Kallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome
White, Gemma V., Edgar, Emma V., Holmes, Duncan S., Lewell, Xiao Qing, Liddle, John, Polyakova, Oxana, Smith, Kathrine J., Thorpe, James H., Walker, Ann L., Wang, Yichen, Young, Robert J., Hovnanian, Alain
Published in Bioorganic & medicinal chemistry letters (15.03.2019)
Published in Bioorganic & medicinal chemistry letters (15.03.2019)
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Structure guided drug design to develop kallikrein 5 inhibitors to treat Netherton syndrome
Walker, Ann L., Bingham, Ryan P., Edgar, Emma V., Ferrie, Alan, Holmes, Duncan S., Liddle, John, Polyakova, Oxana, Rella, Monika, Smith, Kathrine J., Thorpe, James H., Wang, Yichen, White, Gemma V., Young, Robert J., Hovnanian, Alain
Published in Bioorganic & medicinal chemistry letters (15.06.2019)
Published in Bioorganic & medicinal chemistry letters (15.06.2019)
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Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors
Walker, Ann L., Denis, Alexis, Bingham, Ryan P., Bouillot, Anne, Edgar, Emma V., Ferrie, Alan, Holmes, Duncan S., Laroze, Alain, Liddle, John, Fouchet, Marie-Helene, Moquette, Alexandre, Nassau, Pam, Pearce, Andrew C., Polyakova, Oxana, Smith, Kathrine J., Thomas, Pamela, Thorpe, James H., Trottet, Lionel, Wang, Yichen, Hovnanian, Alain
Published in Bioorganic & medicinal chemistry letters (15.10.2019)
Published in Bioorganic & medicinal chemistry letters (15.10.2019)
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Corrigendum to ‘Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors’ [Bioorg. Med. Chem. Lett. 29 (2019) 126675]
Walker, Ann L., Denis, Alexis, Bingham, Ryan P., Bouillot, Anne, Edgar, Emma V., Ferrie, Alan, Holmes, Duncan S., Laroze, Alain, Liddle, John, Fouchet, Marie-Helene, Moquette, Alexandre, Nassau, Pam, Pearce, Andrew C., Polyakova, Oxana, Smith, Kathrine J., Thomas, Pamela, Thorpe, James H., Trottet, Lionel, Wang, Yichen, Hovnanian, Alain
Published in Bioorganic & medicinal chemistry letters (15.01.2020)
Published in Bioorganic & medicinal chemistry letters (15.01.2020)
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Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome
Thorpe, James H., Edgar, Emma V., Smith, Kathrine J., Lewell, Xiao Q., Rella, Monika, White, Gemma V., Polyakova, Oxana, Nassau, Pamela, Walker, Ann L., Holmes, Duncan S., Pearce, Andrew C., Wang, Yichen, Liddle, John, Hovnanian, Alain
Published in Acta crystallographica. Section F, Structural biology communications (01.05.2019)
Published in Acta crystallographica. Section F, Structural biology communications (01.05.2019)
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Pharmacological characterisation and inhibitory effects of (2R,3R,4S,5R)-2-(6-amino-2-{[(1S)-2-hydroxy-1-(phenylmethyl)ethyl]amino}-9H-purin-9-yl)-5-(2-ethyl-2H-tetrazol-5-yl)tetrahydro-3,4-furandiol, a novel ligand that demonstrates both adenosine A(2A) receptor agonist and adenosine A(3) receptor antagonist activity
Bevan, Nicola, Butchers, Peter R, Cousins, Rick, Coates, Jill, Edgar, Emma V, Morrison, Val, Sheehan, Michael J, Reeves, Julian, Wilson, David J
Published in European journal of pharmacology (14.06.2007)
Published in European journal of pharmacology (14.06.2007)
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Journal Article
Pharmacological characterisation and inhibitory effects of (2R,3R,4S,5R)-2-(6-amino-2-{[(1S)-2-hydroxy-1-(phenylmethyl)ethyl]amino}-9H-purin-9-yl)-5-(2-ethyl-2H-tetrazol-5-yl)tetrahydro-3,4-furandiol, a novel ligand that demonstrates both adenosine A2A receptor agonist and adenosine A3 receptor antagonist activity
Bevan, Nicola, Butchers, Peter R., Cousins, Rick, Coates, Jill, Edgar, Emma V., Morrison, Val, Sheehan, Michael J., Reeves, Julian, Wilson, David J.
Published in European journal of pharmacology (14.06.2007)
Published in European journal of pharmacology (14.06.2007)
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Journal Article