Factor VIIIa-mimetic cofactor activity of a bispecific antibody to factors IX/IXa and X/Xa, emicizumab, depends on its ability to bridge the antigens
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Identification and multidimensional optimization of an asymmetric bispecific IgG antibody mimicking the function of factor VIII cofactor activity
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Published in PloS one (28.02.2013)
Published in PloS one (28.02.2013)
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A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model
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Published in Nature medicine (01.10.2012)
Published in Nature medicine (01.10.2012)
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A bispecific antibody NXT007 exerts a hemostatic activity in hemophilia A monkeys enough to keep a nonhemophilic state
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Published in Journal of thrombosis and haemostasis (01.02.2024)
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Cynomolgus monkey model of interleukin‐31‐induced scratching depicts blockade of human interleukin‐31 receptor A by a humanized monoclonal antibody
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Published in Experimental dermatology (01.01.2018)
Published in Experimental dermatology (01.01.2018)
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Factor VIIa inhibitors: Target hopping in the serine protease family using X-ray structure determination
Shiraishi, Takuya, Kadono, Shojiro, Haramura, Masayuki, Kodama, Hirofumi, Ono, Yoshiyuki, Iikura, Hitoshi, Esaki, Tohru, Koga, Takaki, Hattori, Kunihiro, Watanabe, Yoshiaki, Sakamoto, Akihisa, Yoshihashi, Kazutaka, Kitazawa, Takehisa, Esaki, Keiko, Ohta, Masateru, Sato, Haruhiko, Kozono, Toshiro
Published in Bioorganic & medicinal chemistry (15.08.2008)
Published in Bioorganic & medicinal chemistry (15.08.2008)
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Design and Synthesis of Peptidomimetic Factor VIIa Inhibitors
Shiraishi, Takuya, Kadono, Shojiro, Haramura, Masayuki, Kodama, Hirofumi, Ono, Yoshiyuki, Iikura, Hitoshi, Esaki, Tohru, Koga, Takaki, Hattori, Kunihiro, Watanabe, Yoshiaki, Sakamoto, Akihisa, Yoshihashi, Kazutaka, Kitazawa, Takehisa, Esaki, Keiko, Ohta, Masateru, Sato, Haruhiko, Kozono, Toshiro
Published in Chemical & Pharmaceutical Bulletin (01.01.2010)
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Generation of a Humanized Monoclonal Antibody Against Human Parathyroid Hormone-related Protein and its Efficacy Against Humoral Hypercalcemia of Malignancy
ONUMA, Etsuro, SATO, Koh, SAITO, Hidemi, TSUNENARI, Toshiaki, ISHII, Kimie, ESAKI, Keiko, YABUTA, Naohiro, WAKAHARA, Yuji, YAMADA-OKABE, Hisafumi, OGATA, Etsuro
Published in Anticancer research (01.09.2004)
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Published in Anticancer research (01.09.2004)
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Identification of human IgG1 variant with enhanced FcRn binding and without increased binding to rheumatoid factor autoantibody
Maeda, Atsuhiko, Iwayanagi, Yuki, Haraya, Kenta, Tachibana, Tatsuhiko, Nakamura, Genki, Nambu, Takeru, Esaki, Keiko, Hattori, Kunihiro, Igawa, Tomoyuki
Published in mAbs (04.07.2017)
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Identification of tumor vascular antigens by monoclonal antibodies prepared from rat‐tumor‐derived endothelial cells
Ohizumi, Iwao, Tsunoda, Shin‐ichi, Taniguchi, Kenji, Saito, Hiroyuki, Esaki, Keiko, Koizumi, Keiichi, Makimoto, Hiroo, Wakai, Yukiko, Matsui, Junji, Tsutsumi, Yasuo, Nakagawa, Shinsaku, Utoguchi, Naoki, Ohsugi, Yoshiyuki, Mayumi, Tadanori
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Published in International journal of cancer (12.08.1998)
