A novel specific PERK activator reduces toxicity and extends survival in Huntington's disease models
Ganz, Javier, Shacham, Talya, Kramer, Maria, Shenkman, Marina, Eiger, Hagit, Weinberg, Nitai, Iancovici, Ori, Roy, Somnath, Simhaev, Luba, Da’adoosh, Benny, Engel, Hamutal, Perets, Nisim, Barhum, Yael, Portnoy, Moshe, Offen, Daniel, Lederkremer, Gerardo Z.
Published in Scientific reports (23.04.2020)
Published in Scientific reports (23.04.2020)
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Journal Article
Purpurin modulates Tau-derived VQIVYK fibrillization and ameliorates Alzheimer’s disease-like symptoms in animal model
Viswanathan, Guru Krishnakumar, Shwartz, Dana, Losev, Yelena, Arad, Elad, Shemesh, Chen, Pichinuk, Edward, Engel, Hamutal, Raveh, Avi, Jelinek, Raz, Cooper, Itzik, Gosselet, Fabien, Gazit, Ehud, Segal, Daniel
Published in Cellular and molecular life sciences : CMLS (01.07.2020)
Published in Cellular and molecular life sciences : CMLS (01.07.2020)
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Journal Article
Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation
Laor, Dana, Sade, Dorin, Shaham-Niv, Shira, Zaguri, Dor, Gartner, Myra, Basavalingappa, Vasantha, Raveh, Avi, Pichinuk, Edward, Engel, Hamutal, Iwasaki, Keita, Yamamoto, Tatsuyuki, Noothalapati, Hemanth, Gazit, Ehud
Published in Nature communications (08.01.2019)
Published in Nature communications (08.01.2019)
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Journal Article
Structural basis of heterotetrameric assembly and disease mutations in the human cis-prenyltransferase complex
Bar-El, Michal Lisnyansky, Vaňková, Pavla, Yeheskel, Adva, Simhaev, Luba, Engel, Hamutal, Man, Petr, Haitin, Yoni, Giladi, Moshe
Published in Nature communications (19.10.2020)
Published in Nature communications (19.10.2020)
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Journal Article
Integrating in vitro and in silico approaches to evaluate the “dual functionality” of palmatine chloride in inhibiting and disassembling Tau-derived VQIVYK peptide fibrils
Haj, Esraa, Losev, Yelena, Guru KrishnaKumar, V., Pichinuk, Edward, Engel, Hamutal, Raveh, Avi, Gazit, Ehud, Segal, Daniel
Published in Biochimica et biophysica acta. General subjects (01.07.2018)
Published in Biochimica et biophysica acta. General subjects (01.07.2018)
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Journal Article
TOR Complex 2- independent mutations in the regulatory PIF pocket of Gad8AKT1/SGK1 define separate branches of the stress response mechanisms in fission yeast
Pataki, Emese, Simhaev, Luba, Engel, Hamutal, Cohen, Adiel, Kupiec, Martin, Weisman, Ronit
Published in PLoS genetics (01.11.2020)
Published in PLoS genetics (01.11.2020)
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Journal Article
Real-Time Imaging of the Azole Class of Antifungal Drugs in Live Candida Cells
Benhamou, Raphael I, Bibi, Maayan, Steinbuch, Kfir B, Engel, Hamutal, Levin, Maayan, Roichman, Yael, Berman, Judith, Fridman, Micha
Published in ACS chemical biology (21.07.2017)
Published in ACS chemical biology (21.07.2017)
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Journal Article
Classical and Quantum Modeling of Li and Na Diffusion in FePO4
Dixit, Mudit, Engel, Hamutal, Eitan, Reuven, Aurbach, Doron, Levi, Mikhael D, Kosa, Monica, Major, Dan Thomas
Published in Journal of physical chemistry. C (16.07.2015)
Published in Journal of physical chemistry. C (16.07.2015)
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Journal Article
Chemical Chaperones Modulate the Formation of Metabolite Assemblies
Adsi, Hanaa, Levkovich, Shon A, Haimov, Elvira, Kreiser, Topaz, Meli, Massimiliano, Engel, Hamutal, Simhaev, Luba, Karidi-Heller, Shai, Colombo, Giorgio, Gazit, Ehud, Laor Bar-Yosef, Dana
Published in International journal of molecular sciences (25.08.2021)
Published in International journal of molecular sciences (25.08.2021)
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Journal Article
Alleviation of a polyglucosan storage disorder by enhancement of autophagic glycogen catabolism
