Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1
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Published in PloS one (06.02.2015)
Published in PloS one (06.02.2015)
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Distinct amyloid-β and tau-associated microglia profiles in Alzheimer’s disease
Gerrits, Emma, Brouwer, Nieske, Kooistra, Susanne M., Woodbury, Maya E., Vermeiren, Yannick, Lambourne, Mirjam, Mulder, Jan, Kummer, Markus, Möller, Thomas, Biber, Knut, Dunnen, Wilfred F. A. den, De Deyn, Peter P., Eggen, Bart J. L., Boddeke, Erik W. G. M.
Published in Acta neuropathologica (01.05.2021)
Published in Acta neuropathologica (01.05.2021)
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Neurovascular dysfunction in GRN-associated frontotemporal dementia identified by single-nucleus RNA sequencing of human cerebral cortex
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Published in Nature neuroscience (01.08.2022)
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Species-specific metabolic reprogramming in human and mouse microglia during inflammatory pathway induction
Sabogal-Guáqueta, Angélica María, Marmolejo-Garza, Alejandro, Trombetta-Lima, Marina, Oun, Asmaa, Hunneman, Jasmijn, Chen, Tingting, Koistinaho, Jari, Lehtonen, Sarka, Kortholt, Arjan, Wolters, Justina C., Bakker, Barbara M., Eggen, Bart J. L., Boddeke, Erik, Dolga, Amalia
Published in Nature communications (13.10.2023)
Published in Nature communications (13.10.2023)
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APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints
Yin, Zhuoran, Rosenzweig, Neta, Kleemann, Kilian L., Zhang, Xiaoming, Brandão, Wesley, Margeta, Milica A., Schroeder, Caitlin, Sivanathan, Kisha N., Silveira, Sebastian, Gauthier, Christian, Mallah, Dania, Pitts, Kristen M., Durao, Ana, Herron, Shawn, Shorey, Hannah, Cheng, Yiran, Barry, Jen-Li, Krishnan, Rajesh K., Wakelin, Sam, Rhee, Jared, Yung, Anthony, Aronchik, Michael, Wang, Chao, Jain, Nimansha, Bao, Xin, Gerrits, Emma, Brouwer, Nieske, Deik, Amy, Tenen, Daniel G., Ikezu, Tsuneya, Santander, Nicolas G., McKinsey, Gabriel L., Baufeld, Caroline, Sheppard, Dean, Krasemann, Susanne, Nowarski, Roni, Eggen, Bart J. L., Clish, Clary, Tanzi, Rudolph E., Madore, Charlotte, Arnold, Thomas D., Holtzman, David M., Butovsky, Oleg
Published in Nature immunology (01.11.2023)
Published in Nature immunology (01.11.2023)
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Epigenetic regulation of innate immune memory in microglia
Zhang, Xiaoming, Kracht, Laura, Lerario, Antonio M, Dubbelaar, Marissa L, Brouwer, Nieske, Wesseling, Evelyn M, Boddeke, Erik W G M, Eggen, Bart J L, Kooistra, Susanne M
Published in Journal of neuroinflammation (14.05.2022)
Published in Journal of neuroinflammation (14.05.2022)
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The Kaleidoscope of Microglial Phenotypes
Dubbelaar, Marissa L, Kracht, Laura, Eggen, Bart J L, Boddeke, Erik W G M
Published in Frontiers in immunology (31.07.2018)
Published in Frontiers in immunology (31.07.2018)
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Single-nucleus RNA sequencing of midbrain blood-brain barrier cells in schizophrenia reveals subtle transcriptional changes with overall preservation of cellular proportions and phenotypes
Puvogel, Sofía, Alsema, Astrid, Kracht, Laura, Webster, Maree J., Weickert, Cynthia Shannon, Sommer, Iris E. C., Eggen, Bart J. L.
Published in Molecular psychiatry (01.11.2022)
Published in Molecular psychiatry (01.11.2022)
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Identification of clinical disease trajectories in neurodegenerative disorders with natural language processing
Mekkes, Nienke J., Groot, Minke, Hoekstra, Eric, de Boer, Alyse, Dagkesamanskaia, Ekaterina, Bouwman, Sander, Wehrens, Sophie M. T., Herbert, Megan K., Wever, Dennis D., Rozemuller, Annemieke, Eggen, Bart J. L., Huitinga, Inge, Holtman, Inge R.