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Antibody-Based Therapy Targeting Tumor Vascular Endothelial Cells Suppresses Solid Tumor Growth in Rats
Ohizumi, Iwao, Tsunoda, Shin-ichi, Taniguchi, Kenji, Saito, Hiroyuki, Esaki, Keiko, Makimoto, Hiroo, Wakai, Yukiko, Tsutsumi, Yasuo, Nakagawa, Shinsaku, Utoguchi, Naoki, Kaiho, Shin-ichi, Ohsugi, Yoshiyuki, Mayumi, Tadanori
Published in Biochemical and biophysical research communications (18.07.1997)
Published in Biochemical and biophysical research communications (18.07.1997)
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Polypeptide and Carbohydrate Structure of Recombinant Human Interleukin-6 Produced in Chinese Hamster Ovary Cells
Orita, Tetsuro, Oh-eda, Masayoshi, Hasegawa, Masakazu, Kuboniwa, Hitoshi, Esaki, Keiko, Ochi, Norimichi
Published in Journal of biochemistry (Tokyo) (01.02.1994)
Published in Journal of biochemistry (Tokyo) (01.02.1994)
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Anti-NR10 antibody and use thereof
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Year of Publication 06.11.2017
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Year of Publication 06.11.2017
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Generation of a Novel Bispecific Antibody (ACE910) Against Activated Factor IX and Factor X Mimicking the Function of Factor VIII Cofactor Activity
Igawa, Tomoyuki, Sampei, Zenjiro, Soeda, Tetsuhiro, Okuyama-Nishida, Yukiko, Moriyama, Chifumi, Wakabayashi, Tetsuya, Tanaka, Eriko, Muto, Atsushi, Kojima, Tetsuo, Kitazawa, Takehisa, Yoshihashi, Kazutaka, Harada, Aya, Funaki, Miho, Haraya, Kenta, Tatsuhiko, Tachibana, Suzuki, Sachiyo, Esaki, Keiko, Nabuchi, Yoshiaki, Hattori, Kunihiro
Published in Blood (16.11.2012)
Published in Blood (16.11.2012)
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ANTI-NR10 ANTIBODY AND USE THEREOF
KURAMOCHI TAICHI, TACHIBANA TATSUHIKO, OHYAMA SOUHEI, SHIRAIWA HIROTAKE, IGAWA TOMOYUKI, KASUTANI KEIKO, TSUNODA HIROYUKI, ESAKI KEIKO
Year of Publication 27.06.2016
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Year of Publication 27.06.2016
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ANTI-NR10 ANTIBODY AND USE THEREOF
KURAMOCHI TAICHI, TACHIBANA TATSUHIKO, OHYAMA SOUHEI, SHIRAIWA HIROTAKE, IGAWA TOMOYUKI, KASUTANI KEIKO, TSUNODA HIROYUKI, ESAKI KEIKO
Year of Publication 01.06.2016
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Year of Publication 01.06.2016
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HUMANIZED ANTI-EPIREGULIN ANTIBODY, AND CANCER THERAPEUTIC AGENT COMPRISING SAID ANTIBODY AS ACTIVE INGREDIENT
HASHIMOTO ERI, KURAMOCHI TAICHI, TAKEIRI ETSUKO, IGAWA TOMOYUKI, TSUNODA HIROYUKI, ESAKI KEIKO, SUZUKI MASAMI, WATANABE YOSHINORI, MAEDA ATSUHIKO, TAMBA SHIGERO, KATO ATSUHIKO, TACHIBANA TATSUHIKO, SHIRAIWA HIROTAKE, KINOSHITA YASUKO
Year of Publication 04.09.2014
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Year of Publication 04.09.2014
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HUMANIZED ANTI-EPIREGULIN ANTIBODY, AND CANCER THERAPEUTIC AGENT COMPRISING SAID ANTIBODY AS ACTIVE INGREDIENT
SHIRAIWA, HIROTAKE, KINOSHITA, YASUKO, TAKEIRI, ETSUKO, KATO, ATSUHIKO, SUZUKI, MASAMI, TACHIBANA, TATSUHIKO, TANBA, SHIGERO, KURAMOCHI, TAICHI, MAEDA, ATSUHIKO, HASHIMOTO, ERI, IGAWA, TOMOYUKI, ESAKI, KEIKO, WATANABE, YOSHINORI, TSUNODA, HIROYUKI
Year of Publication 04.07.2013
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Year of Publication 04.07.2013
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ANTI-NR10 ANTIBODY AND USE THEREOF
KURAMOCHI TAICHI, TACHIBANA TATSUHIKO, OHYAMA SOUHEI, SHIRAIWA HIROTAKE, IGAWA TOMOYUKI, KASUTANI KEIKO, TSUNODA HIROYUKI, ESAKI KEIKO
Year of Publication 03.09.2010
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Year of Publication 03.09.2010
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