Sampling the conformational space of the catalytic subunit of human γ-secretase
Bai, Xiao-chen, Rajendra, Eeson, Yang, Guanghui, Shi, Yigong, Scheres, Sjors H W
Published in eLife (01.12.2015)
Published in eLife (01.12.2015)
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Journal Article
Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance
Zatreanu, Diana, Robinson, Helen M. R., Alkhatib, Omar, Boursier, Marie, Finch, Harry, Geo, Lerin, Grande, Diego, Grinkevich, Vera, Heald, Robert A., Langdon, Sophie, Majithiya, Jayesh, McWhirter, Claire, Martin, Niall M. B., Moore, Shaun, Neves, Joana, Rajendra, Eeson, Ranzani, Marco, Schaedler, Theresia, Stockley, Martin, Wiggins, Kimberley, Brough, Rachel, Sridhar, Sandhya, Gulati, Aditi, Shao, Nan, Badder, Luned M., Novo, Daniela, Knight, Eleanor G., Marlow, Rebecca, Haider, Syed, Callen, Elsa, Hewitt, Graeme, Schimmel, Joost, Prevo, Remko, Alli, Christina, Ferdinand, Amanda, Bell, Cameron, Blencowe, Peter, Bot, Chris, Calder, Mathew, Charles, Mark, Curry, Jayne, Ekwuru, Tennyson, Ewings, Katherine, Krajewski, Wojciech, MacDonald, Ellen, McCarron, Hollie, Pang, Leon, Pedder, Chris, Rigoreau, Laurent, Swarbrick, Martin, Wheatley, Ed, Willis, Simon, Wong, Ai Ching, Nussenzweig, Andre, Tijsterman, Marcel, Tutt, Andrew, Boulton, Simon J., Higgins, Geoff S., Pettitt, Stephen J., Smith, Graeme C. M., Lord, Christopher J.
Published in Nature communications (17.06.2021)
Published in Nature communications (17.06.2021)
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Journal Article
The Genetic and Biochemical Basis of FANCD2 Monoubiquitination
Rajendra, Eeson, Oestergaard, Vibe H., Langevin, Frédéric, Wang, Meng, Dornan, Gillian L., Patel, Ketan J., Passmore, Lori A.
Published in Molecular cell (05.06.2014)
Published in Molecular cell (05.06.2014)
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Journal Article
Ubiquitin-SUMO Circuitry Controls Activated Fanconi Anemia ID Complex Dosage in Response to DNA Damage
Gibbs-Seymour, Ian, Oka, Yasuyoshi, Rajendra, Eeson, Weinert, Brian T., Passmore, Lori A., Patel, Ketan J., Olsen, Jesper V., Choudhary, Chunaram, Bekker-Jensen, Simon, Mailand, Niels
Published in Molecular cell (08.01.2015)
Published in Molecular cell (08.01.2015)
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Journal Article
A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization
Jeyasekharan, Anand D, Liu, Yang, Hattori, Hiroyoshi, Pisupati, Venkat, Jonsdottir, Asta Bjork, Rajendra, Eeson, Lee, Miyoung, Sundaramoorthy, Elayanambi, Schlachter, Simon, Kaminski, Clemens F, Ofir-Rosenfeld, Yaara, Sato, Ko, Savill, Jane, Ayoub, Nabieh, Venkitaraman, Ashok R
Published in Nature structural & molecular biology (01.10.2013)
Published in Nature structural & molecular biology (01.10.2013)
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Journal Article
The Carboxyl Terminus of Brca2 Links the Disassembly of Rad51 Complexes to Mitotic Entry
Ayoub, Nabieh, Rajendra, Eeson, Su, Xinyi, Jeyasekharan, Anand D., Mahen, Robert, Venkitaraman, Ashok R.
Published in Current biology (14.07.2009)
Published in Current biology (14.07.2009)
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Journal Article
BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange
Shivji, Mahmud K.K, Mukund, Shreyas R, Rajendra, Eeson, Chen, Shaoxia, Short, Judith M, Savill, Jane, Klenerman, David, Venkitaraman, Ashok R
Published in Proceedings of the National Academy of Sciences - PNAS (11.08.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (11.08.2009)
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Journal Article
DNA damage regulates the mobility of Brca2 within the nucleoplasm of living cells
Jeyasekharan, Anand D., Ayoub, Nabieh, Mahen, Robert, Ries, Jonas, Esposito, Alessandro, Rajendra, Eeson, Hattori, Hiroyoshi, Kulkarni, Rajan P., Venkitaraman, Ashok R., Kowalczykowski, Stephen C.
Published in Proceedings of the National Academy of Sciences - PNAS (14.12.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (14.12.2010)
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Journal Article
Interrogation of the protein-protein interactions between human BRCA2 BRC repeats and RAD51 reveals atomistic determinants of affinity
Cole, Daniel J, Rajendra, Eeson, Roberts-Thomson, Meredith, Hardwick, Bryn, McKenzie, Grahame J, Payne, Mike C, Venkitaraman, Ashok R, Skylaris, Chris-Kriton
Published in PLoS computational biology (01.07.2011)
Published in PLoS computational biology (01.07.2011)
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Journal Article
The Structure of Binder of Arl2 (BART) Reveals a Novel G Protein Binding Domain
Bailey, Laura K., Campbell, Louise J., Evetts, Katrina A., Littlefield, Keily, Rajendra, Eeson, Nietlispach, Daniel, Owen, Darerca, Mott, Helen R.
