Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate
Zhang, Yong-Kang, Plattner, Jacob J, Easom, Eric E, Jacobs, Robert T, Guo, Denghui, Freund, Yvonne R, Berry, Pamela, Ciaravino, Vic, Erve, John C. L, Rosenthal, Philip J, Campo, Brice, Gamo, Francisco-Javier, Sanz, Laura M, Cao, Jianxin
Published in Journal of medicinal chemistry (13.07.2017)
Published in Journal of medicinal chemistry (13.07.2017)
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Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation
Sindhe, Kirthana M V, Wu, Wesley, Legac, Jenny, Zhang, Yong-Kang, Easom, Eric E, Cooper, Roland A, Plattner, Jacob J, Freund, Yvonne R, DeRisi, Joseph L, Rosenthal, Philip J
Published in mBio (28.01.2020)
Published in mBio (28.01.2020)
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Discovery of an orally bioavailable isoxazoline benzoxaborole (AN8030) as a long acting animal ectoparasiticide
Zhang, Yong-Kang, Plattner, Jacob J., Easom, Eric E., Zhou, Yasheen, Akama, Tsutomu, Bu, Wei, White, W. Hunter, Defauw, Jean M., Winkle, Joseph R., Balko, Terry W., Guo, Shenghai, Xue, Jian, Cao, Jianxin, Zou, Wuxin
Published in Bioorganic & medicinal chemistry letters (01.12.2015)
Published in Bioorganic & medicinal chemistry letters (01.12.2015)
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Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)‑3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)‑ol (GSK656)
Li, Xianfeng, Hernandez, Vincent, Rock, Fernando L, Choi, Wai, Mak, Yvonne S. L, Mohan, Manisha, Mao, Weimin, Zhou, Yasheen, Easom, Eric E, Plattner, Jacob J, Zou, Wuxin, Pérez-Herrán, Esther, Giordano, Ilaria, Mendoza-Losana, Alfonso, Alemparte, Carlos, Rullas, Joaquín, Angulo-Barturen, Iñigo, Crouch, Sabrinia, Ortega, Fátima, Barros, David, Alley, M. R. K
Published in Journal of medicinal chemistry (12.10.2017)
Published in Journal of medicinal chemistry (12.10.2017)
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Journal Article
Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase
Palencia, Andrés, Li, Xianfeng, Bu, Wei, Choi, Wai, Ding, Charles Z, Easom, Eric E, Feng, Lisa, Hernandez, Vincent, Houston, Paul, Liu, Liang, Meewan, Maliwan, Mohan, Manisha, Rock, Fernando L, Sexton, Holly, Zhang, Suoming, Zhou, Yasheen, Wan, Baojie, Wang, Yuehong, Franzblau, Scott G, Woolhiser, Lisa, Gruppo, Veronica, Lenaerts, Anne J, O'Malley, Theresa, Parish, Tanya, Cooper, Christopher B, Waters, M Gerard, Ma, Zhenkun, Ioerger, Thomas R, Sacchettini, James C, Rullas, Joaquín, Angulo-Barturen, Iñigo, Pérez-Herrán, Esther, Mendoza, Alfonso, Barros, David, Cusack, Stephen, Plattner, Jacob J, Alley, M R K
Published in Antimicrobial agents and chemotherapy (01.10.2016)
Published in Antimicrobial agents and chemotherapy (01.10.2016)
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Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT)
Akama, Tsutomu, Zhang, Yong-Kang, Freund, Yvonne R., Berry, Pamela, Lee, Joanne, Easom, Eric E., Jacobs, Robert T., Plattner, Jacob J., Witty, Michael J., Peter, Rosemary, Rowan, Tim G., Gillingwater, Kirsten, Brun, Reto, Nare, Bakela, Mercer, Luke, Xu, Musheng, Wang, Jiangong, Liang, Hao
Published in Bioorganic & medicinal chemistry letters (01.01.2018)
Published in Bioorganic & medicinal chemistry letters (01.01.2018)
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Journal Article
Benzoxaborole Antimalarial Agents. Part 4. Discovery of Potent 6‑(2-(Alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles
Zhang, Yong-Kang, Plattner, Jacob J, Easom, Eric E, Jacobs, Robert T, Guo, Denghui, Sanders, Virginia, Freund, Yvonne R, Campo, Brice, Rosenthal, Philip J, Bu, Wei, Gamo, Francisco-Javier, Sanz, Laura M, Ge, Min, Li, Liang, Ding, Jie, Yang, Yin
Published in Journal of medicinal chemistry (09.07.2015)
Published in Journal of medicinal chemistry (09.07.2015)
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Journal Article
Optimization of isoxazoline amide benzoxaboroles for identification of a development candidate as an oral long acting animal ectoparasiticide
Zhang, Yong-Kang, Plattner, Jacob J., Easom, Eric E., Akama, Tsutomu, Zhou, Yasheen, White, W. Hunter, Defauw, Jean M., Winkle, Joseph R., Balko, Terry W., Cao, Jianxin, Ge, Zhixin, Yang, Jianzhang
