BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors
Lee, Andrew, Mavaddat, Nasim, Wilcox, Amber N., Cunningham, Alex P., Carver, Tim, Hartley, Simon, Babb de Villiers, Chantal, Izquierdo, Angel, Simard, Jacques, Schmidt, Marjanka K., Walter, Fiona M., Chatterjee, Nilanjan, Garcia-Closas, Montserrat, Tischkowitz, Marc, Pharoah, Paul, Easton, Douglas F., Antoniou, Antonis C.
Published in Genetics in medicine (01.08.2019)
Published in Genetics in medicine (01.08.2019)
Get full text
Journal Article
CanRisk Tool-A Web Interface for the Prediction of Breast and Ovarian Cancer Risk and the Likelihood of Carrying Genetic Pathogenic Variants
Carver, Tim, Hartley, Simon, Lee, Andrew, Cunningham, Alex P, Archer, Stephanie, Babb de Villiers, Chantal, Roberts, Jonathan, Ruston, Rod, Walter, Fiona M, Tischkowitz, Marc, Easton, Douglas F, Antoniou, Antonis C
Published in Cancer epidemiology, biomarkers & prevention (01.03.2021)
Published in Cancer epidemiology, biomarkers & prevention (01.03.2021)
Get full text
Journal Article
Using human genetics to understand the disease impacts of testosterone in men and women
Ruth, Katherine S, Day, Felix R, Tyrrell, Jessica, Thompson, Deborah J, Wood, Andrew R, Mahajan, Anubha, Beaumont, Robin N, Wittemans, Laura, Martin, Susan, Busch, Alexander S., Erzurumluoglu, A. Mesut, Hollis, Benjamin, O’Mara, Tracy A., McCarthy, Mark I, Langenberg, Claudia, Easton, Douglas F, Wareham, Nicholas J, Burgess, Stephen, Murray, Anna, Ong, Ken K, Frayling, Timothy M, Perry, John R. B.
Published in Nature medicine (01.02.2020)
Published in Nature medicine (01.02.2020)
Get full text
Journal Article
Germline BRCA mutation and outcome in young-onset breast cancer (POSH): a prospective cohort study
Copson, Ellen R, Maishman, Tom C, Tapper, Will J, Cutress, Ramsey I, Greville-Heygate, Stephanie, Altman, Douglas G, Eccles, Bryony, Gerty, Sue, Durcan, Lorraine T, Jones, Louise, Evans, D Gareth, Thompson, Alastair M, Pharoah, Paul, Easton, Douglas F, Dunning, Alison M, Hanby, Andrew, Lakhani, Sunil, Eeles, Ros, Gilbert, Fiona J, Hamed, Hisham, Hodgson, Shirley, Simmonds, Peter, Stanton, Louise, Eccles, Diana M
Published in The lancet oncology (01.02.2018)
Published in The lancet oncology (01.02.2018)
Get full text
Journal Article
Comprehensive functional annotation of 77 prostate cancer risk loci
Hazelett, Dennis J, Rhie, Suhn Kyong, Gaddis, Malaina, Yan, Chunli, Lakeland, Daniel L, Coetzee, Simon G, Henderson, Brian E, Noushmehr, Houtan, Cozen, Wendy, Kote-Jarai, Zsofia, Eeles, Rosalind A, Easton, Douglas F, Haiman, Christopher A, Lu, Wange, Farnham, Peggy J, Coetzee, Gerhard A
Published in PLoS genetics (01.01.2014)
Published in PLoS genetics (01.01.2014)
Get full text
Journal Article
Genetic susceptibility to breast cancer
Mavaddat, Nasim, Antoniou, Antonis C., Easton, Douglas F., Garcia-Closas, Montserrat
Published in Molecular oncology (01.06.2010)
Published in Molecular oncology (01.06.2010)
Get full text
Journal Article
Genome-wide association studies in common cancers—what have we learnt?
