Acute and 2-week exposure to prednisolone impair different aspects of β-cell function in healthy men
van Raalte, Daniël H, Nofrate, Valentina, Bunck, Mathijs C, van Iersel, Thijs, Elassaiss Schaap, Jeroen, Nässander, Ulla K, Heine, Robert J, Mari, Andrea, Dokter, Wim H A, Diamant, Michaela
Published in European journal of endocrinology (01.04.2010)
Published in European journal of endocrinology (01.04.2010)
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Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in Melanoma
Hamid, Omid, Robert, Caroline, Daud, Adil, Hodi, F. Stephen, Hwu, Wen-Jen, Kefford, Richard, Wolchok, Jedd D, Hersey, Peter, Joseph, Richard W, Weber, Jeffrey S, Dronca, Roxana, Gangadhar, Tara C, Patnaik, Amita, Zarour, Hassane, Joshua, Anthony M, Gergich, Kevin, Elassaiss-Schaap, Jeroen, Algazi, Alain, Mateus, Christine, Boasberg, Peter, Tumeh, Paul C, Chmielowski, Bartosz, Ebbinghaus, Scot W, Li, Xiaoyun Nicole, Kang, S. Peter, Ribas, Antoni
Published in The New England journal of medicine (11.07.2013)
Published in The New England journal of medicine (11.07.2013)
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Crowdsourced Asparagus Urinary Odor Population Kinetics
Ramamoorthy, Anuradha, Sadler, Brian M., van Hasselt, J.G. Coen, Elassaiss‐Schaap, Jeroen, Kasichayanula, Sreeneeranj, Edwards, Alena Y., van der Graaf, Piet H., Zhang, Lei, Wagner, John A.
Published in CPT: pharmacometrics and systems pharmacology (01.01.2018)
Published in CPT: pharmacometrics and systems pharmacology (01.01.2018)
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Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial
Robert, Caroline, Prof, Ribas, Antoni, Prof, Wolchok, Jedd D, Prof, Hodi, F Stephen, MD, Hamid, Omid, MD, Kefford, Richard, Prof, Weber, Jeffrey S, Prof, Joshua, Anthony M, PhD, Hwu, Wen-Jen, Prof, Gangadhar, Tara C, MD, Patnaik, Amita, MD, Dronca, Roxana, MD, Zarour, Hassane, Prof, Joseph, Richard W, MD, Boasberg, Peter, MD, Chmielowski, Bartosz, MD, Mateus, Christine, MD, Postow, Michael A, MD, Gergich, Kevin, MA, Elassaiss-Schaap, Jeroen, PhD, Li, Xiaoyun Nicole, PhD, Iannone, Robert, MD, Ebbinghaus, Scot W, MD, Kang, S Peter, MD, Daud, Adil, Prof
Published in The Lancet (British edition) (20.09.2014)
Published in The Lancet (British edition) (20.09.2014)
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Lumbar cerebrospinal fluid-to-brain extracellular fluid surrogacy is context-specific: insights from LeiCNS-PK3.0 simulations
Saleh, Mohammed A. A., Loo, Chi Fong, Elassaiss-Schaap, Jeroen, De Lange, Elizabeth C. M.
Published in Journal of pharmacokinetics and pharmacodynamics (01.10.2021)
Published in Journal of pharmacokinetics and pharmacodynamics (01.10.2021)
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Phase I Study of Pembrolizumab (MK-3475; Anti-PD-1 Monoclonal Antibody) in Patients with Advanced Solid Tumors
Patnaik, Amita, Kang, S Peter, Rasco, Drew, Papadopoulos, Kyriakos P, Elassaiss-Schaap, Jeroen, Beeram, Muralidhar, Drengler, Ronald, Chen, Cong, Smith, Lon, Espino, Guillermo, Gergich, Kevin, Delgado, Liliana, Daud, Adil, Lindia, Jill A, Li, Xiaoyun Nicole, Pierce, Robert H, Yearley, Jennifer H, Wu, Dianna, Laterza, Omar, Lehnert, Manfred, Iannone, Robert, Tolcher, Anthony W
Published in Clinical cancer research (01.10.2015)
Published in Clinical cancer research (01.10.2015)
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Journal Article
Baseline Tumor Size Is an Independent Prognostic Factor for Overall Survival in Patients with Melanoma Treated with Pembrolizumab
Joseph, Richard W, Elassaiss-Schaap, Jeroen, Kefford, Richard, Hwu, Wen-Jen, Wolchok, Jedd D, Joshua, Anthony M, Ribas, Antoni, Hodi, F Stephen, Hamid, Omid, Robert, Caroline, Daud, Adil, Dronca, Roxana, Hersey, Peter, Weber, Jeffrey S, Patnaik, Amita, de Alwis, Dinesh P, Perrone, Andrea, Zhang, Jin, Kang, S Peter, Ebbinghaus, Scot, Anderson, Keaven M, Gangadhar, Tara C
Published in Clinical cancer research (15.10.2018)
Published in Clinical cancer research (15.10.2018)
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Drug Distribution in Brain and Cerebrospinal Fluids in Relation to IC.sub.50 Values in Aging and Alzheimer's Disease, Using the Physiologically Based LeiCNS-PK3.0 Model
Saleh, Mohammed A. A, Bloemberg, Julia S, Elassaiss-Schaap, Jeroen, de Lange, Elizabeth C. M
Published in Pharmaceutical research (01.07.2022)
Published in Pharmaceutical research (01.07.2022)
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Pharmacokinetics, pharmacodynamics, safety, and tolerability of BION-1301 in adults with relapsed or refractory multiple myeloma
Elassaiss-Schaap, Jeroen, van Zandvoort, Peter, Lo, Jeannette, Nair, Nitya, Walling, Jackie, Hari, Parameswaran, Bensinger, William
Published in Journal of clinical oncology (20.05.2019)
Published in Journal of clinical oncology (20.05.2019)
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Journal Article
The PBPK LeiCNS-PK3.0 framework predicts Nirmatrelvir (but not Remdesivir or Molnupiravir) to achieve effective concentrations against SARS-CoV-2 in human brain cells
Saleh, Mohammed A.A., Hirasawa, Makoto, Sun, Ming, Gülave, Berfin, Elassaiss-Schaap, Jeroen, de Lange, Elizabeth C.M.
