The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins
Dickey, Chad A, Kamal, Adeela, Lundgren, Karen, Klosak, Natalia, Bailey, Rachel M, Dunmore, Judith, Ash, Peter, Shoraka, Sareh, Zlatkovic, Jelena, Eckman, Christopher B, Patterson, Cam, Dickson, Dennis W, Nahman, Jr, N Stanley, Hutton, Michael, Burrows, Francis, Petrucelli, Leonard
Published in The Journal of clinical investigation (01.03.2007)
Published in The Journal of clinical investigation (01.03.2007)
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Cellular prion protein regulates β-secretase cleavage of the Alzheimer's amyloid precursor protein
Parkin, Edward T, Watt, Nicole T, Hussain, Ishrut, Eckman, Elizabeth A, Eckman, Christopher B, Manson, Jean C, Baybutt, Herbert N, Turner, Anthony J, Hooper, Nigel M
Published in Proceedings of the National Academy of Sciences - PNAS (26.06.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (26.06.2007)
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Insulin-Degrading Enzyme Regulates the Levels of Insulin, Amyloid β-Protein, and the β-Amyloid Precursor Protein Intracellular Domain in vivo
Farris, Wesley, Mansourian, Stefan, Chang, Yang, Lindsley, Loren, Eckman, Elizabeth A., Frosch, Matthew P., Eckman, Christopher B., Tanzi, Rudolph E., Selkoe, Dennis J., Guénette, Suzanne
Published in Proceedings of the National Academy of Sciences - PNAS (01.04.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (01.04.2003)
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Differential Expression of Cholesterol Hydroxylases in Alzheimer's Disease
Brown, 3rd, James, Theisler, Catherine, Silberman, Simone, Magnuson, Debra, Gottardi-Littell, Numa, Lee, John M, Yager, Debra, Crowley, Janet, Sambamurti, Kumar, Rahman, Mohammad M, Reiss, Allison B, Eckman, Christopher B, Wolozin, Benjamin
Published in The Journal of biological chemistry (13.08.2004)
Published in The Journal of biological chemistry (13.08.2004)
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Journal Article
The ACAT Inhibitor CP-113,818 Markedly Reduces Amyloid Pathology in a Mouse Model of Alzheimer's Disease
Hutter-Paier, Birgit, Huttunen, Henri J., Puglielli, Luigi, Eckman, Christopher B., Kim, Doo Yeon, Hofmeister, Alexander, Moir, Robert D., Domnitz, Sarah B., Frosch, Matthew P., Windisch, Manfred, Kovacs, Dora M.
Published in Neuron (Cambridge, Mass.) (14.10.2004)
Published in Neuron (Cambridge, Mass.) (14.10.2004)
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Journal Article
Amyloid-β Peptide Levels in Brain Are Inversely Correlated with Insulysin Activity Levels in vivo
Miller, Bonnie C., Eckman, Elizabeth A., Sambamurti, Kumar, Dobbs, Nicole, Chow, K. Martin, Eckman, Christopher B., Hersh, Louis B., Thiele, Dwain L.
Published in Proceedings of the National Academy of Sciences - PNAS (13.05.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (13.05.2003)
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The Diarylheptanoid (+)-aR,11S-Myricanol and Two Flavones from Bayberry (Myrica cerifera) Destabilize the Microtubule-Associated Protein Tau
Jones, Jeffrey R, Lebar, Matthew D, Jinwal, Umesh K, Abisambra, Jose F, Koren, John, Blair, Laura, O’Leary, John C, Davey, Zachary, Trotter, Justin, Johnson, Amelia G, Weeber, Edwin, Eckman, Christopher B, Baker, Bill J, Dickey, Chad A
Published in Journal of natural products (Washington, D.C.) (28.01.2011)
Published in Journal of natural products (Washington, D.C.) (28.01.2011)
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Journal Article
Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development
Guénette, Suzanne, Chang, Yang, Hiesberger, Thomas, Richardson, James A, Eckman, Christopher B, Eckman, Elizabeth A, Hammer, Robert E, Herz, Joachim
Published in The EMBO journal (25.01.2006)
Published in The EMBO journal (25.01.2006)
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Journal Article
Evidence of a novel mechanism for partial γ-secretase inhibition induced paradoxical increase in secreted amyloid β protein
Barnwell, Eliza, Padmaraju, Vasudevaraju, Baranello, Robert, Pacheco-Quinto, Javier, Crosson, Craig, Ablonczy, Zsolt, Eckman, Elizabeth, Eckman, Christopher B, Ramakrishnan, Viswanathan, Greig, Nigel H, Pappolla, Miguel A, Sambamurti, Kumar
Published in PloS one (21.03.2014)
Published in PloS one (21.03.2014)
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Matrix metalloproteinase-9 contributes to brain extravasation and edema in fulminant hepatic failure mice
Nguyen, Justin H., Yamamoto, Satoshi, Steers, Jeffery, Sevlever, Daniel, Lin, Wenlang, Shimojima, Naoki, Castanedes-Casey, Monica, Genco, Petrina, Golde, Todd, Richelson, Elliott, Dickson, Dennis, McKinney, Michael, Eckman, Christopher B.
