New Perspectives on Drug-Induced Liver Injury Risk Assessment of Acyl Glucuronides
Walles, Markus, Brown, Alan P, Zimmerlin, Alfred, End, Peter
Published in Chemical research in toxicology (20.07.2020)
Published in Chemical research in toxicology (20.07.2020)
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Remibrutinib (LOU064): A selective potent oral BTK inhibitor with promising clinical safety and pharmacodynamics in a randomized phase I trial
Kaul, Martin, End, Peter, Cabanski, Maciej, Schuhler, Carole, Jakab, Annamaria, Kistowska, Magdalena, Kinhikar, Arvind, Maiolica, Alessio, Sinn, Angela, Fuhr, Rainard, Cenni, Bruno
Published in Clinical and translational science (01.09.2021)
Published in Clinical and translational science (01.09.2021)
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Urinary clusterin, cystatin C, β2-microglobulin and total protein as markers to detect drug-induced kidney injury
Dieterle, Frank, Perentes, Elias, Cordier, André, Roth, Daniel R, Verdes, Pablo, Grenet, Olivier, Pantano, Serafino, Moulin, Pierre, Wahl, Daniel, Mahl, Andreas, End, Peter, Staedtler, Frank, Legay, François, Carl, Kevin, Laurie, David, Chibout, Salah-Dine, Vonderscher, Jacky, Maurer, Gérard
Published in Nature biotechnology (01.05.2010)
Published in Nature biotechnology (01.05.2010)
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Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator
Pan, Shifeng, Gray, Nathanael S., Gao, Wenqi, Mi, Yuan, Fan, Yi, Wang, Xing, Tuntland, Tove, Che, Jianwei, Lefebvre, Sophie, Chen, Yu, Chu, Alan, Hinterding, Klaus, Gardin, Anne, End, Peter, Heining, Peter, Bruns, Christian, Cooke, Nigel G., Nuesslein-Hildesheim, Barbara
Published in ACS medicinal chemistry letters (14.03.2013)
Published in ACS medicinal chemistry letters (14.03.2013)
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Novel Bruton’s Tyrosine Kinase inhibitor remibrutinib: Drug‐drug interaction potential as a victim of CYP3A4 inhibitors based on clinical data and PBPK modeling
Huth, Felix, Schiller, Hilmar, Jin, Yi, Poller, Birk, Schuhler, Carole, Weis, Wendy, Woessner, Ralph, Drollmann, Anton, End, Peter
Published in Clinical and translational science (01.01.2022)
Published in Clinical and translational science (01.01.2022)
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Absorption, Distribution, Metabolism, and Elimination of the Direct Renin Inhibitor Aliskiren in Healthy Volunteers
WALDMEIER, Felix, GLAENZEL, Ulrike, WIRZ, Bernard, OBERER, Lukas, SCHMID, Dietmar, SEIBERLING, Michael, VALENCIA, Jessica, RIVIERE, Gilles-Jacques, END, Peter, VAIDYANATHAN, Sujata
Published in Drug metabolism and disposition (01.08.2007)
Published in Drug metabolism and disposition (01.08.2007)
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Drug-induced liver injury: recent advances in diagnosis and risk assessment
Kullak-Ublick, Gerd A, Andrade, Raul J, Merz, Michael, End, Peter, Benesic, Andreas, Gerbes, Alexander L, Aithal, Guruprasad P
Published in Gut (01.06.2017)
Published in Gut (01.06.2017)
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Novel Bruton's tyrosine kinase inhibitor remibrutinib: Assessment of drug-drug interaction potential as a perpetrator of cytochrome P450 enzymes and drug transporters and the impact of covalent binding on possible drug interactions
Schiller, Hilmar, Huth, Felix, Schuhler, Carole, Drollmann, Anton, Kaul, Martin, Woessner, Ralph, Shah, Bharti, Weis, Wendy, End, Peter
Published in European journal of pharmaceutical sciences (01.05.2022)
Published in European journal of pharmaceutical sciences (01.05.2022)
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MO042LNP023: A NOVEL ORAL COMPLEMENT ALTERNATIVE PATHWAY FACTOR B INHIBITOR FOR THE TREATMENT OF GLOMERULAR DISEASE
Webb, Nicholas, Haraldsson, Boerje, Schubart, Anna, Milojevic, Julie, End, Peter, Holbro, Thomas, Junge, Guido
Published in Nephrology, dialysis, transplantation (01.06.2020)
Published in Nephrology, dialysis, transplantation (01.06.2020)
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Addition of iptacopan, an oral factor B inhibitor, to eculizumab in patients with paroxysmal nocturnal haemoglobinuria and active haemolysis: an open-label, single-arm, phase 2, proof-of-concept trial
