Tumor Organoids as a Pre-clinical Cancer Model for Drug Discovery
Weeber, Fleur, Ooft, Salo N., Dijkstra, Krijn K., Voest, Emile E.
Published in Cell chemical biology (21.09.2017)
Published in Cell chemical biology (21.09.2017)
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Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients
Ooft, Salo N, Weeber, Fleur, Dijkstra, Krijn K, McLean, Chelsea M, Kaing, Sovann, van Werkhoven, Erik, Schipper, Luuk, Hoes, Louisa, Vis, Daniel J, van de Haar, Joris, Prevoo, Warner, Snaebjornsson, Petur, van der Velden, Daphne, Klein, Michelle, Chalabi, Myriam, Boot, Henk, van Leerdam, Monique, Bloemendal, Haiko J, Beerepoot, Laurens V, Wessels, Lodewyk, Cuppen, Edwin, Clevers, Hans, Voest, Emile E
Published in Science translational medicine (09.10.2019)
Published in Science translational medicine (09.10.2019)
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Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers
Scheper, Wouter, Kelderman, Sander, Fanchi, Lorenzo F., Linnemann, Carsten, Bendle, Gavin, de Rooij, Marije A. J., Hirt, Christian, Mezzadra, Riccardo, Slagter, Maarten, Dijkstra, Krijn, Kluin, Roelof J. C., Snaebjornsson, Petur, Milne, Katy, Nelson, Brad H., Zijlmans, Henry, Kenter, Gemma, Voest, Emile E., Haanen, John B. A. G., Schumacher, Ton N.
Published in Nature medicine (01.01.2019)
Published in Nature medicine (01.01.2019)
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Challenges in Establishing Pure Lung Cancer Organoids Limit Their Utility for Personalized Medicine
Dijkstra, Krijn K., Monkhorst, Kim, Schipper, Luuk J., Hartemink, Koen J., Smit, Egbert F., Kaing, Sovann, de Groot, Rosa, Wolkers, Monika C., Clevers, Hans, Cuppen, Edwin, Voest, Emile E.
Published in Cell reports (Cambridge) (05.05.2020)
Published in Cell reports (Cambridge) (05.05.2020)
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Pan-cancer whole-genome analyses of metastatic solid tumours
Priestley, Peter, Baber, Jonathan, Lolkema, Martijn P., Steeghs, Neeltje, de Bruijn, Ewart, Shale, Charles, Duyvesteyn, Korneel, Haidari, Susan, van Hoeck, Arne, Onstenk, Wendy, Roepman, Paul, Voda, Mircea, Bloemendal, Haiko J., Tjan-Heijnen, Vivianne C. G., van Herpen, Carla M. L., Labots, Mariette, Witteveen, Petronella O., Smit, Egbert F., Sleijfer, Stefan, Voest, Emile E., Cuppen, Edwin
Published in Nature (London) (01.11.2019)
Published in Nature (London) (01.11.2019)
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Tumor organoid–T-cell coculture systems
Cattaneo, Chiara M., Dijkstra, Krijn K., Fanchi, Lorenzo F., Kelderman, Sander, Kaing, Sovann, van Rooij, Nienke, van den Brink, Stieneke, Schumacher, Ton N., Voest, Emile E.
Published in Nature protocols (01.01.2020)
Published in Nature protocols (01.01.2020)
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Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids
Dijkstra, Krijn K., Cattaneo, Chiara M., Weeber, Fleur, Chalabi, Myriam, van de Haar, Joris, Fanchi, Lorenzo F., Slagter, Maarten, van der Velden, Daphne L., Kaing, Sovann, Kelderman, Sander, van Rooij, Nienke, van Leerdam, Monique E., Depla, Annekatrien, Smit, Egbert F., Hartemink, Koen J., de Groot, Rosa, Wolkers, Monika C., Sachs, Norman, Snaebjornsson, Petur, Monkhorst, Kim, Haanen, John, Clevers, Hans, Schumacher, Ton N., Voest, Emile E.
Published in Cell (06.09.2018)
Published in Cell (06.09.2018)
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Delivering precision oncology to patients with cancer
Mateo, Joaquin, Steuten, Lotte, Aftimos, Philippe, André, Fabrice, Davies, Mark, Garralda, Elena, Geissler, Jan, Husereau, Don, Martinez-Lopez, Iciar, Normanno, Nicola, Reis-Filho, Jorge S., Stefani, Stephen, Thomas, David M., Westphalen, C. Benedikt, Voest, Emile
Published in Nature Medicine (01.04.2022)
Published in Nature Medicine (01.04.2022)
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Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases
Weeber, Fleur, van de Wetering, Marc, Hoogstraat, Marlous, Dijkstra, Krijn K., Krijgsman, Oscar, Kuilman, Thomas, Gadellaa-van Hooijdonk, Christa G. M., van der Velden, Daphne L., Peeper, Daniel S., Cuppen, Edwin P. J. G., Vries, Robert G., Clevers, Hans, Voest, Emile E.
