Negative allosteric modulation of GluN1/GluN3 NMDA receptors
Zhu, Zongjian, Yi, Feng, Epplin, Matthew P., Liu, Ding, Summer, Samantha L., Mizu, Ruth, Shaulsky, Gil, XiangWei, Wenshu, Tang, Weiting, Burger, Pieter B., Menaldino, David S., Myers, Scott J., Liotta, Dennis C., Hansen, Kasper B., Yuan, Hongjie, Traynelis, Stephen F.
Published in Neuropharmacology (01.10.2020)
Published in Neuropharmacology (01.10.2020)
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Discovery of Dihydropyrrolo[1,2‑a]pyrazin-3(4H)‑one-Based Second-Generation GluN2C- and GluN2D-Selective Positive Allosteric Modulators (PAMs) of the N‑Methyl‑d‑Aspartate (NMDA) Receptor
Epplin, Matthew P, Mohan, Ayush, Harris, Lynnea D, Zhu, Zongjian, Strong, Katie L, Bacsa, John, Le, Phuong, Menaldino, David S, Traynelis, Stephen F, Liotta, Dennis C
Published in Journal of medicinal chemistry (23.07.2020)
Published in Journal of medicinal chemistry (23.07.2020)
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Biased modulators of NMDA receptors control channel opening and ion selectivity
Perszyk, Riley E, Swanger, Sharon A, Shelley, Chris, Khatri, Alpa, Fernandez-Cuervo, Gabriela, Epplin, Matthew P, Zhang, Jing, Le, Phuong, Bülow, Pernille, Garnier-Amblard, Ethel, Gangireddy, Pavan Kumar Reddy, Bassell, Gary J, Yuan, Hongjie, Menaldino, David S, Liotta, Dennis C, Liebeskind, Lanny S, Traynelis, Stephen F
Published in Nature chemical biology (01.02.2020)
Published in Nature chemical biology (01.02.2020)
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An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups
Perszyk, Riley, Katzman, Brooke M, Kusumoto, Hirofumi, Kell, Steven A, Epplin, Matthew P, Tahirovic, Yesim A, Moore, Rhonda L, Menaldino, David, Burger, Pieter, Liotta, Dennis C, Traynelis, Stephen F
Published in eLife (24.05.2018)
Published in eLife (24.05.2018)
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The Bioactive Protein-Ligand Conformation of GluN2C-Selective Positive Allosteric Modulators Bound to the NMDA Receptor
Kaiser, Thomas M, Kell, Steven A, Kusumoto, Hirofumi, Shaulsky, Gil, Bhattacharya, Subhrajit, Epplin, Matthew P, Strong, Katie L, Miller, Eric J, Cox, Bryan D, Menaldino, David S, Liotta, Dennis C, Traynelis, Stephen F, Burger, Pieter B
Published in Molecular pharmacology (01.02.2018)
Published in Molecular pharmacology (01.02.2018)
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The Structure–Activity Relationship of a Tetrahydroisoquinoline Class of N‑Methyl‑d‑Aspartate Receptor Modulators that Potentiates GluN2B-Containing N‑Methyl‑d‑Aspartate Receptors
Strong, Katie L, Epplin, Matthew P, Bacsa, John, Butch, Christopher J, Burger, Pieter B, Menaldino, David S, Traynelis, Stephen F, Liotta, Dennis C
Published in Journal of medicinal chemistry (13.07.2017)
Published in Journal of medicinal chemistry (13.07.2017)
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Distinct GluN1 and GluN2 Structural Determinants for Subunit-Selective Positive Allosteric Modulation of N -Methyl-d-aspartate Receptors
Strong, Katie L, Epplin, Matthew P, Ogden, Kevin K, Burger, Pieter B, Kaiser, Thomas M, Wilding, Timothy J, Kusumoto, Hiro, Camp, Chad R, Shaulsky, Gil, Bhattacharya, Subhrajit, Perszyk, Riley E, Menaldino, David S, McDaniel, Miranda J, Zhang, Jing, Le, Phuong, Banke, Tue G, Hansen, Kasper B, Huettner, James E, Liotta, Dennis C, Traynelis, Stephen F
Published in ACS chemical neuroscience (06.01.2021)
Published in ACS chemical neuroscience (06.01.2021)
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The Structure-Activity Relationship of a Tetrahydroisoquinoline Class of N-Methyl-D-Aspartate Receptor Modulators that Potentiates GIuN2B-Containing N-Methyl-D-Aspartate Receptors
Strong, Katie L., Epplin, Matthew P., Bacsa, John, Butch, Christopher J., Burger, Pieter B., Menaldino, David S., Traynelis, Stephen F., Liotta, Dennis C.
Published in Journal of medicinal chemistry (13.07.2017)
Published in Journal of medicinal chemistry (13.07.2017)
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EPPLIN MATTHEW, LAWSON KENNETH VICTOR, ROSEN BRANDON REID, MATA GUILLAUME, HARDMAN CLAYTON, BEATTY JOEL WORLEY, LIU DONGDONG, FOURNIER JEREMY, POWERS JAY PATRICK, DREW SAMUEL LAWRIE, YU KAI, GAL BALINT, PODUNAVAC MASA, MAILYAN ARTUR KARENOVICH, LELETI MANMOHAN REDDY
Year of Publication 16.07.2024
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Year of Publication 16.07.2024
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HIF-2알파의 억제제로서의 테트랄린 및 테트라히드로퀴놀린 화합물
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Year of Publication 23.11.2022
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Year of Publication 23.11.2022
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N-methyl-D-aspartic Acid Receptor Modulators
Liotta, Dennis, Epplin, Matthew, Traynelis, Stephen F, Menaldino, David
Year of Publication 09.11.2023
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Year of Publication 09.11.2023
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N-methyl-D-aspartic acid receptor modulators
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Year of Publication 29.08.2023
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Year of Publication 29.08.2023
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N-methyl-D-aspartic Acid Receptor Modulators
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Year of Publication 25.11.2021
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Year of Publication 25.11.2021
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Year of Publication 04.09.2024
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Year of Publication 04.09.2024
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Year of Publication 01.06.2024
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INHIBITORS OF HIF-2ALPHA AND METHODS OF USE THEREOF
LELETI, Manmohan Reddy, DREW, Samuel Lawrie, EPPLIN, Matthew, MATA, Guillaume, ROSEN, Brandon Reid, HARDMAN, Clayton, FOURNIER, Jeremy, LIU, Dongdong, PODUNAVAC, Maša, LAWSON, Kenneth Victor, YU, Kai, POWERS, Jay Patrick, BEATTY, Joel Worley, GAL, Balint, MAILYAN, Artur Karenovich
Year of Publication 16.05.2024
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N-METHYL-D-ASPARTIC ACID RECEPTOR MODULATORS
TRAYNELIS, Stephen F, EPPLIN, Matthew, MENALDINO, David, LIOTTA, Dennis C
Year of Publication 15.08.2019
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Year of Publication 15.08.2019
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