Risitano, Antonio M, Röth, Alexander, Soret, Juliette, Frieri, Camilla, de Fontbrune, Flore Sicre, Marano, Luana, Alashkar, Ferras, Benajiba, Lina, Marotta, Serena, Rozenberg, Izabela, Milojevic, Julie, End, Peter, Nidamarthy, Prasanna K, Junge, Guido, Peffault de Latour, Régis
Published in The Lancet. Haematology (01.05.2021)
Published in The Lancet. Haematology (01.05.2021)
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LNP023: A Novel Oral Complement Alternative Pathway Factor B Inhibitor Safely and Effectively Reduces Proteinuria in C3 Glomerulopathy: SU-OR39
Wong, Edwin K., Praga, Manuel, Nester, Carla M., Daina, Erica, Remuzzi, Giuseppe, Nidamarthy, Prasanna Kumar, End, Peter R., Milojevic, Julie M., Biondani, Andrea, Trapani, Angelo J., Webb, Nicholas, Junge, Dr Guido
Published in Journal of the American Society of Nephrology (01.10.2020)
Published in Journal of the American Society of Nephrology (01.10.2020)
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Absorption, Distribution, Metabolism, and Excretion of the Oral Prostaglandin D2 Receptor 2 Antagonist Fevipiprant (QAW039) in Healthy Volunteers and In Vitro
Pearson, David, Weiss, H Markus, Jin, Yi, Jaap van Lier, Jan, Erpenbeck, Veit J, Glaenzel, Ulrike, End, Peter, Woessner, Ralph, Eggimann, Fabian, Camenisch, Gian
Published in Drug metabolism and disposition (01.07.2017)
Published in Drug metabolism and disposition (01.07.2017)
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Fevipiprant has a low risk of influencing co-medication pharmacokinetics: Impact on simvastatin and rosuvastatin in different SLCO1B1 genotypes
Poller, Birk, Woessner, Ralph, Barve, Avantika, Tillmann, Hanns-Christian, Vemula, Janardhana, Nica, Alexandra, Elbast, Walid, Schiller, Hilmar, End, Peter, Camenisch, Gian, Weiss, Markus
Published in Pulmonary pharmacology & therapeutics (01.08.2019)
Published in Pulmonary pharmacology & therapeutics (01.08.2019)
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다발성 경화증 치료를 위한 LOU064
JUHNKE MICHAEL, SIN KIM HIEN, YU HUIXIN, BIETH BRUNO, KARAN RAJESH SINGH, GRAHAM GORDON, END PETER, MANN ALLISON DONNA, BHATTACHARYA SOUVIK, ZHANG YING, RAPP KARIN, CENNI BRUNO, PIGEOLET ETIENNE
Year of Publication 26.04.2024
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Year of Publication 26.04.2024
Patent
A Unidirectional 96-Well Fluidic Culture Platform for Upstream Cell Dosing with Subsequent Downstream Nonlinear and Ascending Exposure Gradients for Real-Time and Cell-Based Toxicity Screening Environments
John, Bincy A, Sloan, David J, Jensen, Timothy C, Ramaiahgari, Sreenivasa C, End, Peter, Resh, Gabrielle E, McClelland, Randall E
Published in Applied in vitro toxicology (01.12.2021)
Published in Applied in vitro toxicology (01.12.2021)
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Urinary clusterin, cystatin C, [beta]2-microglobulin and total protein as markers to detect drug-induced kidney injury
Dieterle, Frank, Perentes, Elias, Cordier, André, Roth, Daniel R, Verdes, Pablo, Grenet, Olivier, Pantano, Serafino, Moulin, Pierre, Wahl, Daniel, Mahl, Andreas, End, Peter, Staedtler, Frank, Legay, François, Carl, Kevin, Laurie, David, Chibout, Salah-dine, Vonderscher, Jacky, Maurer, Gérard
Published in Nature biotechnology (01.05.2010)
Published in Nature biotechnology (01.05.2010)
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Urinary clusterin, cystatin C, β2-microglobulin and total protein as markers to detect drug-induced kidney injury : The predictive safety testing consortium
DIETERLE, Frank, PERENTES, Elias, END, Peter, STAEDTLER, Frank, LEGAY, François, CARL, Kevin, LAURIE, David, CHIBOUT, Salah-Dine, VONDERSCHER, Jacky, MAURER, Gérard, CORDIER, André, ROTH, Daniel R, VERDES, Pablo, GRENET, Olivier, PANTANO, Serafino, MOULIN, Pierre, WAHL, Daniel, MAHL, Andreas
Published in Nature biotechnology (2010)
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Published in Nature biotechnology (2010)
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DOSING REGIMES FOR THE TREATMENT OF OCULAR VASCULAR DISEASE
JAFFEE BRUCE, POOR STEPHEN, HOSAGRAHARA VINAYAK, QIU YUBIN, MEREDITH ERIK, END PETER, NEWTON RONALD, BRIGELL MITCHELL
Year of Publication 21.01.2014
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Year of Publication 21.01.2014
Patent