Pathogen-induced activation of disease-suppressive functions in the endophytic root microbiome
Carrión, Víctor J, Perez-Jaramillo, Juan, Cordovez, Viviane, Tracanna, Vittorio, de Hollander, Mattias, Ruiz-Buck, Daniel, Mendes, Lucas W, van Ijcken, Wilfred F J, Gomez-Exposito, Ruth, Elsayed, Somayah S, Mohanraju, Prarthana, Arifah, Adini, van der Oost, John, Paulson, Joseph N, Mendes, Rodrigo, van Wezel, Gilles P, Medema, Marnix H, Raaijmakers, Jos M
Published in Science (American Association for the Advancement of Science) (01.11.2019)
Published in Science (American Association for the Advancement of Science) (01.11.2019)
Get full text
Journal Article
Chaxapeptin, a Lasso Peptide from Extremotolerant Streptomyces leeuwenhoekii Strain C58 from the Hyperarid Atacama Desert
Elsayed, Somayah S, Trusch, Franziska, Deng, Hai, Raab, Andrea, Prokes, Ivan, Busarakam, Kanungnid, Asenjo, Juan A, Andrews, Barbara A, van West, Pieter, Bull, Alan T, Goodfellow, Michael, Yi, Yu, Ebel, Rainer, Jaspars, Marcel, Rateb, Mostafa E
Published in Journal of organic chemistry (16.10.2015)
Published in Journal of organic chemistry (16.10.2015)
Get full text
Journal Article
Discovery of actinomycin L, a new member of the actinomycin family of antibiotics
Machushynets, Nataliia V., Elsayed, Somayah S., Du, Chao, Siegler, Maxime A., de la Cruz, Mercedes, Genilloud, Olga, Hankemeier, Thomas, van Wezel, Gilles P.
Published in Scientific reports (18.02.2022)
Published in Scientific reports (18.02.2022)
Get full text
Journal Article
Dynamic effects of probiotic formula ecologic®825 on human small intestinal ileostoma microbiota: a network theory approach
Jansma, Jack, Thome, Nicola U., Schwalbe, Markus, Chatziioannou, Anastasia Chrysovalantou, Elsayed, Somayah S., van Wezel, Gilles P., van den Abbeele, Pieter, van Hemert, Saskia, El Aidy, Sahar
Published in Gut microbes (31.12.2023)
Published in Gut microbes (31.12.2023)
Get full text
Journal Article
Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides
Kloosterman, Alexander M, Cimermancic, Peter, Elsayed, Somayah S, Du, Chao, Hadjithomas, Michalis, Donia, Mohamed S, Fischbach, Michael A, van Wezel, Gilles P, Medema, Marnix H
Published in PLoS biology (01.12.2020)
Published in PLoS biology (01.12.2020)
Get full text
Journal Article
nanoRAPIDS as an analytical pipeline for the discovery of novel bioactive metabolites in complex culture extracts at the nanoscale
Nuñez Santiago, Isabel, Machushynets, Nataliia V., Mladic, Marija, van Bergeijk, Doris A., Elsayed, Somayah S., Hankemeier, Thomas, van Wezel, Gilles P.
Published in Communications chemistry (01.04.2024)
Published in Communications chemistry (01.04.2024)
Get full text
Journal Article
Unravelling key enzymatic steps in C-ring cleavage during angucycline biosynthesis
Elsayed, Somayah S., van der Heul, Helga U., Xiao, Xiansha, Nuutila, Aleksi, Baars, Laura R., Wu, Changsheng, Metsä-Ketelä, Mikko, van Wezel, Gilles P.
Published in Communications chemistry (18.12.2023)
Published in Communications chemistry (18.12.2023)
Get full text
Journal Article
The ubiquitous catechol moiety elicits siderophore and angucycline production in Streptomyces
van Bergeijk, Doris A., Elsayed, Somayah S., Du, Chao, Santiago, Isabel Nuñez, Roseboom, Anna M., Zhang, Le, Carrión, Victor J., Spaink, Herman P., van Wezel, Gilles P.
Published in Communications chemistry (03.02.2022)
Published in Communications chemistry (03.02.2022)
Get full text
Journal Article
Metabolic engineering of Streptomyces peucetius for biosynthesis of N,N -dimethylated anthracyclines
Hulst, Mandy B, Zhang, Le, van der Heul, Helga U, Du, Chao, Elsayed, Somayah S, Koroleva, Arina, Grocholski, Thadee, Wander, Dennis P A, Metsä-Ketelä, Mikko, Neefjes, Jacques J C, van Wezel, Gilles P
Published in Frontiers in bioengineering and biotechnology (28.02.2024)
Published in Frontiers in bioengineering and biotechnology (28.02.2024)
Get full text
Journal Article
Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lantibiotics
Kloosterman, Alexander M, Cimermancic, Peter, Elsayed, Somayah S, Du, Chao, Hadjithomas, Michalis, Donia, Mohamed S, Fischbach, Michael A, van Wezel, Gilles P, Medema, Marnix H, Roberts, Roland G
Published in PLoS biology (22.12.2020)
Published in PLoS biology (22.12.2020)
Get full text
Journal Article
Artificial intelligence for natural product drug discovery
Mullowney, Michael W., Duncan, Katherine R., Elsayed, Somayah S., Garg, Neha, van der Hooft, Justin J. J., Martin, Nathaniel I., Meijer, David, Terlouw, Barbara R., Biermann, Friederike, Blin, Kai, Durairaj, Janani, Gorostiola González, Marina, Helfrich, Eric J. N., Huber, Florian, Leopold-Messer, Stefan, Rajan, Kohulan, de Rond, Tristan, van Santen, Jeffrey A., Sorokina, Maria, Balunas, Marcy J., Beniddir, Mehdi A., van Bergeijk, Doris A., Carroll, Laura M., Clark, Chase M., Clevert, Djork-Arné, Dejong, Chris A., Du, Chao, Ferrinho, Scarlet, Grisoni, Francesca, Hofstetter, Albert, Jespers, Willem, Kalinina, Olga V., Kautsar, Satria A., Kim, Hyunwoo, Leao, Tiago F., Masschelein, Joleen, Rees, Evan R., Reher, Raphael, Reker, Daniel, Schwaller, Philippe, Segler, Marwin, Skinnider, Michael A., Walker, Allison S., Willighagen, Egon L., Zdrazil, Barbara, Ziemert, Nadine, Goss, Rebecca J. M., Guyomard, Pierre, Volkamer, Andrea, Gerwick, William H., Kim, Hyun Uk, Müller, Rolf, van Wezel, Gilles P., van Westen, Gerard J. P., Hirsch, Anna K. H., Linington, Roger G., Robinson, Serina L., Medema, Marnix H.
