Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes
Park, Eunyoung, Rawson, Shaun, Li, Kunhua, Kim, Byeong-Won, Ficarro, Scott B, Pino, Gonzalo Gonzalez-Del, Sharif, Humayun, Marto, Jarrod A, Jeon, Hyesung, Eck, Michael J
Published in Nature (London) (01.11.2019)
Published in Nature (London) (01.11.2019)
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Journal Article
EGFR Mutations and Resistance to Irreversible Pyrimidine-Based EGFR Inhibitors
Ercan, Dalia, Choi, Hwan Geun, Yun, Cai-Hong, Capelletti, Marzia, Xie, Ting, Eck, Michael J, Gray, Nathanael S, Jänne, Pasi A
Published in Clinical cancer research (01.09.2015)
Published in Clinical cancer research (01.09.2015)
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Journal Article
The FERM domain: organizing the structure and function of FAK
Frame, Margaret C, Eck, Michael J, Patel, Hitesh, Serrels, Bryan, Lietha, Daniel
Published in Nature reviews. Molecular cell biology (01.11.2010)
Published in Nature reviews. Molecular cell biology (01.11.2010)
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Journal Article
Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression
Cai, Weikang, Sakaguchi, Masaji, Kleinridders, Andre, Gonzalez-Del Pino, Gonzalo, Dreyfuss, Jonathan M, O'Neill, Brian T, Ramirez, Alfred K, Pan, Hui, Winnay, Jonathon N, Boucher, Jeremie, Eck, Michael J, Kahn, C Ronald
Published in Nature communications (27.03.2017)
Published in Nature communications (27.03.2017)
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Journal Article
T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
Yun, Cai-Hong, Mengwasser, Kristen E, Toms, Angela V, Woo, Michele S, Greulich, Heidi, Wong, Kwok-Kin, Meyerson, Matthew, Eck, Michael J
Published in Proceedings of the National Academy of Sciences - PNAS (12.02.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (12.02.2008)
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Journal Article
Response Heterogeneity of EGFR and HER2 Exon 20 Insertions to Covalent EGFR and HER2 Inhibitors
Kosaka, Takayuki, Tanizaki, Junko, Paranal, Raymond M, Endoh, Hideki, Lydon, Christine, Capelletti, Marzia, Repellin, Claire E, Choi, Jihyun, Ogino, Atsuko, Calles, Antonio, Ercan, Dalia, Redig, Amanda J, Bahcall, Magda, Oxnard, Geoffrey R, Eck, Michael J, Jänne, Pasi A
Published in Cancer research (Chicago, Ill.) (15.05.2017)
Published in Cancer research (Chicago, Ill.) (15.05.2017)
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Journal Article
Cryo-EM structure of a RAS/RAF recruitment complex
Park, Eunyoung, Rawson, Shaun, Schmoker, Anna, Kim, Byeong-Won, Oh, Sehee, Song, Kangkang, Jeon, Hyesung, Eck, Michael J
Published in Nature communications (29.07.2023)
Published in Nature communications (29.07.2023)
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Journal Article
Structural, biochemical, and clinical characterization of epidermal growth factor receptor (EGFR) exon 20 insertion mutations in lung cancer
Yasuda, Hiroyuki, Park, Eunyoung, Yun, Cai-Hong, Sng, Natasha J, Lucena-Araujo, Antonio R, Yeo, Wee-Lee, Huberman, Mark S, Cohen, David W, Nakayama, Sohei, Ishioka, Kota, Yamaguchi, Norihiro, Hanna, Megan, Oxnard, Geoffrey R, Lathan, Christopher S, Moran, Teresa, Sequist, Lecia V, Chaft, Jamie E, Riely, Gregory J, Arcila, Maria E, Soo, Ross A, Meyerson, Matthew, Eck, Michael J, Kobayashi, Susumu S, Costa, Daniel B
Published in Science translational medicine (18.12.2013)
Published in Science translational medicine (18.12.2013)
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Journal Article
Publisher Correction: Cryo-EM structure of a RAS/RAF recruitment complex
Park, Eunyoung, Rawson, Shaun, Schmoker, Anna, Kim, Byeong-Won, Oh, Sehee, Song, Kangkang, Jeon, Hyesung, Eck, Michael J
