Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease
Kumar, Deepak Kumar Vijaya, Choi, Se Hoon, Washicosky, Kevin J, Eimer, William A, Tucker, Stephanie, Ghofrani, Jessica, Lefkowitz, Aaron, McColl, Gawain, Goldstein, Lee E, Tanzi, Rudolph E, Moir, Robert D
Published in Science translational medicine (25.05.2016)
Published in Science translational medicine (25.05.2016)
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Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection
Eimer, William A., Vijaya Kumar, Deepak Kumar, Navalpur Shanmugam, Nanda Kumar, Rodriguez, Alex S., Mitchell, Teryn, Washicosky, Kevin J., György, Bence, Breakefield, Xandra O., Tanzi, Rudolph E., Moir, Robert D.
Published in Neuron (Cambridge, Mass.) (11.07.2018)
Published in Neuron (Cambridge, Mass.) (11.07.2018)
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Journal Article
Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level
Sadleir, Katherine R, Eimer, William A, Cole, Sarah L, Vassar, Robert
Published in Molecular neurodegeneration (07.01.2015)
Published in Molecular neurodegeneration (07.01.2015)
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Journal Article
The Alzheimer’s β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques
Kandalepas, Patty C., Sadleir, Katherine R., Eimer, William A., Zhao, Jie, Nicholson, Daniel A., Vassar, Robert
Published in Acta neuropathologica (01.09.2013)
Published in Acta neuropathologica (01.09.2013)
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β-Site Amyloid Precursor Protein (APP)-cleaving Enzyme 1 (BACE1)-deficient Mice Exhibit a Close Homolog of L1 (CHL1) Loss-of-function Phenotype Involving Axon Guidance Defects
Hitt, Brian, Riordan, Sean M., Kukreja, Lokesh, Eimer, William A., Rajapaksha, Tharinda W., Vassar, Robert
Published in The Journal of biological chemistry (09.11.2012)
Published in The Journal of biological chemistry (09.11.2012)
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Journal Article
Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection
Eimer, William A., Vijaya Kumar, Deepak Kumar, Navalpur Shanmugam, Nanda Kumar, Rodriguez, Alex S., Mitchell, Teryn, Washicosky, Kevin J., György, Bence, Breakefield, Xandra O., Tanzi, Rudolph E., Moir, Robert D.
Published in Neuron (Cambridge, Mass.) (19.12.2018)
Published in Neuron (Cambridge, Mass.) (19.12.2018)
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APOE4-specific Changes in Aβ Accumulation in a New Transgenic Mouse Model of Alzheimer Disease
Youmans, Katherine L., Tai, Leon M., Nwabuisi-Heath, Evelyn, Jungbauer, Lisa, Kanekiyo, Takahisa, Gan, Ming, Kim, Jungsu, Eimer, William A., Estus, Steve, Rebeck, G.William, Weeber, Edwin J., Bu, Guojun, Yu, Chunjiang, LaDu, Mary Jo
Published in The Journal of biological chemistry (07.12.2012)
Published in The Journal of biological chemistry (07.12.2012)
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Journal Article
The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb
Rajapaksha, Tharinda W, Eimer, William A, Bozza, Thomas C, Vassar, Robert
Published in Molecular neurodegeneration (28.12.2011)
Published in Molecular neurodegeneration (28.12.2011)
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Journal Article
Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease
Sadleir, Katherine R, Eimer, William A, Kaufman, Randal J, Osten, Pavel, Vassar, Robert
Published in PloS one (03.07.2014)
Published in PloS one (03.07.2014)
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Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody
Youmans, Katherine L, Tai, Leon M, Kanekiyo, Takahisa, Stine, Jr, W Blaine, Michon, Sara-Claude, Nwabuisi-Heath, Evelyn, Manelli, Arlene M, Fu, Yifan, Riordan, Sean, Eimer, William A, Binder, Lester, Bu, Guojun, Yu, Chunjiang, Hartley, Dean M, LaDu, Mary Jo
Published in Molecular neurodegeneration (16.03.2012)
Published in Molecular neurodegeneration (16.03.2012)
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Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis
