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Graham, Mark J, Lee, Richard G, Brandt, Teresa A, Tai, Li-Jung, Fu, Wuxia, Peralta, Raechel, Yu, Rosie, Hurh, Eunju, Paz, Erika, McEvoy, Bradley W, Baker, Brenda F, Pham, Nguyen C, Digenio, Andres, Hughes, Steven G, Geary, Richard S, Witztum, Joseph L, Crooke, Rosanne M, Tsimikas, Sotirios
Published in The New England journal of medicine (20.07.2017)
Published in The New England journal of medicine (20.07.2017)
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N-acetyl galactosamine-conjugated antisense drug to APOC3 mRNA, triglycerides and atherogenic lipoprotein levels
Alexander, Veronica J, Xia, Shuting, Hurh, Eunju, Hughes, Steven G, O’Dea, Louis, Geary, Richard S, Witztum, Joseph L, Tsimikas, Sotirios
Published in European heart journal (01.09.2019)
Published in European heart journal (01.09.2019)
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A Phase I, Multicenter, Open-Label, First-in-Human, Dose-Escalation Study of the Oral Smoothened Inhibitor Sonidegib (LDE225) in Patients with Advanced Solid Tumors
RODON, Jordi, TAWBI, Hussein A, LIN YANG, GRANVIL, Camille, EUNJU HURH, ROSE, Kristine L, AMAKYE, Dereck D, DUMMER, Reinhard, MITA, Alain C, THOMAS, Anne L, STOLLER, Ronald G, TURTSCHI, Christian P, BASELGA, Jose, SARANTOPOULOS, John, MAHALINGAM, Devalingam, YAPING SHOU, MOLES, Melissa A
Published in Clinical cancer research (01.04.2014)
Published in Clinical cancer research (01.04.2014)
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Selective targeting of angiopoietin-like 3 (ANGPTL3) with vupanorsen for the treatment of patients with familial partial lipodystrophy (FPLD): results of a proof-of-concept study
Foss-Freitas, Maria C, Akinci, Baris, Neidert, Adam, Bartlett, Victoria J, Hurh, Eunju, Karwatowska-Prokopczuk, Ewa, Oral, Elif A
Published in Lipids in health and disease (05.12.2021)
Published in Lipids in health and disease (05.12.2021)
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Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: implications for AMG 386, an angiopoietin-1/2-neutralizing peptibody
Coxon, Angela, Bready, James, Min, Hosung, Kaufman, Stephen, Leal, Juan, Yu, Dongyin, Lee, Tani Ann, Sun, Ji-Rong, Estrada, Juan, Bolon, Brad, McCabe, James, Wang, Ling, Rex, Karen, Caenepeel, Sean, Hughes, Paul, Cordover, David, Kim, Haejin, Han, Seog Joon, Michaels, Mark L, Hsu, Eric, Shimamoto, Grant, Cattley, Russell, Hurh, Eunju, Nguyen, Linh, Wang, Shao Xiong, Ndifor, Anthony, Hayward, Isaac J, Falcón, Beverly L, McDonald, Donald M, Li, Luke, Boone, Tom, Kendall, Richard, Radinsky, Robert, Oliner, Jonathan D
Published in Molecular cancer therapeutics (01.10.2010)
Published in Molecular cancer therapeutics (01.10.2010)
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Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia
Phelps, Mitch A., Lin, Thomas S., Johnson, Amy J., Hurh, Eunju, Rozewski, Darlene M., Farley, Katherine L., Wu, Di, Blum, Kristie A., Fischer, Beth, Mitchell, Sarah M., Moran, Mollie E., Brooker-McEldowney, Michelle, Heerema, Nyla A., Jarjoura, David, Schaaf, Larry J., Byrd, John C., Grever, Michael R., Dalton, James T.
Published in Blood (19.03.2009)
Published in Blood (19.03.2009)
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Assessment of the Drug Interaction Potential of Unconjugated and GalNAc3-Conjugated 2′-MOE-ASOs
Shemesh, Colby S., Yu, Rosie Z., Warren, Mark S., Liu, Michael, Jahic, Mirza, Nichols, Brandon, Post, Noah, Lin, Song, Norris, Daniel A., Hurh, Eunju, Huang, Jane, Watanabe, Tanya, Henry, Scott P., Wang, Yanfeng
Published in Molecular therapy. Nucleic acids (01.12.2017)
Published in Molecular therapy. Nucleic acids (01.12.2017)
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Vupanorsen, an N-acetyl galactosamine-conjugated antisense drug to ANGPTL3 mRNA, lowers triglycerides and atherogenic lipoproteins in patients with diabetes, hepatic steatosis, and hypertriglyceridaemia
Gaudet, Daniel, Karwatowska-Prokopczuk, Ewa, Baum, Seth J, Hurh, Eunju, Kingsbury, Joyce, Bartlett, Victoria J, Figueroa, Amparo L, Piscitelli, Philip, Singleton, Walter, Witztum, Joseph L, Geary, Richard S, Tsimikas, Sotirios, O'Dea, Louis St. L
Published in European heart journal (21.10.2020)
Published in European heart journal (21.10.2020)
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CFT8634, a Clinical Stage BRD9 Bi DAC™ Degrader, Is Active in a Subset of Multiple Myeloma Cell Line Models and Synergistic When Combined with Pomalidomide
Poling, Laura L, Cocozziello, David, He, Minsheng, Hurh, Eunju, Lobbardi, Riadh, Jackson, Katrina L, Fisher, Stewart L, Pollock, Roy M
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Apolipoprotein C-III reduction in subjects with moderate hypertriglyceridaemia and at high cardiovascular risk