Published in Nature medicine (01.04.2024)
Published in Nature medicine (01.04.2024)
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Transcriptomic analysis of purified human cortical microglia reveals age-associated changes
Galatro, Thais F, Holtman, Inge R, Lerario, Antonio M, Vainchtein, Ilia D, Brouwer, Nieske, Sola, Paula R, Veras, Mariana M, Pereira, Tulio F, Leite, Renata E P, Möller, Thomas, Wes, Paul D, Sogayar, Mari C, Laman, Jon D, den Dunnen, Wilfred, Pasqualucci, Carlos A, Oba-Shinjo, Sueli M, Boddeke, Erik W G M, Marie, Suely K N, Eggen, Bart J L
Published in Nature neuroscience (01.08.2017)
Published in Nature neuroscience (01.08.2017)
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Early-life stress lastingly impacts microglial transcriptome and function under basal and immune-challenged conditions
Reemst, Kitty, Kracht, Laura, Kotah, Janssen M., Rahimian, Reza, van Irsen, Astrid A. S., Congrains Sotomayor, Gonzalo, Verboon, Laura N., Brouwer, Nieske, Simard, Sophie, Turecki, Gustavo, Mechawar, Naguib, Kooistra, Susanne M., Eggen, Bart J. L., Korosi, Aniko
Published in Translational psychiatry (08.12.2022)
Published in Translational psychiatry (08.12.2022)
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Sex-dependent APOE4 neutrophil–microglia interactions drive cognitive impairment in Alzheimer’s disease
Rosenzweig, Neta, Kleemann, Kilian L., Rust, Thomas, Carpenter, Madison, Grucci, Madeline, Aronchik, Michael, Brouwer, Nieske, Valenbreder, Isabel, Cooper-Hohn, Joya, Iyer, Malvika, Krishnan, Rajesh K., Sivanathan, Kisha N., Brandão, Wesley, Yahya, Taha, Durao, Ana, Yin, Zhuoran, Chadarevian, Jean Paul, Properzi, Michael J., Nowarski, Roni, Davtyan, Hayk, Weiner, Howard L., Blurton-Jones, Mathew, Yang, Hyun-Sik, Eggen, Bart J. L., Sperling, Reisa A., Butovsky, Oleg
Published in Nature medicine (03.07.2024)
Published in Nature medicine (03.07.2024)
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Microglia are less pro-inflammatory than myeloid infiltrates in the hippocampus of mice exposed to status epilepticus
Vinet, Jonathan, Vainchtein, Ilia D., Spano, Carlotta, Giordano, Carmela, Bordini, Domenico, Curia, Giulia, Dominici, Massimo, Boddeke, Hendrikus W. G. M., Eggen, Bart J. L., Biagini, Giuseppe
Published in Glia (01.08.2016)
Published in Glia (01.08.2016)
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Transcriptional heterogeneity between primary adult grey and white matter astrocytes underlie differences in modulation of in vitro myelination
Werkman, Inge L, Dubbelaar, Marissa L, van der Vlies, Pieter, de Boer-Bergsma, Jelkje J, Eggen, Bart J L, Baron, Wia
Published in Journal of neuroinflammation (11.12.2020)
Published in Journal of neuroinflammation (11.12.2020)
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Autophagy in Multiple Sclerosis: Two Sides of the Same Coin
Misrielal, Chairi, Mauthe, Mario, Reggiori, Fulvio, Eggen, Bart J L
Published in Frontiers in cellular neuroscience (20.11.2020)
Published in Frontiers in cellular neuroscience (20.11.2020)
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Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease
Wes, Paul D., Holtman, Inge R., Boddeke, Erik W.G.M., Möller, Thomas, Eggen, Bart J.L.
Published in Glia (01.02.2016)
Published in Glia (01.02.2016)
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Whole exome sequencing coupled with unbiased functional analysis reveals new Hirschsprung disease genes
Gui, Hongsheng, Schriemer, Duco, Cheng, William W, Chauhan, Rajendra K, Antiňolo, Guillermo, Berrios, Courtney, Bleda, Marta, Brooks, Alice S, Brouwer, Rutger W W, Burns, Alan J, Cherny, Stacey S, Dopazo, Joaquin, Eggen, Bart J L, Griseri, Paola, Jalloh, Binta, Le, Thuy-Linh, Lui, Vincent C H, Luzón-Toro, Berta, Matera, Ivana, Ngan, Elly S W, Pelet, Anna, Ruiz-Ferrer, Macarena, Sham, Pak C, Shepherd, Iain T, So, Man-Ting, Sribudiani, Yunia, Tang, Clara S M, van den Hout, Mirjam C G N, van der Linde, Herma C, van Ham, Tjakko J, van IJcken, Wilfred F J, Verheij, Joke B G M, Amiel, Jeanne, Borrego, Salud, Ceccherini, Isabella, Chakravarti, Aravinda, Lyonnet, Stanislas, Tam, Paul K H, Garcia-Barceló, Maria-Mercè, Hofstra, Robert M W
Published in Genome Biology (08.03.2017)
Published in Genome Biology (08.03.2017)
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Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter
Miedema, Anneke, Gerrits, Emma, Brouwer, Nieske, Jiang, Qiong, Kracht, Laura, Meijer, Michel, Nutma, Erik, Peferoen-Baert, Regina, Pijnacker, Anna T E, Wesseling, Evelyn M, Wijering, Marion H C, Gabius, Hans-Joachim, Amor, Sandra, Eggen, Bart J L, Kooistra, Susanne M
Published in Acta neuropathologica communications (28.01.2022)
Published in Acta neuropathologica communications (28.01.2022)
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Glia Open Access Database (GOAD): A comprehensive gene expression encyclopedia of glia cells in health and disease
Holtman, Inge R., Noback, Michiel, Bijlsma, Marieke, Duong, Kim N., van der Geest, Marije A., Ketelaars, Peer T., Brouwer, Nieske, Vainchtein, Ilia D., Eggen, Bart J. L., Boddeke, Hendrikus W. G. M.
Published in Glia (01.09.2015)
Published in Glia (01.09.2015)
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Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis
Holtman, Inge R, Raj, Divya D, Miller, Jeremy A, Schaafsma, Wandert, Yin, Zhuoran, Brouwer, Nieske, Wes, Paul D, Möller, Thomas, Orre, Marie, Kamphuis, Willem, Hol, Elly M, Boddeke, Erik W G M, Eggen, Bart J L
Published in Acta neuropathologica communications (23.05.2015)
Published in Acta neuropathologica communications (23.05.2015)
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