Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci
Ellinghaus, David, Jostins, Luke, Spain, Sarah L, Cortes, Adrian, Bethune, Jörn, Han, Buhm, Park, Yu Rang, Raychaudhuri, Soumya, Pouget, Jennie G, Hübenthal, Matthias, Folseraas, Trine, Wang, Yunpeng, Esko, Tonu, Metspalu, Andres, Westra, Harm-Jan, Franke, Lude, Pers, Tune H, Weersma, Rinse K, Collij, Valerie, D'Amato, Mauro, Halfvarson, Jonas, Jensen, Anders Boeck, Lieb, Wolfgang, Degenhardt, Franziska, Forstner, Andreas J, Hofmann, Andrea, Schreiber, Stefan, Mrowietz, Ulrich, Juran, Brian D, Lazaridis, Konstantinos N, Brunak, Søren, Dale, Anders M, Trembath, Richard C, Weidinger, Stephan, Weichenthal, Michael, Ellinghaus, Eva, Elder, James T, Barker, Jonathan N W N, Andreassen, Ole A, McGovern, Dermot P, Karlsen, Tom H, Barrett, Jeffrey C, Parkes, Miles, Brown, Matthew A, Franke, Andre
Published in Nature genetics (01.05.2016)
Published in Nature genetics (01.05.2016)
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A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis
Buch, Stephan, Stickel, Felix, Trépo, Eric, Way, Michael, Herrmann, Alexander, Nischalke, Hans Dieter, Brosch, Mario, Rosendahl, Jonas, Berg, Thomas, Ridinger, Monika, Rietschel, Marcella, McQuillin, Andrew, Frank, Josef, Kiefer, Falk, Schreiber, Stefan, Lieb, Wolfgang, Soyka, Michael, Semmo, Nasser, Aigner, Elmar, Datz, Christian, Schmelz, Renate, Brückner, Stefan, Zeissig, Sebastian, Stephan, Anna-Magdalena, Wodarz, Norbert, Devière, Jacques, Clumeck, Nicolas, Sarrazin, Christoph, Lammert, Frank, Gustot, Thierry, Deltenre, Pierre, Völzke, Henry, Lerch, Markus M, Mayerle, Julia, Eyer, Florian, Schafmayer, Clemens, Cichon, Sven, Nöthen, Markus M, Nothnagel, Michael, Ellinghaus, David, Huse, Klaus, Franke, Andre, Zopf, Steffen, Hellerbrand, Claus, Moreno, Christophe, Franchimont, Denis, Morgan, Marsha Y, Hampe, Jochen
Published in Nature genetics (01.12.2015)
Published in Nature genetics (01.12.2015)
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Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota
Wang, Jun, Thingholm, Louise B, Skiecevičienė, Jurgita, Rausch, Philipp, Kummen, Martin, Hov, Johannes R, Degenhardt, Frauke, Heinsen, Femke-Anouska, Rühlemann, Malte C, Szymczak, Silke, Holm, Kristian, Esko, Tönu, Sun, Jun, Pricop-Jeckstadt, Mihaela, Al-Dury, Samer, Bohov, Pavol, Bethune, Jörn, Sommer, Felix, Ellinghaus, David, Berge, Rolf K, Hübenthal, Matthias, Koch, Manja, Schwarz, Karin, Rimbach, Gerald, Hübbe, Patricia, Pan, Wei-Hung, Sheibani-Tezerji, Raheleh, Häsler, Robert, Rosenstiel, Philipp, D'Amato, Mauro, Cloppenborg-Schmidt, Katja, Künzel, Sven, Laudes, Matthias, Marschall, Hanns-Ulrich, Lieb, Wolfgang, Nöthlings, Ute, Karlsen, Tom H, Baines, John F, Franke, Andre
Published in Nature genetics (01.11.2016)
Published in Nature genetics (01.11.2016)
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Journal Article
Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality
Nakanishi, Tomoko, Pigazzini, Sara, Degenhardt, Frauke, Cordioli, Mattia, Butler-Laporte, Guillaume, Maya-Miles, Douglas, Nafría-Jiménez, Beatriz, Bouysran, Youssef, Niemi, Mari, Palom, Adriana, Ellinghaus, David, Khan, Atlas, Martínez-Bueno, Manuel, Rolker, Selina, Amitano, Sara, Tato, Luisa Roade, Fava, Francesca, Spinner, Christoph D, Prati, Daniele, Bernardo, David, Garcia, Federico, Darcis, Gilles, Fernández-Cadenas, Israel, Holter, Jan Cato, Banales, Jesus, Frithiof, Robert, Kiryluk, Krzysztof, Duga, Stefano, Asselta, Rosanna, Pereira, Alexandre C, Romero-Gómez, Manuel, Bujanda, Luis, Hov, Johannes R, Migeotte, Isabelle, Renieri, Alessandra, Planas, Anna M, Ludwig, Kerstin U, Buti, Maria, Rahmouni, Souad, Alarcón-Riquelme, Marta E, Schulte, Eva C, Franke, Andre, Karlsen, Tom H, Valenti, Luca, Zeberg, Hugo, Richards, J Brent, Ganna, Andrea
Published in The Journal of clinical investigation (01.12.2021)
Published in The Journal of clinical investigation (01.12.2021)
