Novel bicyclic lactam inhibitors of thrombin: potency and selectivity optimization through P1 residues
Lévesque, Sophie, St-Denis, Yves, Bachand, Benoit, Préville, Patrice, Leblond, Lorraine, Winocour, Peter D, Edmunds, Jeremy J, Rubin, J.R, Siddiqui, M.Arshad
Published in Bioorganic & medicinal chemistry letters (17.12.2001)
Published in Bioorganic & medicinal chemistry letters (17.12.2001)
Get full text
Journal Article
Design, Synthesis, and Biological Activity of Potent and Selective Inhibitors of Blood Coagulation Factor Xa
Willardsen, J. Adam, Dudley, Danette A, Cody, Wayne L, Chi, Liguo, McClanahan, Thomas B, Mertz, Thomas E, Potoczak, Ronald E, Narasimhan, Lakshmi S, Holland, Debra R, Rapundalo, Stephen T, Edmunds, Jeremy J
Published in Journal of medicinal chemistry (29.07.2004)
Published in Journal of medicinal chemistry (29.07.2004)
Get full text
Journal Article
Ketopiperazine-based renin inhibitors: Optimization of the “C” ring
Holsworth, Daniel D., Cai, Cuiman, Cheng, Xue-Min, Cody, Wayne L., Downing, Dennis M., Erasga, Noe, Lee, Chitase, Powell, Noel A., Edmunds, Jeremy J., Stier, Michael, Jalaie, Mehran, Zhang, Erli, McConnell, Pat, Ryan, Michael J., Bryant, John, Li, Tingsheng, Kasani, Aparna, Hall, Eric, Subedi, Rajendra, Rahim, Mohammad, Maiti, Samarendra
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
Get full text
Journal Article
The discovery and preparation of disubstituted novel amino-aryl-piperidine-based renin inhibitors
Cody, Wayne L., Holsworth, Daniel D., Powell, Noel A., Jalaie, Mehran, Zhang, Erli, Wang, Wei, Samas, Brian, Bryant, John, Ostroski, Robert, Ryan, Michael J., Edmunds, Jeremy J.
Published in Bioorganic & medicinal chemistry (03.01.2005)
Published in Bioorganic & medicinal chemistry (03.01.2005)
Get full text
Journal Article
Discovery of novel non-peptidic ketopiperazine-based renin inhibitors
Holsworth, Daniel D., Powell, Noel A., Downing, Dennis M., Cai, Cuiman, Cody, Wayne L., Ryan, J. Michael, Ostroski, Robert, Jalaie, Mehran, Bryant, John W., Edmunds, Jeremy J.
Published in Bioorganic & medicinal chemistry (01.04.2005)
Published in Bioorganic & medicinal chemistry (01.04.2005)
Get full text
Journal Article
Benzyl ether structure–activity relationships in a series of ketopiperazine-based renin inhibitors
Powell, Noel A., Clay, Emma H., Holsworth, Daniel D., Bryant, John W., Ryan, Michael J., Jalaie, Mehran, Edmunds, Jeremy J.
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
Get full text
Journal Article
Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors
Powell, Noel A., Clay, Emma H., Holsworth, Daniel D., Bryant, John W., Ryan, Michael J., Jalaie, Mehran, Zhang, Erli, Edmunds, Jeremy J.
Published in Bioorganic & medicinal chemistry letters (02.05.2005)
Published in Bioorganic & medicinal chemistry letters (02.05.2005)
Get full text
Journal Article
Practical Synthesis of 1-Aryl-6-(hydroxymethyl)-2-ketopiperazines via a 6-exo Amide−Epoxide Cyclization
Powell, Noel A, Ciske, Fred L, Clay, Emma C, Cody, Wayne L, Downing, Dennis M, Blazecka, Peter G, Holsworth, Daniel D, Edmunds, Jeremy J
Published in Organic letters (28.10.2004)
Published in Organic letters (28.10.2004)
Get full text
Journal Article
The discovery of fluoropyridine-based inhibitors of the factor VIIa/TF complex—Part 2
Kohrt, Jeffrey T., Filipski, Kevin J., Cody, Wayne L., Cai, Cuiman, Dudley, Danette A., Van Huis, Chad A., Willardsen, J. Adam, Narasimhan, Lakshmi S., Zhang, Erli, Rapundalo, Stephen T., Saiya-Cork, Kamlai, Leadley, Robert J., Edmunds, Jeremy J.
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
Get full text
Journal Article
The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex
Kohrt, Jeffrey T., Filipski, Kevin J., Cody, Wayne L., Cai, Cuiman, Dudley, Danette A., Van Huis, Chad A., Willardsen, J. Adam, Rapundalo, Stephen T., Saiya-Cork, Kamlai, Leadley, Robert J., Narasimhan, Lakshmi, Zhang, Erli, Whitlow, Marc, Adler, Marc, McLean, Kirk, Chou, Yuo-Ling, McKnight, Cecile, Arnaiz, Damian O., Shaw, Kenneth J., Light, David R., Edmunds, Jeremy J.
