Phase 1/2 Study of Lumasiran for Treatment of Primary Hyperoxaluria Type 1: A Placebo-Controlled Randomized Clinical Trial
Frishberg, Yaacov, Deschênes, Georges, Groothoff, Jaap W, Hulton, Sally-Anne, Magen, Daniella, Harambat, Jérôme, Van't Hoff, William G, Lorch, Ulrike, Milliner, Dawn S, Lieske, John C, Haslett, Patrick, Garg, Pushkal P, Vaishnaw, Akshay K, Talamudupula, Sandeep, Lu, Jiandong, Habtemariam, Bahru A, Erbe, David V, McGregor, Tracy L, Cochat, Pierre
Published in Clinical journal of the American Society of Nephrology (01.07.2021)
Published in Clinical journal of the American Society of Nephrology (01.07.2021)
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Journal Article
An Investigational RNAi Therapeutic Targeting Glycolate Oxidase Reduces Oxalate Production in Models of Primary Hyperoxaluria
Liebow, Abigail, Li, Xingsheng, Racie, Timothy, Hettinger, Julia, Bettencourt, Brian R, Najafian, Nader, Haslett, Patrick, Fitzgerald, Kevin, Holmes, Ross P, Erbe, David, Querbes, William, Knight, John
Published in Journal of the American Society of Nephrology (01.02.2017)
Published in Journal of the American Society of Nephrology (01.02.2017)
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Journal Article
Characterising a healthy adult with a rare HAO1 knockout to support a therapeutic strategy for primary hyperoxaluria
McGregor, Tracy L, Hunt, Karen A, Yee, Elaine, Mason, Dan, Nioi, Paul, Ticau, Simina, Pelosi, Marissa, Loken, Perry R, Finer, Sarah, Lawlor, Deborah A, Fauman, Eric B, Huang, Qin Qin, Griffiths, Christopher J, MacArthur, Daniel G, Trembath, Richard C, Oglesbee, Devin, Lieske, John C, Erbe, David V, Wright, John, van Heel, David A
Published in eLife (24.03.2020)
Published in eLife (24.03.2020)
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Crystal Structure of an HSA/FcRn Complex Reveals Recycling by Competitive Mimicry of HSA Ligands at a pH-Dependent Hydrophobic Interface
Schmidt, Michael M., Townson, Sharon A., Andreucci, Amy J., King, Bracken M., Schirmer, Emily B., Murillo, Alec J., Dombrowski, Christian, Tisdale, Alison W., Lowden, Patricia A., Masci, Allyson L., Kovalchin, Joseph T., Erbe, David V., Wittrup, K. Dane, Furfine, Eric S., Barnes, Thomas M.
Published in Structure (London) (05.11.2013)
Published in Structure (London) (05.11.2013)
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Journal Article
A zymogen-like factor Xa variant corrects the coagulation defect in hemophilia
Camire, Rodney M, Ivanciu, Lacramioara, Toso, Raffaella, Margaritis, Paris, Pavani, Giulia, Kim, Haein, Schlachterman, Alexander, Liu, Jian-Hua, Clerin, Valerie, Pittman, Debra D, Rose-Miranda, Rosalind, Shields, Kathleen M, Erbe, David V, Tobin, James F, Arruda, Valder R
Published in Nature biotechnology (01.11.2011)
Published in Nature biotechnology (01.11.2011)
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Association of the transthyretin variant V122I with polyneuropathy among individuals of African ancestry
Parker, Margaret M, Damrauer, Scott M, Tcheandjieu, Catherine, Erbe, David, Aldinc, Emre, Hawkins, Philip N, Gillmore, Julian D, Hull, Leland E, Lynch, Julie A, Joseph, Jacob, Ticau, Simina, Flynn-Carroll, Alexander O, Deaton, Aimee M, Ward, Lucas D, Assimes, Themistocles L, Tsao, Philip S, Chang, Kyong-Mi, Rader, Daniel J, Fitzgerald, Kevin, Vaishnaw, Akshay K, Hinkle, Gregory, Nioi, Paul
Published in Scientific reports (02.06.2021)
Published in Scientific reports (02.06.2021)
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Journal Article
Structure-Based Optimization of Protein Tyrosine Phosphatase 1B Inhibitors: From the Active Site to the Second Phosphotyrosine Binding Site
Wilson, Douglas P, Wan, Zhao-Kui, Xu, Wei-Xin, Kirincich, Steven J, Follows, Bruce C, Joseph-McCarthy, Diane, Foreman, Kenneth, Moretto, Alessandro, Wu, Junjun, Zhu, Min, Binnun, Eva, Zhang, Yan-Ling, Tam, May, Erbe, David V, Tobin, James, Xu, Xin, Leung, Louis, Shilling, Adam, Tam, Steve Y, Mansour, Tarek S, Lee, Jinbo
Published in Journal of medicinal chemistry (20.09.2007)
Published in Journal of medicinal chemistry (20.09.2007)
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Journal Article
Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent
Artis, Dean R, Lin, Jack J, Zhang, Chao, Wang, Weiru, Mehra, Upasana, Perreault, Mylene, Erbe, David, Krupka, Heike I, England, Bruce P, Arnold, James, Plotnikov, Alexander N, Marimuthu, Adhirai, Nguyen, Hoa, Will, Sarah, Signaevsky, Maxime, Kral, John, Cantwell, John, Settachatgull, Calvin, Yan, Douglas S, Fong, Daniel, Oh, Angela, Shi, Shenghua, Womack, Patrick, Powell, Benjamin, Habets, Gaston, West, Brian L, Zhang, Kam Y.J, Milburn, Michael V, Vlasuk, George P, Hirth, K. Peter, Nolop, Keith, Bollag, Gideon, Ibrahim, Prabha N, Tobin, James F