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Legal aspects of privacy-enhancing technologies in genome-wide association studies and their impact on performance and feasibility
Brauneck, Alissa, Schmalhorst, Louisa, Weiss, Stefan, Baumbach, Linda, Völker, Uwe, Ellinghaus, David, Baumbach, Jan, Buchholtz, Gabriele
Published in Genome Biology (13.06.2024)
Published in Genome Biology (13.06.2024)
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Author Correction: Legal aspects of privacy-enhancing technologies in genome-wide association studies and their impact on performance and feasibility
Brauneck, Alissa, Schmalhorst, Louisa, Weiss, Stefan, Baumbach, Linda, Völker, Uwe, Ellinghaus, David, Baumbach, Jan, Buchholtz, Gabriele
Published in Genome Biology (18.06.2024)
Published in Genome Biology (18.06.2024)
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Combined Analysis of Genome-wide Association Studies for Crohn Disease and Psoriasis Identifies Seven Shared Susceptibility Loci
Ellinghaus, David, Ellinghaus, Eva, Nair, Rajan P., Stuart, Philip E., Esko, Tõnu, Metspalu, Andres, Debrus, Sophie, Raelson, John V., Tejasvi, Trilokraj, Belouchi, Majid, West, Sarah L., Barker, Jonathan N., Kõks, Sulev, Kingo, Külli, Balschun, Tobias, Palmieri, Orazio, Annese, Vito, Gieger, Christian, Wichmann, H. Erich, Kabesch, Michael, Trembath, Richard C., Mathew, Christopher G., Abecasis, Gonçalo R., Weidinger, Stephan, Nikolaus, Susanna, Schreiber, Stefan, Elder, James T., Weichenthal, Michael, Nothnagel, Michael, Franke, Andre
Published in American journal of human genetics (06.04.2012)
Published in American journal of human genetics (06.04.2012)
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Host genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota
Moitinho-Silva, Lucas, Degenhardt, Frauke, Rodriguez, Elke, Emmert, Hila, Juzenas, Simonas, Möbus, Lena, Uellendahl-Werth, Florian, Sander, Nicole, Baurecht, Hansjörg, Tittmann, Lukas, Lieb, Wolfgang, Gieger, Christian, Peters, Annette, Ellinghaus, David, Bang, Corinna, Franke, Andre, Weidinger, Stephan, Rühlemann, Malte Christoph
Published in Nature communications (19.10.2022)
Published in Nature communications (19.10.2022)
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Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
Domingues, Francisco S, Vermeire, Séverine, Rutgeerts, Paul, Franke, Andre, Sina, Christian, Rosenstiel, Philip, Wijmenga, Cisca, Sventoraityte, Jurgita, Mayr, Gabriele, Karlsen, Tom H, Nikolaus, Susanna, Balschun, Tobias, Mathew, Christopher G, Stokkers, Pieter C F, Schreiber, Stefan, Albrecht, Mario, Vatn, Morten H, Onnie, Clive M, Ellinghaus, David, Gazouli, Maria, Strachan, David, Nothnagel, Michael, McArdle, Wendy L, Weersma, Rinse K, Krawczak, Michael
Published in Nature genetics (01.11.2008)
Published in Nature genetics (01.11.2008)
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Genome-wide association analysis for chronic venous disease identifies EFEMP1 and KCNH8 as susceptibility loci
Ellinghaus, Eva, Ellinghaus, David, Krusche, Petra, Greiner, Aljoscha, Schreiber, Claudia, Nikolaus, Susanna, Gieger, Christian, Strauch, Konstantin, Lieb, Wolfgang, Rosenstiel, Philip, Frings, Norbert, Fiebig, Andreas, Schreiber, Stefan, Franke, Andre
Published in Scientific reports (04.04.2017)
Published in Scientific reports (04.04.2017)
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Journal Article
A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis
Schaarschmidt, Heidi, ME, Ellinghaus, David, PhD, Rodríguez, Elke, PhD, Kretschmer, Anja, PhD, Baurecht, Hansjörg, MSc, Lipinski, Simone, PhD, Meyer-Hoffert, Ulf, MD, PhD, Harder, Jürgen, PhD, Lieb, Wolfgang, MD, Novak, Natalija, MD, Fölster-Holst, Regina, MD, Esparza-Gordillo, Jorge, PhD, Marenholz, Ingo, PhD, Ruschendorf, Franz, PhD, Hubner, Norbert, PhD, Reischl, Eva, PhD, Waldenberger, Melanie, PhD, Gieger, Christian, PhD, Illig, Thomas, PhD, Kabesch, Michael, MD, Zhang, Xue-Jun, MD, Xiao, Feng-Li, PhD, Lee, Young-Ae, MD, Franke, Andre, PhD, Weidinger, Stephan, MD
