A Metabolic Screening Study of Trichostatin A (TSA) and TSA-Like Histone Deacetylase Inhibitors in Rat and Human Primary Hepatocyte Cultures
Elaut, G, Laus, G, Alexandre, E, Richert, L, Bachellier, P, Tourwé, D, Rogiers, V, Vanhaecke, T
Published in The Journal of pharmacology and experimental therapeutics (01.04.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2007)
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Journal Article
Major Phase I Biotransformation Pathways of Trichostatin A in Rat Hepatocytes and in Rat and Human Liver Microsomes
ELAUT, G, TÖRÖK, G, VINKEN, M, LAUS, G, PAPELEU, P, TOURWE, D, ROGIERS, V
Published in Drug metabolism and disposition (01.12.2002)
Published in Drug metabolism and disposition (01.12.2002)
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Journal Article
Amide analogues of TSA: synthesis, binding mode analysis and HDAC inhibition
Van Ommeslaeghe, K, Elaut, G, Brecx, V, Papeleu, P, Iterbeke, K, Geerlings, P, Tourwé, D, Rogiers, V
Published in Bioorganic & medicinal chemistry letters (02.06.2003)
Published in Bioorganic & medicinal chemistry letters (02.06.2003)
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Journal Article
Effect of oxygen concentration on the expression of glutathione S-transferase activity in periportal and perivenous rat hepatocyte cultures
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Journal Article
Conference Proceeding
Metabolism: a bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54
Coecke, Sandra, Ahr, Hans, Blaauboer, Bas J, Bremer, Susanne, Casati, Silvia, Castell, Josè, Combes, Robert, Corvi, Raffaella, Crespi, Charles L, Cunningham, Michael L, Elaut, Greetje, Eletti, Brighitta, Freidig, Andreas, Gennari, Alessandra, Ghersi-Egea, Jean-François, Guillouzo, Andre, Hartung, Thomas, Hoet, Peter, Ingelman-Sundberg, Magnus, Munn, Sharon, Janssens, Walter, Ladstetter, Bernhard, Leahy, David, Long, Anthony, Meneguz, Annarita, Monshouwer, Mario, Morath, Siegfried, Nagelkerke, Fred, Pelkonen, Olavi, Ponti, Jessica, Prieto, Pilar, Richert, Lysianne, Sabbioni, Enrico, Schaack, Beatrice, Steiling, Winfried, Testai, Emanuela, Vericat, Joan-Albert, Worth, Andrew
Published in Alternatives to laboratory animals (01.02.2006)
Published in Alternatives to laboratory animals (01.02.2006)
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Journal Article
Differential Effects of Histone Deacetylase Inhibitors in Tumor and Normal Cells-What Is the Toxicological Relevance?
Papeleu, Peggy, Vanhaecke, Tamara, Elaut, Greetje, Vinken, Mathieu, Henkens, Tom, Snykers, Sarah, Rogiers, Vera
Published in Critical reviews in toxicology (01.04.2005)
Published in Critical reviews in toxicology (01.04.2005)
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Journal Article
Trichostatin A induces differential cell cycle arrests but does not induce apoptosis in primary cultures of mitogen-stimulated rat hepatocytes
Papeleu, Peggy, Loyer, Pascal, Vanhaecke, Tamara, Elaut, Greetje, Geerts, Albert, Guguen-Guillouzo, Christiane, Rogiers, Vera
Published in Journal of hepatology (01.09.2003)
Published in Journal of hepatology (01.09.2003)
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Journal Article
Inhibition of NF-κB activation by the histone deacetylase inhibitor 4-Me2N-BAVAH induces an early G1 cell cycle arrest in primary hepatocytes
Papeleu, P., Wullaert, A., Elaut, G., Henkens, T., Vinken, M., Laus, G., Tourwé, D., Beyaert, R., Rogiers, V., Vanhaecke, T.
