A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects
Talukdar, Saswata, Zhou, Yingjiang, Li, Dongmei, Rossulek, Michelle, Dong, Jennifer, Somayaji, Veena, Weng, Yan, Clark, Ronald, Lanba, Adhiraj, Owen, Bryn M., Brenner, Martin B., Trimmer, Jeffrey K., Gropp, Kathryn E., Chabot, Jeffrey R., Erion, Derek M., Rolph, Timothy P., Goodwin, Bryan, Calle, Roberto A.
Published in Cell metabolism (08.03.2016)
Published in Cell metabolism (08.03.2016)
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Journal Article
Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
Kumashiro, Naoki, Erion, Derek M, Zhang, Dongyan, Kahn, Mario, Beddow, Sara A, Chu, Xin, Still, Christopher D, Gerhard, Glenn S, Han, Xianlin, Dziura, James, Petersen, Kitt Falk, Samuel, Varman T, Shulman, Gerald I
Published in Proceedings of the National Academy of Sciences - PNAS (27.09.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (27.09.2011)
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Journal Article
The promise of human organoids in the digestive system
Funata, Masaaki, Nio, Yasunori, Erion, Derek M., Thompson, Wendy L., Takebe, Takanori
Published in Cell death and differentiation (01.01.2021)
Published in Cell death and differentiation (01.01.2021)
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Journal Article
STAT3 inhibition of gluconeogenesis is downregulated by SirT1
Shulman, Gerald I, Horvath, Tamas L, Nie, Yongzhan, Yuan, Zhenglong, Erion, Derek M, Dietrich, Marcelo, Gao, Qian
Published in Nature cell biology (01.04.2009)
Published in Nature cell biology (01.04.2009)
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Journal Article
UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals
Horvath, Tamas L, Diano, Sabrina, Andrews, Zane B, Liu, Zhong-Wu, Walllingford, Nicholas, Erion, Derek M, Borok, Erzsebet, Friedman, Jeffery M, Tschöp, Matthias H, Shanabrough, Marya, Cline, Gary, Shulman, Gerald I, Coppola, Anna, Gao, Xiao-Bing
Published in Nature (14.08.2008)
Published in Nature (14.08.2008)
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Journal Article
Acetyl-CoA carboxylase 1 and 2 inhibition ameliorates steatosis and hepatic fibrosis in a MC4R knockout murine model of nonalcoholic steatohepatitis
Matsumoto, Mitsuharu, Yashiro, Hiroaki, Ogino, Hitomi, Aoyama, Kazunobu, Nambu, Tadahiro, Nakamura, Sayuri, Nishida, Mayumi, Wang, Xiaolun, Erion, Derek M, Kaneko, Manami
Published in PloS one (28.01.2020)
Published in PloS one (28.01.2020)
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Journal Article
SirT1 Regulates Adipose Tissue Inflammation
GILLUM, Matthew P, KOTAS, Maya E, BANKS, Alexander S, LI QIANG, BHANOT, Sanjay, OLEFSKY, Jerrold M, SEARS, Dorothy D, CAPRIO, Sonia, SHULMAN, Gerald I, ERION, Derek M, KURSAWE, Romy, CHATTERJEE, Paula, NEAD, Kevin T, MUISE, Eric S, HSIAO, Jennifer J, FREDERICK, David W, YONEMITSU, Shin
Published in Diabetes (New York, N.Y.) (01.12.2011)
Published in Diabetes (New York, N.Y.) (01.12.2011)
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Journal Article
Adipocyte OGT governs diet-induced hyperphagia and obesity
Li, Min-Dian, Vera, Nicholas B., Yang, Yunfan, Zhang, Bichen, Ni, Weiming, Ziso-Qejvanaj, Enida, Ding, Sheng, Zhang, Kaisi, Yin, Ruonan, Wang, Simeng, Zhou, Xu, Fang, Ethan X., Xu, Tian, Erion, Derek M., Yang, Xiaoyong
Published in Nature communications (30.11.2018)
Published in Nature communications (30.11.2018)
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Journal Article
Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction
Gutierrez, Jemy A., Liu, Wei, Perez, Sylvie, Xing, Gang, Sonnenberg, Gabriele, Kou, Kou, Blatnik, Matt, Allen, Richard, Weng, Yan, Vera, Nicholas B., Chidsey, Kristin, Bergman, Arthur, Somayaji, Veena, Crowley, Collin, Clasquin, Michelle F., Nigam, Anu, Fulham, Melissa A., Erion, Derek M., Ross, Trenton T., Esler, William P., Magee, Thomas V., Pfefferkorn, Jeffrey A., Bence, Kendra K., Birnbaum, Morris J., Tesz, Gregory J.
