Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma
Asquith, Christopher R. M, Naegeli, Kaleb M, East, Michael P, Laitinen, Tuomo, Havener, Tammy M, Wells, Carrow I, Johnson, Gary L, Drewry, David H, Zuercher, William J, Morris, David C
Published in Journal of medicinal chemistry (09.05.2019)
Published in Journal of medicinal chemistry (09.05.2019)
Get full text
Journal Article
Characterization of Recombinant ELMOD (Cell Engulfment and Motility Domain) Proteins as GTPase-activating Proteins (GAPs) for ARF Family GTPases
Ivanova, Anna A., East, Michael P., Yi, Slee L., Kahn, Richard A.
Published in The Journal of biological chemistry (18.04.2014)
Published in The Journal of biological chemistry (18.04.2014)
Get full text
Journal Article
SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK)
Asquith, Christopher R. M, Berger, Benedict-Tilman, Wan, Jing, Bennett, James M, Capuzzi, Stephen J, Crona, Daniel J, Drewry, David H, East, Michael P, Elkins, Jonathan M, Fedorov, Oleg, Godoi, Paulo H, Hunter, Debra M, Knapp, Stefan, Müller, Susanne, Torrice, Chad D, Wells, Carrow I, Earp, H. Shelton, Willson, Timothy M, Zuercher, William J
Published in Journal of medicinal chemistry (14.03.2019)
Published in Journal of medicinal chemistry (14.03.2019)
Get full text
Journal Article
ELMO Domains, Evolutionary and Functional Characterization of a Novel GTPase-activating Protein (GAP) Domain for Arf Protein Family GTPases
East, Michael P., Bowzard, J.Bradford, Dacks, Joel B., Kahn, Richard A.
Published in The Journal of biological chemistry (16.11.2012)
Published in The Journal of biological chemistry (16.11.2012)
Get full text
Journal Article
Identification and Optimization of 4‐Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase
Asquith, Christopher R. M., Laitinen, Tuomo, Bennett, James M., Godoi, Paulo H., East, Michael P., Tizzard, Graham J., Graves, Lee M., Johnson, Gary L., Dornsife, Ronna E., Wells, Carrow I., Elkins, Jonathan M., Willson, Timothy M., Zuercher, William J.
Published in ChemMedChem (08.01.2018)
Published in ChemMedChem (08.01.2018)
Get full text
Journal Article
Synthesis and Evaluation of Novel 1,2,6-Thiadiazinone Kinase Inhibitors as Potent Inhibitors of Solid Tumors
Kalogirou, Andreas S., East, Michael P., Laitinen, Tuomo, Torrice, Chad D., Maffuid, Kaitlyn A., Drewry, David H., Koutentis, Panayiotis A., Johnson, Gary L., Crona, Daniel J., Asquith, Christopher R. M.
Published in Molecules (Basel, Switzerland) (29.09.2021)
Published in Molecules (Basel, Switzerland) (29.09.2021)
Get full text
Journal Article
BIRC6 mediates imatinib resistance independently of Mcl-1
Okumu, Denis O, East, Michael P, Levine, Merlin, Herring, Laura E, Zhang, Raymond, Gilbert, Thomas S K, Litchfield, David W, Zhang, Yanping, Graves, Lee M
Published in PloS one (16.05.2017)
Published in PloS one (16.05.2017)
Get full text
Journal Article
FOXA1 and adaptive response determinants to HER2 targeted therapy in TBCRC 036
Angus, Steven P., Stuhlmiller, Timothy J., Mehta, Gaurav, Bevill, Samantha M., Goulet, Daniel R., Olivares-Quintero, J. Felix, East, Michael P., Tanioka, Maki, Zawistowski, Jon S., Singh, Darshan, Sciaky, Noah, Chen, Xin, He, Xiaping, Rashid, Naim U., Chollet-Hinton, Lynn, Fan, Cheng, Soloway, Matthew G., Spears, Patricia A., Jefferys, Stuart, Parker, Joel S., Gallagher, Kristalyn K., Forero-Torres, Andres, Krop, Ian E., Thompson, Alastair M., Murthy, Rashmi, Gatza, Michael L., Perou, Charles M., Earp, H. Shelton, Carey, Lisa A., Johnson, Gary L.