Published in Bioorganic & medicinal chemistry letters (01.07.2016)
Published in Bioorganic & medicinal chemistry letters (01.07.2016)
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Synthesis and structure–activity relationships of novel benzoxaboroles as a new class of antimalarial agents
Zhang, Yong-Kang, Plattner, Jacob J., Freund, Yvonne R., Easom, Eric E., Zhou, Yasheen, Gut, Jiri, Rosenthal, Philip J., Waterson, David, Gamo, Francisco-Javier, Angulo-Barturen, Inigo, Ge, Min, Li, Zhiya, Li, Lingchao, Jian, Yong, Cui, Han, Wang, Hailong, Yang, Jian
Published in Bioorganic & medicinal chemistry letters (15.01.2011)
Published in Bioorganic & medicinal chemistry letters (15.01.2011)
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Journal Article
Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles
Zhang, Yong-Kang, Plattner, Jacob J., Freund, Yvonne R., Easom, Eric E., Zhou, Yasheen, Ye, Long, Zhou, Huchen, Waterson, David, Gamo, Francisco-Javier, Sanz, Laura M., Ge, Min, Li, Zhiya, Li, Lingchao, Wang, Hailong, Cui, Han
Published in Bioorganic & medicinal chemistry letters (01.02.2012)
Published in Bioorganic & medicinal chemistry letters (01.02.2012)
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Macrofilaricidal Benzimidazole–Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 1. Amide Linked Analogs
Akama, Tsutomu, Freund, Yvonne R, Berry, Pamela W, Carter, David S, Easom, Eric E, Jarnagin, Kurt, Lunde, Christopher S, Plattner, Jacob J, Rock, Fernando, Stefanakis, Rianna, Fischer, Chelsea, Bulman, Christina A, Lim, Kee Chong, Suzuki, Brian M, Tricoche, Nancy, Mansour, Abdelmoneim, DiCosty, Utami, McCall, Scott, Carson, Ben, McCall, John W, McKerrow, James, Hübner, Marc P, Specht, Sabine, Hoerauf, Achim, Lustigman, Sara, Sakanari, Judy A, Jacobs, Robert T
Published in ACS infectious diseases (14.02.2020)
Published in ACS infectious diseases (14.02.2020)
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Journal Article
An efficient synthesis for a new class antimalarial agent, 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole
Zhang, Yong-Kang, Plattner, Jacob J., Easom, Eric E., Waterson, David, Ge, Min, Li, Zhiya, Li, Lingchao, Jian, Yong
Published in Tetrahedron letters (27.07.2011)
Published in Tetrahedron letters (27.07.2011)
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Journal Article
Macrofilaricidal Benzimidazole–Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 2. Ketone Linked Analogs
Carter, David S, Jacobs, Robert T, Freund, Yvonne R, Berry, Pamela W, Akama, Tsutomu, Easom, Eric E, Lunde, Christopher S, Rock, Fernando, Stefanakis, Rianna, McKerrow, James, Fischer, Chelsea, Bulman, Christina A, Lim, Kee Chong, Suzuki, Brian M, Tricoche, Nancy, Sakanari, Judy A, Lustigman, Sara, Plattner, Jacob J
Published in ACS infectious diseases (14.02.2020)
Published in ACS infectious diseases (14.02.2020)
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Journal Article
Benzoxaborole antimalarial agents. Part 3: design and syntheses of (carboxy-13C-3,3-2H2)-labeled and (3-14C)-labeled 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles
Zhang, Yong-Kang, Plattner, Jacob J., Easom, Eric E., Liu, Liang, Retz, Daniel M., Ge, Min, Zhou, Hui-Hong
Published in Journal of labelled compounds & radiopharmaceuticals (30.05.2012)
Published in Journal of labelled compounds & radiopharmaceuticals (30.05.2012)
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Journal Article
Benzoxaborole Antimalarial Agents. Part 4. Discovery of Potent 6-(2-(Alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-be n zoxaboroles
Zhang, Yong-Kang, Plattner, Jacob J, Easom, Eric E, Jacobs, Robert T, Guo, Denghui, Sanders, Virginia, Freund, Yvonne R, Campo, Brice, Rosenthal, Philip J, Bu, Wei, Gamo, Francisco-Javier, Sanz, Laura M, Ge, Min, Li, Liang, Ding, Jie, Yang, Yin
Published in Journal of medicinal chemistry (11.06.2015)
Published in Journal of medicinal chemistry (11.06.2015)
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A comparison of Bayesian/sampling global optimization techniques
Stuckman, B.E., Easom, E.E.
Published in IEEE transactions on systems, man, and cybernetics (01.09.1992)
Published in IEEE transactions on systems, man, and cybernetics (01.09.1992)
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