journal of medicinal chemistry (13.05.2021)

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Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin‑4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist

Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin‑4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist

by Ericson, Mark D, Doering, Skye R, Larson, Courtney M, Freeman, Katie T, LaVoi, Travis M, Donow, Haley M, Santos, Radleigh G, Cho, Rachel H, Koerperich, Zoe M, Giulianotti, Marc A, Pinilla, Clemencia, Houghten, Richard A, Haskell-Luevano, Carrie
Published in Journal of medicinal chemistry (14.10.2021)

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A Macrocyclic Agouti-Related Protein/[Nle4,DPhe7]α-Melanocyte Stimulating Hormone Chimeric Scaffold Produces Subnanomolar Melanocortin Receptor Ligands

A Macrocyclic Agouti-Related Protein/[Nle4,DPhe7]α-Melanocyte Stimulating Hormone Chimeric Scaffold Produces Subnanomolar Melanocortin Receptor Ligands

by Ericson, Mark D, Freeman, Katie T, Schnell, Sathya M, Haskell-Luevano, Carrie
Published in Journal of medicinal chemistry (26.01.2017)

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Multiresidue Tetrapeptide Substitutions Yield a 140-fold Selective Melanocortin-3 over Melanocortin-4 Receptor Agonist

Multiresidue Tetrapeptide Substitutions Yield a 140-fold Selective Melanocortin-3 over Melanocortin-4 Receptor Agonist

by Ericson, Mark D., Shaikh, Romessa, Larson, Courtney M., Freeman, Katie T., Haskell-Luevano, Carrie
Published in ACS medicinal chemistry letters (14.01.2021)

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Single Nucleotide Polymorphisms in the Melanocortin His-Phe-Arg-Trp Sequences Decrease Tetrapeptide Potency and Efficacy

Single Nucleotide Polymorphisms in the Melanocortin His-Phe-Arg-Trp Sequences Decrease Tetrapeptide Potency and Efficacy

by Winget, Marshall D, Ericson, Mark D, Freeman, Katie T, Haskell-Luevano, Carrie
Published in ACS medicinal chemistry letters (12.03.2020)

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