Modeling long-term tumor growth and kill after combinations of radiation and radiosensitizing agents
Cardilin, Tim, Almquist, Joachim, Jirstrand, Mats, Zimmermann, Astrid, Lignet, Floriane, El Bawab, Samer, Gabrielsson, Johan
Published in Cancer chemotherapy and pharmacology (01.06.2019)
Published in Cancer chemotherapy and pharmacology (01.06.2019)
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Journal Article
Using thrombocytopenia modeling to investigate the mechanisms underlying platelet depletion induced by pan‐proteasome inhibitors
Lignet, Floriane, Becker, Andreas D., Gimmi, Claude, Rohdich, Felix, El Bawab, Samer
Published in CPT: pharmacometrics and systems pharmacology (01.05.2022)
Published in CPT: pharmacometrics and systems pharmacology (01.05.2022)
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Journal Article
Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases
Clarke, Paul A, Ortiz-Ruiz, Maria-Jesus, TePoele, Robert, Adeniji-Popoola, Olajumoke, Box, Gary, Court, Will, Czasch, Stephanie, El Bawab, Samer, Esdar, Christina, Ewan, Ken, Gowan, Sharon, De Haven Brandon, Alexis, Hewitt, Phillip, Hobbs, Stephen M, Kaufmann, Wolfgang, Mallinger, Aurélie, Raynaud, Florence, Roe, Toby, Rohdich, Felix, Schiemann, Kai, Simon, Stephanie, Schneider, Richard, Valenti, Melanie, Weigt, Stefan, Blagg, Julian, Blaukat, Andree, Dale, Trevor C, Eccles, Suzanne A, Hecht, Stefan, Urbahns, Klaus, Workman, Paul, Wienke, Dirk
Published in eLife (09.12.2016)
Published in eLife (09.12.2016)
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Journal Article
First-in-Man Phase I Trial of the Selective MET Inhibitor Tepotinib in Patients with Advanced Solid Tumors
Falchook, Gerald S, Kurzrock, Razelle, Amin, Hesham M, Xiong, Wenyuan, Fu, Siqing, Piha-Paul, Sarina A, Janku, Filip, Eskandari, Ghazaleh, Catenacci, Daniel V, Klevesath, Manfred, Bruns, Rolf, Stammberger, Uz, Johne, Andreas, Bladt, Friedhelm, Friese-Hamim, Manja, Girard, Pascal, El Bawab, Samer, Hong, David S
Published in Clinical cancer research (15.03.2020)
Published in Clinical cancer research (15.03.2020)
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Journal Article
A first-in-man phase 1 study of the DNA-dependent protein kinase inhibitor peposertib (formerly M3814) in patients with advanced solid tumours
van Bussel, Mark T. J., Awada, Ahmad, de Jonge, Maja J. A., Mau-Sørensen, Morten, Nielsen, Dorte, Schöffski, Patrick, Verheul, Henk M. W., Sarholz, Barbara, Berghoff, Karin, El Bawab, Samer, Kuipers, Mirjam, Damstrup, Lars, Diaz-Padilla, Ivan, Schellens, Jan H. M.
Published in British journal of cancer (16.02.2021)
Published in British journal of cancer (16.02.2021)
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Journal Article
Glucosamine induces cell-cycle arrest and hypertrophy of mesangial cells: implication of gangliosides
Masson, Elodie, Wiernsperger, Nicolas, Lagarde, Michel, El Bawab, Samer
Published in Biochemical journal (01.06.2005)
Published in Biochemical journal (01.06.2005)
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Journal Article
Identification of a novel amidase motif in neutral ceramidase
Galadari, Sehamuddin, Wu, Bill X, Mao, Cungui, Roddy, Patrick, El Bawab, Samer, Hannun, Yusuf A
Published in Biochemical journal (01.02.2006)
Published in Biochemical journal (01.02.2006)
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Journal Article
Translational pharmacokinetic‐pharmacodynamic modeling of preclinical and clinical data of the oral MET inhibitor tepotinib to determine the recommended phase II dose
Xiong, Wenyuan, Friese‐Hamim, Manja, Johne, Andreas, Stroh, Christopher, Klevesath, Manfred, Falchook, Gerald S., Hong, David S., Girard, Pascal, El Bawab, Samer
Published in CPT: pharmacometrics and systems pharmacology (01.05.2021)
Published in CPT: pharmacometrics and systems pharmacology (01.05.2021)
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Journal Article
Exposure-response modeling improves selection of radiation and radiosensitizer combinations
Cardilin, Tim, Almquist, Joachim, Jirstrand, Mats, Zimmermann, Astrid, Lignet, Floriane, El Bawab, Samer, Gabrielsson, Johan
Published in Journal of pharmacokinetics and pharmacodynamics (01.04.2022)
Published in Journal of pharmacokinetics and pharmacodynamics (01.04.2022)
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Journal Article
Substrate specificity of rat brain ceramidase
El Bawab, Samer, Usta, Julnar, Roddy, Patrick, Szulc, Zdzislaw M, Bielawska, Alicja, Hannun, Yusuf A
Published in Journal of lipid research (01.01.2002)
Published in Journal of lipid research (01.01.2002)
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Journal Article
Bimodal Effect of Advanced Glycation End Products on Mesangial Cell Proliferation Is Mediated by Neutral Ceramidase Regulation and Endogenous Sphingolipids
Geoffroy, Karen, Wiernsperger, Nicolas, Lagarde, Michel, El Bawab, Samer
Published in The Journal of biological chemistry (13.08.2004)
Published in The Journal of biological chemistry (13.08.2004)
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Journal Article
A Novel PBPK Modeling Approach to Assess Cytochrome P450 Mediated Drug‐Drug Interaction Potential of the Cytotoxic Prodrug Evofosfamide
Lüpfert, Christian, Dyroff, Martin, Richter, Oliver, Gallemann, Dieter, El Bawab, Samer, Dolgos, Hugues, Jung, Don, Hecht, Stefan, Johne, Andreas
Published in CPT: pharmacometrics and systems pharmacology (01.12.2018)
Published in CPT: pharmacometrics and systems pharmacology (01.12.2018)
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Journal Article
Characterization of Novel PI3Kδ Inhibitors as Potential Therapeutics for SLE and Lupus Nephritis in Pre-Clinical Studies
Haselmayer, Philipp, Camps, Montserrat, Muzerelle, Mathilde, El Bawab, Samer, Waltzinger, Caroline, Bruns, Lisa, Abla, Nada, Polokoff, Mark A, Jond-Necand, Carole, Gaudet, Marilène, Benoit, Audrey, Bertschy Meier, Dominique, Martin, Catherine, Gretener, Denise, Lombardi, Maria Stella, Grenningloh, Roland, Ladel, Christoph, Petersen, Jørgen Søberg, Gaillard, Pascale, Ji, Hong
Published in Frontiers in immunology (2014)
Published in Frontiers in immunology (2014)
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Journal Article
Molecular Cloning and Characterization of a Human Mitochondrial Ceramidase
El Bawab, Samer, Roddy, Patrick, Qian, Ting, Bielawska, Alicja, Lemasters, John J., Hannun, Yusuf A.
Published in The Journal of biological chemistry (14.07.2000)
Published in The Journal of biological chemistry (14.07.2000)
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Journal Article
Purification and Characterization of a Membrane-bound Nonlysosomal Ceramidase from Rat Brain
El Bawab, Samer, Bielawska, Alicja, Hannun, Yusuf A.
Published in The Journal of biological chemistry (24.09.1999)
Published in The Journal of biological chemistry (24.09.1999)
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Journal Article