First-in-human phase I study of JPH203, an L-type amino acid transporter 1 inhibitor, in patients with advanced solid tumors
Okano, Naohiro, Naruge, Daisuke, Kawai, Kirio, Kobayashi, Takaaki, Nagashima, Fumio, Endou, Hitoshi, Furuse, Junji
Published in Investigational new drugs (01.10.2020)
Published in Investigational new drugs (01.10.2020)
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Journal Article
Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc
Lee, Yongchan, Wiriyasermkul, Pattama, Jin, Chunhuan, Quan, Lili, Ohgaki, Ryuichi, Okuda, Suguru, Kusakizako, Tsukasa, Nishizawa, Tomohiro, Oda, Kazumasa, Ishitani, Ryuichiro, Yokoyama, Takeshi, Nakane, Takanori, Shirouzu, Mikako, Endou, Hitoshi, Nagamori, Shushi, Kanai, Yoshikatsu, Nureki, Osamu
Published in Nature structural & molecular biology (01.06.2019)
Published in Nature structural & molecular biology (01.06.2019)
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Journal Article
l‐Type amino acid transporter 1 inhibitors inhibit tumor cell growth
Oda, Koji, Hosoda, Noriko, Endo, Hiroshi, Saito, Kunio, Tsujihara, Kenji, Yamamura, Michio, Sakata, Takeshi, Anzai, Naohiko, Wempe, Michael F., Kanai, Yoshikatsu, Endou, Hitoshi
Published in Cancer science (01.01.2010)
Published in Cancer science (01.01.2010)
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Journal Article
The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5)
Cormerais, Yann, Massard, Pierre André, Vucetic, Milica, Giuliano, Sandy, Tambutté, Eric, Durivault, Jerome, Vial, Valérie, Endou, Hitoshi, Wempe, Michael F., Parks, Scott K., Pouyssegur, Jacques
Published in The Journal of biological chemistry (23.02.2018)
Published in The Journal of biological chemistry (23.02.2018)
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Journal Article
Pharmacologic inhibition of LAT1 predominantly suppresses transport of large neutral amino acids and downregulates global translation in cancer cells
Nishikubo, Kou, Ohgaki, Ryuichi, Okanishi, Hiroki, Okuda, Suguru, Xu, Minhui, Endou, Hitoshi, Kanai, Yoshikatsu
Published in Journal of cellular and molecular medicine (01.10.2022)
Published in Journal of cellular and molecular medicine (01.10.2022)
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Journal Article
L-type amino-acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer
Sakata, Takeshi, Ferdous, Golam, Tsuruta, Tomoko, Satoh, Takefumi, Baba, Shiro, Muto, Tomoko, Ueno, Akinori, Kanai, Yoshikatsu, Endou, Hitoshi, Okayasu, Isao
Published in Pathology international (01.01.2009)
Published in Pathology international (01.01.2009)
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Journal Article
Amino acid transporter LAT1 in tumor-associated vascular endothelium promotes angiogenesis by regulating cell proliferation and VEGF-A-dependent mTORC1 activation
Quan, Lili, Ohgaki, Ryuichi, Hara, Saori, Okuda, Suguru, Wei, Ling, Okanishi, Hiroki, Nagamori, Shushi, Endou, Hitoshi, Kanai, Yoshikatsu
Published in Journal of experimental & clinical cancer research (30.11.2020)
Published in Journal of experimental & clinical cancer research (30.11.2020)
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Journal Article
Antitumor effect of dimethyl itaconate on thymic carcinoma by targeting LDHA-mTOR axis
Hayashi, Keitaro, Nakazato, Yoshimasa, Ouchi, Motoshi, Fujita, Tomoe, Endou, Hitoshi, Chida, Masayuki
Published in Life sciences (1973) (01.10.2021)
Published in Life sciences (1973) (01.10.2021)
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Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth
Cormerais, Yann, Giuliano, Sandy, LeFloch, Renaud, Front, Benoît, Durivault, Jerome, Tambutté, Eric, Massard, Pierre-André, de la Ballina, Laura Rodriguez, Endou, Hitoshi, Wempe, Michael F, Palacin, Manuel, Parks, Scott K, Pouyssegur, Jacques
Published in Cancer research (Chicago, Ill.) (01.08.2016)
Published in Cancer research (Chicago, Ill.) (01.08.2016)
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Journal Article
Organic Anion Transporter Family: Current Knowledge
