MEK1 mutations confer resistance to MEK and B-RAF inhibition
Emery, Caroline M, Vijayendran, Krishna G, Zipser, Marie C, Sawyer, Allison M, Niu, Lili, Kim, Jessica J, Hatton, Charles, Chopra, Rajiv, Oberholzer, Patrick A, Karpova, Maria B, MacConaill, Laura E, Zhang, Jianming, Gray, Nathanael S, Sellers, William R, Dummer, Reinhard, Garraway, Levi A
Published in Proceedings of the National Academy of Sciences - PNAS (01.12.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (01.12.2009)
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Journal Article
BRAF-inhibitor Associated MEK Mutations Increase RAF-Dependent and -Independent Enzymatic Activity
Emery, Caroline M, Monaco, Kelli-Ann, Wang, Ping, Balak, Marissa, Freeman, Alyson, Meltzer, Jodi, Delach, Scott M, Rakiec, Daniel, Ruddy, David A, Korn, Joshua M, Haling, Jacob, Acker, Michael G, Caponigro, Giordano
Published in Molecular cancer research (01.10.2017)
Published in Molecular cancer research (01.10.2017)
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Journal Article
Gene Expression Ratios Lead to Accurate and Translatable Predictors of DR5 Agonism across Multiple Tumor Lineages
Reddy, Anupama, Growney, Joseph D, Wilson, Nick S, Emery, Caroline M, Johnson, Jennifer A, Ward, Rebecca, Monaco, Kelli A, Korn, Joshua, Monahan, John E, Stump, Mark D, Mapa, Felipa A, Wilson, Christopher J, Steiger, Janine, Ledell, Jebediah, Rickles, Richard J, Myer, Vic E, Ettenberg, Seth A, Schlegel, Robert, Sellers, William R, Huet, Heather A, Lehár, Joseph
Published in PloS one (17.09.2015)
Published in PloS one (17.09.2015)
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Correction: Gene Expression Ratios Lead to Accurate and Translatable Predictors of DR5 Agonism across Multiple Tumor Lineages
Reddy, Anupama, Growney, Joseph D, Wilson, Nick S, Emery, Caroline M, Johnson, Jennifer A, Ward, Rebecca, Monaco, Kelli A, Korn, Joshua, Monahan, John E, Stump, Mark D, Mapa, Felipa A, Wilson, Christopher J, Steiger, Janine, Ledell, Jebediah, Rickles, Richard J, Myer, Vic E, Ettenberg, Seth A, Schlegel, Robert, Sellers, William R, Huet, Heather A, Lehár, Joseph
Published in PloS one (05.01.2016)
Published in PloS one (05.01.2016)
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First-in-Class ERK1/2 Inhibitor Ulixertinib (BVD-523) in Patients with MAPK Mutant Advanced Solid Tumors: Results of a Phase I Dose-Escalation and Expansion Study
Sullivan, Ryan J, Infante, Jeffrey R, Janku, Filip, Wong, Deborah Jean Lee, Sosman, Jeffrey A, Keedy, Vicki, Patel, Manish R, Shapiro, Geoffrey I, Mier, James W, Tolcher, Anthony W, Wang-Gillam, Andrea, Sznol, Mario, Flaherty, Keith, Buchbinder, Elizabeth, Carvajal, Richard D, Varghese, Anna M, Lacouture, Mario E, Ribas, Antoni, Patel, Sapna P, DeCrescenzo, Gary A, Emery, Caroline M, Groover, Anna L, Saha, Saurabh, Varterasian, Mary, Welsch, Dean J, Hyman, David M, Li, Bob T
Published in Cancer discovery (01.02.2018)
Published in Cancer discovery (01.02.2018)
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Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib)
Germann, Ursula A, Furey, Brinley F, Markland, William, Hoover, Russell R, Aronov, Alex M, Roix, Jeffrey J, Hale, Michael, Boucher, Diane M, Sorrell, David A, Martinez-Botella, Gabriel, Fitzgibbon, Matthew, Shapiro, Paul, Wick, Michael J, Samadani, Ramin, Meshaw, Kathryn, Groover, Anna, DeCrescenzo, Gary, Namchuk, Mark, Emery, Caroline M, Saha, Saurabh, Welsch, Dean J
