Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro
END, David W, SMETS, Gerda, DEVINE, Ann, WOUTERS, Walter, BOWDEN, Charles, TODD, Alison V, APPLEGATE, Tanya L, FUERY, Caroline J, ANGIBAUD, Patrick, VENET, Marc, SANZ, Gerard, POIGNET, Herve, SKRZAT, Stacy
Published in Cancer research (Chicago, Ill.) (2001)
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Published in Cancer research (Chicago, Ill.) (2001)
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Phase I Trial and Pharmacokinetic Study of the Farnesyltransferase Inhibitor Tipifarnib in Children With Refractory Solid Tumors or Neurofibromatosis Type I and Plexiform Neurofibromas
WIDEMANN, Brigitte C, SALZER, Wanda L, JAYAPRAKASH, Nalini, ZANNIKOS, Peter, BALIS, Frank M, ARCECI, Robert J, BLANEY, Susan M, FOX, Elizabeth, END, David, GILLESPIE, Andrea, WHITCOMB, Patricia, PALUMBO, Joseph S, PITNEY, Aaron
Published in Journal of clinical oncology (20.01.2006)
Published in Journal of clinical oncology (20.01.2006)
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Journal Article
Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial
Karp, Judith E., Lancet, Jeffrey E., Kaufmann, Scott H., End, David W., Wright, John J., Bol, Kees, Horak, Ivan, Tidwell, Michael L., Liesveld, Jane, Kottke, Timothy J., Ange, Dawn, Buddharaju, Laxmi, Gojo, Ivana, Highsmith, W. Edward, Belly, Robert T., Hohl, Raymond J., Rybak, Mary Ellen, Thibault, Alain, Rosenblatt, Joseph
Published in Blood (01.06.2001)
Published in Blood (01.06.2001)
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Journal Article
Farnesyl protein transferase inhibitor ZARNESTRA R115777 - history of a discovery
Venet, Marc, End, David, Angibaud, Patrick
Published in Current topics in medicinal chemistry (01.01.2003)
Published in Current topics in medicinal chemistry (01.01.2003)
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Current status of clinical trials of farnesyltransferase inhibitors
Karp, J E, Kaufmann, S H, Adjei, A A, Lancet, J E, Wright, J J, End, D W
Published in Current opinion in oncology (01.11.2001)
Published in Current opinion in oncology (01.11.2001)
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Impact on farnesyltransferase inhibition of 4-chlorophenyl moiety replacement in the Zarnestra ® series
Angibaud, Patrick, Mevellec, Laurence, Meyer, Christophe, Bourdrez, Xavier, Lezouret, Patricia, Pilatte, Isabelle, Poncelet, Virginie, Roux, Bruno, Merillon, Sophie, End, David W., Van Dun, Jacky, Wouters, Walter, Venet, Marc
Published in European journal of medicinal chemistry (01.05.2007)
Published in European journal of medicinal chemistry (01.05.2007)
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Journal Article
Chemoprevention of Benzo(a)pyrene-induced Lung Tumors in Mice by the Farnesyltransferase Inhibitor R115777
GUNNING, William T, KRAMER, Paula M, LUBET, Ronald A, STEELE, Vernon E, END, David W, WOUTERS, Walter, PEREIRA, Michael A
Published in Clinical cancer research (01.05.2003)
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Published in Clinical cancer research (01.05.2003)
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Effects of the farnesyl transferase inhibitor R115777 (Zarnestra) on mammary carcinogenesis: prevention, therapy, and role of HaRas mutations
Lubet, Ronald A, Christov, Konstantin, You, Ming, Yao, Ruisheng, Steele, Vernon E, End, David W, Juliana, M Margaret, Grubbs, Clinton J
Published in Molecular cancer therapeutics (01.04.2006)
Published in Molecular cancer therapeutics (01.04.2006)
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Journal Article
Efficacy of the farnesyltransferase inhibitor R115777 in a rat mammary tumor model: role of Ha-ras mutations and use of microarray analysis in identifying potential targets
Yao, Ruisheng, Wang, Yian, Lu, Yan, Lemon, William J., End, David W., Grubbs, Clinton J., Lubet, Ronald A., You, Ming
Published in Carcinogenesis (New York) (01.07.2006)
Published in Carcinogenesis (New York) (01.07.2006)
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Journal Article
5-Imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors
