Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells
Molenaar, Jan J, Ebus, Marli E, Geerts, Dirk, Koster, Jan, Lamers, Fieke, Valentijn, Linda J, Westerhout, Ellen M, Versteeg, Rogier, Caron, Huib N
Published in Proceedings of the National Academy of Sciences - PNAS (04.08.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (04.08.2009)
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Enhancer of zeste homologue 2 plays an important role in neuroblastoma cell survival independent of its histone methyltransferase activity
Bate-Eya, Laurel T, Gierman, Hinco J, Ebus, Marli E, Koster, Jan, Caron, Huib N, Versteeg, Rogier, Dolman, M. Emmy M, Molenaar, Jan J
Published in European journal of cancer (1990) (01.04.2017)
Published in European journal of cancer (1990) (01.04.2017)
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Knockdown of survivin (BIRC5) causes apoptosis in neuroblastoma via mitotic catastrophe
Lamers, Fieke, van der Ploeg, Ida, Schild, Linda, Ebus, Marli E, Koster, Jan, Hansen, Bo R, Koch, Troels, Versteeg, Rogier, Caron, Huib N, Molenaar, Jan J
Published in Endocrine-related cancer (01.12.2011)
Published in Endocrine-related cancer (01.12.2011)
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MEK inhibition causes BIM stabilization and increased sensitivity to BCL-2 family member inhibitors in RAS-MAPK-mutated neuroblastoma
Eleveld, Thomas F, Vernooij, Lindy, Schild, Linda, Koopmans, Bianca, Alles, Lindy K, Ebus, Marli E, Dandis, Rana, van Tinteren, Harm, Caron, Huib N, Koster, Jan, van Noesel, Max M, Tytgat, Godelieve A M, Eising, Selma, Versteeg, Rogier, Dolman, M Emmy M, Molenaar, Jan J
Published in Frontiers in oncology (21.02.2023)
Published in Frontiers in oncology (21.02.2023)
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Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes
MOLENAAR, Jan J, KOSTER, Jan, EBUS, Marli E, HANEVELD, Franciska, LAKEMAN, Arjan, SCHILD, Linda, MOLENAAR, Piet, STROEKEN, Peter, NOESEL, Max M. Van, ØRA, Ingrid, SANTO, Evan E, CARON, Huib N, ZWIJNENBURG, Danny A, WESTERHOUT, Ellen M, VERSTEEG, Rogier, SLUIS, Peter Van, VALENTIJN, Linda J, DER PLOEG, Ida Van, HAMDI, Mohamed, NES, Johan Van, WESTERMAN, Bart A, ARKEL, Jennemiek Van
Published in Nature (London) (29.03.2012)
Published in Nature (London) (29.03.2012)
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Journal Article
LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression
MOLENAAR, Jan J, DOMINGO-FERNANDEZ, Raquel, BROEKMANS, Marloes, HANEVELD, Franciska, VOLCKMANN, Richard, BRAY, Isabella, HEUKAMP, Lukas, SPRÜSSEL, Annika, T, Theresa, KIECKBUSCH, Kristina, KLEIN-HITPASS, Ludger, FISCHER, Matthias, EBUS, Marli E, VANDESOMPELE, Jo, SCHRAMM, Alexander, NOESEL, Max M.van, VARESIO, Luigi, SPELEMAN, Frank, EGGERT, Angelika, STALLINGS, Raymond L, CARON, Huib N, VERSTEEG, Rogier, SCHULTE, Johannes H, LINDNER, Sven, KOSTER, Jan, DRABEK, Ksenija, MESTDAGH, Pieter, SLUIS, Peter Van, VALENTIJN, Linda J, NES, Johan Van
Published in Nature genetics (01.11.2012)
Published in Nature genetics (01.11.2012)
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RAS-MAPK pathway-driven tumor progression is associated with loss of CIC and other genomic aberrations in neuroblastoma
Eleveld, Thomas F, Schild, Linda, Koster, Jan, Zwijnenburg, Danny A, Alles, Lindy K, Ebus, Marli E, Volckmann, Richard, Tytgat, Godelieve A M, van Sluis, Peter, Versteeg, Rogier, Molenaar, Jan J
Published in Cancer research (Chicago, Ill.) (01.11.2018)
Published in Cancer research (Chicago, Ill.) (01.11.2018)
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Journal Article
Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma
