Discovery and optimization of Lu AF58801, a novel, selective and brain penetrant positive allosteric modulator of alpha-7 nicotinic acetylcholine receptors: Attenuation of subchronic phencyclidine (PCP)-induced cognitive deficits in rats following oral administration
Eskildsen, Jorgen, Redrobe, John P., Sams, Anette G., Dekermendjian, Kim, Laursen, Morten, Boll, Jette B., Papke, Roger L., Bundgaard, Christoffer, Frederiksen, Kristen, Bastlund, Jesper F.
Published in Bioorganic & medicinal chemistry letters (01.01.2014)
Published in Bioorganic & medicinal chemistry letters (01.01.2014)
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The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin
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Published in Bioorganic & medicinal chemistry letters (01.01.2014)
Published in Bioorganic & medicinal chemistry letters (01.01.2014)
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Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor-ligand complex
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Published in Acta crystallographica. Section D, Biological crystallography. (01.02.2014)
Published in Acta crystallographica. Section D, Biological crystallography. (01.02.2014)
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Substituted Tetraoxa[8]circulenes - New Members of the Liquid Crystal Family
Eskildsen, Jørgen, Reenberg, Theis, Christensen, Jørn Bolstad
Published in European journal of organic chemistry (01.04.2000)
Published in European journal of organic chemistry (01.04.2000)
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MUSCARINIC AGONISTS
ESKILDSEN JORGEN, LUHRS LAUREN M, GIL DANIEL W, OLSSON ROGER, BURSTEIN ETHAN S, WHEELER LARRY A
Year of Publication 23.12.2015
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Year of Publication 23.12.2015
Patent
Antipsychotic compounds show inhibition of the human nicotinic acetylcholine α-7 receptor at high concentrations
Frederiksen, Kristen, Bundgaard, Christoffer, Dekermendjian, Kim, Redrobe, John P., FullertonStøier, Jonatan, Eskildsen, Jørgen, Bastlund, Jesper F.
Published in Biochemical pharmacology (15.10.2013)
Published in Biochemical pharmacology (15.10.2013)
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Agonist Response Induced by Nicotinic α-7 Agonist is Inhibited by Antipsychotic Drugs
Frederiksen, Kristen, Jessen, Maja, Støier, Jonatan Fullerton, Dekermendjian, Kim, Redrobe, John Paul, Bundgaard, Christoffer, Eskildsen, Jørgen Calí, Bastlund, Jesper Frank
Published in Biophysical journal (28.01.2014)
Published in Biophysical journal (28.01.2014)
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Journal Article
Discovery of Lu AF58801, a novel, selective and brain penetrant positive allosteric modulator of alpha-7 nicotinic acetylcholine receptors: Attenuation of subchronic phencyclidine (PCP)-induced cognitive deficits in rats following oral administration
Bastlund, Jesper F., Bundgaard, Christoffer, Dekermendjian, Kim, Papke, Roger L., Redrobe, John P., Frederiksen, Kristen, Eskildsen, Jørgen
Published in Biochemical pharmacology (15.10.2013)
Published in Biochemical pharmacology (15.10.2013)
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