Mechanistic Investigations of the Mitochondrial Complex I Inhibitor Rotenone in the Context of Pharmacological and Safety Evaluation
Heinz, Sabrina, Freyberger, Alexius, Lawrenz, Bettina, Schladt, Ludwig, Schmuck, Gabriele, Ellinger-Ziegelbauer, Heidrun
Published in Scientific reports (04.04.2017)
Published in Scientific reports (04.04.2017)
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Journal Article
Development and validation of a high-throughput transcriptomic biomarker to address 21st century genetic toxicology needs
Li, Heng-Hong, Chen, Renxiang, Hyduke, Daniel R., Williams, Andrew, Frötschl, Roland, Ellinger-Ziegelbauer, Heidrun, O’Lone, Raegan, Yauk, Carole L., Aubrecht, Jiri, Fornace, Albert J.
Published in Proceedings of the National Academy of Sciences - PNAS (19.12.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (19.12.2017)
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Journal Article
Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations
Albrecht, Wiebke, Kappenberg, Franziska, Brecklinghaus, Tim, Stoeber, Regina, Marchan, Rosemarie, Zhang, Mian, Ebbert, Kristina, Kirschner, Hendrik, Grinberg, Marianna, Leist, Marcel, Moritz, Wolfgang, Cadenas, Cristina, Ghallab, Ahmed, Reinders, Jörg, Vartak, Nachiket, van Thriel, Christoph, Golka, Klaus, Tolosa, Laia, Castell, José V., Damm, Georg, Seehofer, Daniel, Lampen, Alfonso, Braeuning, Albert, Buhrke, Thorsten, Behr, Anne-Cathrin, Oberemm, Axel, Gu, Xiaolong, Kittana, Naim, van de Water, Bob, Kreiling, Reinhard, Fayyaz, Susann, van Aerts, Leon, Smedsrød, Bård, Ellinger-Ziegelbauer, Heidrun, Steger-Hartmann, Thomas, Gundert-Remy, Ursula, Zeigerer, Anja, Ullrich, Anett, Runge, Dieter, Lee, Serene M. L., Schiergens, Tobias S., Kuepfer, Lars, Aguayo-Orozco, Alejandro, Sachinidis, Agapios, Edlund, Karolina, Gardner, Iain, Rahnenführer, Jörg, Hengstler, Jan G.
Published in Archives of toxicology (01.06.2019)
Published in Archives of toxicology (01.06.2019)
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Journal Article
Prediction of a carcinogenic potential of rat hepatocarcinogens using toxicogenomics analysis of short-term in vivo studies
Ellinger-Ziegelbauer, Heidrun, Gmuender, Hans, Bandenburg, Arnd, Ahr, Hans Juergen
Published in Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis (01.01.2008)
Published in Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis (01.01.2008)
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Journal Article
Quantitative targeted bile acid profiling as new markers for DILI in a model of methapyrilene-induced liver injury in rats
Slopianka, Markus, Herrmann, Anne, Pavkovic, Mira, Ellinger-Ziegelbauer, Heidrun, Ernst, Rainer, Mally, Angela, Keck, Matthias, Riefke, Bjoern
Published in Toxicology (Amsterdam) (01.07.2017)
Published in Toxicology (Amsterdam) (01.07.2017)
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Journal Article
The sGC Activator Runcaciguat Has Kidney Protective Effects and Prevents a Decline of Kidney Function in ZSF1 Rats
Kraehling, Jan R, Benardeau, Agnes, Schomber, Tibor, Popp, Laura, Vienenkoetter, Julia, Ellinger-Ziegelbauer, Heidrun, Pavkovic, Mira, Hartmann, Elke, Siudak, Krystyna, Freyberger, Alexius, Hagelschuer, Ina, Mathar, Ilka, Hueser, Joerg, Hahn, Michael G, Geiss, Volker, Eitner, Frank, Sandner, Peter
Published in International journal of molecular sciences (01.09.2023)
Published in International journal of molecular sciences (01.09.2023)
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Journal Article
Beyond miR-122: Identification of MicroRNA Alterations in Blood During a Time Course of Hepatobiliary Injury and Biliary Hyperplasia in Rats
Church, Rachel J, Otieno, Monicah, McDuffie, James Eric, Singh, Bhanu, Sonee, Manisha, Hall, LeRoy, Watkins, Paul B, Ellinger-Ziegelbauer, Heidrun, Harrill, Alison H
Published in Toxicological sciences (01.03.2016)
Published in Toxicological sciences (01.03.2016)
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Journal Article
A cross-industry survey on photosafety evaluation of pharmaceuticals after implementation of ICH S10
Bauer, Daniel, Buckley, Lorrene A., Delafoy, Laure, Ellinger-Ziegelbauer, Heidrun, Fellows, Mick D., Gerets, Helga H.J., Howe, Jonathan, Kaijser, Gerry, Nicolette, John, Pettersen, Betty A., Schimpf, Brian
Published in Regulatory toxicology and pharmacology (01.10.2021)
Published in Regulatory toxicology and pharmacology (01.10.2021)
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Journal Article
Comparison of the expression profiles induced by genotoxic and nongenotoxic carcinogens in rat liver
Ellinger-Ziegelbauer, Heidrun, Stuart, Barry, Wahle, Brad, Bomann, Werner, Ahr, Hans Juergen