Anzai, Naohiko, Kanai, Yoshikatsu, Endou, Hitoshi
Published in Journal of Pharmacological Sciences (01.01.2006)
Published in Journal of Pharmacological Sciences (01.01.2006)
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Journal Article
Inhibition of cancer-type amino acid transporter LAT1 suppresses B16-F10 melanoma metastasis in mouse models
Shi, Zitong, Kaneda-Nakashima, Kazuko, Ohgaki, Ryuichi, Xu, Minhui, Okanishi, Hiroki, Endou, Hitoshi, Nagamori, Shushi, Kanai, Yoshikatsu
Published in Scientific reports (25.08.2023)
Published in Scientific reports (25.08.2023)
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Journal Article
Expression of L-type amino acid transporter 1 is a poor prognostic factor for Non-Hodgkin's lymphoma
Jigjidkhorloo, Narangerel, Kanekura, Kohsuke, Matsubayashi, Jun, Akahane, Daigo, Fujita, Koji, Oikawa, Keiki, Kurata, Atsushi, Takanashi, Masakatsu, Endou, Hitoshi, Nagao, Toshitaka, Gotoh, Akihiko, Norov, Oyundelger, Kuroda, Masahiko
Published in Scientific reports (04.11.2021)
Published in Scientific reports (04.11.2021)
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Journal Article
L-type amino acid transporter 1 (LAT1)-specific inhibitor is effective against T cell-mediated nasal hyperresponsiveness
Kaminuma, Osamu, Nishimura, Tomoe, Saeki, Mayumi, Yamasaki, Norimasa, Ogata, Sawako, Fujita, Tomoe, Endou, Hitoshi, Hayashi, Keitaro
Published in Allergology international (01.07.2020)
Published in Allergology international (01.07.2020)
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Journal Article
LAT1-specific inhibitor ameliorates severe autoimmune arthritis in SKG mouse
Owada, Takayoshi, Kurasawa, Kazuhiro, Endou, Hitoshi, Fujita, Tomoe, Anzai, Naohiko, Hayashi, Keitaro
Published in International immunopharmacology (01.08.2022)
Published in International immunopharmacology (01.08.2022)
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Journal Article
l‐type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms
Kaira, Kyoichi, Oriuchi, Noboru, Imai, Hisao, Shimizu, Kimihiro, Yanagitani, Noriko, Sunaga, Noriaki, Hisada, Takeshi, Tanaka, Shigebumi, Ishizuka, Tamotsu, Kanai, Yoshikatsu, Endou, Hitoshi, Nakajima, Takashi, Mori, Masatomo
Published in Cancer science (01.12.2008)
Published in Cancer science (01.12.2008)
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Journal Article
c-Myc is crucial for the expression of LAT1 in MIA Paca-2 human pancreatic cancer cells
HAYASHI, KEITARO, JUTABHA, PROMSUK, ENDOU, HITOSHI, ANZAI, NAOHIKO
Published in Oncology reports (01.09.2012)
Published in Oncology reports (01.09.2012)
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Journal Article
Combination effects of amino acid transporter LAT1 inhibitor nanvuranlat and cytotoxic anticancer drug gemcitabine on pancreatic and biliary tract cancer cells
Nishikubo, Kou, Ohgaki, Ryuichi, Liu, Xingming, Okanishi, Hiroki, Xu, Minhui, Endou, Hitoshi, Kanai, Yoshikatsu
Published in Cancer cell international (15.06.2023)
Published in Cancer cell international (15.06.2023)
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Journal Article
Plasma Urate Level Is Directly Regulated by a Voltage-driven Urate Efflux Transporter URATv1 (SLC2A9) in Humans
Anzai, Naohiko, Ichida, Kimiyoshi, Jutabha, Promsuk, Kimura, Toru, Babu, Ellappan, Jin, Chun Ji, Srivastava, Sunena, Kitamura, Kenichiro, Hisatome, Ichiro, Endou, Hitoshi, Sakurai, Hiroyuki
Published in The Journal of biological chemistry (03.10.2008)
Published in The Journal of biological chemistry (03.10.2008)
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Journal Article
Inhibition of the amino‐acid transporter LAT1 demonstrates anti‐neoplastic activity in medulloblastoma
Cormerais, Yann, Pagnuzzi‐Boncompagni, Marina, Schrötter, Sandra, Giuliano, Sandy, Tambutté, Eric, Endou, Hitoshi, Wempe, Michael F., Pagès, Gilles, Pouysségur, Jacques, Picco, Vincent
Published in Journal of cellular and molecular medicine (01.04.2019)
Published in Journal of cellular and molecular medicine (01.04.2019)
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