Comparison of the effects of sodium phenobarbital in wild type and humanized constitutive androstane receptor (CAR)/pregnane X receptor (PXR) mice and in cultured mouse, rat and human hepatocytes
Haines, Corinne, Elcombe, Barbara M., Chatham, Lynsey R., Vardy, Audrey, Higgins, Larry G., Elcombe, Clifford R., Lake, Brian G.
Published in Toxicology (Amsterdam) (01.03.2018)
Published in Toxicology (Amsterdam) (01.03.2018)
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Transgenic animal models in toxicology: historical perspectives and future outlook
Boverhof, Darrell R, Chamberlain, Mark P, Elcombe, Clifford R, Gonzalez, Frank J, Heflich, Robert H, Hernández, Lya G, Jacobs, Abigail C, Jacobson-Kram, David, Luijten, Mirjam, Maggi, Adriana, Manjanatha, Mugimane G, Benthem, Jan van, Gollapudi, B Bhaskar
Published in Toxicological sciences (01.06.2011)
Published in Toxicological sciences (01.06.2011)
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Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator
Elcombe, Clifford R., Peffer, Richard C., Wolf, Douglas C., Bailey, Jason, Bars, Remi, Bell, David, Cattley, Russell C., Ferguson, Stephen S., Geter, David, Goetz, Amber, Goodman, Jay I., Hester, Susan, Jacobs, Abigail, Omiecinski, Curtis J., Schoeny, Rita, Xie, Wen, Lake, Brian G.
Published in Critical reviews in toxicology (01.01.2014)
Published in Critical reviews in toxicology (01.01.2014)
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Stochastic Pharmacokinetic-Pharmacodynamic Modeling for Assessing the Systemic Health Risk of Perfluorooctanoate (PFOA)
Convertino, Matteo, Church, Timothy R, Olsen, Geary W, Liu, Yang, Doyle, Eddie, Elcombe, Clifford R, Barnett, Anna L, Samuel, Leslie M, MacPherson, Iain R, Evans, Thomas R J
Published in Toxicological sciences (01.05.2018)
Published in Toxicological sciences (01.05.2018)
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Hepatocellular hypertrophy and cell proliferation in Sprague–Dawley rats from dietary exposure to potassium perfluorooctanesulfonate results from increased expression of xenosensor nuclear receptors PPARα and CAR/PXR
Elcombe, Clifford R, Elcombe, Barbara M, Foster, John R, Chang, Shu-Ching, Ehresman, David J, Butenhoff, John L
Published in Toxicology (Amsterdam) (11.03.2012)
Published in Toxicology (Amsterdam) (11.03.2012)
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Human Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogens Phenobarbital and Chlordane In Vivo
Ross, Jillian, Plummer, Simon M., Rode, Anja, Scheer, Nico, Bower, Conrad C., Vogel, Ortwin, Henderson, Colin J., Wolf, C. Roland, Elcombe, Clifford R.
Published in Toxicological sciences (01.08.2010)
Published in Toxicological sciences (01.08.2010)
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Assessment of the Intestinal Absorption of Higher Olefins by the Everted Gut Sac Model in Combination with In Silico New Approach Methodologies
Shi, Quan, Carrillo, Juan-Carlos, Penman, Michael G., Manton, Jason, Fioravanzo, Elena, Powrie, Robert H., Elcombe, Clifford R., Borsboom-Patel, Tilly, Tian, Yuan, Shen, Hua, Boogaard, Peter J.
Published in Chemical research in toxicology (15.08.2022)
Published in Chemical research in toxicology (15.08.2022)
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Comparison of the hepatic and thyroid gland effects of sodium phenobarbital and pregnenolone-16α-carbonitrile in wild-type and constitutive androstane receptor (CAR)/pregnane X receptor (PXR) knockout rats
Haines, Corinne, Chatham, Lynsey R, Vardy, Audrey, Elcombe, Clifford R, Foster, John R, Lake, Brian G
Published in Xenobiotica (01.02.2019)
Published in Xenobiotica (01.02.2019)
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Journal Article
Comparison of the hepatic and thyroid gland effects of sodium phenobarbital in wild type and constitutive androstane receptor (CAR) knockout rats and pregnenolone-16α-carbonitrile in wild type and pregnane X receptor (PXR) knockout rats
Haines, Corinne, Chatham, Lynsey R., Vardy, Audrey, Elcombe, Clifford R., Foster, John R., Lake, Brian G.
