Peripheral blood CD34+ cells efficiently engraft human cytokine knock-in mice
Saito, Yasuyuki, Ellegast, Jana M., Rafiei, Anahita, Song, Yuanbin, Kull, Daniel, Heikenwalder, Mathias, Rongvaux, Anthony, Halene, Stephanie, Flavell, Richard A., Manz, Markus G.
Published in Blood (06.10.2016)
Published in Blood (06.10.2016)
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MPL expression on AML blasts predicts peripheral blood neutropenia and thrombocytopenia
Rauch, Philipp J., Ellegast, Jana M., Widmer, Corinne C., Fritsch, Kristin, Goede, Jeroen S., Valk, Peter J.M., Löwenberg, Bob, Takizawa, Hitoshi, Manz, Markus G.
Published in Blood (03.11.2016)
Published in Blood (03.11.2016)
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inv(16) and NPM1mut AMLs engraft human cytokine knock-in mice
Ellegast, Jana M., Rauch, Philipp J., Kovtonyuk, Larisa V., Müller, Rouven, Wagner, Ulrich, Saito, Yasuyuki, Wildner-Verhey van Wijk, Nicole, Fritz, Christine, Rafiei, Anahita, Lysenko, Veronika, Dudkiewicz, Ewa, Theocharides, Alexandre P., Soldini, Davide, Goede, Jeroen S., Flavell, Richard A., Manz, Markus G.
Published in Blood (27.10.2016)
Published in Blood (27.10.2016)
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Generation of Humanized Mice for Analysis of Human Dendritic Cells
Saito, Yasuyuki, Ellegast, Jana M, Manz, Markus G
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2016)
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2016)
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Journal Article
The ETS transcription factor ETV6 constrains the transcriptional activity of EWS–FLI to promote Ewing sarcoma
Lu, Diana Y., Ellegast, Jana M., Ross, Kenneth N., Malone, Clare F., Lin, Shan, Mabe, Nathaniel W., Dharia, Neekesh V., Meyer, Ashleigh, Conway, Amy, Su, Angela H., Selich-Anderson, Julia, Taslim, Cenny, Byrum, Andrea K., Seong, Bo Kyung A., Adane, Biniam, Gray, Nathanael S., Rivera, Miguel N., Lessnick, Stephen L., Stegmaier, Kimberly
Published in Nature cell biology (01.02.2023)
Published in Nature cell biology (01.02.2023)
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PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy
Miller, Peter G., Sperling, Adam S., Mayerhofer, Christina, McConkey, Marie E., Ellegast, Jana M., Da Silva, Carmen, Cohen, Drew N., Wang, Chuqi, Sharda, Azeem, Yan, Ni, Saha, Subha, Schluter, Cameron, Schechter, Ilexa, Słabicki, Mikołaj, Sandoval, Brittany, Kahn, Josephine, Boettcher, Steffen, Gibson, Christopher J., Scadden, David T., Stegmaier, Kimberly, Bhatt, Shruti, Lindsley, R. Coleman, Ebert, Benjamin L.
Published in Blood (14.12.2023)
Published in Blood (14.12.2023)
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Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2
LaRochelle, Jonathan R., Fodor, Michelle, Ellegast, Jana M., Liu, Xiaoxi, Vemulapalli, Vidyasiri, Mohseni, Morvarid, Stams, Travis, Buhrlage, Sara J., Stegmaier, Kimberly, LaMarche, Matthew J., Acker, Michael G., Blacklow, Stephen C.
Published in Bioorganic & medicinal chemistry (15.12.2017)
Published in Bioorganic & medicinal chemistry (15.12.2017)
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Journal Article
Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts
Ellegast, Jana M, Alexe, Gabriela, Hamze, Amanda, Lin, Shan, Uckelmann, Hannah J, Rauch, Philipp J, Pimkin, Maxim, Ross, Linda S, Dharia, Neekesh V, Robichaud, Amanda L, Conway, Amy Saur, Khalid, Delan, Perry, Jennifer A, Wunderlich, Mark, Benajiba, Lina, Pikman, Yana, Nabet, Behnam, Gray, Nathanael S, Orkin, Stuart H, Stegmaier, Kimberly
Published in Cancer discovery (06.07.2022)
Published in Cancer discovery (06.07.2022)
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Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small-molecule inhibitor
Roux, Blandine, Vaganay, Camille, Vargas, Jesse D, Alexe, Gabriela, Benaksas, Chaima, Pardieu, Bryann, Fenouille, Nina, Ellegast, Jana M, Malolepsza, Edyta, Ling, Frank, Sodaro, Gaetano, Ross, Linda, Pikman, Yana, Conway, Amy S, Tang, Yangzhong, Wu, Tony, Anderson, Daniel J, Le Moigne, Ronan, Zhou, Han-Jie, Luciano, Frédéric, Hartigan, Christina R, Galinsky, Ilene, DeAngelo, Daniel J, Stone, Richard M, Auberger, Patrick, Schenone, Monica, Carr, Steven A, Guirouilh-Barbat, Josée, Lopez, Bernard, Khaled, Mehdi, Lage, Kasper, Hermine, Olivier, Hemann, Michael T, Puissant, Alexandre, Stegmaier, Kimberly, Benajiba, Lina
Published in Science translational medicine (31.03.2021)