Varghese, Jajini Susan, Easton, Douglas F
Published in Current opinion in genetics & development (01.06.2010)
Published in Current opinion in genetics & development (01.06.2010)
Get full text
Journal Article
Combined quantitative measures of ER, PR, HER2, and KI67 provide more prognostic information than categorical combinations in luminal breast cancer
Abubakar, Mustapha, Figueroa, Jonine, Ali, H. Raza, Blows, Fiona, Lissowska, Jolanta, Caldas, Carlos, Easton, Douglas F., Sherman, Mark E., Garcia-Closas, Montserrat, Dowsett, Mitch, Pharoah, Paul D.
Published in Modern pathology (01.09.2019)
Published in Modern pathology (01.09.2019)
Get full text
Journal Article
The contribution of rare variation to prostate cancer heritability
Mancuso, Nicholas, Rohland, Nadin, Rand, Kristin A, Tandon, Arti, Allen, Alexander, Quinque, Dominique, Mallick, Swapan, Li, Heng, Stram, Alex, Sheng, Xin, Kote-Jarai, Zsofia, Easton, Douglas F, Eeles, Rosalind A, Le Marchand, Loic, Lubwama, Alex, Stram, Daniel, Watya, Stephen, Conti, David V, Henderson, Brian, Haiman, Christopher A, Pasaniuc, Bogdan, Reich, David
Published in Nature genetics (01.01.2016)
Published in Nature genetics (01.01.2016)
Get full text
Journal Article
Evaluating clinician acceptability of the prototype CanRisk tool for predicting risk of breast and ovarian cancer: A multi-methods study
Archer, Stephanie, Babb de Villiers, Chantal, Scheibl, Fiona, Carver, Tim, Hartley, Simon, Lee, Andrew, Cunningham, Alex P, Easton, Douglas F, McIntosh, Jennifer G, Emery, Jon, Tischkowitz, Marc, Antoniou, Antonis C, Walter, Fiona M
Published in PloS one (06.03.2020)
Published in PloS one (06.03.2020)
Get full text
Journal Article
PALB2 , which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene
Rahman, Nazneen, Seal, Sheila, Thompson, Deborah, Kelly, Patrick, Renwick, Anthony, Elliott, Anna, Reid, Sarah, Spanova, Katarina, Barfoot, Rita, Chagtai, Tasnim, Jayatilake, Hiran, McGuffog, Lesley, Hanks, Sandra, Evans, D Gareth, Eccles, Diana, Easton, Douglas F, Stratton, Michael R
Published in Nature genetics (01.02.2007)
Published in Nature genetics (01.02.2007)
Get full text
Journal Article
The contributions of breast density and common genetic variation to breast cancer risk
Vachon, Celine M, Pankratz, V Shane, Scott, Christopher G, Haeberle, Lothar, Ziv, Elad, Jensen, Matthew R, Brandt, Kathleen R, Whaley, Dana H, Olson, Janet E, Heusinger, Katharina, Hack, Carolin C, Jud, Sebastian M, Beckmann, Matthias W, Schulz-Wendtland, Ruediger, Tice, Jeffrey A, Norman, Aaron D, Cunningham, Julie M, Purrington, Kristen S, Easton, Douglas F, Sellers, Thomas A, Kerlikowske, Karla, Fasching, Peter A, Couch, Fergus J
Published in JNCI : Journal of the National Cancer Institute (01.05.2015)
Published in JNCI : Journal of the National Cancer Institute (01.05.2015)
Get full text
Journal Article
A Systematic Genetic Assessment of 1,433 Sequence Variants of Unknown Clinical Significance in the BRCA1 and BRCA2 Breast Cancer–Predisposition Genes
Easton, Douglas F., Deffenbaugh, Amie M., Pruss, Dmitry, Frye, Cynthia, Wenstrup, Richard J., Allen-Brady, Kristina, Tavtigian, Sean V., Monteiro, Alvaro N.A., Iversen, Edwin S., Couch, Fergus J., Goldgar, David E.