Published in Journal of allergy and clinical immunology (01.09.2015)
Published in Journal of allergy and clinical immunology (01.09.2015)
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Protein-coding variants contribute to the risk of atopic dermatitis and skin-specific gene expression
Mucha, Sören, Baurecht, Hansjörg, Novak, Natalija, Rodríguez, Elke, Bej, Saptarshi, Mayr, Gabriele, Emmert, Hila, Stölzl, Dora, Gerdes, Sascha, Jung, Eun Suk, Degenhardt, Frauke, Hübenthal, Matthias, Ellinghaus, Eva, Kässens, Jan Christian, Wienbrandt, Lars, Lieb, Wolfgang, Müller-Nurasyid, Martina, Hotze, Melanie, Dand, Nick, Grosche, Sarah, Marenholz, Ingo, Arnold, Andreas, Homuth, Georg, Schmidt, Carsten O., Wehkamp, Ulrike, Nöthen, Markus M., Hoffmann, Per, Paternoster, Lavinia, Standl, Marie, Bønnelykke, Klaus, Ahluwalia, Tarunveer S., Bisgaard, Hans, Peters, Annette, Gieger, Christian, Waldenberger, Melanie, Schulz, Holger, Strauch, Konstantin, Werfel, Thomas, Lee, Young-Ae, Wolfien, Markus, Rosenstiel, Philip, Wolkenhauer, Olaf, Schreiber, Stefan, Franke, Andre, Weidinger, Stephan, Ellinghaus, David
Published in Journal of allergy and clinical immunology (01.04.2020)
Published in Journal of allergy and clinical immunology (01.04.2020)
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DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon
Fazio, Antonella, Bordoni, Dora, Kuiper, Jan W. P., Weber-Stiehl, Saskia, Stengel, Stephanie T., Arnold, Philipp, Ellinghaus, David, Ito, Go, Tran, Florian, Messner, Berith, Henning, Anna, Bernardes, Joana P., Häsler, Robert, Luzius, Anne, Imm, Simon, Hinrichsen, Finn, Franke, Andre, Huber, Samuel, Nikolaus, Susanna, Aden, Konrad, Schreiber, Stefan, Sommer, Felix, Natoli, Gioacchino, Mishra, Neha, Rosenstiel, Philip
Published in Nature communications (21.10.2022)
Published in Nature communications (21.10.2022)
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Local genetic variation of inflammatory bowel disease in Basque population and its effect in risk prediction
Garcia-Etxebarria, Koldo, Merino, Olga, Gaite-Reguero, Adrián, Rodrigues, Pedro M., Herrarte, Amaia, Etxart, Ane, Ellinghaus, David, Alonso-Galan, Horacio, Franke, Andre, Marigorta, Urko M., Bujanda, Luis, D’Amato, Mauro
Published in Scientific reports (01.03.2022)
Published in Scientific reports (01.03.2022)
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Construction and benchmarking of a multi-ethnic reference panel for the imputation of HLA class I and II alleles
Degenhardt, Frauke, Wendorff, Mareike, Wittig, Michael, Ellinghaus, Eva, Datta, Lisa W, Schembri, John, Ng, Siew C, Rosati, Elisa, Hübenthal, Matthias, Ellinghaus, David, Jung, Eun Suk, Lieb, Wolfgang, Abedian, Shifteh, Malekzadeh, Reza, Cheon, Jae Hee, Ellul, Pierre, Sood, Ajit, Midha, Vandana, Thelma, B K, Wong, Sunny H, Schreiber, Stefan, Yamazaki, Keiko, Kubo, Michiaki, Boucher, Gabrielle, Rioux, John D, Lenz, Tobias L, Brant, Steven R, Franke, Andre
Published in Human molecular genetics (15.06.2019)
Published in Human molecular genetics (15.06.2019)
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Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci
Folseraas, Trine, Melum, Espen, Rausch, Philipp, Juran, Brian D, Ellinghaus, Eva, Shiryaev, Alexey, Laerdahl, Jon K, Ellinghaus, David, Schramm, Christoph, Weismüller, Tobias J, Gotthardt, Daniel Nils, Hov, Johannes Roksund, Clausen, Ole Petter, Weersma, Rinse K, Janse, Marcel, Boberg, Kirsten Muri, Björnsson, Einar, Marschall, Hanns-Ulrich, Cleynen, Isabelle, Rosenstiel, Philip, Holm, Kristian, Teufel, Andreas, Rust, Christian, Gieger, Christian, Wichmann, H-Erich, Bergquist, Annika, Ryu, Euijung, Ponsioen, Cyriel Y, Runz, Heiko, Sterneck, Martina, Vermeire, Severine, Beuers, Ulrich, Wijmenga, Cisca, Schrumpf, Erik, Manns, Michael P, Lazaridis, Konstantinos N, Schreiber, Stefan, Baines, John F, Franke, Andre, Karlsen, Tom H
Published in Journal of hepatology (01.08.2012)
Published in Journal of hepatology (01.08.2012)
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