Published in Science translational medicine (31.03.2021)
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Journal Article
Resistance Mechanisms to SYK Inhibition in Acute Myeloid Leukemia
Cremer, Anjali, Ellegast, Jana M, Alexe, Gabriela, Frank, Elizabeth S, Ross, Linda, Chu, S Haihua, Pikman, Yana, Robichaud, Amanda, Goodale, Amy, Häupl, Björn, Mohr, Sebastian, Rao, Arati V, Walker, Alison R, Blachly, James S, Piccioni, Federica, Armstrong, Scott A, Byrd, John C, Oellerich, Thomas, Stegmaier, Kimberly
Published in Cancer discovery (01.02.2020)
Published in Cancer discovery (01.02.2020)
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A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia
Harada, Taku, Heshmati, Yaser, Kalfon, Jérémie, Perez, Monika W, Xavier Ferrucio, Juliana, Ewers, Jazmin, Hubbell Engler, Benjamin, Kossenkov, Andrew, Ellegast, Jana M, Yi, Joanna S, Bowker, Allyson, Zhu, Qian, Eagle, Kenneth, Liu, Tianxin, Kai, Yan, Dempster, Joshua M, Kugener, Guillaume, Wickramasinghe, Jayamanna, Herbert, Zachary T, Li, Charles H, Vrabič Koren, Jošt, Weinstock, David M, Paralkar, Vikram R, Nabet, Behnam, Lin, Charles Y, Dharia, Neekesh V, Stegmaier, Kimberly, Orkin, Stuart H, Pimkin, Maxim
Published in Genes & development (01.03.2022)
Published in Genes & development (01.03.2022)
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Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33
Azoitei, Ninel, Hoffmann, Christopher M, Ellegast, Jana M, Ball, Claudia R, Obermayer, Kerstin, Gößele, Ulrike, Koch, Britta, Faber, Katrin, Genze, Felicitas, Schrader, Mark, Kestler, Hans A, Döhner, Hartmut, Chiosis, Gabriela, Glimm, Hanno, Fröhling, Stefan, Scholl, Claudia
Published in The Journal of experimental medicine (09.04.2012)
Published in The Journal of experimental medicine (09.04.2012)
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Journal Article
Development of human hemato-lymphoid system in human cytokine knock-IN RAG2-/- IL2RG-/- mice engrafted with peripheral blood mobilized CD34+ cells
Saito, Yasuyuki, Ellegast, Jana M, Kull, Daniel, Heikenwälder, Mathias, Flavell, Richard A, Manz, Markus G
Published in Experimental hematology (01.09.2015)
Published in Experimental hematology (01.09.2015)
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Identifying Targeted Therapies for CBFA2T3 - GLIS2 Acute Myeloid Leukemia
Gonzales, Fanny, Lin, Shan, Khalid, Delan, Ellegast, Jana M, Alexe, Gabriela, Stegmaier, Kimberly
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Leukemia core transcriptional circuitry is a sparsely interconnected hierarchy stabilized by incoherent feed-forward loops
Harada, Taku, Kalfon, Jérémie, Perez, Monika W, Eagle, Kenneth, Braes, Flora Dievenich, Batley, Rashad, Heshmati, Yaser, Ferrucio, Juliana Xavier, Ewers, Jazmin, Mehta, Stuti, Kossenkov, Andrew, Ellegast, Jana M, Bowker, Allyson, Wickramasinghe, Jayamanna, Nabet, Behnam, Paralkar, Vikram R, Dharia, Neekesh V, Stegmaier, Kimberly, Orkin, Stuart H, Pimkin, Maxim
Published in bioRxiv : the preprint server for biology (15.03.2023)
Published in bioRxiv : the preprint server for biology (15.03.2023)
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Mechanisms of the CBFA2T3-GLIS2 Fusion in AML Maintenance
Gonzales, Fanny C, Lin, Shan, Khalid, Delan, Ellegast, Jana M, Alexe, Gabriela, Stegmaier, Kimberly
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Functional Dissection of Cellular Programs to Uncover Novel Gene Dependencies in AML
Ellegast, Jana M, Alexe, Gabriela, Baniya, Subha, Hamze, Amanda, Taillon, Audrey, Adane, Biniam, Saur Conway, Amy, Zhang, Tinghu, Gray, Nathanael S, Armstrong, Scott A, Stegmaier, Kimberly
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Unleashing Cell-Intrinsic Inflammation As a Strategy to Kill AML Blasts
Ellegast, Jana M, Alexe, Gabriela, Hamze, Amanda, Lin, Shan, Pimkin, Maxim, Ross, Linda, Dharia, Neekesh V, Robinchaud, Amanda L, Conway, Amy, Khalid, Delan, Wunderlich, Mark, Benajiba, Lina, Nabet, Behnam, Gray, Nathanael S, Orkin, Stuart H., Stegmaier, Kimberly
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Resistance Mechanisms to SYK Inhibition in AML
Cremer, Anjali, Ellegast, Jana M, Pikman, Yana, Alexe, Gabriela, Ross, Linda, Goodale, Amy, Piccioni, Federica, Frank, Elizabeth S, Oellerich, Thomas, Stegmaier, Kimberly
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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