Tardif, Jean-Claude, Karwatowska-Prokopczuk, Ewa, Amour, Eric St, Ballantyne, Christie M, Shapiro, Michael D, Moriarty, Patrick M, Baum, Seth J, Hurh, Eunju, Bartlett, Victoria J, Kingsbury, Joyce, Figueroa, Amparo L, Alexander, Veronica J, Tami, Joseph, Witztum, Joseph L, Geary, Richard S, O’Dea, Louis St L, Tsimikas, Sotirios, Gaudet, Daniel
Published in European heart journal (06.04.2022)
Published in European heart journal (06.04.2022)
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Phase I study of oral sonidegib (LDE225) in pediatric brain and solid tumors and a phase II study in children and adults with relapsed medulloblastoma
Kieran, Mark W, Chisholm, Julia, Casanova, Michela, Brandes, Alba A, Aerts, Isabelle, Bouffet, Eric, Bailey, Simon, Leary, Sarah, MacDonald, Tobey J, Mechinaud, Francoise, Cohen, Kenneth J, Riccardi, Riccardo, Mason, Warren, Hargrave, Darren, Kalambakas, Stacey, Deshpande, Priya, Tai, Feng, Hurh, Eunju, Geoerger, Birgit
Published in Neuro-oncology (Charlottesville, Va.) (19.10.2017)
Published in Neuro-oncology (Charlottesville, Va.) (19.10.2017)
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Exposure-Response Analysis of Sonidegib (LDE225), an Oral Inhibitor of the Hedgehog Signaling Pathway, for Effectiveness and Safety in Patients With Advanced Solid Tumors
Zhou, Jocelyn, Quinlan, Michelle, Hurh, Eunju, Sellami, Dalila
Published in Journal of clinical pharmacology (01.11.2016)
Published in Journal of clinical pharmacology (01.11.2016)
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Efficacy and safety of volanesorsen in patients with multifactorial chylomicronaemia (COMPASS): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial
Gouni-Berthold, Ioanna, Alexander, Veronica J, Yang, Qingqing, Hurh, Eunju, Steinhagen-Thiessen, Elisabeth, Moriarty, Patrick M, Hughes, Stephen G, Gaudet, Daniel, Hegele, Robert A, O'Dea, Louis St L, Stroes, Erik S G, Tsimikas, Sotirios, Witztum, Joseph L, Agarwal, Abhay, Ballantyne, Christie, Baum, Seth, Bergeron, Jean, Bruckert, Eric, Burdick, Richard, Castro-Cabezas, Manuel, Cervi, Mark, Corder, Clinton, DuFour, Robert, Farrington, Cecil Murray, Francis, Gordon, Galitz, Lawrence, Hamstead, Steven, Hemphill, Linda, Huffman, Cynthia, Issa, Basil, Julius, Ulrich, Kane, John, Krempf, Michel, Martin, Steven, Powell, James, Shultzaberger, Richard, Thompson, Craig, Thompson-Hargrave, Letitia, Toth, Peter, Turner, Traci, Valero, Rene, Verges, Bruno, Visseren, Frank L J, Vyas, Pankaj, Yataco, Alberto
Published in The lancet. Diabetes & endocrinology (01.05.2021)
Published in The lancet. Diabetes & endocrinology (01.05.2021)
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A phase 1/2 study of CFT1946, a novel, bifunctional degradation activating compound (BIDAC) degrader, of mutant BRAF V600 as monotherapy and in combination with trametinib, in mutant BRAF V600 solid tumors
McKean, Meredith, Spira, Alexander I., Rosen, Ezra, Subbiah, Vivek, Moreno, Victor, Gambardella, Valentina, Vieito, Maria, Saavedra, Omar, Cousin, Sophie, Cassier, Philippe Alexandre, Lobbardi, Riadh, Schönborn-Kellenberger, Oliver, Hurh, Eunju, Ruisi, Mary M., Buchbinder, Elizabeth Iannotti
Published in Journal of clinical oncology (01.06.2023)
Published in Journal of clinical oncology (01.06.2023)
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Efficacy and safety of pelacarsen in lowering Lp(a) in healthy Japanese subjects
Karwatowska‑Prokopczuk, Ewa, Lesogor, Anastasia, Yan, Jing-He, Hurh, Eunju, Hoenlinger, Angelika, Margolskee, Alison, Xia, Shuting, Tsimikas, Sotirios
Published in Journal of clinical lipidology (01.01.2023)
Published in Journal of clinical lipidology (01.01.2023)
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Assessment of efficacy and safety of volanesorsen for treatment of metabolic complications in patients with familial partial lipodystrophy: Results of the BROADEN study
Oral, Elif A., Garg, Abhimanyu, Tami, Joseph, Huang, Eric A., O'Dea, Louis St.L., Schmidt, Hartmut, Tiulpakov, Anatoly, Mertens, Ann, Alexander, Veronica J., Watts, Lynnetta, Hurh, Eunju, Witztum, Joseph L., Geary, Richard S., Tsimikas, Sotirios
Published in Journal of clinical lipidology (01.11.2022)
Published in Journal of clinical lipidology (01.11.2022)
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Exposure-QT analysis for sonidegib (LDE225), an oral inhibitor of the hedgehog signaling pathway, for measures of the QT prolongation potential in healthy subjects and in patients with advanced solid tumors
Quinlan, Michelle, Zhou, Jocelyn, Hurh, Eunju, Sellami, Dalila
Published in European journal of clinical pharmacology (01.12.2016)
Published in European journal of clinical pharmacology (01.12.2016)
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