Published in Journal of hepatology (01.06.2006)
Published in Journal of hepatology (01.06.2006)
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Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling
Roosterman, Dirk, Cottrell, Graeme S, Padilla, Benjamin E, Muller, Laurent, Eckman, Christopher B, Bunnett, Nigel W, Steinhoff, Martin
Published in Proceedings of the National Academy of Sciences - PNAS (10.07.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (10.07.2007)
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Single-dose intracerebroventricular administration of galactocerebrosidase improves survival in a mouse model of globoid cell leukodystrophy
Lee, Wing C, Tsoi, Yuen K, Troendle, Frederick J, DeLucia, Michael W, Ahmed, Zeshan, Dicky, Chad A, Dickson, Dennis W, Eckman, Christopher B
Published in The FASEB journal (01.08.2007)
Published in The FASEB journal (01.08.2007)
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Comprehensive and innovative techniques for liver transplantation in rats: a surgical guide
Hori, Tomohide, Nguyen, Justin H, Zhao, Xiangdong, Ogura, Yasuhiro, Hata, Toshiyuki, Yagi, Shintaro, Chen, Feng, Baine, Ann-Marie T, Ohashi, Norifumi, Eckman, Christopher B, Herdt, Aimee R, Egawa, Hiroto, Takada, Yasutsugu, Oike, Fumitaka, Sakamoto, Seisuke, Kasahara, Mureo, Ogawa, Kohei, Hata, Koichiro, Iida, Taku, Yonekawa, Yukihide, Sibulesky, Lena, Kuribayashi, Kagemasa, Kato, Takuma, Saito, Kanako, Wang, Linan, Torii, Mie, Sahara, Naruhiko, Kamo, Naoko, Sahara, Tomoko, Yasutomi, Motohiko, Uemoto, Shinji
Published in World journal of gastroenterology : WJG (07.07.2010)
Published in World journal of gastroenterology : WJG (07.07.2010)
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Matrix metalloproteinase-9 contributes to parenchymal hemorrhage and necrosis in the remnant liver after extended hepatectomy in mice
Ohashi, Norifumi, Hori, Tomohide, Chen, Florence, Jermanus, Sura, Eckman, Christopher B, Nakao, Akimasa, Uemoto, Shinji, Nguyen, Justin H
Published in World journal of gastroenterology : WJG (21.05.2012)
Published in World journal of gastroenterology : WJG (21.05.2012)
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Major amyloid-β degrading enzymes endothelin-converting enzyme-2 and neprilysin are expressed by distinct populations of GABAergic interneurons in hippocampus and neocortex
Pacheco-Quinto, Javier, Eckman, Christopher B, Eckman, Elizabeth A
Published in Neurobiology of aging (01.12.2016)
Published in Neurobiology of aging (01.12.2016)
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Journal Article
Enzyme replacement therapy results in substantial improvements in early clinical phenotype in a mouse model of globoid cell leukodystrophy
Lee, Wing C, Courtenay, Andrew, Troendle, Frederick J, Stallings-Mann, Melody L, Dickey, Chad A, DeLucia, Michael W, Dickson, Dennis W, Eckman, Christopher B
Published in The FASEB journal (01.09.2005)
Published in The FASEB journal (01.09.2005)
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