Published in Nature communications (07.09.2023)
Published in Nature communications (07.09.2023)
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Journal Article
Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
Beyett, Tyler S, To, Ciric, Heppner, David E, Rana, Jaimin K, Schmoker, Anna M, Jang, Jaebong, De Clercq, Dries J H, Gomez, Gabriel, Scott, David A, Gray, Nathanael S, Jänne, Pasi A, Eck, Michael J
Published in Nature communications (09.05.2022)
Published in Nature communications (09.05.2022)
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Journal Article
Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6
Park, Eunyoung, Kim, Nayoung, Ficarro, Scott B, Zhang, Yi, Lee, Byung Il, Cho, Ahye, Kim, Kihong, Park, Angela K J, Park, Woong-Yang, Murray, Bradley, Meyerson, Matthew, Beroukhim, Rameen, Marto, Jarrod A, Cho, Jeonghee, Eck, Michael J
Published in Nature structural & molecular biology (01.09.2015)
Published in Nature structural & molecular biology (01.09.2015)
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Journal Article
Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes
Goñi, Guillermina M, Epifano, Carolina, Boskovic, Jasminka, Camacho-Artacho, Marta, Zhou, Jing, Bronowska, Agnieszka, Martín, M Teresa, Eck, Michael J, Kremer, Leonor, Gräter, Frauke, Gervasio, Francesco Luigi, Perez-Moreno, Mirna, Lietha, Daniel
Published in Proceedings of the National Academy of Sciences - PNAS (05.08.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (05.08.2014)
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Journal Article
The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancers
Sasaki, Takaaki, Okuda, Katsuhiro, Zheng, Wei, Butrynski, James, Capelletti, Marzia, Wang, Liping, Gray, Nathanael S, Wilner, Keith, Christensen, James G, Demetri, George, Shapiro, Geoffrey I, Rodig, Scott J, Eck, Michael J, Jänne, Pasi A
Published in Cancer research (Chicago, Ill.) (15.12.2010)
Published in Cancer research (Chicago, Ill.) (15.12.2010)
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Journal Article
Structure and Ubiquitination-Dependent Activation of TANK-Binding Kinase 1
Tu, Daqi, Zhu, Zehua, Zhou, Alicia Y., Yun, Cai-hong, Lee, Kyung-Eun, Toms, Angela V., Li, Yiqun, Dunn, Gavin P., Chan, Edmond, Thai, Tran, Yang, Shenghong, Ficarro, Scott B., Marto, Jarrod A., Jeon, Hyesung, Hahn, William C., Barbie, David A., Eck, Michael J.
Published in Cell reports (Cambridge) (01.03.2013)
Published in Cell reports (Cambridge) (01.03.2013)
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Journal Article
The structural basis of PTEN regulation by multi-site phosphorylation
Dempsey, Daniel R, Viennet, Thibault, Iwase, Reina, Park, Eunyoung, Henriquez, Stephanie, Chen, Zan, Jeliazkov, Jeliazko R, Palanski, Brad A, Phan, Kim L, Coote, Paul, Gray, Jeffrey J, Eck, Michael J, Gabelli, Sandra B, Arthanari, Haribabu, Cole, Philip A
Published in Nature structural & molecular biology (01.10.2021)
Published in Nature structural & molecular biology (01.10.2021)
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Journal Article
Structural Basis for the Autoinhibition of Focal Adhesion Kinase
Lietha, Daniel, Cai, Xinming, Ceccarelli, Derek F.J., Li, Yiqun, Schaller, Michael D., Eck, Michael J.
Published in Cell (15.06.2007)
Published in Cell (15.06.2007)
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Journal Article
Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival
Wang, Yubao, Begley, Michael, Li, Qing, Huang, Hai-Tsang, Lako, Ana, Eck, Michael J., Gray, Nathanael S., Mitchison, Timothy J., Cantley, Lewis C., Zhao, Jean J.
Published in Proceedings of the National Academy of Sciences - PNAS (30.08.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (30.08.2016)
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