O'Connor, Tracy, Sadleir, Katherine R., Maus, Erika, Velliquette, Rodney A., Zhao, Jie, Cole, Sarah L., Eimer, William A., Hitt, Brian, Bembinster, Leslie A., Lammich, Sven, Lichtenthaler, Stefan F., Hébert, Sébastien S., De Strooper, Bart, Haass, Christian, Bennett, David A., Vassar, Robert
Published in Neuron (Cambridge, Mass.) (26.12.2008)
Published in Neuron (Cambridge, Mass.) (26.12.2008)
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Sensory Dysfunction, Microbial Infections, and Host Responses in Alzheimer's Disease
Bathini, Praveen, Brai, Emanuele, Balin, Brian J, Bimler, Lynn, Corry, David B, Devanand, Davangere P, Doty, Richard L, Ehrlich, Garth D, Eimer, William A, Fulop, Tamas, Hahn, David L, Hammond, Christine J, Infanti, Joseph, Itzhaki, Ruth, Lathe, Richard, Little, Christopher Scott, McLeod, Rima, Moein, Shima T, Nelson, Amy R, Perry, George, Shemesh, Or A, Tanzi, Rudolph E, Webley, Wilmore C, Schultek, Nikki M, Alberi Auber, Lavinia
Published in The Journal of infectious diseases (10.09.2024)
Published in The Journal of infectious diseases (10.09.2024)
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Journal Article
The Alzheimer's [beta]-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb
Rajapaksha, Tharinda W, Eimer, William A, Bozza, Thomas C, Vassar, Robert
Published in Molecular neurodegeneration (28.12.2011)
Published in Molecular neurodegeneration (28.12.2011)
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Journal Article
Establishment of a consensus protocol to explore the brain pathobiome in patients with mild cognitive impairment and Alzheimer's disease: Research outline and call for collaboration
Lathe, Richard, Schultek, Nikki M, Balin, Brian J, Ehrlich, Garth D, Auber, Lavinia Alberi, Perry, George, Breitschwerdt, Edward B, Corry, David B, Doty, Richard L, Rissman, Robert A, Nara, Peter L, Itzhaki, Ruth, Eimer, William A, Tanzi, Rudolph E
Published in Alzheimer's & dementia (01.11.2023)
Published in Alzheimer's & dementia (01.11.2023)
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Journal Article
Specificity of Toll-Like Receptor 2 and Dectin-1 Signaling in CNS Macrophages
Vijaya Kumar, Deepak Kumar, Eimer, William A, Ramakrishnan, Sreejith
Published in The Journal of neuroscience (09.12.2015)
Published in The Journal of neuroscience (09.12.2015)
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Journal Article
Mutant Allele-Specific CRISPR Disruption in DYT1 Dystonia Fibroblasts Restores Cell Function
Cruz, Lilian, György, Bence, Cheah, Pike See, Kleinstiver, Benjamin P., Eimer, William A., Garcia, Sara P., Sharma, Nutan, Ozelius, Laurie J., Bragg, D. Cristopher, Joung, J. Keith, Norberto de Souza, Osmar, Macedo Timmers, Luis Fernando Saraiva, Breakefield, Xandra O.
Published in Molecular therapy. Nucleic acids (04.09.2020)
Published in Molecular therapy. Nucleic acids (04.09.2020)
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SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC)
Proal, Amy D., VanElzakker, Michael B., Aleman, Soo, Bach, Katie, Boribong, Brittany P., Buggert, Marcus, Cherry, Sara, Chertow, Daniel S., Davies, Helen E., Dupont, Christopher L., Deeks, Steven G., Eimer, William, Ely, E. Wesley, Fasano, Alessio, Freire, Marcelo, Geng, Linda N., Griffin, Diane E., Henrich, Timothy J., Iwasaki, Akiko, Izquierdo-Garcia, David, Locci, Michela, Mehandru, Saurabh, Painter, Mark M., Peluso, Michael J., Pretorius, Etheresia, Price, David A., Putrino, David, Scheuermann, Richard H., Tan, Gene S., Tanzi, Rudolph E., VanBrocklin, Henry F., Yonker, Lael M., Wherry, E. John
Published in Nature immunology (01.10.2023)
Published in Nature immunology (01.10.2023)
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Journal Article
SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC) (vol 24, pg 1616, 2023)
Proal, AD, VanElzakker, MB, Aleman, S, Bach, K, Boribong, BP, Buggert, M, Cherry, S, Chertow, DS, Davies, HE, Dupont, CL
Published in NATURE IMMUNOLOGY (18.09.2023)
Published in NATURE IMMUNOLOGY (18.09.2023)
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