Poon, Evon, Liang, Tong, Jamin, Yann, Walz, Susanne, Kwok, Colin, Hakkert, Anne, Barker, Karen, Urban, Zuzanna, Thway, Khin, Zeid, Rhamy, Hallsworth, Albert, Box, Gary, Ebus, Marli E, Licciardello, Marco P, Sbirkov, Yordan, Lazaro, Glori, Calton, Elizabeth, Costa, Barbara M, Valenti, Melanie, De Haven Brandon, Alexis, Webber, Hannah, Tardif, Nicolas, Almeida, Gilberto S, Christova, Rossitza, Boysen, Gunther, Richards, Mark W, Barone, Giuseppe, Ford, Anthony, Bayliss, Richard, Clarke, Paul A, De Bono, Johann, Gray, Nathanael S, Blagg, Julian, Robinson, Simon P, Eccles, Suzanne A, Zheleva, Daniella, Bradner, James E, Molenaar, Jan, Vivanco, Igor, Eilers, Martin, Workman, Paul, Lin, Charles Y, Chesler, Louis
Published in The Journal of clinical investigation (01.11.2020)
Published in The Journal of clinical investigation (01.11.2020)
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Journal Article
Defects in 8-oxo-guanine repair pathway cause high frequency of C > A substitutions in neuroblastoma
van den Boogaard, Marlinde L, Oka, Rurika, Hakkert, Anne, Schild, Linda, Ebus, Marli E, van Gerven, Michael R, Zwijnenburg, Danny A, Molenaar, Piet, Hoyng, Lieke L, Dolman, M Emmy M, Essing, Anke H W, Koopmans, Bianca, Helleday, Thomas, Drost, Jarno, van Boxtel, Ruben, Versteeg, Rogier, Koster, Jan, Molenaar, Jan J
Published in Proceedings of the National Academy of Sciences - PNAS (07.09.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (07.09.2021)
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Journal Article
Cyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent Neuroblastoma
Dolman, M Emmy M, Poon, Evon, Ebus, Marli E, den Hartog, Ilona J M, van Noesel, Carel J M, Jamin, Yann, Hallsworth, Albert, Robinson, Simon P, Petrie, Kevin, Sparidans, Rolf W, Kok, Robbert J, Versteeg, Rogier, Caron, Huib N, Chesler, Louis, Molenaar, Jan J
Published in Clinical cancer research (15.11.2015)
Published in Clinical cancer research (15.11.2015)
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Newly-derived neuroblastoma cell lines propagated in serum-free media recapitulate the genotype and phenotype of primary neuroblastoma tumours
Bate-Eya, Laurel T, Ebus, Marli E, Koster, Jan, den Hartog, Ilona J.M, Zwijnenburg, Danny A, Schild, Linda, van der Ploeg, Ida, Dolman, M. Emmy M, Caron, Huib N, Versteeg, Rogier, Molenaar, Jan J
Published in European journal of cancer (1990) (01.02.2014)
Published in European journal of cancer (1990) (01.02.2014)
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Journal Article
Targeted BCL2 inhibition effectively inhibits neuroblastoma tumour growth
Lamers, Fieke, Schild, Linda, den Hartog, Ilona J.M, Ebus, Marli E, Westerhout, Ellen M, Ora, Ingrid, Koster, Jan, Versteeg, Rogier, Caron, Huib N, Molenaar, Jan J
Published in European journal of cancer (1990) (01.11.2012)
Published in European journal of cancer (1990) (01.11.2012)
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Journal Article
Copy number defects of G1-Cell cycle genes in neuroblastoma are frequent and correlate with high expression of E2F target genes and a poor prognosis
Molenaar, Jan J., Koster, Jan, Ebus, Marli E., van Sluis, Peter, Westerhout, Ellen M., de Preter, Katleen, Gisselsson, David, Øra, Ingrid, Speleman, Frank, Caron, Huib N., Versteeg, Rogier
Published in Genes chromosomes & cancer (01.01.2012)
Published in Genes chromosomes & cancer (01.01.2012)
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Differential mRNA expression of Ara-C–metabolizing enzymes explains Ara-C sensitivity in MLL gene–rearranged infant acute lymphoblastic leukemia
Stam, Ronald W., den Boer, Monique L., Meijerink, Jules P.P., Ebus, Marli E.G., Peters, Godefridus J., Noordhuis, Paul, Janka-Schaub, Gritta E., Armstrong, Scott A., Korsmeyer, Stanley J., Pieters, Rob
Published in Blood (15.02.2003)
