Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models
Li, Fu, Emmerton, Kim K, Jonas, Mechthild, Zhang, Xinqun, Miyamoto, Jamie B, Setter, Jocelyn R, Nicholas, Nicole D, Okeley, Nicole M, Lyon, Robert P, Benjamin, Dennis R, Law, Che-Leung
Published in Cancer research (Chicago, Ill.) (01.05.2016)
Published in Cancer research (Chicago, Ill.) (01.05.2016)
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Journal Article
Orthogonal Cysteine Protection Enables Homogeneous Multi‐Drug Antibody–Drug Conjugates
Levengood, Matthew R., Zhang, Xinqun, Hunter, Joshua H., Emmerton, Kim K., Miyamoto, Jamie B., Lewis, Timothy S., Senter, Peter D.
Published in Angewandte Chemie International Edition (16.01.2017)
Published in Angewandte Chemie International Edition (16.01.2017)
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Journal Article
Development of Novel Quaternary Ammonium Linkers for Antibody-Drug Conjugates
Burke, Patrick J, Hamilton, Joseph Z, Pires, Thomas A, Setter, Jocelyn R, Hunter, Joshua H, Cochran, Julia H, Waight, Andrew B, Gordon, Kristine A, Toki, Brian E, Emmerton, Kim K, Zeng, Weiping, Stone, Ivan J, Senter, Peter D, Lyon, Robert P, Jeffrey, Scott C
Published in Molecular cancer therapeutics (01.05.2016)
Published in Molecular cancer therapeutics (01.05.2016)
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Journal Article
Glucuronide-Linked Antibody-Tubulysin Conjugates Display Activity in MDR + and Heterogeneous Tumor Models
Burke, Patrick J, Hamilton, Joseph Z, Pires, Thomas A, Lai, Holden W H, Leiske, Christopher I, Emmerton, Kim K, Waight, Andrew B, Senter, Peter D, Lyon, Robert P, Jeffrey, Scott C
Published in Molecular cancer therapeutics (01.08.2018)
Published in Molecular cancer therapeutics (01.08.2018)
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Journal Article
The Methylene Alkoxy Carbamate Self-Immolative Unit: Utilization for the Targeted Delivery of Alcohol-Containing Payloads with Antibody-Drug Conjugates
Kolakowski, Robert V., Haelsig, Karl T., Emmerton, Kim K., Leiske, Chris I., Miyamoto, Jamie B., Cochran, Julia H., Lyon, Robert P., Senter, Peter D., Jeffrey, Scott C.
Published in Angewandte Chemie International Edition (04.07.2016)
Published in Angewandte Chemie International Edition (04.07.2016)
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Journal Article
Novel Auristatins with High Bystander and Cytotoxic Activities in Drug Efflux-positive Tumor Models
Moquist, Philip N, Bovee, Tim D, Waight, Andrew B, Mitchell, Jamie A, Miyamoto, Jamie B, Mason, Marsha L, Emmerton, Kim K, Stevens, Nicole, Balasubramanian, Cindy, Simmons, Jessica K, Lyon, Robert P, Senter, Peter D, Doronina, Svetlana O
Published in Molecular cancer therapeutics (01.02.2021)
Published in Molecular cancer therapeutics (01.02.2021)
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Journal Article
Development of Novel Antibody-Camptothecin Conjugates
Lyski, Ryan D, Bou, Lauren B, Lau, Uland Y, Meyer, David W, Cochran, Julia H, Okeley, Nicole M, Emmerton, Kim K, Zapata, Francisco, Simmons, Jessica K, Trueblood, Esther S, Ortiz, David J, Zaval, Margo C, Snead, Katie M, Jin, Steven, Farr, Lauren M, Ryan, Maureen C, Senter, Peter D, Jeffrey, Scott C
Published in Molecular cancer therapeutics (01.02.2021)
Published in Molecular cancer therapeutics (01.02.2021)
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Journal Article
Improving Antibody‐Tubulysin Conjugates through Linker Chemistry and Site‐Specific Conjugation
Hamilton, Joseph Z., Pires, Thomas A., Mitchell, Jamie A., Cochran, Julia H., Emmerton, Kim K., Zaval, Margo, Stone, Ivan J., Anderson, Martha E., Jin, Steven, Waight, Andrew B., Lyon, Robert P., Senter, Peter D., Jeffrey, Scott C., Burke, Patrick J.
Published in ChemMedChem (08.04.2021)
Published in ChemMedChem (08.04.2021)
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Journal Article
The Methylene Alkoxy Carbamate Self-Immolative Unit: Utilization for the Targeted Delivery of Alcohol-Containing Payloads with Antibody-Drug Conjugates
Kolakowski, Robert V., Haelsig, Karl T., Emmerton, Kim K., Leiske, Chris I., Miyamoto, Jamie B., Cochran, Julia H., Lyon, Robert P., Senter, Peter D., Jeffrey, Scott C.
Published in Angewandte Chemie (04.07.2016)
Published in Angewandte Chemie (04.07.2016)
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Journal Article
Abstract A097: Tubulysin ADC payloads: An antimitotic drug class that retains activity in multidrug resistant models
Burke, Patrick J, Hamilton, Joseph Z, Pires, Thomas A, Emmerton, Kim K, Senter, Peter D, Jeffrey, Scott C
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
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Journal Article
Abstract 982: Development of homogeneous dual-drug ADCs: Application to the co-delivery of auristatin payloads with complementary antitumor activities
Levengood, Matthew R., Zhang, Xinqun, Emmerton, Kim K., Hunter, Joshua H., Senter, Peter D.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Front Cover: Improving Antibody‐Tubulysin Conjugates through Linker Chemistry and Site‐Specific Conjugation (ChemMedChem 7/2021)
Hamilton, Joseph Z., Pires, Thomas A., Mitchell, Jamie A., Cochran, Julia H., Emmerton, Kim K., Zaval, Margo, Stone, Ivan J., Anderson, Martha E., Jin, Steven, Waight, Andrew B., Lyon, Robert P., Senter, Peter D., Jeffrey, Scott C., Burke, Patrick J.
Published in ChemMedChem (08.04.2021)
Published in ChemMedChem (08.04.2021)
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Journal Article
Abstract 2803: Novel auristatins with high activity on efflux-positive models and demonstrable bystander activity
Moquist, Philip N., Bovee, Tim D., Waight, Andrew B., Owen, Sarah, Mitchell, Jamie A., Zaval, Margo, Quick, Marsha, Sandall, Sharsti, Emmerton, Kim K., Blesie, Nicole, Lyon, Robert P., Senter, Peter, Doronina, Svetlana
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 1649: Impact of linker and conjugation site on tubulysin M ADC stability and in vivo activity
Burke, Patrick J., Hamilton, Joseph Z., Pires, Thomas A., Leiske, Christopher I., Cochran, Julia H., Setter, Jocelyn R., Emmerton, Kim K., Waight, Andrew B., Senter, Peter D., Lyon, Robert P., Jeffrey, Scott C.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 56: Antibody-drug conjugates containing glucuronide-tubulysin payloads display activity in MDR+ and heterogeneous tumor models
Burke, Patrick J., Hamilton, Joseph Z., Hunter, Joshua H., Cochran, Julia H., Pires, Thomas A., Leiske, Christopher I., Emmerton, Kim K., Senter, Peter D., Lyon, Robert P., Jeffrey, Scott C.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article