Progress in Understanding and Treating SCN2A-Mediated Disorders
Sanders, Stephan J., Campbell, Arthur J., Cottrell, Jeffrey R., Moller, Rikke S., Wagner, Florence F., Auldridge, Angie L., Bernier, Raphael A., Catterall, William A., Chung, Wendy K., Empfield, James R., George, Alfred L., Hipp, Joerg F., Khwaja, Omar, Kiskinis, Evangelos, Lal, Dennis, Malhotra, Dheeraj, Millichap, John J., Otis, Thomas S., Petrou, Steven, Pitt, Geoffrey, Schust, Leah F., Taylor, Cora M., Tjernagel, Jennifer, Spiro, John E., Bender, Kevin J.
Published in Trends in neurosciences (Regular ed.) (01.07.2018)
Published in Trends in neurosciences (Regular ed.) (01.07.2018)
Get full text
Journal Article
The contribution of Na V 1.6 to the efficacy of voltage-gated sodium channel inhibitors in wild type and Na V 1.6 gain-of-function (GOF) mouse seizure control
Johnson, Jr, James P, Focken, Thilo, Karimi Tari, Parisa, Dube, Celine, Goodchild, Samuel J, Andrez, Jean-Christophe, Bankar, Girish, Burford, Kristen, Chang, Elaine, Chowdhury, Sultan, Christabel, Jessica, Dean, Richard, de Boer, Gina, Dehnhardt, Christoph, Gong, Wei, Grimwood, Michael, Hussainkhel, Angela, Jia, Qi, Khakh, Kuldip, Lee, Stephanie, Li, Jenny, Lin, Sophia, Lindgren, Andrea, Lofstrand, Verner, Mezeyova, Janette, Nelkenbrecher, Karen, Shuart, Noah Gregory, Sojo, Luis, Sun, Shaoyi, Waldbrook, Matthew, Wesolowski, Steven, Wilson, Michael, Xie, Zhiwei, Zenova, Alla, Zhang, Wei, Scott, Fiona L, Cutts, Alison J, Sherrington, Robin P, Winquist, Raymond, Cohen, Charles J, Empfield, James R
Published in British journal of pharmacology (01.10.2024)
Published in British journal of pharmacology (01.10.2024)
Get more information
Journal Article
The contribution of NaV1.6 to the efficacy of voltage‐gated sodium channel inhibitors in wild type and NaV1.6 gain‐of‐function (GOF) mouse seizure control
Johnson, James P., Focken, Thilo, Karimi Tari, Parisa, Dube, Celine, Goodchild, Samuel J., Andrez, Jean‐Christophe, Bankar, Girish, Burford, Kristen, Chang, Elaine, Chowdhury, Sultan, Christabel, Jessica, Dean, Richard, Boer, Gina, Dehnhardt, Christoph, Gong, Wei, Grimwood, Michael, Hussainkhel, Angela, Jia, Qi, Khakh, Kuldip, Lee, Stephanie, Li, Jenny, Lin, Sophia, Lindgren, Andrea, Lofstrand, Verner, Mezeyova, Janette, Nelkenbrecher, Karen, Shuart, Noah Gregory, Sojo, Luis, Sun, Shaoyi, Waldbrook, Matthew, Wesolowski, Steven, Wilson, Michael, Xie, Zhiwei, Zenova, Alla, Zhang, Wei, Scott, Fiona L., Cutts, Alison J., Sherrington, Robin P., Winquist, Raymond, Cohen, Charles J., Empfield, James R.
Published in British journal of pharmacology (01.10.2024)
Published in British journal of pharmacology (01.10.2024)
Get full text
Journal Article
Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy
Focken, Thilo, Burford, Kristen, Grimwood, Michael E, Zenova, Alla, Andrez, Jean-Christophe, Gong, Wei, Wilson, Michael, Taron, Matt, Decker, Shannon, Lofstrand, Verner, Chowdhury, Sultan, Shuart, Noah, Lin, Sophia, Goodchild, Samuel J, Young, Clint, Soriano, Maegan, Tari, Parisa K, Waldbrook, Matthew, Nelkenbrecher, Karen, Kwan, Rainbow, Lindgren, Andrea, de Boer, Gina, Lee, Stephanie, Sojo, Luis, DeVita, Robert J, Cohen, Charles J, Wesolowski, Steven S, Johnson, J. P, Dehnhardt, Christoph M, Empfield, James R
Published in Journal of medicinal chemistry (14.11.2019)
Published in Journal of medicinal chemistry (14.11.2019)
Get full text
Journal Article
Identification of aryl sulfonamides as novel and potent inhibitors of NaV1.5
Sun, Shaoyi, Jia, Qi, Zenova, Alla Y., Lin, Sophia, Hussainkhel, Angela, Mezeyova, Janette, Chang, Elaine, Goodchild, Samuel J., Xie, Zhiwei, Lindgren, Andrea, de Boer, Gina, Kwan, Rainbow, Khakh, Kuldip, Sojo, Luis, Bichler, Paul, Johnson, J.P., Empfield, James R., Cohen, Charles J., Dehnhardt, Christoph M., Dean, Richard
Published in Bioorganic & medicinal chemistry letters (01.08.2021)
Published in Bioorganic & medicinal chemistry letters (01.08.2021)
Get full text
Journal Article
NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats
