l-Serine Deficiency Elicits Intracellular Accumulation of Cytotoxic Deoxysphingolipids and Lipid Body Formation
Esaki, Kayoko, Sayano, Tomoko, Sonoda, Chiaki, Akagi, Takumi, Suzuki, Takeshi, Ogawa, Takuya, Okamoto, Masahiro, Yoshikawa, Takeo, Hirabayashi, Yoshio, Furuya, Shigeki
Published in The Journal of biological chemistry (05.06.2015)
Published in The Journal of biological chemistry (05.06.2015)
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Deficiency of Schnurri-2, an MHC Enhancer Binding Protein, Induces Mild Chronic Inflammation in the Brain and Confers Molecular, Neuronal, and Behavioral Phenotypes Related to Schizophrenia
TAKAO, Keizo, KOBAYASHI, Katsunori, KUROIWA, Mahomi, MAEDA, Jun, ATSUZAWA, Kimie, ESAKI, Kayoko, YAMAGUCHI, Shun, FURUYA, Shigeki, TAKAGI, Tsuyoshi, WALTON, Noah M, HAYASHI, Nobuhiro, SUZUKI, Hidenori, HAGIHARA, Hideo, HIGUCHI, Makoto, USUDA, Nobuteru, SUHARA, Tetsuya, NISHI, Akinori, MATSUMOTO, Mitsuyuki, ISHII, Shunsuke, MIYAKAWA, Tsuyoshi, OHIRA, Koji, SHOJI, Hirotaka, HATTORI, Satoko, KOSHIMIZU, Hisatsugu, UMEMORI, Juzoh, TOYAMA, Keiko, NAKAMURA, Hironori K
Published in Neuropsychopharmacology (New York, N.Y.) (01.07.2013)
Published in Neuropsychopharmacology (New York, N.Y.) (01.07.2013)
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Hepatocyte-Specific Phgdh-Deficient Mice Culminate in Mild Obesity, Insulin Resistance, and Enhanced Vulnerability to Protein Starvation
Hamano, Momoko, Esaki, Kayoko, Moriyasu, Kazuki, Yasuda, Tokio, Mohri, Sinya, Tashiro, Kosuke, Hirabayashi, Yoshio, Furuya, Shigeki
Published in Nutrients (29.09.2021)
Published in Nutrients (29.09.2021)
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Brain-specific Phgdh Deletion Reveals a Pivotal Role for l-Serine Biosynthesis in Controlling the Level of d-Serine, an N-methyl-d-aspartate Receptor Co-agonist, in Adult Brain
Yang, Jung Hoon, Wada, Akira, Yoshida, Kazuyuki, Miyoshi, Yurika, Sayano, Tomoko, Esaki, Kayoko, Kinoshita, Masami O., Tomonaga, Shozo, Azuma, Norihiro, Watanabe, Masahiko, Hamase, Kenji, Zaitsu, Kiyoshi, Machida, Takeo, Messing, Albee, Itohara, Shigeyoshi, Hirabayashi, Yoshio, Furuya, Shigeki
Published in The Journal of biological chemistry (31.12.2010)
Published in The Journal of biological chemistry (31.12.2010)
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Investigation of betaine as a novel psychotherapeutic for schizophrenia
Ohnishi, Tetsuo, Balan, Shabeesh, Toyoshima, Manabu, Maekawa, Motoko, Ohba, Hisako, Watanabe, Akiko, Iwayama, Yoshimi, Fujita, Yuko, Tan, Yunfei, Hisano, Yasuko, Shimamoto-Mitsuyama, Chie, Nozaki, Yayoi, Esaki, Kayoko, Nagaoka, Atsuko, Matsumoto, Junya, Hino, Mizuki, Mataga, Nobuko, Hayashi-Takagi, Akiko, Hashimoto, Kenji, Kunii, Yasuto, Kakita, Akiyoshi, Yabe, Hirooki, Yoshikawa, Takeo
Published in EBioMedicine (01.07.2019)
Published in EBioMedicine (01.07.2019)
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SPTLC2 variants are associated with early‐onset ALS and FTD due to aberrant sphingolipid synthesis
Naruse, Hiroya, Ishiura, Hiroyuki, Esaki, Kayoko, Mitsui, Jun, Satake, Wataru, Greimel, Peter, Shingai, Nanoka, Machino, Yuka, Kokubo, Yasumasa, Hamaguchi, Hirotoshi, Oda, Tetsuya, Ikkaku, Tomoko, Yokota, Ichiro, Takahashi, Yuji, Suzuki, Yuta, Matsukawa, Takashi, Goto, Jun, Koh, Kishin, Takiyama, Yoshihisa, Morishita, Shinichi, Yoshikawa, Takeo, Tsuji, Shoji, Toda, Tatsushi
Published in Annals of clinical and translational neurology (01.04.2024)
Published in Annals of clinical and translational neurology (01.04.2024)
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l‐Serine deficiency caused by genetic Phgdh deletion leads to robust induction of 4E‐BP1 and subsequent repression of translation initiation in the developing central nervous system
Sayano, Tomoko, Kawakami, Yuriko, Kusada, Wataru, Suzuki, Takeshi, Kawano, Yuki, Watanabe, Akihiro, Takashima, Kana, Arimoto, Yashiho, Esaki, Kayoko, Wada, Akira, Yoshizawa, Fumiaki, Watanabe, Masahiko, Okamoto, Masahiro, Hirabayashi, Yoshio, Furuya, Shigeki
Published in The FEBS journal (01.03.2013)
Published in The FEBS journal (01.03.2013)
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A potential role of fatty acid binding protein 4 in the pathophysiology of autism spectrum disorder