Published in Molecular cancer therapeutics (01.11.2017)
Published in Molecular cancer therapeutics (01.11.2017)
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Journal Article
C-RAF Mutations Confer Resistance to RAF Inhibitors
ANTONY, Rajee, EMERY, Caroline M, SAWYER, Allison M, GARRAWAY, Levi A
Published in Cancer research (Chicago, Ill.) (01.08.2013)
Published in Cancer research (Chicago, Ill.) (01.08.2013)
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Journal Article
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
Emery, Caroline M, Hieronymus, Haley, Zhao, Jean J, Boehm, Jesse S, Golub, Todd, Yang, Xiaoping, Root, David E, Roberts, Thomas M, Hahn, William C, Hill, David E, Wilson, Christopher J, Weber, Barbara L, Garraway, Levi A, Johnson, Laura A, Kim, Sungjoon, Harris, Jennifer L, Kim, So Young, Vidal, Marc, Finan, Peter M, Myer, Vic E, Sellers, William R, Barretina, Jordi, Alkan, Ozan, Thomas, Sapana R, Wardwell, Leslie, Cogdill, Alexandria P, Dummer, Reinhard, Schlegel, Robert, Stransky, Nicolas, Flaherty, Keith T, Wargo, Jennifer A, Murray, Ryan R, Johannessen, Cory M, Salehi-Ashtiani, Kourosh, Caponigro, Giordano
Published in Nature (London) (16.12.2010)
Published in Nature (London) (16.12.2010)
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Journal Article
Correction: Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples
MacConaill, Laura E., Campbell, Catarina D., Kehoe, Sarah M., Bass, Adam J., Hatton, Charles, Niu, Lili, Davis, Matt, Yao, Keluo, Hanna, Megan, Mondal, Chandrani, Luongo, Lauren, Emery, Caroline M., Baker, Alissa C., Philips, Juliet, Goff, Deborah J., Fiorentino, Michelangelo, Rubin, Mark A., Polyak, Kornelia, Chan, Jennifer, Wang, Yuexiang, Fletcher, Jonathan A., Santagata, Sandro, Corso, Gianni, Roviello, Franco, Shivdasani, Ramesh, Kieran, Mark W., Ligon, Keith L., Stiles, Charles D., Hahn, William C., Meyerson, Matthew L., Garraway, Levi A.
Published in PloS one (01.12.2009)
Published in PloS one (01.12.2009)
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Journal Article
Abstract 2692: The combination of ulixertinib (ERK1/2 Inhibitor) and KRASG12C inhibition demonstrates significant efficacy in preclinical models
Knoerzer, Deborah, Reddy, Anupama, Box, Jessica A., Groover, Anna, Kreider, Brent, Teresk, Martin, Emery, Caroline M.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Abstract 2693: Combining ulixertinib (ERK1/2 Inhibitor) with EGFR and BRAF inhibition yields significant efficacy in preclinical BRAF V600E mutant colorectal cancer models
Knoerzer, Deborah, Reddy, Anupama, Box, Jessica A., Groover, Anna, Kreider, Brent, Teresk, Martin, Emery, Caroline M.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Profiling critical cancer gene mutations in clinical tumor samples
MacConaill, Laura E, Campbell, Catarina D, Kehoe, Sarah M, Bass, Adam J, Hatton, Charles, Niu, Lili, Davis, Matt, Yao, Keluo, Hanna, Megan, Mondal, Chandrani, Luongo, Lauren, Emery, Caroline M, Baker, Alissa C, Philips, Juliet, Goff, Deborah J, Fiorentino, Michelangelo, Rubin, Mark A, Polyak, Kornelia, Chan, Jennifer, Wang, Yuexiang, Fletcher, Jonathan A, Santagata, Sandro, Corso, Gianni, Roviello, Franco, Shivdasani, Ramesh, Kieran, Mark W, Ligon, Keith L, Stiles, Charles D, Hahn, William C, Meyerson, Matthew L, Garraway, Levi A