Published in European journal of pharmaceutical sciences (01.02.2023)
Published in European journal of pharmaceutical sciences (01.02.2023)
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An asymptotic description of a basic FcRn-regulated clearance mechanism and its implications for PBPK modelling of large antibodies
Kátai, Csaba B, Smithline, Shepard J, Thalhauser, Craig J, Bosgra, Sieto, Elassaiss-Schaap, Jeroen
Published in Journal of pharmacokinetics and pharmacodynamics (24.06.2024)
Published in Journal of pharmacokinetics and pharmacodynamics (24.06.2024)
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Journal Article
Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice
Saleh, Mohammed A. A., Gülave, Berfin, Campagne, Olivia, Stewart, Clinton F., Elassaiss-Schaap, Jeroen, de Lange, Elizabeth C. M.
Published in Pharmaceutical research (01.11.2023)
Published in Pharmaceutical research (01.11.2023)
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Journal Article
Drug Distribution in Brain and Cerebrospinal Fluids in Relation to IC50 Values in Aging and Alzheimer’s Disease, Using the Physiologically Based LeiCNS-PK3.0 Model
Saleh, Mohammed A. A., Bloemberg, Julia S., Elassaiss-Schaap, Jeroen, de Lange, Elizabeth C. M.
Published in Pharmaceutical research (01.07.2022)
Published in Pharmaceutical research (01.07.2022)
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Journal Article
Drug Distribution in Brain and Cerebrospinal Fluids in Relation to IC 50 Values in Aging and Alzheimer's Disease, Using the Physiologically Based LeiCNS-PK3.0 Model
Saleh, Mohammed A A, Bloemberg, Julia S, Elassaiss-Schaap, Jeroen, de Lange, Elizabeth C M
Published in Pharmaceutical research (23.05.2022)
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Published in Pharmaceutical research (23.05.2022)
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Abstract 3780: Preclinical pharmacokinetics, pharmacodynamics and safety of BION-1301, a first-in-class antibody targeting APRIL for the treatment of multiple myeloma
Dulos, John, Driessen, Lilian, Zandvoort, Peter van, Crommert, Jos van de, Nair, Nitya, Randlev, Britta, Cock, Eduard de, Schaap, Jeroen Elassaiss, Eenennaam, Hans van, Elsas, Andrea van
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Safety and tolerability of BION-1301 in adults with relapsed or refractory multiple myeloma
Bensinger, William, Raptis, Anastasios, Berenson, James R., Spira, Alexander I., Nooka, Ajay K., Chaudhry, Maria, van Zandvoort, Peter, Nair, Nitya, Lo, Jeannette, Elassaiss-Schaap, Jeroen, Walling, Jackie, Hari, Parameswaran
Published in Journal of clinical oncology (20.05.2019)
Published in Journal of clinical oncology (20.05.2019)
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Journal Article
Bion-1301, a First-in-Class APRIL Neutralizing Antibody for the Treatment of Multiple Myeloma: Preclinical Safety, and Analysis of Pharmacokinetics — Pharmacodynamics Relationship
Dulos, John, Driessen, Lilian, van Zandvoort, Peter, van de Crommert, Jos, Skoble, Justin, Nair, Nitya, Randlev, Britta, de Cock, Eduard, Elassaiss Schaap, Jeroen, Eenennaam, Hans, van Elsas, Andrea
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Journal Article
Correction: Baseline Tumor Size Is an Independent Prognostic Factor for Overall Survival in Patients with Melanoma Treated with Pembrolizumab
Joseph, Richard W, Elassaiss-Schaap, Jeroen, Kefford, Richard, Hwu, Wen-Jen, Wolchok, Jedd D, Joshua, Anthony M, Ribas, Antoni, Hodi, F Stephen, Hamid, Omid, Robert, Caroline, Daud, Adil, Dronca, Roxana, Hersey, Peter, Weber, Jeffrey S, Patnaik, Amita, de Alwis, Dinesh P, Perrone, Andrea, Zhang, Jin, Kang, S Peter, Ebbinghaus, Scot, Anderson, Keaven M, Gangadhar, Tara C
Published in Clinical cancer research (01.12.2018)
Published in Clinical cancer research (01.12.2018)
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Journal Article
Model-based analysis of the relationship between pembrolizumab (MK-3475) exposure and efficacy in patients with advanced or metastatic melanoma
Joseph, Richard Wayne, Gangadhar, Tara C., Puzanov, Igor, Robert, Caroline, Hamid, Omid, Dummer, Reinhard, Ribas, Antoni, Mehnert, Janice M., Daud, Adil, Celentano, Kellie Ann, Lindia, Jill Ann, Chatterjee, Manash Shankar, Turner, David C., Mayawala, Kapil, Elassaiss-Schaap, Jeroen, de Alwis, Dinesh Prasad, Li, Xiaoyun Nicole, Ebbinghaus, Scot, Kang, Soonmo Peter, Kefford, Richard
Published in Journal of clinical oncology (20.05.2015)
Published in Journal of clinical oncology (20.05.2015)
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