N-Substituted tertiary and O-substituted quaternary carbon stereogenic centers by site-, diastereo- and enantioselective vinylogous Mannich reactions
Silverio, Daniel L., Fu, Peng, Carswell, Emma L., Snapper, Marc L., Hoveyda, Amir H.
Published in Tetrahedron letters (03.06.2015)
Published in Tetrahedron letters (03.06.2015)
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Journal Article
Practical and Highly Enantioselective Synthesis of β-Alkynyl-β-amino Esters through Ag-Catalyzed Asymmetric Mannich Reactions of Silylketene Acetals and Alkynyl Imines
Josephsohn, Nathan S, Carswell, Emma L, Snapper, Marc L, Hoveyda, Amir H
Published in Organic letters (23.06.2005)
Published in Organic letters (23.06.2005)
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Journal Article
Si-free enolate Claisen rearrangements of enamido substrates
Harker, Wesley R. R., Carswell, Emma L., Carbery, David R.
Published in Organic & biomolecular chemistry (21.02.2012)
Published in Organic & biomolecular chemistry (21.02.2012)
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Journal Article
Optimization of TEAD P‑Site Binding Fragment Hit into In Vivo Active Lead MSC-4106
Heinrich, Timo, Peterson, Carl, Schneider, Richard, Garg, Sakshi, Schwarz, Daniel, Gunera, Jakub, Seshire, Anita, Kötzner, Lisa, Schlesiger, Sarah, Musil, Djordje, Schilke, Heike, Doerfel, Benjamin, Diehl, Patrizia, Böpple, Pia, Lemos, Ana R., Sousa, Pedro M. F., Freire, Filipe, Bandeiras, Tiago M., Carswell, Emma, Pearson, Nicholas, Sirohi, Sameer, Hooker, Mollie, Trivier, Elisabeth, Broome, Rebecca, Balsiger, Alexander, Crowden, Abigail, Dillon, Christian, Wienke, Dirk
Published in Journal of medicinal chemistry (14.07.2022)
Published in Journal of medicinal chemistry (14.07.2022)
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Journal Article
Discovery of reversible and covalent TEAD 1 selective inhibitors MSC-1254 and MSC-5046 based on one scaffold
Carswell, Emma, Heinrich, Timo, Petersson, Carl, Gunera, Jakub, Garg, Sakshi, Schwarz, Daniel, Schlesiger, Sarah, Fischer, Frank, Eichhorn, Thomas, Calder, Mathew, Smith, Geoffrey, MacDonald, Ellen, Wilson, Hollie, Hazel, Katherine, Trivier, Elisabeth, Broome, Rebecca, Balsiger, Alexander, Sirohi, Sameer, Musil, Djordje, Freire, Filipe, Schilke, Heike, Dillon, Christian, Wienke, Dirk
Published in Bioorganic & medicinal chemistry letters (01.12.2024)
Published in Bioorganic & medicinal chemistry letters (01.12.2024)
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Journal Article
Design and synthesis of novel proline based factor XIa selective inhibitors as leads for potential new anticoagulants
Hussain, Zahid, Cooke, Andrew J., Neelamkavil, Santhosh, Brown, Lindsay, Carswell, Emma, Geissler, Wayne M., Guo, Zhuyan, Hawes, Brian, Kelly, Terri M., Kiyoi, Yasuko, Lai, KehDih, Lesburg, Charles, Pow, Eleanor, Zang, Yi, Wood, Harold B., Edmondson, Scott D., Liu, Weiguo
Published in Bioorganic & medicinal chemistry letters (15.08.2020)
Published in Bioorganic & medicinal chemistry letters (15.08.2020)
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Journal Article
ChemInform Abstract: N-Substituted Tertiary and O-Substituted Quaternary Carbon Stereogenic Centers by Site-, Diastereo- and Enantioselective Vinylogous Mannich Reactions
Silverio, Daniel L., Fu, Peng, Carswell, Emma L., Snapper, Marc L., Hoveyda, Amir H.