Published in The Journal of biological chemistry (09.01.2009)
Published in The Journal of biological chemistry (09.01.2009)
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Journal Article
Scc2 Is a Potent Activator of Cohesin’s ATPase that Promotes Loading by Binding Scc1 without Pds5
Petela, Naomi J., Gligoris, Thomas G., Metson, Jean, Lee, Byung-Gil, Voulgaris, Menelaos, Hu, Bin, Kikuchi, Sotaro, Chapard, Christophe, Chen, Wentao, Rajendra, Eeson, Srinivisan, Madhusudhan, Yu, Hongtao, Löwe, Jan, Nasmyth, Kim A.
Published in Molecular cell (21.06.2018)
Published in Molecular cell (21.06.2018)
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Journal Article
Structure of the Fanconi anaemia monoubiquitin ligase complex
Shakeel, Shabih, Rajendra, Eeson, Alcón, Pablo, O’Reilly, Francis, Chorev, Dror S., Maslen, Sarah, Degliesposti, Gianluca, Russo, Christopher J., He, Shaoda, Hill, Chris H., Skehel, J. Mark, Scheres, Sjors H. W., Patel, Ketan J., Rappsilber, Juri, Robinson, Carol V., Passmore, Lori A.
Published in Nature (London) (01.11.2019)
Published in Nature (London) (01.11.2019)
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Journal Article
Assessment of DNA Double Strand Break Repair Activity Using High-throughput and Quantitative Luminescence-based Reporter Assays
Grande, Diego, Rajendra, Eeson, Mason, Bethany, Galbiati, Alessandro, Boulton, Simon J, Smith, Graeme C M, Robinson, Helen M R
Published in Journal of visualized experiments (14.06.2024)
Published in Journal of visualized experiments (14.06.2024)
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Journal Article
Abundance of the Fanconi anaemia core complex is regulated by the RuvBL1 and RuvBL2 AAA+ ATPases
Rajendra, Eeson, Garaycoechea, Juan I, Patel, Ketan J, Passmore, Lori A
Published in Nucleic acids research (16.12.2014)
Published in Nucleic acids research (16.12.2014)
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Journal Article
Quantitative, titratable and high-throughput reporter assays to measure DNA double strand break repair activity in cells
Rajendra, Eeson, Grande, Diego, Mason, Bethany, Di Marcantonio, Daniela, Armstrong, Lucy, Hewitt, Graeme, Elinati, Elias, Galbiati, Alessandro, Boulton, Simon J, Heald, Robert A, Smith, Graeme C M, Robinson, Helen M R
Published in Nucleic acids research (28.02.2024)
Published in Nucleic acids research (28.02.2024)
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Journal Article
Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta
Stockley, Martin L., Ferdinand, Amanda, Benedetti, Giovanni, Blencowe, Peter, Boyd, Susan M., Calder, Mat, Charles, Mark D., Edwardes, Lucy V., Ekwuru, Tennyson, Finch, Harry, Galbiati, Alessandro, Geo, Lerin, Grande, Diego, Grinkevich, Vera, Holliday, Nicholas D., Krajewski, Wojciech W., MacDonald, Ellen, Majithiya, Jayesh B., McCarron, Hollie, McWhirter, Claire L., Patel, Viral, Pedder, Chris, Rajendra, Eeson, Ranzani, Marco, Rigoreau, Laurent J. M., Robinson, Helen M. R., Schaedler, Theresia, Sirina, Julija, Smith, Graeme C. M., Swarbrick, Martin E., Turnbull, Andrew P., Willis, Simon, Heald, Robert A.
Published in Journal of medicinal chemistry (27.10.2022)
Published in Journal of medicinal chemistry (27.10.2022)
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Journal Article
Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models
Rodriguez-Berriguete, Gonzalo, Ranzani, Marco, Prevo, Remko, Puliyadi, Rathi, Machado, Nicole, Bolland, Hannah R, Millar, Val, Ebner, Daniel, Boursier, Marie, Cerutti, Aurora, Cicconi, Alessandro, Galbiati, Alessandro, Grande, Diego, Grinkevich, Vera, Majithiya, Jayesh B, Piscitello, Desiree, Rajendra, Eeson, Stockley, Martin L, Boulton, Simon J, Hammond, Ester M, Heald, Robert A, Smith, Graeme C M, Robinson, Helen M R, Higgins, Geoff S
Published in Clinical cancer research (14.04.2023)
Published in Clinical cancer research (14.04.2023)
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Journal Article
essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells
Hochegger, Helfrid, Dejsuphong, Donniphat, Sonoda, Eiichiro, Saberi, Alihossein, Rajendra, Eeson, Kirk, Jane, Hunt, Tim, Takeda, Shunichi
Published in The Journal of cell biology (16.07.2007)
Published in The Journal of cell biology (16.07.2007)
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Journal Article
Correction to “Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta”
Stockley, Martin L., Benedetti, Giovanni, Blencowe, Peter, Boulton, Simon J., Boyd, Susan M., Calder, Mat, Charles, Mark D., Edwardes, Lucy V., Ekwuru, Tennyson, Ferdinand, Amanda, Finch, Harry, Galbiati, Alessandro, Geo, Lerin, Grande, Diego, Grinkevich, Vera, Higgins, Geoff S., Holliday, Nicholas D., Krajewski, Wojciech W., MacDonald, Ellen, Majithiya, Jayesh B., McCarron, Hollie, McWhirter, Claire L., Patel, Viral, Pedder, Chris, Rajendra, Eeson, Ranzani, Marco, Rigoreau, Laurent J. M., Robinson, Helen M. R., Schaedler, Theresia, Sirina, Julija, Smith, Graeme C. M., Swarbrick, Martin E., Turnbull, Andrew P., Willis, Simon, Zemla, Aleksandra, Heald, Robert A.
Published in Journal of medicinal chemistry (09.03.2023)
Published in Journal of medicinal chemistry (09.03.2023)
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