Kakhlon, Or, Vaknin, Hilla, Mishra, Kumudesh, D’Souza, Jeevitha, Marisat, Monzer, Sprecher, Uri, Wald‐Altman, Shane, Dukhovny, Anna, Raviv, Yuval, Da’adoosh, Benny, Engel, Hamutal, Benhamron, Sandrine, Nitzan, Keren, Sweetat, Sahar, Permyakova, Anna, Mordechai, Anat, Akman, Hasan Orhan, Rosenmann, Hanna, Lossos, Alexander, Tam, Joseph, Minassian, Berge A., Weil, Miguel
Published in EMBO molecular medicine (07.10.2021)
Published in EMBO molecular medicine (07.10.2021)
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Journal Article
Inhibition of tau amyloid formation and disruption of its preformed fibrils by Naphthoquinone–Dopamine hybrid
Paul, Ashim, Viswanathan, Guru KrishnaKumar, Huber, Adi, Arad, Elad, Engel, Hamutal, Jelinek, Raz, Gazit, Ehud, Segal, Daniel
Published in The FEBS journal (01.07.2021)
Published in The FEBS journal (01.07.2021)
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Journal Article
Targeting phenylalanine assemblies as a prospective disease-modifying therapy for phenylketonuria
Shaham-Niv, Shira, Ezra, Assaf, Zaguri, Dor, Shotan, Stav Roni, Haimov, Elvira, Engel, Hamutal, Brider, Tamara, Simhaev, Luba, Barr, Haim Michael, Adler-Abramovich, Lihi, Gazit, Ehud
Published in Biophysical chemistry (01.05.2024)
Published in Biophysical chemistry (01.05.2024)
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Journal Article
Allosteric inhibitors targeting the calmodulin-PIP2 interface of SK4 K + channels for atrial fibrillation treatment
Burg, Shira, Shapiro, Shir, Peretz, Asher, Haimov, Elvira, Redko, Boris, Yeheskel, Adva, Simhaev, Luba, Engel, Hamutal, Raveh, Avi, Ben-Bassat, Ariel, Murninkas, Michael, Polak, Rotem, Haitin, Yoni, Etzion, Yoram, Attali, Bernard
Published in Proceedings of the National Academy of Sciences - PNAS (23.08.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (23.08.2022)
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Journal Article
The contribution of individual residues of an aggregative hexapeptide derived from the human γD-crystallin to its amyloidogenicity
Abu-Hussien, Malak, Viswanathan, Guru Krishnakumar, Simhaev, Luba, Paul, Ashim, Engel, Hamutal, Gazit, Ehud, Segal, Daniel
Published in International journal of biological macromolecules (15.03.2022)
Published in International journal of biological macromolecules (15.03.2022)
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Journal Article
Inhibition of amyloid fibrillation of γD-crystallin model peptide by the cochineal Carmine
Abu-Hussien, Malak, Viswanathan, Guru Krishnakumar, Borisover, Lia, Mimouni, Michael, Engel, Hamutal, Zayit-Soudry, Shiri, Gazit, Ehud, Segal, Daniel
Published in International journal of biological macromolecules (01.02.2021)
Published in International journal of biological macromolecules (01.02.2021)
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Journal Article
Path-Integral Calculations of Nuclear Quantum Effects in Model Systems, Small Molecules, and Enzymes via Gradient-Based Forward Corrector Algorithms
Azuri, Asaf, Engel, Hamutal, Doron, Dvir, Major, Dan Thomas
Published in Journal of chemical theory and computation (10.05.2011)
Published in Journal of chemical theory and computation (10.05.2011)
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Journal Article
Nuclear quantum effects in chemical reactions via higher-order path-integral calculations
Engel, Hamutal, Eitan, Reuven, Azuri, Asaf, Major, Dan Thomas
Published in Chemical physics (01.04.2015)
Published in Chemical physics (01.04.2015)
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Journal Article
Momentum Distribution as a Fingerprint of Quantum Delocalization in Enzymatic Reactions: Open-Chain Path-Integral Simulations of Model Systems and the Hydride Transfer in Dihydrofolate Reductase
Engel, Hamutal, Doron, Dvir, Kohen, Amnon, Major, Dan Thomas
Published in Journal of chemical theory and computation (10.04.2012)
Published in Journal of chemical theory and computation (10.04.2012)
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Journal Article