Published in ChemInform (01.09.2015)
Published in ChemInform (01.09.2015)
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Journal Article
Development of chiral heteroleptic magnesium amides; asymmetric deprotonations mediated by six-membered metallocyclic amidomagnesium naphtholates
Carswell, Emma L., Kerr, William J., McArthur, Duncan, Pažický, Marek, Watson, Allan J.B.
Published in Tetrahedron (07.10.2014)
Published in Tetrahedron (07.10.2014)
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Journal Article
ChemInform Abstract: Development of Chiral Heteroleptic Magnesium Amides; Asymmetric Deprotonations Mediated by Six-Membered Metallocyclic Amidomagnesium Naphtholates
Carswell, Emma L., Kerr, William J., McArthur, Duncan, Pazick�, Marek, Watson, Allan J. B.
Published in ChemInform (01.03.2015)
Published in ChemInform (01.03.2015)
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Journal Article
Imidazopyridyl compounds as aldosterone synthase inhibitors
Whitehead, Brent R., Lo, Michael M.-C., Ali, Amjad, Park, Min K., Hoyt, Scott B., Xiong, Yusheng, Cai, Jiaqiang, Carswell, Emma, Cooke, Andrew, MacLean, John, Ratcliffe, Paul, Robinson, John, Bennett, D. Jonathan, Clemas, Joseph A., Wisniewski, Tom, Struthers, Mary, Cully, Doris, MacNeil, Douglas J.
Published in Bioorganic & medicinal chemistry letters (15.01.2017)
Published in Bioorganic & medicinal chemistry letters (15.01.2017)
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Journal Article
Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys
Hoyt, Scott B, Park, Min K, London, Clare, Xiong, Yusheng, Tata, Jim, Bennett, D. Jonathan, Cooke, Andrew, Cai, Jiaqiang, Carswell, Emma, Robinson, John, MacLean, John, Brown, Lindsay, Belshaw, Simone, Clarkson, Thomas R, Liu, Kun, Liang, Gui-Bai, Struthers, Mary, Cully, Doris, Wisniewski, Tom, Ren, Ning, Bopp, Charlene, Sok, Andrea, Cai, Tian-Quan, Stribling, Sloan, Pai, Lee-Yuh, Ma, Xiuying, Metzger, Joe, Verras, Andreas, McMasters, Daniel, Chen, Qing, Tung, Elaine, Tang, Wei, Salituro, Gino, Buist, Nicole, Kuethe, Jeff, Rivera, Nelo, Clemas, Joe, Zhou, Gaochao, Gibson, Jack, Maxwell, Carrie Ann, Lassman, Mike, McLaughlin, Theresa, Castro-Perez, Jose, Szeto, Daphne, Forrest, Gail, Hajdu, Richard, Rosenbach, Mark, Ali, Amjad
Published in ACS medicinal chemistry letters (14.05.2015)
Published in ACS medicinal chemistry letters (14.05.2015)
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Journal Article
High-resolution crystal structures of factor XIa coagulation factor in complex with nonbasic high-affinity synthetic inhibitors
Fradera, Xavier, Kazemier, Bert, Carswell, Emma, Cooke, Andrew, Oubrie, Arthur, Hamilton, William, Dempster, Maureen, Krapp, Stephan, Nagel, Susanna, Jestel, Anja
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.04.2012)
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.04.2012)
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Journal Article
Tricyclic heterocycles
Gunera, Jakub, Carswell, Emma, HEINRICH, Timo, Koetzner, Lisa, Schlesiger, Sarah, Blum, Andreas
Year of Publication 26.09.2024
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Year of Publication 26.09.2024
Patent
TRICYCLIC HETEROCYCLES
SCHLESIGER, Sarah, KOETZNER, Lisa, UNZUE LOPEZ, Andrea, HEINRICH, Timo, PETERSSON, Carl, GUNERA, Jakub, CARSWELL, Emma
Year of Publication 04.09.2024
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Year of Publication 04.09.2024
Patent
TRICYCLIC HETEROCYCLES
Gunera, Jakub, Carswell, Emma, Heinrich, Timo, Koetzner, Lisa, Schlesiger, Sarah, Blum, Andreas
Year of Publication 15.08.2024
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Year of Publication 15.08.2024
Patent