p53-Dependent Nestin Regulation Links Tumor Suppression to Cellular Plasticity in Liver Cancer
Tschaharganeh, Darjus F., Xue, Wen, Calvisi, Diego F., Evert, Matthias, Michurina, Tatyana V., Dow, Lukas E., Banito, Ana, Katz, Sarah F., Kastenhuber, Edward R., Weissmueller, Susann, Huang, Chun-Hao, Lechel, Andre, Andersen, Jesper B., Capper, David, Zender, Lars, Longerich, Thomas, Enikolopov, Grigori, Lowe, Scott W.
Published in Cell (31.07.2014)
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A Gain-of-Function p53-Mutant Oncogene Promotes Cell Fate Plasticity and Myeloid Leukemia through the Pluripotency Factor FOXH1
Loizou, Evangelia, Banito, Ana, Livshits, Geulah, Ho, Yu-Jui, Koche, Richard P, Sánchez-Rivera, Francisco J, Mayle, Allison, Chen, Chi-Chao, Kinalis, Savvas, Bagger, Frederik O, Kastenhuber, Edward R, Durham, Benjamin H, Lowe, Scott W
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Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas
Ebbesen, Saya H., Scaltriti, Maurizio, Bialucha, Carl U., Morse, Natasha, Kastenhuber, Edward R., Wen, Hannah Y., Dow, Lukas E., Baselga, José, Lowe, Scott W.
Published in Proceedings of the National Academy of Sciences - PNAS (15.03.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (15.03.2016)
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IDH Mutation and Neuroglial Developmental Features Define Clinically Distinct Subclasses of Lower Grade Diffuse Astrocytic Glioma
GOROVETS, Daniel, KANNAN, Kasthuri, CHAN, Timothy A, HUSE, Jason T, SHEN, Ronglai, KASTENHUBER, Edward R, ISLAMDOUST, Nasrin, CAMPOS, Carl, PENTSOVA, Elena, HEGUY, Adriana, JHANWAR, Suresh C, MELLINGHOFF, Ingo K
Published in Clinical cancer research (01.05.2012)
Published in Clinical cancer research (01.05.2012)
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Dicer-regulated microRNAs 222 and 339 promote resistance of cancer cells to cytotoxic T-lymphocytes by down-regulation of ICAM-1
Ueda, Ryo, Kohanbash, Gary, Sasaki, Kotaro, Fujita, Mitsugu, Zhu, Xinmei, Kastenhuber, Edward R, McDonald, Heather A, Potter, Douglas M, Hamilton, Ronald L, Lotze, Michael T, Khan, Saleem A, Sobol, Robert W, Okada, Hideho
Published in Proceedings of the National Academy of Sciences - PNAS (30.06.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (30.06.2009)
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Epinephrine inhibits PI3Kα via the Hippo kinases
Lin, Ting-Yu, Ramsamooj, Shakti, Perrier, Tiffany, Liberatore, Katarina, Lantier, Louise, Vasan, Neil, Karukurichi, Kannan, Hwang, Seo-Kyoung, Kesicki, Edward A., Kastenhuber, Edward R., Wiederhold, Thorsten, Yaron, Tomer M., Huntsman, Emily M., Zhu, Mengmeng, Ma, Yilun, Paddock, Marcia N., Zhang, Guoan, Hopkins, Benjamin D., McGuinness, Owen, Schwartz, Robert E., Ersoy, Baran A., Cantley, Lewis C., Johnson, Jared L., Goncalves, Marcus D.
Published in Cell reports (Cambridge) (26.12.2023)
Published in Cell reports (Cambridge) (26.12.2023)
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Systemic Inhibition of Transforming Growth Factor-β in Glioma-Bearing Mice Improves the Therapeutic Efficacy of Glioma-Associated Antigen Peptide Vaccines
Ueda, Ryo, Fujita, Mitsugu, Zhu, Xinmei, Sasaki, Kotaro, Kastenhuber, Edward R, Kohanbash, Gary, McDonald, Heather A, Harper, Jay, Lonning, Scott, Okada, Hideho
Published in Clinical cancer research (01.11.2009)
Published in Clinical cancer research (01.11.2009)
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TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions
Shirole, Nitin H, Pal, Debjani, Kastenhuber, Edward R, Senturk, Serif, Boroda, Joseph, Pisterzi, Paola, Miller, Madison, Munoz, Gustavo, Anderluh, Marko, Ladanyi, Marc, Lowe, Scott W, Sordella, Raffaella
Published in eLife (19.10.2016)
Published in eLife (19.10.2016)
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Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers
Morris, Luc G. T, Taylor, Barry S, Bivona, Trever G, Gong, Yongxing, Eng, Stephanie, Brennan, Cameron W, Kaufman, Andrew, Kastenhuber, Edward R, Banuchi, Victoria E, Singh, Bhuvanesh, Heguy, Adriana, Viale, Agnes, Mellinghoff, Ingo K, Huse, Jason, Ganly, Ian, Chan, Timothy A
Published in Proceedings of the National Academy of Sciences - PNAS (22.11.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (22.11.2011)
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Role of Type 1 IFNs in Antiglioma Immunosurveillance-Using Mouse Studies to Guide Examination of Novel Prognostic Markers in Humans
FUJITA, Mitsugu, SCHEURER, Michael E, DECKER, Stacy A, MCDONALD, Heather A, KOHANBASH, Gary, KASTENHUBER, Edward R, KATO, Hisashi, BONDY, Melissa L, OHLFEST, John R, OKADA, Hideho
Published in Clinical cancer research (01.07.2010)
Published in Clinical cancer research (01.07.2010)
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Effective Immunotherapy against Murine Gliomas Using Type 1 Polarizing Dendritic Cells―Significant Roles of CXCL10
FUJITA, Mitsugu, XINMEI ZHU, KALINSKI, Pawel, OKADA, Hideho, UEDA, Ryo, SASAKI, Kotaro, KOHANBASH, Gary, KASTENHUBER, Edward R, MCDONALD, Heather A, GIBSON, Gregory A, WATKINS, Simon C, MUTHUSWAMY, Ravikumar
Published in Cancer research (Chicago, Ill.) (15.02.2009)
Published in Cancer research (Chicago, Ill.) (15.02.2009)
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Whole exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma
Kannan, Kasthuri, Inagaki, Akiko, Silber, Joachim, Gorovets, Daniel, Zhang, Jianan, Kastenhuber, Edward R., Heguy, Adriana, Petrini, John H., Chan, Timothy A., Huse, Jason T.