Published in Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis (04.08.2005)
Published in Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis (04.08.2005)
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Journal Article
Application of toxicogenomics to study mechanisms of genotoxicity and carcinogenicity
Ellinger-Ziegelbauer, Heidrun, Aubrecht, Jiri, Kleinjans, Jos C., Ahr, Hans-Juergen
Published in Toxicology letters (10.04.2009)
Published in Toxicology letters (10.04.2009)
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Journal Article
Performance of Novel Kidney Biomarkers in Preclinical Toxicity Studies
Hoffmann, Dana, Adler, Melanie, Vaidya, Vishal S., Rached, Eva, Mulrane, Laoighse, Gallagher, William M., Callanan, John J., Gautier, Jean C., Matheis, Katja, Staedtler, Frank, Dieterle, Frank, Brandenburg, Arnd, Sposny, Alexandra, Hewitt, Philip, Ellinger-Ziegelbauer, Heidrun, Bonventre, Joseph V., Dekant, Wolfgang, Mally, Angela
Published in Toxicological sciences (01.07.2010)
Published in Toxicological sciences (01.07.2010)
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Journal Article
EU Framework 6 Project: Predictive Toxicology (PredTox)—overview and outcome
Suter, Laura, Schroeder, Susanne, Meyer, Kirstin, Gautier, Jean-Charles, Amberg, Alexander, Wendt, Maria, Gmuender, Hans, Mally, Angela, Boitier, Eric, Ellinger-Ziegelbauer, Heidrun, Matheis, Katja, Pfannkuch, Friedlieb
Published in Toxicology and applied pharmacology (15.04.2011)
Published in Toxicology and applied pharmacology (15.04.2011)
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Journal Article
Two approaches for estimating the lower limit of quantitation (LLOQ) of microRNA levels assayed as exploratory biomarkers by RT-qPCR
Wolfinger, Russell D, Beedanagari, Sudheer, Boitier, Eric, Chen, Tao, Couttet, Philippe, Ellinger-Ziegelbauer, Heidrun, Guillemain, Gregory, Mariet, Claire, Mouritzen, Peter, O'Lone, Raegan, Pine, P Scott, Sharapova, Tatiana, Yan, Jian, Yuen, Peter S, Thompson, Karol L
Published in BMC biotechnology (02.02.2018)
Published in BMC biotechnology (02.02.2018)
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Journal Article
Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes
Schug, Markus, Stöber, Regina, Heise, Tanja, Mielke, Hans, Gundert-Remy, Ursula, Godoy, Patricio, Reif, Raymond, Blaszkewicz, Meinolf, Ellinger-Ziegelbauer, Heidrun, Ahr, Hans-Jürgen, Selinski, Silvia, Günther, Georgia, Marchan, Rosemarie, Sachinidis, Agapios, Nüssler, Andreas, Oberemm, Axel, Hengstler, Jan G.
Published in Archives of toxicology (01.02.2013)
Published in Archives of toxicology (01.02.2013)
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Journal Article
Integrated Genotoxicity Testing of three anti-infective drugs using the TGx-DDI transcriptomic biomarker and high-throughput CometChip ® assay in TK6 cells
Buick, Julie K, Rowan-Carroll, Andrea, Gagné, Rémi, Williams, Andrew, Chen, Renxiang, Li, Heng-Hong, Fornace, Jr, Albert J, Chao, Christy, Engelward, Bevin P, Frötschl, Roland, Ellinger-Ziegelbauer, Heidrun, Pettit, Syril D, Aubrecht, Jiri, Yauk, Carole L
Published in Frontiers in toxicology (23.09.2022)
Published in Frontiers in toxicology (23.09.2022)
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Journal Article
Characterization and Interlaboratory Comparison of a Gene Expression Signature for Differentiating Genotoxic Mechanisms
Ellinger-Ziegelbauer, Heidrun, Fostel, Jennifer M., Aruga, Chinami, Bauer, Daniel, Boitier, Eric, Deng, Shibing, Dickinson, Donna, Le Fevre, Anne-Celine, Fornace, Albert J., Grenet, Olivier, Gu, Yizhong, Hoflack, Jean-Christophe, Shiiyama, Masako, Smith, Roger, Snyder, Ronald D., Spire, Catherine, Tanaka, Gotaro, Aubrecht, Jiri
Published in Toxicological sciences (01.08.2009)
Published in Toxicological sciences (01.08.2009)
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Journal Article
Characteristic Expression Profiles Induced by Genotoxic Carcinogens in Rat Liver
Ellinger-Ziegelbauer, Heidrun, Stuart, Barry, Wahle, Brad, Bomann, Werner, Ahr, Hans-Jürgen
Published in Toxicological sciences (01.01.2004)
Published in Toxicological sciences (01.01.2004)
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Journal Article
Establishment of a protocol for the gene expression analysis of laser microdissected rat kidney samples with affymetrix genechips
Stemmer, Kerstin, Ellinger-Ziegelbauer, Heidrun, Lotz, Kerstin, Ahr, Hans-J., Dietrich, Daniel R.
Published in Toxicology and applied pharmacology (15.11.2006)
Published in Toxicology and applied pharmacology (15.11.2006)
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