Randomized Phase II Study of Paclitaxel plus Alisertib versus Paclitaxel plus Placebo as Second-Line Therapy for SCLC: Primary and Correlative Biomarker Analyses
Owonikoko, Taofeek K., Niu, Huifeng, Nackaerts, Kristiaan, Csoszi, Tibor, Ostoros, Gyula, Mark, Zsuzsanna, Baik, Christina, Joy, Anil Abraham, Chouaid, Christos, Jaime, Jesus Corral, Kolek, Vitezslav, Majem, Margarita, Roubec, Jaromir, Santos, Edgardo S., Chiang, Anne C., Speranza, Giovanna, Belani, Chandra P., Chiappori, Alberto, Patel, Manish R., Czebe, Krisztina, Byers, Lauren, Bahamon, Brittany, Li, Cong, Sheldon-Waniga, Emily, Kong, Eric F., Williams, Miguel, Badola, Sunita, Shin, Hyunjin, Bedford, Lisa, Ecsedy, Jeffrey A., Bryant, Matthew, Jones, Sian, Simmons, John, Leonard, E. Jane, Ullmann, Claudio Dansky, Spigel, David R.
Published in Journal of thoracic oncology (01.02.2020)
Published in Journal of thoracic oncology (01.02.2020)
Get full text
Journal Article
Characterization of Alisertib (MLN8237), an Investigational Small-Molecule Inhibitor of Aurora A Kinase Using Novel In Vivo Pharmacodynamic Assays
MANFREDI, Mark G, ECSEDY, Jeffrey A, WYSONG, Deborah R, JANOWICK, David A, HYER, Marc L, LEROY, Patrick J, GERSHMAN, Rachel E, SILVA, Matthew D, GERMANOS, Melissa S, BOLEN, Joseph B, CLAIBORNE, Christopher F, SELLS, Todd B, CHAKRAVARTY, Arijit, SILVERMAN, Lee, MENGKUN ZHANG, HOAR, Kara M, STROUD, Stephen G, WEI CHEN, SHINDE, Vaishali, HUCK, Jessica J
Published in Clinical cancer research (15.12.2011)
Published in Clinical cancer research (15.12.2011)
Get full text
Journal Article
Connecting the Dots: Therapy-Induced Senescence and a Tumor-Suppressive Immune Microenvironment
Vilgelm, Anna E, Johnson, C Andrew, Prasad, Nripesh, Yang, Jinming, Chen, Sheau-Chiann, Ayers, Gregory D, Pawlikowski, Jeff S, Raman, Dayanidhi, Sosman, Jeffrey A, Kelley, Mark, Ecsedy, Jeffrey A, Shyr, Yu, Levy, Shawn E, Richmond, Ann
Published in JNCI : Journal of the National Cancer Institute (01.06.2016)
Published in JNCI : Journal of the National Cancer Institute (01.06.2016)
Get full text
Journal Article
MLN8054, a Small-Molecule Inhibitor of Aurora A, Causes Spindle Pole and Chromosome Congression Defects Leading to Aneuploidy
Hoar, Kara, Chakravarty, Arijit, Rabino, Claudia, Wysong, Deborah, Bowman, Douglas, Roy, Natalie, Ecsedy, Jeffrey A.
Published in Molecular and Cellular Biology (01.06.2007)
Published in Molecular and Cellular Biology (01.06.2007)
Get full text
Journal Article
Inhibition of Aurora A enhances radiosensitivity in selected lung cancer cell lines
Liu, Ningbo, Wang, Yong Antican, Sun, Yunguang, Ecsedy, Jeffrey, Sun, Jifeng, Li, Xue, Wang, Ping
Published in Respiratory research (23.10.2019)
Published in Respiratory research (23.10.2019)
Get full text
Journal Article
Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase
Manfredi, Mark G, Ecsedy, Jeffrey A, Meetze, Kristan A, Balani, Suresh K, Burenkova, Olga, Chen, Wei, Galvin, Katherine M, Hoar, Kara M, Huck, Jessica J, LeRoy, Patrick J, Ray, Emily T, Sells, Todd B, Stringer, Bradley, Stroud, Stephen G, Vos, Tricia J, Weatherhead, Gabriel S, Wysong, Deborah R, Zhang, Mengkun, Bolen, Joseph B, Claiborne, Christopher F
Published in Proceedings of the National Academy of Sciences - PNAS (06.03.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (06.03.2007)
Get full text
Journal Article
Mdm2 and aurora kinase a inhibitors synergize to block melanoma growth by driving apoptosis and immune clearance of tumor cells
Vilgelm, Anna E, Pawlikowski, Jeff S, Liu, Yan, Hawkins, Oriana E, Davis, Tyler A, Smith, Jessica, Weller, Kevin P, Horton, Linda W, McClain, Colt M, Ayers, Gregory D, Turner, David C, Essaka, David C, Stewart, Clinton F, Sosman, Jeffrey A, Kelley, Mark C, Ecsedy, Jeffrey A, Johnston, Jeffrey N, Richmond, Ann
Published in Cancer research (Chicago, Ill.) (01.01.2015)
Published in Cancer research (Chicago, Ill.) (01.01.2015)
Get full text
Journal Article
Aurora kinase A inhibition leads to p73-dependent apoptosis in p53-deficient cancer cells
Dar, Altaf A, Belkhiri, Abbes, Ecsedy, Jeffrey, Zaika, Alexander, El-Rifai, Wael
Published in Cancer research (Chicago, Ill.) (01.11.2008)