Published in American journal of human genetics (01.11.2007)
Published in American journal of human genetics (01.11.2007)
Get full text
Journal Article
Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles
Rahman, Nazneen, Seal, Sheila, Thompson, Deborah, Renwick, Anthony, Elliott, Anna, Kelly, Patrick, Barfoot, Rita, Chagtai, Tasnim, Jayatilake, Hiran, Ahmed, Munaza, Spanova, Katarina, North, Bernard, McGuffog, Lesley, Evans, D Gareth, Eccles, Diana, Easton, Douglas F, Stratton, Michael R
Published in Nature genetics (01.11.2006)
Published in Nature genetics (01.11.2006)
Get full text
Journal Article
Evidence of a Causal Association Between Insulinemia and Endometrial Cancer: A Mendelian Randomization Analysis
Nead, Kevin T, Sharp, Stephen J, Thompson, Deborah J, Painter, Jodie N, Savage, David B, Semple, Robert K, Barker, Adam, Perry, John R B, Attia, John, Dunning, Alison M, Easton, Douglas F, Holliday, Elizabeth, Lotta, Luca A, O'Mara, Tracy, McEvoy, Mark, Pharoah, Paul D P, Scott, Rodney J, Spurdle, Amanda B, Langenberg, Claudia, Wareham, Nicholas J, Scott, Robert A
Published in JNCI : Journal of the National Cancer Institute (01.09.2015)
Published in JNCI : Journal of the National Cancer Institute (01.09.2015)
Get full text
Journal Article
Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14
Ruark, Elise, Seal, Sheila, McDonald, Heather, Zhang, Feng, Elliot, Anna, Lau, KingWai, Perdeaux, Elizabeth, Rapley, Elizabeth, Eeles, Rosalind, Peto, Julian, Kote-Jarai, Zsofia, Muir, Kenneth, Nsengimana, Jeremie, Shipley, Janet, Bishop, D Timothy, Stratton, Michael R, Easton, Douglas F, Huddart, Robert A, Rahman, Nazneen, Turnbull, Clare
Published in Nature genetics (01.06.2013)
Published in Nature genetics (01.06.2013)
Get full text
Journal Article
Potential of polygenic risk scores for improving population estimates of women’s breast cancer genetic risks
Wolfson, Michael, Gribble, Steve, Pashayan, Nora, Easton, Douglas F., Antoniou, Antonis C., Lee, Andrew, van Katwyk, Sasha, Simard, Jacques
Published in Genetics in medicine (01.11.2021)
Published in Genetics in medicine (01.11.2021)
Get full text
Journal Article
Identification of 31 loci for mammographic density phenotypes and their associations with breast cancer risk
Sieh, Weiva, Rothstein, Joseph H., Klein, Robert J., Alexeeff, Stacey E., Sakoda, Lori C., Jorgenson, Eric, McBride, Russell B., Graff, Rebecca E., McGuire, Valerie, Achacoso, Ninah, Acton, Luana, Liang, Rhea Y., Lipson, Jafi A., Rubin, Daniel L., Yaffe, Martin J., Easton, Douglas F., Schaefer, Catherine, Risch, Neil, Whittemore, Alice S., Habel, Laurel A.
Published in Nature communications (09.10.2020)
Published in Nature communications (09.10.2020)
Get full text
Journal Article
A genome-wide association study of testicular germ cell tumor
Stratton, Michael R, Rapley, Elizabeth A, Turnbull, Clare, Al Olama, Ali Amin, Dermitzakis, Emmanouil T, Linger, Rachel, Huddart, Robert A, Renwick, Anthony, Hughes, Deborah, Hines, Sarah, Seal, Sheila, Morrison, Jonathan, Nsengimana, Jeremie, Deloukas, Panagiotis, Rahman, Nazneen, Bishop, D Timothy, Easton, Douglas F
Published in Nature genetics (01.07.2009)
Published in Nature genetics (01.07.2009)
Get full text
Journal Article
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
Rubinsztein, David C, Ravikumar, Brinda, Vacher, Coralie, Berger, Zdenek, Davies, Janet E, Luo, Shouqing, Oroz, Lourdes G, Scaravilli, Francesco, Easton, Douglas F, Duden, Rainer, O'Kane, Cahir J
Published in Nature genetics (01.06.2004)
Published in Nature genetics (01.06.2004)
Get full text
Journal Article