Published in Toxicology (Amsterdam) (01.05.2018)
Published in Toxicology (Amsterdam) (01.05.2018)
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Prediction of Rodent Nongenotoxic Carcinogenesis: Evaluation of Biochemical and Tissue Changes in Rodents Following Exposure to Nine Nongenotoxic NTP Carcinogens
Elcombe, Clifford R., Odum, Jenny, Foster, John R., Stone, Susan, Hasmall, Susan, Soames, Anthony R., Kimber, Ian, Ashby, John
Published in Environmental health perspectives (01.04.2002)
Published in Environmental health perspectives (01.04.2002)
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Metazachlor: mode of action analysis for rat liver tumour formation and human relevance
Wiemann, Christiane, Goettel, Manuela, Vardy, Audrey, Elcombe, Barbara M, Elcombe, Clifford R, Chatham, Lynsey R, Wang, Hongbing, Li, Linhao, Buesen, Roland, Honarvar, Naveed, Treumann, Silke, Marxfeld, Heike, Groeters, Sibylle, Lake, Brian G
Published in Toxicology (Amsterdam) (01.10.2019)
Published in Toxicology (Amsterdam) (01.10.2019)
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Journal Article
Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors
Luisier, Raphaëlle, Lempiäinen, Harri, Scherbichler, Nina, Braeuning, Albert, Geissler, Miriam, Dubost, Valerie, Müller, Arne, Scheer, Nico, Chibout, Salah-Dine, Hara, Hisanori, Picard, Frank, Theil, Diethilde, Couttet, Philippe, Vitobello, Antonio, Grenet, Olivier, Grasl-Kraupp, Bettina, Ellinger-Ziegelbauer, Heidrun, Thomson, John P, Meehan, Richard R, Elcombe, Clifford R, Henderson, Colin J, Wolf, C Roland, Schwarz, Michael, Moulin, Pierre, Terranova, Rémi, Moggs, Jonathan G
Published in Toxicological sciences (01.06.2014)
Published in Toxicological sciences (01.06.2014)
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Journal Article
Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors
Luisier, Raphaëlle, Lempiäinen, Harri, Scherbichler, Nina, Braeuning, Albert, Geissler, Miriam, Dubost, Valerie, Müller, Arne, Scheer, Nico, Chibout, Salah-Dine, Hara, Hisanori, Picard, Frank, Theil, Diethilde, Couttet, Philippe, Vitobello, Antonio, Grenet, Olivier, Grasl-Kraupp, Bettina, Ellinger-Ziegelbauer, Heidrun, Thomson, John P., Meehan, Richard R., Elcombe, Clifford R., Henderson, Colin J., Wolf, C. Roland, Schwarz, Michael, Moulin, Pierre, Terranova, Rémi, Moggs, Jonathan G.
Published in Toxicological sciences (01.06.2014)
Published in Toxicological sciences (01.06.2014)
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Journal Article
Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPARα and CAR/PXR
Elcombe, Clifford R, Elcombe, Barbara M, Foster, John R, Farrar, David G, Jung, Reinhard, Chang, Shu-Ching, Kennedy, Gerald L, Butenhoff, John L
Published in Archives of toxicology (01.10.2010)
Published in Archives of toxicology (01.10.2010)
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Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice
Chanas, Simon A, Jiang, Qing, McMahon, Michael, McWalter, Gail K, McLellan, Lesley I, Elcombe, Clifford R, Henderson, Colin J, Wolf, C Roland, Moffat, Graeme J, Itoh, Ken, Yamamoto, Masayuki, Hayes, John D
Published in Biochemical journal (15.07.2002)
Published in Biochemical journal (15.07.2002)
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Identification of transcription factors and coactivators affected by dibutylphthalate interactions in fetal rat testes
Plummer, Simon M, Dan, Dhritiman, Quinney, Joanne, Hallmark, Nina, Phillips, Richard D, Millar, Michael, Macpherson, Sheila, Elcombe, Clifford R
Published in Toxicological sciences (01.04.2013)
Published in Toxicological sciences (01.04.2013)
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Journal Article
Evaluation of hepatic and thyroid responses in male Sprague Dawley rats for up to eighty-four days following seven days of dietary exposure to potassium perfluorooctanesulfonate
Elcombe, Clifford R, Elcombe, Barbara M, Foster, John R, Chang, Shu-Ching, Ehresman, David J, Noker, Patricia E, Butenhoff, John L
Published in Toxicology (Amsterdam) (11.03.2012)
Published in Toxicology (Amsterdam) (11.03.2012)
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Journal Article
Biochemical and genetic characterization of a murine class Kappa glutathione S-transferase
Jowsey, Ian R, Thomson, Rachel E, Orton, Terry C, Elcombe, Clifford R, Hayes, John D
Published in Biochemical journal (15.07.2003)
Published in Biochemical journal (15.07.2003)
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