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
Get full text
Journal Article
DISCOVERY OF A NOVEL SERIES OF ORALLY-ACTIVE NONPEPTIDE ENDOTHELIN-A (ET(A)) RECEPTOR-SELECTIVE ANTAGONISTS
DOHERTY, AM, PATT, WC, EDMUNDS, JJ, BERRYMAN, KA, REISDORPH, BR, PLUMMER, MS, SHAHRIPOUR, A, LEE, C, CHENG, XM, WALKER, DM, HALEEN, SJ, KEISER, JA, FLYNN, MA, WELCH, KM, HALLAK, H, TAYLOR, DG, REYNOLDS, EE
Published in Journal of medicinal chemistry (14.04.1995)
Published in Journal of medicinal chemistry (14.04.1995)
Get full text
Journal Article
Applications of crotyldiisopinocampheylboranes in synthesis: a formal total synthesis of (+)-calyculin A
Anderson, OP, Barrett, AGM, Edmunds, JJ, Hachiya, SI, Hendrix, JA, Horita, K, Malecha, JW, Parkinson, CJ, VanSickle, A
Published in Canadian journal of chemistry (01.11.2001)
Published in Canadian journal of chemistry (01.11.2001)
Get full text
Journal Article
An efficient synthesis of 2-(3-(4-amidinophenylcarbamoyl)naphthalen-2-yl)-5-((2,2-methylpropyl)carbamoyl)benzoic acid: a factor VIIa inhibitor discovered by the Ono Pharmaceutical Company
Kohrt, Jeffrey T, Filipski, Kevin J, Rapundalo, Stephen T, Cody, Wayne L, Edmunds, Jeremy J
Published in Tetrahedron letters (2000)
Published in Tetrahedron letters (2000)
Get full text
Journal Article
In vitro and in vivo antithrombotic activity of PD-198961, a novel synthetic factor Xa inhibitor
Chi, Liguo, Peng, Yun-Wen, Gibson, Glenn, Hicks, Gary, Mertz, Thomas E, Rapundalo, Stephen, Janiczek, Nancy, Edmunds, Jeremy J, Leadley, Robert
Published in Journal of cardiovascular pharmacology (01.10.2004)
Published in Journal of cardiovascular pharmacology (01.10.2004)
Get more information
Journal Article
Novel bicyclic lactam inhibitors of thrombin: Highly potent and selective inhibitors
ST-DENIS, Yves, LEVESQUE, Sophie, BACHAND, Benoit, EDMUNDS, Jeremy J, LEBLOND, Lorraine, PREVILLE, Patrice, TARAZI, Micheline, WINOCOUR, Peter D, SIDDIQUI, M. Arshad
Published in Bioorganic & medicinal chemistry letters (22.04.2002)
Published in Bioorganic & medicinal chemistry letters (22.04.2002)
Get full text
Journal Article
Potent and selective bicyclic lactam inhibitors of thrombin. Part 4: Transition state inhibitors
BACHAND, Benoit, TARAZI, Micheline, ST-DENIS, Yves, EDMUNDS, Jeremy J, WINOCOUR, Peter D, LEBLOND, Lorraine, SIDDIQUI, M. Arshad
Published in Bioorganic & medicinal chemistry letters (12.02.2001)
Published in Bioorganic & medicinal chemistry letters (12.02.2001)
Get full text
Journal Article
Synthesis of Novel Tricyclic Aryltriazole-3-Thione Compounds
Cai, Cuiman, Plummer, Janet S., Connor, David, Holsworth, Daniel D., Edmunds, Jeremy J.
Published in Synthetic communications (01.01.2005)
Published in Synthetic communications (01.01.2005)
Get full text
Journal Article
Applications of crotyldiisopinocampheylboranes in synthesis: a formal total synthesis of (+)-calyculin A
Anderson, Oren P, Barrett, Anthony GM, Edmunds, Jeremy J, Hachiya, Shun-Ichiro, Hendrix, James A, Horita, Kiyoshi, Malecha, James W, Parkinson, Christopher J, VanSickle, Andrew
Published in Canadian journal of chemistry (01.11.2001)
Published in Canadian journal of chemistry (01.11.2001)
Get full text
Journal Article
Synthesis of 4-(R)-Naphthalene-2-yloxy-1-(1-Phenyl-(S)-Ethyl)-Pyrrolidin-3-(R)-ol and 4-(S)-Naphthalen-2-yloxy-1-(1-Phenyl-(S)-Ethyl)-Pyrrolidin-3-(S)-ol: Versatile Chiral Intermediates for Synthesis
Holsworth, Daniel D., Stier, Michael, Wang, Wei, Edmunds, Jeremy J., Li, Tingsheng, Maiti, Samarendra N.
Published in Synthetic communications (31.12.2004)
Published in Synthetic communications (31.12.2004)
Get full text
Journal Article
An Expeditious Synthesis of 6-Alkyl-5-(4′-amino-phenyl)-pyrimidine-2,4-diamines
Holsworth, Daniel D., Jeremy, Michael Stier, Edmunds, J., He, Wei, Place, Samuel, Maiti, Samarendra
Published in Synthetic communications (01.10.2003)
Published in Synthetic communications (01.10.2003)
Get full text
Journal Article