Published in Oncotarget (31.10.2012)
Published in Oncotarget (31.10.2012)
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Optimized base editors enable efficient editing in cells, organoids and mice
Zafra, Maria Paz, Schatoff, Emma M, Katti, Alyna, Foronda, Miguel, Breinig, Marco, Schweitzer, Anabel Y, Simon, Amber, Han, Teng, Goswami, Sukanya, Montgomery, Emma, Thibado, Jordana, Kastenhuber, Edward R, Sánchez-Rivera, Francisco J, Shi, Junwei, Vakoc, Christopher R, Lowe, Scott W, Tschaharganeh, Darjus F, Dow, Lukas E
Published in Nature biotechnology (01.10.2018)
Published in Nature biotechnology (01.10.2018)
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Inducible in vivo genome editing with CRISPR-Cas9
Dow, Lukas E, Fisher, Jonathan, O'Rourke, Kevin P, Muley, Ashlesha, Kastenhuber, Edward R, Livshits, Geulah, Tschaharganeh, Darjus F, Socci, Nicholas D, Lowe, Scott W
Published in Nature biotechnology (01.04.2015)
Published in Nature biotechnology (01.04.2015)
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p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression
Moon, Sung-Hwan, Huang, Chun-Hao, Houlihan, Shauna L., Regunath, Kausik, Freed-Pastor, William A., Morris, John P., Tschaharganeh, Darjus F., Kastenhuber, Edward R., Barsotti, Anthony M., Culp-Hill, Rachel, Xue, Wen, Ho, Yu-Jui, Baslan, Timour, Li, Xiang, Mayle, Allison, de Stanchina, Elisa, Zender, Lars, Tong, David R., D’Alessandro, Angelo, Lowe, Scott W., Prives, Carol
Published in Cell (24.01.2019)
Published in Cell (24.01.2019)
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DNAJB1–PRKACA fusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma
Kastenhuber, Edward R., Lalazar, Gadi, Houlihan, Shauna L., Tschaharganeh, Darjus F., Baslan, Timour, Chen, Chi-Chao, Requena, David, Tian, Sha, Bosbach, Benedikt, Wilkinson, John E., Simon, Sanford M., Lowe, Scott W.
Published in Proceedings of the National Academy of Sciences - PNAS (12.12.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (12.12.2017)
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Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants
Sánchez-Rivera, Francisco J., Diaz, Bianca J., Kastenhuber, Edward R., Schmidt, Henri, Katti, Alyna, Kennedy, Margaret, Tem, Vincent, Ho, Yu-Jui, Leibold, Josef, Paffenholz, Stella V., Barriga, Francisco M., Chu, Kevan, Goswami, Sukanya, Wuest, Alexandra N., Simon, Janelle M., Tsanov, Kaloyan M., Chakravarty, Debyani, Zhang, Hongxin, Leslie, Christina S., Lowe, Scott W., Dow, Lukas E.
Published in Nature biotechnology (01.06.2022)
Published in Nature biotechnology (01.06.2022)
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A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin-MLL Inhibition
Soto-Feliciano, Yadira M, Sánchez-Rivera, Francisco J, Perner, Florian, Barrows, Douglas W, Kastenhuber, Edward R, Ho, Yu-Jui, Carroll, Thomas, Xiong, Yijun, Anand, Disha, Soshnev, Alexey A, Gates, Leah, Beytagh, Mary Clare, Cheon, David, Gu, Shengqing, Liu, X Shirley, Krivtsov, Andrei V, Meneses, Maximiliano, de Stanchina, Elisa, Stone, Richard M, Armstrong, Scott A, Lowe, Scott W, Allis, C David
Published in Cancer discovery (09.01.2023)
Published in Cancer discovery (09.01.2023)
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18F-Fluorodeoxy-glucose Positron Emission Tomography Marks MYC-Overexpressing Human Basal-Like Breast Cancers
PALASKAS, Nicolaos, LARSON, Steven M, KASTENHUBER, Edward R, TASCHEREAU, Richard, PLAISIER, Seema B, TRAN, Chris, HEGUY, Adriana, HONG WU, SANDER, Chris, PHELPS, Michael E, BRENNAN, Cameron, PORT, Elisa, SCHULTZ, Nikolaus, HUSE, Jason T, GRAEBER, Thomas G, MELLINGHOFF, Ingo K, KOMISOPOULOU, Evangelia, WONG, Justin, ROHLE, Dan, CAMPOS, Carl, YANNUZZI, Nicolas, OSBORNE, Joseph R, LINKOV, Irina
Published in Cancer research (Chicago, Ill.) (01.08.2011)
Published in Cancer research (Chicago, Ill.) (01.08.2011)
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