Published in Proceedings of the National Academy of Sciences - PNAS (06.01.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (06.01.2009)
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Journal Article
Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses
Somers, William S, Stamper, Carin C, Zhang, Yan, Tobin, James F, Erbe, David V, Ikemizu, Shinji, Davis, Simon J, Stahl, Mark L, Seehra, Jasbir, Mosyak, Lidia
Published in Nature (London) (29.03.2001)
Published in Nature (London) (29.03.2001)
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Journal Article
Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: Capturing interactions with Asp48
Wan, Zhao-Kui, Lee, Jinbo, Xu, Weixin, Erbe, David V., Joseph-McCarthy, Diane, Follows, Bruce C., Zhang, Yan-Ling
Published in Bioorganic & medicinal chemistry letters (15.09.2006)
Published in Bioorganic & medicinal chemistry letters (15.09.2006)
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Journal Article
Ertiprotafib Improves Glycemic Control and Lowers Lipids via Multiple Mechanisms
Erbe, David V, Wang, Suyue, Zhang, Yan-Ling, Harding, Kimberly, Kung, Leslie, Tam, May, Stolz, Leslie, Xing, Yuzhe, Furey, Sarah, Qadri, Ariful, Klaman, Lori D, Tobin, James F
Published in Molecular pharmacology (01.01.2005)
Published in Molecular pharmacology (01.01.2005)
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Journal Article
Structure-Based Optimization of Protein Tyrosine Phosphatase-1 B Inhibitors: Capturing Interactions with Arginine 24
Wan, Zhao-Kui, Lee, Jinbo, Hotchandani, Rajeev, Moretto, Alessandro, Binnun, Eva, Wilson, Douglas P., Kirincich, Steve J., Follows, Bruce C., Ipek, Manus, Xu, Weixin, Joseph-McCarthy, Diane, Zhang, Yan-Ling, Tam, May, Erbe, David V., Tobin, James F., Li, Wei, Tam, Steve Y., Mansour, Tarek S., Wu, Junjun
Published in ChemMedChem (20.10.2008)
Published in ChemMedChem (20.10.2008)
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Journal Article
Small Molecule Ligands Define a Binding Site on the Immune Regulatory Protein B7.1
Erbe, David V., Wang, Suyue, Xing, Yuzhe, Tobin, James F.
Published in The Journal of biological chemistry (01.03.2002)
Published in The Journal of biological chemistry (01.03.2002)
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Journal Article
An enzyme-linked immunosorbent assay to measure insulin receptor dephosphorylation by PTP1B
Zhang, Yan-Ling, Tam, May, Kirincich, Steve, Wan, Zhao-Kui, Wilson, Doug, Wu, Jun Jun, Lee, Jinbo, Tobin, James F., Erbe, David V.
Published in Analytical biochemistry (15.06.2007)
Published in Analytical biochemistry (15.06.2007)
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Journal Article
Reduction in urinary oxalate excretion in mouse models of Primary Hyperoxaluria by RNA interference inhibition of liver lactate dehydrogenase activity
Wood, Kyle D., Holmes, Ross P., Erbe, David, Liebow, Abigail, Fargue, Sonia, Knight, John
Published in Biochimica et biophysica acta. Molecular basis of disease (01.09.2019)
Published in Biochimica et biophysica acta. Molecular basis of disease (01.09.2019)
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Journal Article
Activation of PPARγ by Sartans
Erbe, David V., Gartrell, Katherine, Will, Sarah, Perreault, Mylene, Wang, Suyue, Tobin, James F.
Published in Drug development research (01.07.2006)
Published in Drug development research (01.07.2006)
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Journal Article
Conference Proceeding
Neurofilament Light Chain as a Biomarker of Hereditary Transthyretin-Mediated Amyloidosis
Ticau, Simina, Sridharan, Gautham V, Tsour, Shira, Cantley, William L, Chan, Amy, Gilbert, Jason A, Erbe, David, Aldinc, Emre, Reilly, Mary M, Adams, David, Polydefkis, Michael, Fitzgerald, Kevin, Vaishnaw, Akshay, Nioi, Paul
Published in Neurology (19.01.2021)
Published in Neurology (19.01.2021)
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Journal Article
P- and E-Selectin Use Common Sites for Carbohydrate Ligand Recognition and Cell Adhesion
Erbe, David V., Watson, Susan R., Presta, Leonard G., Wolitzky, Barry A., Foxall, Carroll, Brandley, Brian K., Lasky, Laurence A.
Published in The Journal of cell biology (01.03.1993)
Published in The Journal of cell biology (01.03.1993)
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