Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure
Eizirik, Décio L., Pasquali, Lorenzo, Cnop, Miriam
Published in Nature reviews. Endocrinology (01.07.2020)
Published in Nature reviews. Endocrinology (01.07.2020)
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The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines
Eizirik, Décio L, Sammeth, Michael, Bouckenooghe, Thomas, Bottu, Guy, Sisino, Giorgia, Igoillo-Esteve, Mariana, Ortis, Fernanda, Santin, Izortze, Colli, Maikel L, Barthson, Jenny, Bouwens, Luc, Hughes, Linda, Gregory, Lorna, Lunter, Gerton, Marselli, Lorella, Marchetti, Piero, McCarthy, Mark I, Cnop, Miriam
Published in PLoS genetics (01.03.2012)
Published in PLoS genetics (01.03.2012)
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The role of inflammation in insulitis and β-cell loss in type 1 diabetes
Eizirik, Décio L, Colli, Maikel L, Ortis, Fernanda
Published in Nature reviews. Endocrinology (01.04.2009)
Published in Nature reviews. Endocrinology (01.04.2009)
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CXCL14, a Brown Adipokine that Mediates Brown-Fat-to-Macrophage Communication in Thermogenic Adaptation
Cereijo, Rubén, Gavaldà-Navarro, Aleix, Cairó, Montserrat, Quesada-López, Tania, Villarroya, Joan, Morón-Ros, Samantha, Sánchez-Infantes, David, Peyrou, Marion, Iglesias, Roser, Mampel, Teresa, Turatsinze, Jean-Valery, Eizirik, Décio L., Giralt, Marta, Villarroya, Francesc
Published in Cell metabolism (06.11.2018)
Published in Cell metabolism (06.11.2018)
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Vitamin D3 Induces Tolerance in Human Dendritic Cells by Activation of Intracellular Metabolic Pathways
Ferreira, Gabriela Bomfim, Vanherwegen, An-Sofie, Eelen, Guy, Gutiérrez, Ana Carolina Fierro, Van Lommel, Leentje, Marchal, Kathleen, Verlinden, Lieve, Verstuyf, Annemieke, Nogueira, Tatiane, Georgiadou, Maria, Schuit, Frans, Eizirik, Décio L., Gysemans, Conny, Carmeliet, Peter, Overbergh, Lut, Mathieu, Chantal
Published in Cell reports (Cambridge) (10.02.2015)
Published in Cell reports (Cambridge) (10.02.2015)
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Initiation and execution of lipotoxic ER stress in pancreatic β-cells
Cunha, Daniel A, Hekerman, Paul, Ladrière, Laurence, Bazarra-Castro, Angie, Ortis, Fernanda, Wakeham, Marion C, Moore, Fabrice, Rasschaert, Joanne, Cardozo, Alessandra K, Bellomo, Elisa, Overbergh, Lutgart, Mathieu, Chantal, Lupi, Roberto, Hai, Tsonwin, Herchuelz, Andre, Marchetti, Piero, Rutter, Guy A, Eizirik, Décio L, Cnop, Miriam
Published in Journal of cell science (15.07.2008)
Published in Journal of cell science (15.07.2008)
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RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate
CNOP, Miriam, ABDULKARIM, Baroj, BUGLIANI, Marco, LADRIERE, Laurence, MARSELLI, Lorella, MCCARTHY, Mark I, MARCHETTI, Piero, SAMMETH, Michael, EIZIRIK, Décio L, BOTTU, Guy, CUNHA, Daniel A, IGOILLO-ESTEVE, Mariana, MASINI, Matilde, TURATSINZE, Jean-Valery, GRIEBEL, Thasso, VILLATE, Olatz, SANTIN, Izortze
Published in Diabetes (New York, N.Y.) (01.06.2014)
Published in Diabetes (New York, N.Y.) (01.06.2014)
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Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes
Cosentino, Cristina, Toivonen, Sanna, Diaz Villamil, Esteban, Atta, Mohamed, Ravanat, Jean-Luc, Demine, Stéphane, Schiavo, Andrea Alex, Pachera, Nathalie, Deglasse, Jean-Philippe, Jonas, Jean-Christophe, Balboa, Diego, Otonkoski, Timo, Pearson, Ewan R, Marchetti, Piero, Eizirik, Décio L, Cnop, Miriam, Igoillo-Esteve, Mariana
Published in Nucleic acids research (02.11.2018)
Published in Nucleic acids research (02.11.2018)
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The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes
Quesada-López, Tania, Cereijo, Rubén, Turatsinze, Jean-Valery, Planavila, Anna, Cairó, Montserrat, Gavaldà-Navarro, Aleix, Peyrou, Marion, Moure, Ricardo, Iglesias, Roser, Giralt, Marta, Eizirik, Decio L., Villarroya, Francesc
Published in Nature communications (17.11.2016)
Published in Nature communications (17.11.2016)
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MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells
Grieco, Fabio Arturo, Sebastiani, Guido, Juan-Mateu, Jonas, Villate, Olatz, Marroqui, Laura, Ladrière, Laurence, Tugay, Ksenya, Regazzi, Romano, Bugliani, Marco, Marchetti, Piero, Dotta, Francesco, Eizirik, Décio L
Published in Diabetes (New York, N.Y.) (01.01.2017)
Published in Diabetes (New York, N.Y.) (01.01.2017)
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SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic β -Cells and in the Human Pancreas Microvasculature
Fignani, Daniela, Licata, Giada, Brusco, Noemi, Nigi, Laura, Grieco, Giuseppina E, Marselli, Lorella, Overbergh, Lut, Gysemans, Conny, Colli, Maikel L, Marchetti, Piero, Mathieu, Chantal, Eizirik, Decio L, Sebastiani, Guido, Dotta, Francesco
Published in Frontiers in endocrinology (Lausanne) (13.11.2020)
Published in Frontiers in endocrinology (Lausanne) (13.11.2020)
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The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes
Ramos-Rodríguez, Mireia, Raurell-Vila, Helena, Colli, Maikel L., Alvelos, Maria Inês, Subirana-Granés, Marc, Juan-Mateu, Jonàs, Norris, Richard, Turatsinze, Jean-Valery, Nakayasu, Ernesto S., Webb-Robertson, Bobbie-Jo M., Inshaw, Jamie R. J., Marchetti, Piero, Piemonti, Lorenzo, Esteller, Manel, Todd, John A., Metz, Thomas O., Eizirik, Décio L., Pasquali, Lorenzo
Published in Nature genetics (01.11.2019)
Published in Nature genetics (01.11.2019)
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Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK–NRF2 pathway
Cunha, Daniel A, Cito, Monia, Carlsson, Per-Ola, Vanderwinden, Jean-Marie, Molkentin, Jeffery D, Bugliani, Marco, Marchetti, Piero, Eizirik, Décio L, Cnop, Miriam
Published in Cell death and differentiation (01.12.2016)
Published in Cell death and differentiation (01.12.2016)
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Citrullinated glucose-regulated protein 78 is an autoantigen in type 1 diabetes
Rondas, Dieter, Crèvecoeur, Inne, D'Hertog, Wannes, Ferreira, Gabriela Bomfim, Staes, An, Garg, Abhishek D, Eizirik, Decio L, Agostinis, Patrizia, Gevaert, Kris, Overbergh, Lut, Mathieu, Chantal
Published in Diabetes (New York, N.Y.) (01.02.2015)
Published in Diabetes (New York, N.Y.) (01.02.2015)
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Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress―Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis
CUNHA, Daniel A, IGOILLO-ESTEVE, Mariana, MARSELLI, Lorella, MARCHETTI, Piero, HARDING, Heather P, RON, David, EIZIRIK, Décio L, CNOP, Miriam, GURZOV, Esteban N, GERMANO, Carla M, NAAMANE, Najib, MARHFOUR, Ihsane, FUKAYA, Makiko, VANDERWINDEN, Jean-Marie, GYSEMANS, Conny, MATHIEU, Chantal
Published in Diabetes (New York, N.Y.) (01.11.2012)
Published in Diabetes (New York, N.Y.) (01.11.2012)
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Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells
Demine, Stéphane, Schiavo, Andrea Alex, Marín-Cañas, Sandra, Marchetti, Piero, Cnop, Miriam, Eizirik, Decio L
Published in Stem cell research & therapy (03.01.2020)
Published in Stem cell research & therapy (03.01.2020)
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PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon-γ–Induced Pancreatic β-Cell Apoptosis
MOORE, Fabrice, COLLI, Maikel L, CNOP, Miriam, IGOILLO ESTEVE, Mariana, CARDOZO, Alessandra K, CUNHA, Daniel A, BUGLIANI, Marco, MARCHETTI, Piero, EIZIRIK, Décio L
Published in Diabetes (New York, N.Y.) (01.06.2009)
Published in Diabetes (New York, N.Y.) (01.06.2009)
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