Angibaud, Patrick, Bourdrez, Xavier, Devine, Ann, End, David W, Freyne, Eddy, Ligny, Yannick, Muller, Philippe, Mannens, Geert, Pilatte, Isabelle, Poncelet, Virginie, Skrzat, Stacy, Smets, Gerda, Van Dun, Jacky, Van Remoortere, Pieter, Venet, Marc, Wouters, Walter
Published in Bioorganic & medicinal chemistry letters (05.05.2003)
Published in Bioorganic & medicinal chemistry letters (05.05.2003)
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Journal Article
Substituted azoloquinolines and -quinazolines as new potent Farnesyl Protein Transferase inhibitors
ANGIBAUD, Patrick, BOURDREZ, Xavier, MEYER, Christophe, MULLER, Philippe, PILATTE, Isabelle, PONCELET, Virginie, ROUX, Bruno, SMETS, Gerda, VAN DUN, Jacky, VAN REMOORTERE, Pieter, VENET, Marc, WOUTERS, Walter, END, David W, FREYNE, Eddy, JANICOT, Michel, LEZOURET, Patricia, LIGNY, Yannick, MANNENS, Geert, DAMSCH, Siegrid, MEVELLEC, Laurence
Published in Bioorganic & medicinal chemistry letters (15.12.2003)
Published in Bioorganic & medicinal chemistry letters (15.12.2003)
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Journal Article
4-Methyl-1,2,4-triazol-3-yl heterocycle as an alternative to the 1-methylimidazol-5-yl moiety in the farnesyltransferase inhibitor ZARNESTRA
ANGIBAUD, Patrick, SAHA, Ashis K, PONCELET, Virginie, ROUX, Bruno, SMETS, Gerda, VAN DUN, Jacky, VENET, Marc, WOUTERS, Walter, BOURDREZ, Xavier, END, David W, FREYNE, Eddy, LEZOURET, Patricia, MANNENS, Geert, MEVELLEC, Laurence, MEYER, Christophe, PILATTE, Isabelle
Published in Bioorganic & medicinal chemistry letters (15.12.2003)
Published in Bioorganic & medicinal chemistry letters (15.12.2003)
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Journal Article
Interactions of Abiraterone, Eplerenone, and Prednisolone with Wild-Type and Mutant Androgen Receptor: A Rationale for Increasing Abiraterone Exposure or Combining with MDV3100—Letter
End, David, Molina, Arturo, Todd, Mary, Meyers, Michael L.
Published in Cancer research (Chicago, Ill.) (01.05.2013)
Published in Cancer research (Chicago, Ill.) (01.05.2013)
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Discovery and Clinical Evaluation of 1-{N-[2-(Amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a Thrombin Inhibitor with an Oxyguanidine P1 Motif
Lu, Tianbao, Markotan, Thomas, Ballentine, Shelley K, Giardino, Edward C, Spurlino, John, Brown, Kathryn, Maryanoff, Bruce E, Tomczuk, Bruce E, Damiano, Bruce P, Shukla, Umesh, End, David, Andrade-Gordon, Patricia, Bone, Roger F, Player, Mark R
Published in Journal of medicinal chemistry (25.02.2010)
Published in Journal of medicinal chemistry (25.02.2010)
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Journal Article
Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: a rationale for increasing abiraterone exposure or combining with MDV3100
End, David, Molina, Arturo, Todd, Mary, Meyers, Michael L
Published in Cancer research (Chicago, Ill.) (01.05.2013)
Published in Cancer research (Chicago, Ill.) (01.05.2013)
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Nonclinical safety assessment of a synthetic peptide thrombopoietin agonist: effects on platelets, bone homeostasis, and immunogenicity and the implications for clinical safety monitoring of adverse bone effects
Knight, Elaine, Eichenbaum, Gary, Hillsamer, Verna, Greway, Tony, Tonelli, Alfred, Han-Hsu, Helen, Zakszewski, Cindy, Yurkow, Edward, Shukla, Umesh, End, David, Louden, Calvert
Published in International journal of toxicology (01.08.2011)
Published in International journal of toxicology (01.08.2011)
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Journal Article
Corrections to Discovery and Clinical Evaluation of 1-{N-[2-(Amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a Thrombin Inhibitor with an Oxyguanidine P1 Motif
Lu, Tianbao, Markotan, Thomas, Ballentine, Shelley K, Giardino, Edward C, Spurlino, John, Brown, Kathryn, Maryanoff, Bruce E, Tomczuk, Bruce E, Damiano, Bruce P, Shukla, Umesh, End, David, Andrade-Gordon, Patricia, Bone, Roger F, Player, Mark R
Published in Journal of medicinal chemistry (22.04.2010)
Published in Journal of medicinal chemistry (22.04.2010)
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