Discovery of hydroxy pyrimidine Factor IXa inhibitors
Jayne, Charles L., Andreani, Teresa, Chan, Tin-Yau, Chelliah, Mariappan V., Clasby, Martin C., Dwyer, Michael, Eagen, Keith A., Fried, Steve, Greenlee, William J., Guo, Zhuyan, Hawes, Brian, Hruza, Alan, Ingram, Richard, Keertikar, Kartik M., Neelamkavil, Santhosh, Reichert, Paul, Xia, Yan, Chackalamannil, Samuel
Published in Bioorganic & medicinal chemistry letters (01.08.2020)
Published in Bioorganic & medicinal chemistry letters (01.08.2020)
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Journal Article
Design, Synthesis, and Activity of 2,6-Diphenoxypyridine-Derived Factor Xa Inhibitors
Phillips, Gary, Davey, David D, Eagen, Keith A, Koovakkat, Sunil K, Liang, Amy, Ng, Howard P, Pinkerton, Michael, Trinh, Lan, Whitlow, Marc, Beatty, Alicia M, Morrissey, Michael M
Published in Journal of medicinal chemistry (20.05.1999)
Published in Journal of medicinal chemistry (20.05.1999)
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Journal Article
Design, Synthesis, and Activity of a Novel Series of Factor Xa Inhibitors: Optimization of Arylamidine Groups
Phillips, Gary, Guilford, William J, Buckman, Brad O, Davey, David D, Eagen, Keith A, Koovakkat, Sunil, Liang, Amy, McCarrick, Meg, Mohan, Raju, Ng, Howard P, Pinkerton, Michael, Subramanyam, Babu, Ho, Elena, Trinh, Lan, Whitlow, Marc, Wu, Shung, Xu, Wei, Morrissey, Michael M
Published in Journal of medicinal chemistry (06.06.2002)
Published in Journal of medicinal chemistry (06.06.2002)
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Journal Article
Structure–Activity relationships of substituted benzothiophene-anthranilamide factor Xa inhibitors
Chou, Yuo-Ling, Davey, David D, Eagen, Keith A, Griedel, Brian D, Karanjawala, Rushad, Phillips, Gary B, Sacchi, Karna L, Shaw, Kenneth J, Wu, Shung C, Lentz, Dao, Liang, Amy M, Trinh, Lan, Morrissey, Michael M, Kochanny, Monica J
Published in Bioorganic & medicinal chemistry letters (10.02.2003)
Published in Bioorganic & medicinal chemistry letters (10.02.2003)
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Journal Article
Design, Synthesis, and Biological Activity of Novel Factor Xa Inhibitors: 4-Aryloxy Substituents of 2,6-Diphenoxypyridines
Ng, Howard P., Buckman, Brad O., Eagen, Keith A., Guilford, William J., Kochanny, Monica J., Mohan, Raju, Shaw, Kenneth J., Wu, Shung C., Lentz, Dao, Liang, Amy, Trinh, Lan, Ho, Elena, Smith, David, Subramanyam, Babu, Vergona, Ron, Walters, Janette, White, Kathy A., Sullivan, Mark E., Morrissey, Michael M., Phillips, Gary B.
Published in Bioorganic & medicinal chemistry (01.03.2002)
Published in Bioorganic & medicinal chemistry (01.03.2002)
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Journal Article
Allosteric Inhibitors of Inducible Nitric Oxide Synthase Dimerization Discovered via Combinatorial Chemistry
McMillan, Kirk, Adler, Marc, Auld, Douglas S., Baldwin, John J., Blasko, Eric, Browne, Leslie J., Chelsky, Daniel, Davey, David, Dolle, Ronald E., Eagen, Keith A., Erickson, Shawn, Feldman, Richard I., Glaser, Charles B., Mallari, Cornell, Morrissey, Michael M., Michael H. J. Ohlmeyer, Pan, Gonghua, Parkinson, John F., Phillips, Gary B., Polokoff, Mark A., Sigal, Nolan H., Vergona, Ronald, Whitlow, Marc, Young, Tish A., Devlin, James J.
