Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex
Jnoff, Eric, Albrecht, Claudia, Barker, John J., Barker, Oliver, Beaumont, Edward, Bromidge, Steven, Brookfield, Frederick, Brooks, Mark, Bubert, Christian, Ceska, Tom, Corden, Vincent, Dawson, Graham, Duclos, Stephanie, Fryatt, Tara, Genicot, Christophe, Jigorel, Emilie, Kwong, Jason, Maghames, Rosemary, Mushi, Innocent, Pike, Richard, Sands, Zara A., Smith, Myron A., Stimson, Christopher C., Courade, Jean-Philippe
Published in ChemMedChem (01.04.2014)
Published in ChemMedChem (01.04.2014)
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Crystal structure of human peptidylarginine deiminase type VI (PAD6) provides insights into its inactivity
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Validation of a small molecule inhibitor of PDE6D-RAS interaction with favorable anti-leukemic effects
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Structural insights into WcbI, a novel polysaccharide-biosynthesis enzyme
Vivoli, Mirella, Ayres, Emily, Beaumont, Edward, Isupov, Michail N, Harmer, Nicholas J
Published in IUCrJ (01.01.2014)
Published in IUCrJ (01.01.2014)
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Development of a Selective Inhibitor of Protein Arginine Deiminase 2
Muth, Aaron, Subramanian, Venkataraman, Beaumont, Edward, Nagar, Mitesh, Kerry, Philip, McEwan, Paul, Srinath, Hema, Clancy, Kathleen, Parelkar, Sangram, Thompson, Paul R
Published in Journal of medicinal chemistry (13.04.2017)
Published in Journal of medicinal chemistry (13.04.2017)
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Small Molecule Inhibition of PDE6D-RAS Interaction Suppresses the Growth of Acute Lymphoblastic Leukemia Cell Lines
Canovas Nunes, Sara, Xu, Haiming, De Vita, Serena, Anighoro, Andrew, Autelitano, Francois, Beaumont, Edward, Klingbeil, Pamela, McGuinness, Meaghan, Duvert, Beatrice, Harris, Chad E., Yang, Lu, Pokharel, Sheela Pangeni, Chen, Chun-Wei David, Ermann, Monika, Williams, David A.
Published in Blood (23.11.2021)
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Synchronous Photoinitiation of Endothelial NO Synthase Activity by a Nanotrigger Targeted at Its NADPH Site
Beaumont, Edward, Lambry, Jean-Christophe, Gautier, Clément, Robin, Anne-Claire, Gmouh, Said, Berka, Vladimir, Tsai, Ah-Lim, Blanchard-Desce, Mireille, Slama-Schwok, Anny
Published in Journal of the American Chemical Society (21.02.2007)
Published in Journal of the American Chemical Society (21.02.2007)
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Journal Article
Inside Cover: Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex (ChemMedChem 4/2014)
Jnoff, Eric, Albrecht, Claudia, Barker, John J., Barker, Oliver, Beaumont, Edward, Bromidge, Steven, Brookfield, Frederick, Brooks, Mark, Bubert, Christian, Ceska, Tom, Corden, Vincent, Dawson, Graham, Duclos, Stephanie, Fryatt, Tara, Genicot, Christophe, Jigorel, Emilie, Kwong, Jason, Maghames, Rosemary, Mushi, Innocent, Pike, Richard, Sands, Zara A., Smith, Myron A., Stimson, Christopher C., Courade, Jean-Philippe
Published in ChemMedChem (01.04.2014)
Published in ChemMedChem (01.04.2014)
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Journal Article
NO Formation by Neuronal NO-Synthase can be Controlled by Ultrafast Electron Injection from a Nanotrigger
Beaumont, Edward, Lambry, Jean-Christophe, Blanchard-Desce, Mireille, Martasek, Pavel, Panda, Satya P, van Faassen, Ernst E.H, Brochon, Jean-Claude, Deprez, Eric, Slama-Schwok, Anny
Published in Chembiochem : a European journal of chemical biology (02.03.2009)
Published in Chembiochem : a European journal of chemical biology (02.03.2009)
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Journal Article
O46. Photoinduced electron transfer from a novel nanotrigger addressed to the NADPH site within the endothelial NO-synthase to the flavin moieties of the protein
Beaumont, Edward, Robin, Anne-Claire, Berka, Vladimir, Tsai, Ah-Lim, Blanchard-Desce, Mireille, Lambry, Jean-Christophe, Slama-Schwok, Anny
Published in Nitric oxide (01.06.2006)
Published in Nitric oxide (01.06.2006)
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Journal Article
Photoinduced electron transfer from a novel nanotrigger addressed to the NADPH site within the endothelial NO-synthase to the flavin moieties of the protein
Beaumont, Edward, Robin, Anne-Claire, Berka, Vladimir, Tsai, Ah-Lim, Blanchard-Desce, Mireille, Lambry, Jean-Christophe, Slama-Schwok, Anny
Published in Nitric oxide (2006)
Published in Nitric oxide (2006)
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Heteroaryl inhibitors of PAD4
Papadopoulos, Kostas, Gadouleau, Elise, Monck, Nat, Beaumont, Edward, Palfrey, Jordan, Tye, Heather, Meniconi, Mirco, Woods, Philip A, Gleave, Laura, Kerry, Philip Stephen, Atton, Holly, Devraj, Rajesh, Kumaravel, Gnanasambandam, Lecci, Cristina
Year of Publication 13.02.2024
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Year of Publication 13.02.2024
Patent
HETEROARYL INHIBITORS OF PAD4
Papadopoulos, Kostas, Gadouleau, Elise, Monck, Nat, Beaumont, Edward, Palfrey, Jordan, Tye, Heather, Meniconi, Mirco, Gleave, Laura, Kerry, Philip Stephen, Atton, Holly, Devraj, Rajesh, Kumaravel, Gnanasambandam, Lecci, Cristina
Year of Publication 24.06.2021
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Year of Publication 24.06.2021
Patent
HETEROARYL INHIBITORS OF PAD4
Papadopoulos, Kostas, Gadouleau, Elise, Monck, Nat, Beaumont, Edward, Palfrey, Jordan, Tye, Heather, Meniconi, Mirco, Woods, Philip A, Gleave, Laura, Kerry, Philip Stephen, Atton, Holly, Devraj, Rajesh, Kumaravel, Gnanasambandam, Lecci, Cristina
Year of Publication 17.03.2022
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Year of Publication 17.03.2022
Patent
Validation of a small molecule inhibitor of PDE6D-RAS interaction with potent anti-leukemic effects
Sara Canovas Nunes, De Vita, Serena, Anighoro, Andrew, Autelitano, Francois, Beaumont, Edward, Klingbeil, Pamela, Mcguinness, Meaghan, Duvert, Beatrice, Harris, Chad, Lu, Yang, Pokharel, Sheela Pangeni, Chun-Wei, Chen, Ermann, Monika, Williams, David A, Xu, Haiming
Published in bioRxiv (14.03.2022)
Published in bioRxiv (14.03.2022)
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Paper