Published in NPJ breast cancer (12.05.2021)
Published in NPJ breast cancer (12.05.2021)
Get full text
Journal Article
TLK2: a target for cancer and viral latency
Pozzetti, Luca, East, Michael P, Laitinen, Tuomo, Asquith, Christopher R M
Published in Nature reviews. Drug discovery (17.10.2024)
Published in Nature reviews. Drug discovery (17.10.2024)
Get full text
Journal Article
BCKDK: an emerging kinase target for metabolic diseases and cancer
East, Michael P., Laitinen, Tuomo, Asquith, Christopher R. M.
Published in Nature reviews. Drug discovery (01.07.2021)
Published in Nature reviews. Drug discovery (01.07.2021)
Get full text
Journal Article
Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related Analogues
Graves, Paul R, Aponte-Collazo, Lucas J, Fennell, Emily M. J, Graves, Adam C, Hale, Andrew E, Dicheva, Nedyalka, Herring, Laura E, Gilbert, Thomas S. K, East, Michael P, McDonald, Ian M, Lockett, Matthew R, Ashamalla, Hani, Moorman, Nathaniel J, Karanewsky, Donald S, Iwanowicz, Edwin J, Holmuhamedov, Ekhson, Graves, Lee M
Published in ACS chemical biology (17.05.2019)
Published in ACS chemical biology (17.05.2019)
Get full text
Journal Article
CDC42BPA/MRCKα: a kinase target for brain, ovarian and skin cancers
East, Michael P., Asquith, Christopher R. M.
Published in Nature reviews. Drug discovery (01.03.2021)
Published in Nature reviews. Drug discovery (01.03.2021)
Get full text
Journal Article
PKMYT1: a forgotten member of the WEE1 family
Asquith, Christopher R. M., Laitinen, Tuomo, East, Michael P.
Published in Nature reviews. Drug discovery (01.03.2020)
Published in Nature reviews. Drug discovery (01.03.2020)
Get full text
Journal Article
PRM-LIVE with Trapped Ion Mobility Spectrometry and Its Application in Selectivity Profiling of Kinase Inhibitors
Zhu, He, Ficarro, Scott B, Alexander, William M, Fleming, Laura E, Adelmant, Guillaume, Zhang, Tinghu, Willetts, Matthew, Decker, Jens, Brehmer, Sven, Krause, Michael, East, Michael P, Gray, Nathanael S, Johnson, Gary L, Kruppa, Gary, Marto, Jarrod A
Published in Analytical chemistry (Washington) (19.10.2021)
Published in Analytical chemistry (Washington) (19.10.2021)
Get full text
Journal Article
RIOK2: straddling the kinase/ATPase line
Asquith, Christopher R. M., East, Michael P., Zuercher, William J.
Published in Nature reviews. Drug discovery (01.07.2019)
Published in Nature reviews. Drug discovery (01.07.2019)
Get full text
Journal Article
FGFR4 regulates tumor subtype differentiation in luminal breast cancer and metastatic disease
Garcia-Recio, Susana, Thennavan, Aatish, East, Michael P, Parker, Joel S, Cejalvo, Juan M, Garay, Joseph P, Hollern, Daniel P, He, Xiaping, Mott, Kevin R, Galván, Patricia, Fan, Cheng, Selitsky, Sara R, Coffey, Alisha R, Marron, David, Brasó-Maristany, Fara, Burgués, Octavio, Albanell, Joan, Rojo, Federico, Lluch, Ana, de Dueñas, Eduardo Martinez, Rosen, Jeffery M, Johnson, Gary L, Carey, Lisa A, Prat, Aleix, Perou, Charles M
Published in The Journal of clinical investigation (01.09.2020)
Published in The Journal of clinical investigation (01.09.2020)
Get full text
Journal Article
PIP5K1A: a potential target for cancers with KRAS or TP53 mutations
East, Michael P., Laitinen, Tuomo, Asquith, Christopher R. M.
Published in Nature reviews. Drug discovery (01.07.2020)
Published in Nature reviews. Drug discovery (01.07.2020)
Get full text
Journal Article