DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response
Colis, Laureen, Peltonen, Karita, Sirajuddin, Paul, Liu, Hester, Sanders, Sara, Ernst, Glen, Barrow, James C, Laiho, Marikki
Published in Oncotarget (30.06.2014)
Published in Oncotarget (30.06.2014)
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Journal Article
The IP6K Inhibitor LI-2242 Ameliorates Diet-Induced Obesity, Hyperglycemia, and Hepatic Steatosis in Mice by Improving Cell Metabolism and Insulin Signaling
Mukherjee, Sandip, Chakraborty, Molee, Haubner, Jake, Ernst, Glen, DePasquale, Michael, Carpenter, Danielle, Barrow, James C, Chakraborty, Anutosh
Published in Biomolecules (Basel, Switzerland) (20.05.2023)
Published in Biomolecules (Basel, Switzerland) (20.05.2023)
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Journal Article
TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway
Ghoshal, Sarbani, Zhu, Qingzhang, Asteian, Alice, Lin, Hua, Xu, Haifei, Ernst, Glen, Barrow, James C, Xu, Baoji, Cameron, Michael D, Kamenecka, Theodore M, Chakraborty, Anutosh
Published in Molecular metabolism (Germany) (01.10.2016)
Published in Molecular metabolism (Germany) (01.10.2016)
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Journal Article
Bicyclo((aryl)methyl)benzamides as inhibitors of GlyT1
Varnes, Jeffrey G., Xiong, Hui, Forst, Janet M., Holmquist, Christopher R., Ernst, Glen E., Frietze, William, Dembofsky, Bruce, Andisik, Don W., Palmer, William E., Hinkley, Lindsay, Steelman, Gary B., Wilkins, Deidre E., Tian, Gaochao, Jonak, Gerald, Potts, William M., Wang, Xia, Brugel, Todd A., Alhambra, Cristóbal, Wood, Michael W., Veale, Chris A., Albert, Jeffrey S.
Published in Bioorganic & medicinal chemistry letters (01.04.2018)
Published in Bioorganic & medicinal chemistry letters (01.04.2018)
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Journal Article
Efficient synthesis of a 7-azabicyclo[2.2.1]heptane based GlyT1 uptake inhibitor
Xiong, Hui, Frietze, William, Andisik, Donald W., Ernst, Glen E., Palmer, William E., Hinkley, Lindsay, Varnes, Jeffrey G., Albert, Jeffrey S., Veale, Chris A.
Published in Tetrahedron letters (22.12.2010)
Published in Tetrahedron letters (22.12.2010)
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Journal Article
4-Piperidin-4-ylidenemethyl-benzamides as δ-opioid receptor agonists for CNS indications: Identifying clinical candidates
Dantzman, Cathy L., King, Megan M., Ernst, Glen E., Wang, Xia, McCauley, John P., Andisik, Donald W., Brush, Kelly, Bui, Khanh H., Frietze, William, Hoesch, Valerie, Liu, Jay, Palmer, William E., Spear, Nathan, Hudzik, Thomas J., Wesolowski, Steven S.
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
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Journal Article
Multiparameter exploration of piperazine derivatives as δ-opioid receptor agonists for CNS indications
McCauley, John P., Dantzman, Cathy L., King, Megan M., Ernst, Glen E., Wang, Xia, Brush, Kelly, Palmer, William E., Frietze, William, Andisik, Donald W., Hoesch, Valerie, Doring, Kenneth, Hulsizer, James, Bui, Khanh H., Liu, Jay, Hudzik, Thomas J., Wesolowski, Steven S.
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
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Journal Article
Synthesis and characterization of novel isoform-selective IP6K1 inhibitors
Wormald, Michael M., Ernst, Glen, Wei, Huijun, Barrow, James C.
Published in Bioorganic & medicinal chemistry letters (01.10.2019)
Published in Bioorganic & medicinal chemistry letters (01.10.2019)
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Journal Article
Identification and Characterization of a Blood–Brain Barrier Penetrant Inositol Hexakisphosphate Kinase (IP6K) Inhibitor
Heitmann, Tyler, Liao, Gangling, Ernst, Glen, Poslusney, Michael, van Kralingen, Thomas, Li, Ye, Masi, Megan, DePasquale, Michael, Buchler, Ingrid, Wei, Huijun, Carr, Gregory V., Shlevkov, Evgeny, Lu, Mengsi, Jessen, Henning, Barrow, James C.