Published in Blood (15.02.2003)
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Journal Article
Neuroblastoma is composed of two super-enhancer-associated differentiation states
van Groningen, Tim, Koster, Jan, Valentijn, Linda J, Zwijnenburg, Danny A, Akogul, Nurdan, Hasselt, Nancy E, Broekmans, Marloes, Haneveld, Franciska, Nowakowska, Natalia E, Bras, Johannes, van Noesel, Carel J M, Jongejan, Aldo, van Kampen, Antoine H, Koster, Linda, Baas, Frank, van Dijk-Kerkhoven, Lianne, Huizer-Smit, Margriet, Lecca, Maria C, Chan, Alvin, Lakeman, Arjan, Molenaar, Piet, Volckmann, Richard, Westerhout, Ellen M, Hamdi, Mohamed, van Sluis, Peter G, Ebus, Marli E, Molenaar, Jan J, Tytgat, Godelieve A, Westerman, Bart A, van Nes, Johan, Versteeg, Rogier
Published in Nature genetics (01.08.2017)
Published in Nature genetics (01.08.2017)
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Journal Article
Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations
Eleveld, Thomas F, Oldridge, Derek A, Bernard, Virginie, Koster, Jan, Colmet Daage, Léo, Diskin, Sharon J, Schild, Linda, Bentahar, Nadia Bessoltane, Bellini, Angela, Chicard, Mathieu, Lapouble, Eve, Combaret, Valérie, Legoix-Né, Patricia, Michon, Jean, Pugh, Trevor J, Hart, Lori S, Rader, JulieAnn, Attiyeh, Edward F, Wei, Jun S, Zhang, Shile, Naranjo, Arlene, Gastier-Foster, Julie M, Hogarty, Michael D, Asgharzadeh, Shahab, Smith, Malcolm A, Guidry Auvil, Jaime M, Watkins, Thomas B K, Zwijnenburg, Danny A, Ebus, Marli E, van Sluis, Peter, Hakkert, Anne, van Wezel, Esther, van der Schoot, C Ellen, Westerhout, Ellen M, Schulte, Johannes H, Tytgat, Godelieve A, Dolman, M Emmy M, Janoueix-Lerosey, Isabelle, Gerhard, Daniela S, Caron, Huib N, Delattre, Olivier, Khan, Javed, Versteeg, Rogier, Schleiermacher, Gudrun, Molenaar, Jan J, Maris, John M
Published in Nature genetics (01.08.2015)
Published in Nature genetics (01.08.2015)
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Journal Article
Abstract A26: High frequency of Cytosine to Adenine mutations in neuroblastoma correlates with genomic aberrations in 8-Oxo-Guanine repair pathway
Hakkert, Anne, Ebus, Marli E., Versteeg, Rogier, Huib, Caron N., Koster, Jan, Molenaar, Jan J.
Published in Molecular cancer research (01.04.2017)
Published in Molecular cancer research (01.04.2017)
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Journal Article
Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma
Poon, Evon, Liang, Tong, Jamin, Yann, Walz, Susanne, Kwok, Colin, Hakkert, Anne, Barker, Karen, Urban, Zuzanna, Thway, Khin, Zeid, Rhamy, Hallsworth, Albert, Box, Gary, Ebus, Marli E, Licciardello, Marco P, Sbirkov, Yordan, Lazaro, Glori, Calton, Elizabeth, Costa, Barbara M, Valenti, Melanie, Brandon, Alexis De Haven, Webber, Hannah, Tardif, Nicolas, Almeida, Gilberto S, Christova, Rossitza, Boysen, Gunther, Richards, Mark W, Barone, Giuseppe, d, Anthony, Bayliss, Richard, Clarke, Paul A, DE BONO, Johann, Gray, Nathanael S, Blagg, Julian, Robinson, Simon P, Eccles, Suzanne A, Zheleva, Daniella, Bradner, James E, Molenaar, Jan, Vivanco, Igor, Eilers, Martin, Workman, Paul, Lin, Charles Y, Chesler, Louis
Published in The Journal of clinical investigation (01.11.2020)
Published in The Journal of clinical investigation (01.11.2020)
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Journal Article
Abstract B41: Whole genome sequencing identifies tumor evolution events in relapse neuroblastoma
Eleveld, Thomas F., Schild, Linda, Koster, Jan, Zwijnenburg, Danny, Ebus, Marli E., van, Peter Sluis, Schulte, Johannes H., Caron, Huib N., Versteeg, Rogier, Molenaar, Jan J.
Published in Cancer research (Chicago, Ill.) (15.10.2014)
Published in Cancer research (Chicago, Ill.) (15.10.2014)
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