Published in Nature reviews. Drug discovery (01.11.2023)
Published in Nature reviews. Drug discovery (01.11.2023)
Get full text
Journal Article
The plant stress hormone jasmonic acid evokes defensive responses in streptomycetes
van der Meij, Anne, Elsayed, Somayah S, Du, Chao, Willemse, Joost, Wood, Thomas M, Martin, Nathaniel I, Raaijmakers, Jos M, van Wezel, Gilles P
Published in Applied and environmental microbiology (29.11.2023)
Published in Applied and environmental microbiology (29.11.2023)
Get full text
Journal Article
Divergence of Classical and C‑Ring-Cleaved Angucyclines: Elucidation of Early Tailoring Steps in Lugdunomycin and Thioangucycline Biosynthesis
Nuutila, Aleksi, Xiao, Xiansha, van der Heul, Helga U., van Wezel, Gilles P., Dinis, Pedro, Elsayed, Somayah S., Metsä-Ketelä, Mikko
Published in ACS chemical biology (17.05.2024)
Published in ACS chemical biology (17.05.2024)
Get full text
Journal Article
Discovery of a Single Monooxygenase that Catalyzes Carbamate Formation and Ring Contraction in the Biosynthesis of the Legonmycins
Huang, Sheng, Tabudravu, Jioji, Elsayed, Somayah S., Travert, Jeanne, Peace, Doe, Tong, Ming Him, Kyeremeh, Kwaku, Kelly, Sharon M., Trembleau, Laurent, Ebel, Rainer, Jaspars, Marcel, Yu, Yi, Deng, Hai
Published in Angewandte Chemie International Edition (19.10.2015)
Published in Angewandte Chemie International Edition (19.10.2015)
Get full text
Journal Article
Taxonomic and metabolic diversity of Actinomycetota isolated from faeces of a 28,000‐year‐old mammoth
Bergeijk, Doris A., Augustijn, Hannah E., Elsayed, Somayah S., Willemse, Joost, Carrión, Victor J., Du, Chao, Urem, Mia, Grigoreva, Lena V., Cheprasov, Maksim Y., Grigoriev, Semyon, Jansen, Hans, Wintermans, Bas, Budding, Andries E., Spaink, Herman P., Medema, Marnix H., Wezel, Gilles P.
Published in Environmental microbiology (01.02.2024)
Published in Environmental microbiology (01.02.2024)
Get full text
Journal Article
Atypical Spirotetronate Polyketides Identified in the Underexplored Genus Streptacidiphilus
Elsayed, Somayah S, Genta-Jouve, Grégory, Carrión, Víctor J, Nibbering, Peter H, Siegler, Maxime A, de Boer, Wietse, Hankemeier, Thomas, van Wezel, Gilles P
Published in Journal of organic chemistry (21.08.2020)
Published in Journal of organic chemistry (21.08.2020)
Get full text
Journal Article
Discovery and Derivatization of Tridecaptin Antibiotics with Altered Host Specificity and Enhanced Bioactivity
Machushynets, Nataliia V., Al Ayed, Karol, Terlouw, Barbara R., Du, Chao, Buijs, Ned P., Willemse, Joost, Elsayed, Somayah S., Schill, Julian, Trebosc, Vincent, Pieren, Michel, Alexander, Francesca M., Cochrane, Stephen A., Liles, Mark R., Medema, Marnix H., Martin, Nathaniel I., van Wezel, Gilles P.
Published in ACS chemical biology (17.05.2024)
Published in ACS chemical biology (17.05.2024)
Get full text
Journal Article
Functional and Structural Insights into a Novel Promiscuous Ketoreductase of the Lugdunomycin Biosynthetic Pathway
Xiao, Xiansha, Elsayed, Somayah S, Wu, Changsheng, van der Heul, Helga U, Metsä-Ketelä, Mikko, Du, Chao, Prota, Andrea E, Chen, Chun-Chi, Liu, Weidong, Guo, Rey-Ting, Abrahams, Jan Pieter, van Wezel, Gilles P
Published in ACS chemical biology (18.09.2020)
Published in ACS chemical biology (18.09.2020)
Get full text
Journal Article
Total Synthesis and Structure Assignment of the Relacidine Lipopeptide Antibiotics and Preparation of Analogues with Enhanced Stability
Al Ayed, Karol, Zamarbide Losada, Denise, Machushynets, Nataliia V., Terlouw, Barbara, Elsayed, Somayah S., Schill, Julian, Trebosc, Vincent, Pieren, Michel, Medema, Marnix H., van Wezel, Gilles P., Martin, Nathaniel I.
Published in ACS infectious diseases (14.04.2023)
Published in ACS infectious diseases (14.04.2023)
Get full text
Journal Article