Maekawa, Motoko, Ohnishi, Tetsuo, Toyoshima, Manabu, Shimamoto-Mitsuyama, Chie, Hamazaki, Kei, Balan, Shabeesh, Wada, Yuina, Esaki, Kayoko, Takagai, Shu, Tsuchiya, Kenji J, Nakamura, Kazuhiko, Iwata, Yasuhide, Nara, Takahiro, Iwayama, Yoshimi, Toyota, Tomoko, Nozaki, Yayoi, Ohba, Hisako, Watanabe, Akiko, Hisano, Yasuko, Matsuoka, Shigeru, Tsujii, Masatsugu, Mori, Norio, Matsuzaki, Hideo, Yoshikawa, Takeo
Published in Brain communications (01.01.2020)
Published in Brain communications (01.01.2020)
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Exon resequencing of H3K9 methyltransferase complex genes, EHMT1, EHTM2 and WIZ, in Japanese autism subjects
Balan, Shabeesh, Iwayama, Yoshimi, Maekawa, Motoko, Toyota, Tomoko, Ohnishi, Tetsuo, Toyoshima, Manabu, Shimamoto, Chie, Esaki, Kayoko, Yamada, Kazuo, Iwata, Yasuhide, Suzuki, Katsuaki, Ide, Masayuki, Ota, Motonori, Fukuchi, Satoshi, Tsujii, Masatsugu, Mori, Norio, Shinkai, Yoichi, Yoshikawa, Takeo
Published in Molecular autism (06.10.2014)
Published in Molecular autism (06.10.2014)
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Adaptive response to l‐serine deficiency is mediated by p38 MAPK activation via 1‐deoxysphinganine in normal fibroblasts
Sayano, Tomoko, Kawano, Yuki, Kusada, Wataru, Arimoto, Yashiho, Esaki, Kayoko, Hamano, Momoko, Udono, Miyako, Katakura, Yoshinori, Ogawa, Takuya, Kato, Hisanori, Hirabayashi, Yoshio, Furuya, Shigeki
Published in FEBS open bio (01.04.2016)
Published in FEBS open bio (01.04.2016)
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Evidence for Altered Metabolism of Sphingosine-1-Phosphate in the Corpus Callosum of Patients with Schizophrenia
Esaki, Kayoko, Balan, Shabeesh, Iwayama, Yoshimi, Shimamoto-Mitsuyama, Chie, Hirabayashi, Yoshio, Dean, Brian, Yoshikawa, Takeo
Published in Schizophrenia bulletin (21.09.2020)
Published in Schizophrenia bulletin (21.09.2020)
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Soy Peptide Ingestion Increases Neuroactive Amino Acids in the Adult Brain of Wild-Type and Genetically Engineered Serine-Deficient Mice
Esaki, Kayoko, Kokido, Takashi, Ohmori, Taketo, Tsukino, Mariko, Ohshima, Toshihisa, Furuya, Shigeki , Division of Systems Biology, Graduate School of Bioresource and Bioenvironmental Sciences, Bio-Architecture Center, Kyushu University, Fukuoka
Published in Journal of nutrition & food sciences (2011)
Published in Journal of nutrition & food sciences (2011)
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Lipid Pathology of the Corpus Callosum in Schizophrenia and the Potential Role of Abnormal Gene Regulatory Networks with Reduced Microglial Marker Expression
Shimamoto-Mitsuyama, Chie, Nakaya, Akihiro, Esaki, Kayoko, Balan, Shabeesh, Iwayama, Yoshimi, Ohnishi, Tetsuo, Maekawa, Motoko, Toyota, Tomoko, Dean, Brian, Yoshikawa, Takeo
Published in Cerebral cortex (New York, N.Y. 1991) (01.01.2021)
Published in Cerebral cortex (New York, N.Y. 1991) (01.01.2021)
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ASCT1 (Slc1a4) transporter is a physiologic regulator of brain D-serine and neurodevelopment
Kaplan, Eitan, Zubedat, Salman, Radzishevsky, Inna, Valenta, Alec C., Rechnitz, Ohad, Sason, Hagit, Sajrawi, Clara, Bodner, Oded, Konno, Kohtarou, Esaki, Kayoko, Derdikman, Dori, Yoshikawa, Takeo, Watanabe, Masahiko, Kennedy, Robert T., Billard, Jean-Marie, Avital, Avi, Wolosker, Herman
Published in Proceedings of the National Academy of Sciences - PNAS (18.09.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (18.09.2018)
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Impairment of serine transport across the blood-brain barrier by deletion of Slc38a5 causes developmental delay and motor dysfunction
Radzishevsky, Inna, Odeh, Maali, Bodner, Oded, Zubedat, Salman, Shaulov, Lihi, Litvak, Maxim, Esaki, Kayoko, Yoshikawa, Takeo, Agranovich, Bella, Li, Wen-Hong, Radzishevsky, Alex, Gottlieb, Eyal, Avital, Avi, Wolosker, Herman
Published in Proceedings of the National Academy of Sciences - PNAS (17.10.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (17.10.2023)
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