Published in Cancer research (Chicago, Ill.) (01.11.2008)
Get full text
Journal Article
The Investigational Aurora Kinase A Inhibitor MLN8237 Induces Defects in Cell Viability and Cell-Cycle Progression in Malignant Bladder Cancer Cells In Vitro and In Vivo
NING ZHOU, SINGH, Kamini, HANSEL, Donna E, MIR, Maria C, PARKER, Yvonne, LINDNER, Daniel, DREICER, Robert, ECSEDY, Jeffrey A, ZHONGFA ZHANG, TEH, Bin T, ALMASAN, Alexandru
Published in Clinical cancer research (01.04.2013)
Published in Clinical cancer research (01.04.2013)
Get full text
Journal Article
Combining an Aurora Kinase Inhibitor and a Death Receptor Ligand/Agonist Antibody Triggers Apoptosis in Melanoma Cells and Prevents Tumor Growth in Preclinical Mouse Models
Liu, Yan, Hawkins, Oriana E, Vilgelm, Anna E, Pawlikowski, Jeffrey S, Ecsedy, Jeffrey A, Sosman, Jeffrey A, Kelley, Mark C, Richmond, Ann
Published in Clinical cancer research (01.12.2015)
Published in Clinical cancer research (01.12.2015)
Get full text
Journal Article
MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors
Sells, Todd B., Chau, Ryan, Ecsedy, Jeffrey A., Gershman, Rachel E., Hoar, Kara, Huck, Jessica, Janowick, David A., Kadambi, Vivek J., LeRoy, Patrick J., Stirling, Matthew, Stroud, Stephen G., Vos, Tricia J., Weatherhead, Gabriel S., Wysong, Deborah R., Zhang, Mengkun, Balani, Suresh K., Bolen, Joseph B., Manfredi, Mark G., Claiborne, Christopher F.
Published in ACS medicinal chemistry letters (11.06.2015)
Published in ACS medicinal chemistry letters (11.06.2015)
Get full text
Journal Article
Phase I study of MLN8237—investigational Aurora A kinase inhibitor—in relapsed/refractory multiple myeloma, Non-Hodgkin lymphoma and chronic lymphocytic leukemia
Kelly, Kevin R., Shea, Thomas C., Goy, André, Berdeja, Jesus G., Reeder, Craig B., McDonagh, Kevin T., Zhou, Xiaofei, Danaee, Hadi, Liu, Hua, Ecsedy, Jeffrey A., Niu, Huifeng, Benaim, Ely, Padmanabhan Iyer, Swaminathan
Published in Investigational new drugs (01.06.2014)
Published in Investigational new drugs (01.06.2014)
Get full text
Journal Article
The selective Aurora-A kinase inhibitor MLN8237 (alisertib) potently inhibits proliferation of glioblastoma neurosphere tumor stem-like cells and potentiates the effects of temozolomide and ionizing radiation
Hong, Xin, O’Donnell, James P., Salazar, Clarence R., Van Brocklyn, James R., Barnett, Kahlil D., Pearl, Dennis K., deCarvalho, Ana C., Ecsedy, Jeffrey A., Brown, Stephen L., Mikkelsen, Tom, Lehman, Norman L.
Published in Cancer chemotherapy and pharmacology (01.05.2014)
Published in Cancer chemotherapy and pharmacology (01.05.2014)
Get full text
Journal Article
Aurora A is differentially expressed in gliomas, is associated with patient survival in glioblastoma and is a potential chemotherapeutic target in gliomas
Lehman, Norman L., O'Donnell, James P., Whiteley, Lisa J., Stapp, Robert T., Lehman, Trang D., Roszka, Kathleen M., Schultz, Lonni R., Williams, Caitlin J., Mikkelsen, Tom, Brown, Stephen L., Ecsedy, Jeffrey A., Poisson, Laila M.
Published in Cell cycle (Georgetown, Tex.) (01.02.2012)
Published in Cell cycle (Georgetown, Tex.) (01.02.2012)
Get full text
Journal Article
Ras-Driven Transcriptome Analysis Identifies Aurora Kinase A as a Potential Malignant Peripheral Nerve Sheath Tumor Therapeutic Target
PATEL, Ami V, EAVES, David, MILLER, Shyra J, RATNER, Nancy, JESSEN, Walter J, RIZVI, Tilat A, ECSEDY, Jeffrey A, QIAN, Mark G, ARONOW, Bruce J, PERENTESIS, John P, SERRA, Eduard, CRIPE, Timothy P
Published in Clinical cancer research (15.09.2012)
Published in Clinical cancer research (15.09.2012)
Get full text
Journal Article
Translational exposure-efficacy modeling to optimize the dose and schedule of taxanes combined with the investigational Aurora A kinase inhibitor MLN8237 (alisertib)
Huck, Jessica J, Zhang, Mengkun, Mettetal, Jerome, Chakravarty, Arijit, Venkatakrishnan, Karthik, Zhou, Xiaofei, Kleinfield, Rob, Hyer, Marc L, Kannan, Karuppiah, Shinde, Vaishali, Dorner, Andy, Manfredi, Mark G, Shyu, Wen Chyi, Ecsedy, Jeffrey A
Published in Molecular cancer therapeutics (01.09.2014)
Published in Molecular cancer therapeutics (01.09.2014)
Get full text
Journal Article