Published in Proceedings of the National Academy of Sciences - PNAS (15.02.2000)
Published in Proceedings of the National Academy of Sciences - PNAS (15.02.2000)
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Journal Article
Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3,5-difluoro- 6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylglycine (ZK-807834): A Potent, Selective, and Orally Active Inhibitor of the Blood Coagulation Enzyme Factor Xa
Phillips, Gary B, Buckman, Brad O, Davey, David D, Eagen, Keith A, Guilford, William J, Hinchman, Josephine, Ho, Elena, Koovakkat, Sunil, Liang, Amy, Light, David R, Mohan, Raju, Ng, Howard P, Post, Joseph M, Shaw, Kenneth J, Smith, Dave, Subramanyam, Babu, Sullivan, Mark E, Trinh, Lan, Vergona, Ron, Walters, Janette, White, Kathy, Whitlow, Marc, Wu, Shung, Xu, Wei, Morrissey, Michael M
Published in Journal of medicinal chemistry (10.09.1998)
Published in Journal of medicinal chemistry (10.09.1998)
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Journal Article
Design, Synthesis, and Biological Activity of Novel Factor Xa Inhibitors: 4-Aryloxy Substituents of 2,6-Diphenoxypyridines††See ref. 1
Ng, Howard P., Buckman, Brad O., Eagen, Keith A., Guilford, William J., Kochanny, Monica J., Mohan, Raju, Shaw, Kenneth J., Wu, Shung C., Lentz, Dao, Liang, Amy, Trinh, Lan, Ho, Elena, Smith, David, Subramanyam, Babu, Vergona, Ron, Walters, Janette, White, Kathy A., Sullivan, Mark E., Morrissey, Michael M., Phillips, Gary B.
Published in Bioorganic & medicinal chemistry (01.03.2002)
Published in Bioorganic & medicinal chemistry (01.03.2002)
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Journal Article
Thrombin receptor antagonists
XIA, YAN, EAGEN, KEITH, A, CHACKALAMANNIL, SAMUEL, CHELLIAH, MARIAPPAN, V
Year of Publication 04.03.2015
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Year of Publication 04.03.2015
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Heterocyclic compounds as factor IXA inhibitors
Chackalamannil, Samuel, Chelliah, Mariappan, V, Wang, Li Yuan, Xia, Yan, Clasby, Martin, C, Greenlee, William J, Gao, Xiaobang, Vaccaro, Henry, Chan, Tin-yau, Mckittrick, Brian, Pu, Haiyan, Eagen, Keith A
Year of Publication 27.06.2018
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Year of Publication 27.06.2018
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Thrombin receptor antagonists
XIA, YAN, EAGEN, KEITH, A, CHACKALAMANNIL, SAMUEL, CHELLIAH, MARIAPPAN, V
Year of Publication 14.10.2009
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Year of Publication 14.10.2009
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Thrombin receptor antagonists
XIA, YAN, EAGEN, KEITH, A, CHACKALAMANNIL, SAMUEL, CHELLIAH, MARIAPPAN, V
Year of Publication 01.07.2009
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Year of Publication 01.07.2009
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Thrombin receptor antagonists
Chackalamannil, Samuel, Chelliah, Mariappan V, Xia, Yan, Eagen, Keith A
Year of Publication 10.02.2009
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Year of Publication 10.02.2009
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Thrombin receptor antagonists
XIA, YAN, EAGEN, KEITH A, CHELLIAH, MARIAPPAN V, CHACKALAMANNIL, SAMUEL
Year of Publication 25.09.2008
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Year of Publication 25.09.2008
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Heterocyclic compounds as factor IXA inhibitors
XIA, YAN, CHAN, TIN-YAU, MCKITTRICK, BRIAN, WANG, LI YUAN, GREENLEE, WILLIAM J, EAGEN, KEITH A, VACCARO, HENRY, PU, HAIYAN, CLASBY, MARTIN, C, CHACKALAMANNIL, SAMUEL, GAO, XIAOBANG, CHELLIAH, MARIAPPAN, V
Year of Publication 26.11.2014
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Year of Publication 26.11.2014
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THROMBIN RECEPTOR ANTAGONISTS
XIA, YAN, EAGEN, KEITH, A, CHACKALAMANNIL, SAMUEL, CHELLIAH, MARIAPPAN, V
Year of Publication 04.07.2007
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Year of Publication 04.07.2007
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THROMBIN RECEPTOR ANTAGONISTS
XIA, YAN, EAGEN, KEITH, A, CHACKALAMANNIL, SAMUEL, CHELLIAH, MARIAPPAN, V
Year of Publication 04.01.2007
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Year of Publication 04.01.2007
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