Evaluation of moxifloxacin in canine and non‐human primate telemetry assays: Comparison of QTc interval prolongation by timepoint and concentration‐QTc analysis
Chui, Ray W., Baublits, Joel, Chandra, Fiona A., Jones, Zack W., Engwall, Michael J., Vargas, Hugo M.
Published in Clinical and translational science (01.11.2021)
Published in Clinical and translational science (01.11.2021)
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Evaluation of levocetirizine in beagle dog and cynomolgus monkey telemetry assays: Defining the no QTc effect profile by timepoint and concentration‐QTc analysis
Engwall, Michael J., Baublits, Joel, Chandra, Fiona A., Jones, Zack W., Wahlstrom, Jan, Chui, Ray W., Vargas, Hugo M.
Published in Clinical and translational science (01.03.2023)
Published in Clinical and translational science (01.03.2023)
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Nonclinical strategy considerations for safety pharmacology: evaluation of biopharmaceuticals
Vargas, Hugo M, Amouzadeh, Hamid R, Engwall, Michael J
Published in Expert opinion on drug safety (01.01.2013)
Published in Expert opinion on drug safety (01.01.2013)
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The evaluation of drug-induced changes in cardiac inotropy in dogs: Results from a HESI-sponsored consortium
Guth, Brian D., Chiang, Alan Y., Doyle, Jennifer, Engwall, Michael J., Guillon, Jean-Michel, Hoffmann, Peter, Koerner, John, Mittelstadt, Scott, Ottinger, Sean, Pierson, Jennifer Beck, Pugsley, Michael K., Rossman, Eric I., Walisser, Jacqueline, Sarazan, R. Dustan
Published in Journal of pharmacological and toxicological methods (01.09.2015)
Published in Journal of pharmacological and toxicological methods (01.09.2015)
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Clinical Implications and Translation of an Off-Target Pharmacology Profiling Hit: Adenosine Uptake Inhibition In Vitro
Amouzadeh, Hamid R., Dimery, Isaiah, Werner, Jonathan, Ngarmchamnanrith, Gataree, Engwall, Michael J, Vargas, Hugo M., Arrindell, Deborah
Published in Translational oncology (01.10.2019)
Published in Translational oncology (01.10.2019)
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QT prolongation and proarrhythmia by moxifloxacin: concordance of preclinical models in relation to clinical outcome
Chen, Xian, Cass, Jessica D, Bradley, Jenifer A, Dahm, Corinn M, Sun, Zhuoqian, Kadyszewski, Edmund, Engwall, Michael J, Zhou, Jun
Published in British journal of pharmacology (01.11.2005)
Published in British journal of pharmacology (01.11.2005)
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The in vivo QTc core assay: An evaluation of QTc variability, detection sensitivity and implications for the improvement of conscious dog and non-human primate telemetry studies
Baublits, Joel, Vargas, Hugo M., Engwall, Michael J.
Published in Journal of pharmacological and toxicological methods (01.05.2021)
Published in Journal of pharmacological and toxicological methods (01.05.2021)
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Corrigendum to “The in vivo QTc core assay: An evaluation of QTc variability, detection sensitivity and implications for the improvement of conscious dog and non-human primate telemetry studies” [Journal of Pharmacological and Toxicological Methods 109 (2021) 107067]
Baublits, Joel, Vargas, Hugo M., Engwall, Michael J.
Published in Journal of pharmacological and toxicological methods (01.11.2021)
Published in Journal of pharmacological and toxicological methods (01.11.2021)
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Time for a Fully Integrated Nonclinical–Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective
Vargas, Hugo M., Rolf, Michael G., Wisialowski, Todd A., Achanzar, William, Bahinski, Anthony, Bass, Alan, Benson, Charles T, Chaudhary, Khuram W., Couvreur, Nicolas, Dota, Corina, Engwall, Michael J, Michael Foley, C., Gallacher, David, Greiter‐Wilke, Andrea, Guillon, Jean‐Michel, Guth, Brian, Himmel, Herbert M., Hegele‐Hartung, Christa, Ito, Maki, Jenkinson, Stephen, Chiba, Katsuyoshi, Lagrutta, Armando, Levesque, Paul, Martel, Eric, Okai, Yoshiko, Peri, Ravikumar, Pointon, Amy, Qu, Yusheng, Teisman, Ard, Traebert, Martin, Yoshinaga, Takashi, Gintant, Gary A., Leishman, Derek J., Valentin, Jean‐Pierre
Published in Clinical pharmacology and therapeutics (01.02.2021)
Published in Clinical pharmacology and therapeutics (01.02.2021)
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Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As
Rossman, Eric I., Wisialowski, Todd A., Vargas, Hugo M., Valentin, Jean-Pierre, Rolf, Michael G., Roche, Brian M., Riley, Steve, Pugsley, Michael K., Nichols, Jill, Li, Dingzhou, Leishman, Derek J., Kleiman, Robert B., Greiter-Wilke, Andrea, Gintant, Gary A., Engwall, Michael J., Delaunois, Annie, Authier, Simon
Published in Journal of pharmacological and toxicological methods (01.09.2023)
Published in Journal of pharmacological and toxicological methods (01.09.2023)
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Safety Pharmacology Evaluation of Biopharmaceuticals
Amouzadeh, Hamid R, Engwall, Michael J, Vargas, Hugo M
Published in Handbook of experimental pharmacology (2015)
Published in Handbook of experimental pharmacology (2015)
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The evaluation of endpoint variability and implications for study statistical power and sample size in conscious instrumented dogs
Chiang, Alan Y., Guth, Brian D., Pugsley, Michael K., Foley, C. Michael, Doyle, Jennifer M., Engwall, Michael J., Koerner, John E., Parish, Stanley T., Dustan Sarazan, R.
Published in Journal of pharmacological and toxicological methods (01.07.2018)
Published in Journal of pharmacological and toxicological methods (01.07.2018)
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ILSI–HESI cardiovascular safety subcommittee dataset: An analysis of the statistical properties of QT interval and rate-corrected QT interval (QTc)
Chiang, Alan Y., Bass, Alan S., Cooper, Murray M., Engwall, Michael J., Menton, Ronald G., Thomas, Karluss
Published in Journal of pharmacological and toxicological methods (01.09.2007)
Published in Journal of pharmacological and toxicological methods (01.09.2007)
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Health and environmental sciences institute integrated strategies working group: Update on the evaluation of drug-induced changes in the cardiac inotropy in dogs
Engwall, Michael J., Walisser, Jacqueline A., Saul, Jim, Dustan Sarazan, R., Guth, Brian, Market, Michael, Skinner, Matthew, Guillon, Jean-Michel, Ottinger, Sean, Heyen, Jonathan R., Cools, Frank, Hoffmann, Peter K., Rossman, Eric I., Pierson, Jennifer B.
Published in Journal of pharmacological and toxicological methods (01.11.2014)
Published in Journal of pharmacological and toxicological methods (01.11.2014)
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The effects of carotid body hypocapnia on ventilation in goats
Daristotle, Leighann, Berssenbrugge, Anne D., Engwall, Michael J., Bisgard, Gerald E.
Published in Respiration physiology (01.02.1990)
Published in Respiration physiology (01.02.1990)
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