Published in Molecular metabolism (Germany) (01.06.2021)
Published in Molecular metabolism (Germany) (01.06.2021)
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Journal Article
SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats
Erion, Derek M, Yonemitsu, Shin, Nie, Yongzhan, Nagai, Yoshio, Gillum, Matthew P, Hsiao, Jennifer J, Iwasaki, Takanori, Stark, Romana, Weismann, Dirk, Yu, Xing Xian, Murray, Susan F, Bhanot, Sanjay, Monia, Brett P, Horvath, Tamas L, Gao, Qian, Samuel, Varman T, Shulman, Gerald I
Published in Proceedings of the National Academy of Sciences - PNAS (07.07.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (07.07.2009)
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Journal Article
Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2)
Futatsugi, Kentaro, Kung, Daniel W, Orr, Suvi T. M, Cabral, Shawn, Hepworth, David, Aspnes, Gary, Bader, Scott, Bian, Jianwei, Boehm, Markus, Carpino, Philip A, Coffey, Steven B, Dowling, Matthew S, Herr, Michael, Jiao, Wenhua, Lavergne, Sophie Y, Li, Qifang, Clark, Ronald W, Erion, Derek M, Kou, Kou, Lee, Kyuha, Pabst, Brandon A, Perez, Sylvie M, Purkal, Julie, Jorgensen, Csilla C, Goosen, Theunis C, Gosset, James R, Niosi, Mark, Pettersen, John C, Pfefferkorn, Jeffrey A, Ahn, Kay, Goodwin, Bryan
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
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Journal Article
Role of patatin‐like phospholipase domain‐containing 3 on lipid‐induced hepatic steatosis and insulin resistance in rats
Kumashiro, Naoki, Yoshimura, Toru, Cantley, Jennifer L., Majumdar, Sachin K., Guebre‐Egziabher, Fitsum, Kursawe, Romy, Vatner, Daniel F., Fat, Ioana, Kahn, Mario, Erion, Derek M., Zhang, Xian‐Man, Zhang, Dongyan, Manchem, Vara Prasad, Bhanot, Sanjay, Gerhard, Glenn S., Petersen, Kitt F., Cline, Gary W., Samuel, Varman T., Shulman, Gerald I.
Published in Hepatology (Baltimore, Md.) (01.05.2013)
Published in Hepatology (Baltimore, Md.) (01.05.2013)
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Journal Article
The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats
Erion, Derek M, Lapworth, Amanda, Amor, Paul A, Bai, Guoyun, Vera, Nicholas B, Clark, Ronald W, Yan, Qingyun, Zhu, Yimin, Ross, Trenton T, Purkal, Julie, Gorgoglione, Matthew, Zhang, Guodong, Bonato, Vinicius, Baker, Levenia, Barucci, Nicole, D'Aquila, Theresa, Robertson, Alan, Aiello, Robert J, Yan, Jiangli, Trimmer, Jeff, Rolph, Timothy P, Pfefferkorn, Jeffrey A
Published in PloS one (23.05.2014)
Published in PloS one (23.05.2014)
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Journal Article
The Role of the Carbohydrate Response Element-Binding Protein in Male Fructose-Fed Rats
Erion, Derek M, Popov, Violetta, Hsiao, Jennifer J, Vatner, Daniel, Mitchell, Kisha, Yonemitsu, Shin, Nagai, Yoshio, Kahn, Mario, Gillum, Matthew P, Dong, Jianying, Murray, Susan F, Manchem, Vara Prasad, Bhanot, Sanjay, Cline, Gary W, Shulman, Gerald I, Samuel, Varman T
Published in Endocrinology (Philadelphia) (01.01.2013)
Published in Endocrinology (Philadelphia) (01.01.2013)
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Journal Article
N-acylphosphatidylethanolamine, a Gut- Derived Circulating Factor Induced by Fat Ingestion, Inhibits Food Intake
Gillum, Matthew P., Zhang, Dongyan, Zhang, Xian-Man, Erion, Derek M., Jamison, Rachel A., Choi, Cheolsoo, Dong, Jianying, Shanabrough, Marya, Duenas, Hillary R., Frederick, David W., Hsiao, Jennifer J., Horvath, Tamas L., Lo, Chun Min, Tso, Pat, Cline, Gary W., Shulman, Gerald I.
Published in Cell (28.11.2008)
Published in Cell (28.11.2008)
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Journal Article
Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis
Shepherd, Emma L., Saborano, Raquel, Northall, Ellie, Matsuda, Kae, Ogino, Hitomi, Yashiro, Hiroaki, Pickens, Jason, Feaver, Ryan E., Cole, Banumathi K., Hoang, Stephen A., Lawson, Mark J., Olson, Matthew, Figler, Robert A., Reardon, John E., Nishigaki, Nobuhiro, Wamhoff, Brian R., Günther, Ulrich L., Hirschfield, Gideon, Erion, Derek M., Lalor, Patricia F.
Published in JHEP reports (01.04.2021)
Published in JHEP reports (01.04.2021)
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Journal Article
FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in whole-body glucose homeostasis
Mottillo, Emilio P, Desjardins, Eric M, Fritzen, Andreas M, Zou, Vito Z, Crane, Justin D, Yabut, Julian M, Kiens, Bente, Erion, Derek M, Lanba, Adhiraj, Granneman, James G, Talukdar, Saswata, Steinberg, Gregory R
Published in Molecular metabolism (Germany) (01.06.2017)
Published in Molecular metabolism (Germany) (01.06.2017)
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Journal Article
The Mammalian INDY Homolog Is Induced by CREB in a Rat Model of Type 2 Diabetes
NEUSCHÄFER-RUBE, Frank, LIESKE, Stefanie, TOLKACHOV, Alexander, SCHUPP, Michael, PATHE-NEUSCHÄFER-RUBE, Andrea, PFEIFFER, Andreas F. H, SHUTMAN, Gerald I, PUSCHEL, Gerhard P, BIRKENFELD, Andreas L, KUNA, Manuela, HENKEL, Janin, PERRY, Rachel J, ERION, Derek M, PESTA, Dominik, WILLMES, Diana M, BRACHS, Sebastian, VON LOEFFELHOLZ, Christian
Published in Diabetes (New York, N.Y.) (01.03.2014)
Published in Diabetes (New York, N.Y.) (01.03.2014)
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