Published in PloS one (18.11.2009)
Published in PloS one (18.11.2009)
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Abstract 1057: Significant efficacy demonstrated with the combination of ulixertinib (ERK1/2 inhibitor) and CDK4/6 inhibitors in MAPK altered models
Emery, Caroline M., Corgiat, Brian, Davis, Justin, Sorrell, David, Johnson, Mitch, Kreider, Brent, Knoerzer, Deborah
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Gene Expression Ratios Lead to Accurate and Translatable Predictors of DR5 Agonism across Multiple Tumor Lineages: e0138486
Reddy, Anupama, Growney, Joseph D, Wilson, Nick S, Emery, Caroline M, Johnson, Jennifer A, Ward, Rebecca, Monaco, Kelli A, Korn, Joshua, Monahan, John E, Stump, Mark D
Published in PloS one (01.09.2015)
Published in PloS one (01.09.2015)
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Journal Article
Correction: Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples
MacConaill, Laura E., Campbell, Catarina D., Kehoe, Sarah M., Bass, Adam J., Hatton, Charles, Niu, Lili, Davis, Matt, Yao, Keluo, Hanna, Megan, Mondal, Chandrani, Luongo, Lauren, Emery, Caroline M., Baker, Alissa C., Philips, Juliet, Goff, Deborah J., Fiorentino, Michelangelo, Rubin, Mark A., Polyak, Kornelia, Chan, Jennifer, Wang, Yuexiang, Fletcher, Jonathan A., Santagata, Sandro, Corso, Gianni, Roviello, Franco, Shivdasani, Ramesh, Kieran, Mark W., Ligon, Keith L., Stiles, Charles D., Hahn, William C., Meyerson, Matthew L., Garraway, Levi A.
Published in PloS one (01.09.2010)
Published in PloS one (01.09.2010)
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Journal Article
COT/MAP3K8 drives resistance to RAF inhibition through MAP kinase pathway reactivation
Johannessen, Cory M., Boehm, Jesse S., Kim, So Young, Thomas, Sapana R., Wardwell, Leslie, Johnson, Laura A., Emery, Caroline M., Stransky, Nicolas, Cogdill, Alexandria P., Barretina, Jordi, Caponigro, Giordano, Hieronymus, Haley, Murray, Ryan R., Salehi-Ashtiani, Kourosh, Hill, David E., Vidal, Marc, Zhao, Jean J., Yang, Xiaoping, Alkan, Ozan, Kim, Sungjoon, Harris, Jennifer L., Wilson, Christopher J., Myer, Vic E., Finan, Peter M., Root, David E., Roberts, Thomas M., Golub, Todd, Flaherty, Keith T., Dummer, Reinhard, Weber, Barbara, Sellers, William R., Schlegel, Robert, Wargo, Jennifer A., Hahn, William C., Garraway, Levi A.
Published in Nature (London) (24.11.2010)
Published in Nature (London) (24.11.2010)
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Journal Article
Correction: Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples
Laura E. MacConaill, Catarina D. Campbell, Sarah M. Kehoe, Adam J. Bass, Charles Hatton, Lili Niu, Matt Davis, Keluo Yao, Megan Hanna, Chandrani Mondal, Lauren Luongo, Caroline M. Emery, Alissa C. Baker, Juliet Philips, Deborah J. Goff, Michelangelo Fiorentino, Mark A. Rubin, Kornelia Polyak, Jennifer Chan, Yuexiang Wang, Jonathan A. Fletcher, Sandro Santagata, Gianni Corso, Franco Roviello, Ramesh Shivdasani, Mark W. Kieran, Keith L. Ligon, Charles D. Stiles, William C. Hahn, Matthew L. Meyerson, Levi A. Garraway
Published in PloS one (01.01.2010)
Published in PloS one (01.01.2010)
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