Discovery of NV-5138, the first selective Brain mTORC1 activator
Sengupta, Shomit, Giaime, Emilie, Narayan, Sridhar, Hahm, Seung, Howell, Jessica, O'Neill, David, Vlasuk, George P, Saiah, Eddine
Published in Scientific reports (11.03.2019)
Published in Scientific reports (11.03.2019)
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A small molecule inhibitor of Rheb selectively targets mTORC1 signaling
Mahoney, Sarah J, Narayan, Sridhar, Molz, Lisa, Berstler, Lauren A, Kang, Seong A, Vlasuk, George P, Saiah, Eddine
Published in Nature communications (07.02.2018)
Published in Nature communications (07.02.2018)
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Huntington's disease phenotypes are improved via mTORC1 modulation by small molecule therapy
Sophie St-Cyr, Daniel D Child, Emilie Giaime, Alicia R Smith, Christine J Pascua, Seung Hahm, Eddine Saiah, Beverly L Davidson
Published in PloS one (29.08.2022)
Published in PloS one (29.08.2022)
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Journal Article
Huntington’s disease phenotypes are improved via mTORC1 modulation by small molecule therapy
St-Cyr, Sophie, Child, Daniel D, Giaime, Emilie, Smith, Alicia R, Pascua, Christine J, Hahm, Seung, Saiah, Eddine, Davidson, Beverly L
Published in PloS one (29.08.2022)
Published in PloS one (29.08.2022)
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Journal Article
Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose Transporters
Kang, Seong A, O'Neill, David J, Machl, Andreas W, Lumpkin, Casey J, Galda, Stephanie N, Sengupta, Shomit, Mahoney, Sarah J, Howell, Jessica J, Molz, Lisa, Hahm, Seung, Vlasuk, George P, Saiah, Eddine
Published in Cell chemical biology (19.09.2019)
Published in Cell chemical biology (19.09.2019)
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Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation
Kato, Taro, Pothula, Santosh, Liu, Rong-Jian, Duman, Catharine H., Terwilliger, Rosemarie, Vlasuk, George P., Saiah, Eddine, Hahm, Seung, Duman, Ronald S.
Published in The Journal of clinical investigation (03.06.2019)
Published in The Journal of clinical investigation (03.06.2019)
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Diazine Indole Acetic Acids as Potent, Selective, and Orally Bioavailable Antagonists of Chemoattractant Receptor Homologous Molecule Expressed on Th2 Cells (CRTH2) for the Treatment of Allergic Inflammatory Diseases
Kaila, Neelu, Huang, Adrian, Moretto, Alessandro, Follows, Bruce, Janz, Kristin, Lowe, Michael, Thomason, Jennifer, Mansour, Tarek S, Hubeau, Cedric, Page, Karen, Morgan, Paul, Fish, Susan, Xu, Xin, Williams, Cara, Saiah, Eddine
Published in Journal of medicinal chemistry (14.06.2012)
Published in Journal of medicinal chemistry (14.06.2012)
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Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD)
Wu, Yuchuan, Li, Jianchang, Wu, Junjun, Morgan, Paul, Xu, Xin, Rancati, Fabio, Vallese, Stefania, Raveglia, Luca, Hotchandani, Rajeev, Fuller, Nathan, Bard, Joel, Cunningham, Kristina, Fish, Susan, Krykbaev, Rustem, Tam, Steve, Goldman, Samuel J., Williams, Cara, Mansour, Tarek S., Saiah, Eddine, Sypek, Joseph, Li, Wei
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
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Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes
Wan, Zhao-Kui, Chenail, Eva, Li, Huan-Qiu, Ipek, Manus, Xiang, Jason, Suri, Vipin, Hahm, Seung, Bard, Joel, Svenson, Kristine, Xu, Xin, Tian, Xianbin, Wang, Mengmeng, Li, Xiangping, Johnson, Christian E, Qadri, Ariful, Panza, Darrell, Perreault, Mylene, Mansour, Tarek S, Tobin, James F, Saiah, Eddine
Published in ACS medicinal chemistry letters (10.01.2013)
Published in ACS medicinal chemistry letters (10.01.2013)
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Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation
Kato, Taro, Pothula, Santosh, Liu, Rong-Jian, Duman, Catharine H, Terwilliger, Rosemarie, Vlasuk, George P, Saiah, Eddine, Hahm, Seung, Duman, Ronald S
Published in The Journal of clinical investigation (03.06.2019)
Published in The Journal of clinical investigation (03.06.2019)
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Small Molecules That Target Protein Misfolding
Gavrin, Lori Krim, Denny, Rajiah Aldrin, Saiah, Eddine
Published in Journal of medicinal chemistry (27.12.2012)
Published in Journal of medicinal chemistry (27.12.2012)
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Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of ((S)-2,2-Difluorocyclopropyl)((1R,5S)-3-(2-(1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841
Fensome, Andrew, Ambler, Catherine M., Arnold, Eric, Banker, Mary Ellen, Brown, Matthew F., Chrencik, Jill, Clark, James D., Dowty, Martin E., Efremov, Ivan V., Flick, Andrew, Gerstenberger, Brian S., Gopalsamy, Ariamala, Hayward, Matthew M., Hegen, Martin, Hollingshead, Brett D., Jussif, Jason, Knafels, John D., Limburg, David C., Lin, David, Lin, Tsung H., Pierce, Betsy S., Saiah, Eddine, Sharma, Raman, Symanowicz, Peter T., Telliez, Jean-Baptiste, Trujillo, John I., Vajdos, Felix F., Vincent, Fabien, Wan, Zhao-Kui, Xing, Li, Yang, Xiaojing, Yang, Xin, Zhang, Liying
Published in Journal of medicinal chemistry (11.10.2018)
Published in Journal of medicinal chemistry (11.10.2018)
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CHEMISTRY AND BIOLOGY OF THE 2-BETA-ALKYL-3-BETA-PHENYL ANALOGS OF COCAINE - SUBNANOMOLAR AFFINITY LIGANDS THAT SUGGEST A NEW PHARMACOPHORE MODEL AT THE C-2 POSITION
KOZIKOWSKI, AP, SAIAH, MKE, JOHNSON, KM, BERGMANN, JS
Published in Journal of medicinal chemistry (04.08.1995)
Published in Journal of medicinal chemistry (04.08.1995)
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Recent developments in targeting protein misfolding diseases
Denny, Rajiah Aldrin, Gavrin, Lori Krim, Saiah, Eddine
Published in Bioorganic & medicinal chemistry letters (01.04.2013)
Published in Bioorganic & medicinal chemistry letters (01.04.2013)
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Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases
Gerstenberger, Brian S, Ambler, Catherine, Arnold, Eric P, Banker, Mary-Ellen, Brown, Matthew F, Clark, James D, Dermenci, Alpay, Dowty, Martin E, Fensome, Andrew, Fish, Susan, Hayward, Matthew M, Hegen, Martin, Hollingshead, Brett D, Knafels, John D, Lin, David W, Lin, Tsung H, Owen, Dafydd R, Saiah, Eddine, Sharma, Raman, Vajdos, Felix F, Xing, Li, Yang, Xiaojing, Yang, Xin, Wright, Stephen W
Published in Journal of medicinal chemistry (25.11.2020)
Published in Journal of medicinal chemistry (25.11.2020)
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MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USES THEREOF
EDDINE SAIAH, SRIDHAR NARAYAN, KRISTINA MICHELLE FETALVERO, SHOMIT SENGUPTA, DAVID JOHN O'NEILL
Year of Publication 29.05.2024
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Year of Publication 29.05.2024
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