Published in Cell proliferation (01.10.2007)
Published in Cell proliferation (01.10.2007)
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Journal Article
Hepatocytes in suspension
Elaut, Greetje, Papeleu, Peggy, Vinken, Mathieu, Henkens, Tom, Snykers, Sarah, Vanhaecke, Tamara, Rogiers, Vera
Published in Methods in molecular biology (Clifton, N.J.) (2006)
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Published in Methods in molecular biology (Clifton, N.J.) (2006)
Journal Article
Spontaneous apoptosis, necrosis, energy status, glutathione levels and biotransformation capacities of isolated rat hepatocytes in suspension: Effect of the incubation medium
Elaut, Greetje, Vanhaecke, Tamara, Heyden, Yvan Vander, Rogiers, Vera
Published in Biochemical pharmacology (15.06.2005)
Published in Biochemical pharmacology (15.06.2005)
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Journal Article
Inhibition of NF- Kappa B activation by the histone deacetylase inhibitor 4-Me sub(2)N-BAVAH induces an early G sub(1) cell cycle arrest in primary hepatocytes
Papeleu, P, Wullaert, A, Elaut, G, Henkens, T, Vinken, M, Laus, G, Tourwe, D, Beyaert, R, Rogiers, V, Vanhaecke, T
Published in Cell proliferation (01.12.2007)
Published in Cell proliferation (01.12.2007)
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Journal Article
Inhibition of NF-κB activation by the histone deacetylase inhibitor 4-Me2N-BAVAH induces an early G1 cell cycle arrest in primary hepatocytes
Papeleu, P., Wullaert, A., Elaut, G., Henkens, T., Vinken, M., Laus, G., Tourwé, D., Beyaert, R., Rogiers, V., Vanhaecke, T.
Published in Cell proliferation (01.12.2007)
Published in Cell proliferation (01.12.2007)
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Journal Article
Inhibition of NF‐κB activation by the histone deacetylase inhibitor 4‐Me 2 N‐BAVAH induces an early G 1 cell cycle arrest in primary hepatocytes
Papeleu, P., Wullaert, A., Elaut, G., Henkens, T., Vinken, M., Laus, G., Tourwé, D., Beyaert, R., Rogiers, V., Vanhaecke, T.
Published in Cell proliferation (01.12.2007)
Published in Cell proliferation (01.12.2007)
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Journal Article
Inhibition of NF‐κB activation by the histone deacetylase inhibitor 4‐Me 2 N‐BAVAH induces an early G 1 cell cycle arrest in primary hepatocytes
Papeleu, P., Wullaert, A., Elaut, G., Henkens, T., Vinken, M., Laus, G., Tourwé, D., Beyaert, R., Rogiers, V., Vanhaecke, T.
Published in Cell proliferation (01.10.2007)
Published in Cell proliferation (01.10.2007)
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Journal Article
Inhibition of NF-kappaB activation by the histone deacetylase inhibitor 4-Me2N-BAVAH induces an early G1 cell cycle arrest in primary hepatocytes
Papeleu, P, Wullaert, A, Elaut, G, Henkens, T, Vinken, M, Laus, G, Tourwé, D, Beyaert, R, Rogiers, V, Vanhaecke, T
Published in Cell proliferation (01.10.2007)
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Published in Cell proliferation (01.10.2007)
Journal Article
Rat hepatocyte suspensions as a suitable in vitro model for studying the biotransformation of histone deacetylase inhibitors
Elaut, Greetje, Török, Gabriëlla, Papeleu, Peggy, Vanhaecke, Tamara, Laus, Georges, Tourwé, Dirk, Rogiers, Vera
Published in Alternatives to laboratory animals (01.06.2004)
Published in Alternatives to laboratory animals (01.06.2004)
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Journal Article
284 Benzamide-based trichostatin a analogues are potent and metabolically stable inhibitors of histone deacetylase
Elaut, G., Laus, G., Papeleu, P., Breckx, V., Van Hemel, J., Erra, M., Brosch, G., Snykers, S., Vanhaecke, T., Tourwé, D., Rogiers, V.
Published in Toxicology letters (01.09.2003)
Published in Toxicology letters (01.09.2003)
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Journal Article
Proliferation of epidermal growth factor-stimulated hepatocytes in a hormonally defined serum-free medium
Papeleu, Peggy, Loyer, Pascal, Vanhaecke, Tamara, Henkens, Tom, Elaut, Greetje, Guguen-Guillouzo, Christiane, Rogiers, Vera
Published in Alternatives to laboratory animals (01.06.2004)
Published in Alternatives to laboratory animals (01.06.2004)
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Journal Article