Published in Proceedings of the National Academy of Sciences - PNAS (27.10.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (27.10.2015)
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The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies
Angus, Lindsay, Smid, Marcel, Wilting, Saskia M., van Riet, Job, Van Hoeck, Arne, Nguyen, Luan, Nik-Zainal, Serena, Steenbruggen, Tessa G., Tjan-Heijnen, Vivianne C. G., Labots, Mariette, van Riel, Johanna M. G. H., Bloemendal, Haiko J., Steeghs, Neeltje, Lolkema, Martijn P., Voest, Emile E., van de Werken, Harmen J. G., Jager, Agnes, Cuppen, Edwin, Sleijfer, Stefan, Martens, John W. M.
Published in Nature genetics (01.10.2019)
Published in Nature genetics (01.10.2019)
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Fixed Dosing of Monoclonal Antibodies in Oncology
Hendrikx, Jeroen J.M.A., Haanen, John B.A.G., Voest, Emile E., Schellens, Jan H.M., Huitema, Alwin D.R., Beijnen, Jos H.
Published in The oncologist (Dayton, Ohio) (01.10.2017)
Published in The oncologist (Dayton, Ohio) (01.10.2017)
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Identification of patient-specific CD4+ and CD8+ T cell neoantigens through HLA-unbiased genetic screens
Cattaneo, Chiara M., Battaglia, Thomas, Urbanus, Jos, Moravec, Ziva, Voogd, Rhianne, de Groot, Rosa, Hartemink, Koen J., Haanen, John B. A. G., Voest, Emile E., Schumacher, Ton N., Scheper, Wouter
Published in Nature biotechnology (01.06.2023)
Published in Nature biotechnology (01.06.2023)
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Caring for patients with cancer in the COVID-19 era
van de Haar, Joris, Hoes, Louisa R., Coles, Charlotte E., Seamon, Kenneth, Fröhling, Stefan, Jäger, Dirk, Valenza, Franco, de Braud, Filippo, De Petris, Luigi, Bergh, Jonas, Ernberg, Ingemar, Besse, Benjamin, Barlesi, Fabrice, Garralda, Elena, Piris-Giménez, Alejandro, Baumann, Michael, Apolone, Giovanni, Soria, Jean Charles, Tabernero, Josep, Caldas, Carlos, Voest, Emile E.
Published in Nature medicine (01.05.2020)
Published in Nature medicine (01.05.2020)
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The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact
van Dessel, Lisanne F., van Riet, Job, Smits, Minke, Zhu, Yanyun, Hamberg, Paul, van der Heijden, Michiel S., Bergman, Andries M., van Oort, Inge M., de Wit, Ronald, Voest, Emile E., Steeghs, Neeltje, Yamaguchi, Takafumi N., Livingstone, Julie, Boutros, Paul C., Martens, John W. M., Sleijfer, Stefan, Cuppen, Edwin, Zwart, Wilbert, van de Werken, Harmen J. G., Mehra, Niven, Lolkema, Martijn P.
Published in Nature communications (20.11.2019)
Published in Nature communications (20.11.2019)
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Third-Line Therapy in Metastatic Colorectal Cancer
van de Haar, Joris, Valeri, Nicola, Voest, Emile E., Tabernero, Josep, Fakih, Marwan, Prager, Gerald W.
Published in The New England journal of medicine (13.07.2023)
Published in The New England journal of medicine (13.07.2023)
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Multiple low dose therapy as an effective strategy to treat EGFR inhibitor-resistant NSCLC tumours
Fernandes Neto, João M., Nadal, Ernest, Bosdriesz, Evert, Ooft, Salo N., Farre, Lourdes, McLean, Chelsea, Klarenbeek, Sjoerd, Jurgens, Anouk, Hagen, Hannes, Wang, Liqin, Felip, Enriqueta, Martinez-Marti, Alex, Vidal, August, Voest, Emile, Wessels, Lodewyk F. A., van Tellingen, Olaf, Villanueva, Alberto, Bernards, René
Published in Nature communications (22.06.2020)
Published in Nature communications (22.06.2020)
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