Published in Journal of medicinal chemistry (22.08.2024)
Published in Journal of medicinal chemistry (22.08.2024)
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Journal Article
Fragment-Based Screening Identifies New Quinazolinone-Based Inositol Hexakisphosphate Kinase (IP6K) Inhibitors
Heitmann, Tyler, Liao, Gangling, de León, Pablo, Ernst, Glen, Buchler, Ingrid, Wei, Huijun, Shlevkov, Evgeny, Brown, Dean, Fitzek, Martina, Collier, Matthew, Smith, David M., Barrow, James C.
Published in ACS medicinal chemistry letters (14.12.2023)
Published in ACS medicinal chemistry letters (14.12.2023)
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Journal Article
Design, Synthesis, and Structure-Activity Relationships of Pyridoquinazolinecarboxamides as RNA Polymerase I Inhibitors
Colis, Laureen, Ernst, Glen, Sanders, Sara, Liu, Hester, Sirajuddin, Paul, Peltonen, Karita, DePasquale, Michael, Barrow, James C., Laiho, Marikki
Published in Journal of medicinal chemistry (12.06.2014)
Published in Journal of medicinal chemistry (12.06.2014)
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Journal Article
Optimization of 8‑Hydroxyquinolines as Inhibitors of Catechol O‑Methyltransferase
Buchler, Ingrid, Akuma, Daniel, Au, Vinh, Carr, Gregory, de León, Pablo, DePasquale, Michael, Ernst, Glen, Huang, Yifang, Kimos, Martha, Kolobova, Anna, Poslusney, Michael, Wei, Huijun, Swinnen, Dominique, Montel, Florian, Moureau, Florence, Jigorel, Emilie, Schulze, Monika-Sarah E. D, Wood, Martyn, Barrow, James C
Published in Journal of medicinal chemistry (08.11.2018)
Published in Journal of medicinal chemistry (08.11.2018)
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Journal Article
Identification of Small-Molecule Inhibitors of Human Inositol Hexakisphosphate Kinases by High-Throughput Screening
Liao, Gangling, Ye, Wenjuan, Heitmann, Tyler, Ernst, Glen, DePasquale, Michael, Xu, Laiyi, Wormald, Michael, Hu, Xin, Ferrer, Marc, Harmel, Robert K, Fiedler, Dorothea, Barrow, James, Wei, Huijun
Published in ACS pharmacology & translational science (09.04.2021)
Published in ACS pharmacology & translational science (09.04.2021)
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Journal Article
Novel inhibitors of As(III) S-adenosylmethionine methyltransferase (AS3MT) identified by virtual screening
Bürli, Roland W., Wei, Huijun, Ernst, Glen, Mariga, Abigail, Hardern, Ian M., Herlihy, Kara, Cross, Alan J., Wesolowski, Steven S., Chen, Hongming, McKay, Ronald D.G., Weinberger, Daniel R., Brandon, Nicholas J., Barrow, James C.
Published in Bioorganic & medicinal chemistry letters (15.10.2018)
Published in Bioorganic & medicinal chemistry letters (15.10.2018)
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Journal Article
Synthesis and Evaluation of Bicyclic Hydroxypyridones as Inhibitors of Catechol O‑Methyltransferase
Ernst, Glen, Akuma, Daniel, Au, Vinh, Buchler, Ingrid P, Byers, Spencer, Carr, Gregory V, Defays, Sabine, de León, Pablo, Demaude, Thierry, DePasquale, Michael, Durieu, Véronique, Huang, Yifang, Jigorel, Emilie, Kimos, Martha, Kolobova, Anna, Montel, Florian, Moureau, Florence, Poslusney, Michael, Swinnen, Dominique, Vandergeten, Marie-Christine, Van houtvin, Nathalie, Wei, Huijun, White, Noelle, Wood, Martyn, Barrow, James C
Published in ACS medicinal chemistry letters (14.11.2019)
Published in ACS medicinal chemistry letters (14.11.2019)
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Journal Article
Synthesis of three alpha 7 agonists in labeled form
Elmore, Charles S., Landvatter, Scott, Dorff, Peter N., Powell, Mark E., Killick, David, Blake, Timothy, Hall, James, Heys, J. Richard, Harding, John, Urbanek, Rebecca, Ernst, Glen
Published in Journal of labelled compounds & radiopharmaceuticals (15.05.2014)
Published in Journal of labelled compounds & radiopharmaceuticals (15.05.2014)
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