Johnson, JP, Focken, Thilo, Khakh, Kuldip, Tari, Parisa Karimi, Dube, Celine, Goodchild, Samuel J, Andrez, Jean-Christophe, Bankar, Girish, Bogucki, David, Burford, Kristen, Chang, Elaine, Chowdhury, Sultan, Dean, Richard, de Boer, Gina, Decker, Shannon, Dehnhardt, Christoph, Feng, Mandy, Gong, Wei, Grimwood, Michael, Hasan, Abid, Hussainkhel, Angela, Jia, Qi, Lee, Stephanie, Li, Jenny, Lin, Sophia, Lindgren, Andrea, Lofstrand, Verner, Mezeyova, Janette, Namdari, Rostam, Nelkenbrecher, Karen, Shuart, Noah Gregory, Sojo, Luis, Sun, Shaoyi, Taron, Matthew, Waldbrook, Matthew, Weeratunge, Diana, Wesolowski, Steven, Williams, Aaron, Wilson, Michael, Xie, Zhiwei, Yoo, Rhena, Young, Clint, Zenova, Alla, Zhang, Wei, Cutts, Alison J, Sherrington, Robin P, Pimstone, Simon N, Winquist, Raymond, Cohen, Charles J, Empfield, James R
Published in eLife (02.03.2022)
Published in eLife (02.03.2022)
Get full text
Journal Article
Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective Na V 1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy
Focken, Thilo, Burford, Kristen, Grimwood, Michael E, Zenova, Alla, Andrez, Jean-Christophe, Gong, Wei, Wilson, Michael, Taron, Matt, Decker, Shannon, Lofstrand, Verner, Chowdhury, Sultan, Shuart, Noah, Lin, Sophia, Goodchild, Samuel J, Young, Clint, Soriano, Maegan, Tari, Parisa K, Waldbrook, Matthew, Nelkenbrecher, Karen, Kwan, Rainbow, Lindgren, Andrea, de Boer, Gina, Lee, Stephanie, Sojo, Luis, DeVita, Robert J, Cohen, Charles J, Wesolowski, Steven S, Johnson, Jr, J P, Dehnhardt, Christoph M, Empfield, James R
Published in Journal of medicinal chemistry (14.11.2019)
Published in Journal of medicinal chemistry (14.11.2019)
Get full text
Journal Article
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate
Alelyunas, Yun W., Empfield, James R., McCarthy, Dennis, Spreen, Russell C., Bui, Khanh, Pelosi-Kilby, Luciana, Shen, Cindy
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
Get full text
Journal Article
Lessons learned from candidate drug attrition
Empfield, James R, Leeson, Paul D
Published in IDrugs : the investigational drugs journal (01.12.2010)
Get more information
Published in IDrugs : the investigational drugs journal (01.12.2010)
Journal Article
Total synthesis of (.+-.)-breynolide, an aglycon derivative of the orally active hypocholesterolemic agent breynin A
Smith, Amos B, Empfield, James R, Rivero, Ralph A, Vaccaro, Henry A, Duan, James J. W, Sulikowski, Michelle M
Published in Journal of the American Chemical Society (01.11.1992)
Published in Journal of the American Chemical Society (01.11.1992)
Get full text
Journal Article
Synthesis of 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5h )-triones as NMDA glycine-site antagonists
BROWN, Dean G, URBANEK, Rebecca A, XIAO, Wenhua, DYROFF, Martin C, LEE, Chi-Ming C, TRIVEDI, Shephali, NEILSON, Kathy L, KEITH, Richard A, BARE, Thomas M, MCLAREN, Frances M, HORCHLER, Carey L, MURPHY, Megan, STEELMAN, Gary B, EMPFIELD, James R, FORST, Janet M, HERZOG, Keith J
Published in Bioorganic & medicinal chemistry letters (20.10.2003)
Published in Bioorganic & medicinal chemistry letters (20.10.2003)
Get full text
Journal Article
Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective Na(V)1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy
Focken, Thilo, Burford, Kristen, Grimwood, Michael E., Zenova, Alla, Andrez, Jean-Christophe, Gong, Wei, Wilson, Michael, Taron, Matt, Decker, Shannon, Lofstrand, Verner, Chowdhury, Sultan, Shuart, Noah, Lin, Sophia, Goodchild, Samuel J., Young, Clint, Soriano, Maegan, Tari, Parisa K., Waldbrook, Matthew, Nelkenbrecher, Karen, Kwan, Rainbow, Lindgren, Andrea, de Boer, Gina, Lee, Stephanie, Sojo, Luis, DeVita, Robert J., Cohen, Charles J., Wesolowski, Steven S., Johnson, J. P., Dehnhardt, Christoph M., Empfield, James R.
Published in Journal of medicinal chemistry (14.11.2019)
Published in Journal of medicinal chemistry (14.11.2019)
Get full text
Journal Article
Identification of aryl sulfonamides as novel and potent inhibitors of Na(V)1.5
Sun, Shaoyi, Jia, Qi, Zenova, Alla Y., Lin, Sophia, Hussainkhel, Angela, Mezeyova, Janette, Chang, Elaine, Goodchild, Samuel J., Xie, Zhiwei, Lindgren, Andrea, de Boer, Gina, Kwan, Rainbow, Khakh, Kuldip, Sojo, Luis, Bichler, Paul, Johnson Jr, J. P., Empfield, James R., Cohen, Charles J., Dehnhardt, Christoph M., Dean, Richard
Published in Bioorganic & medicinal chemistry letters (01.08.2021)
Published in Bioorganic & medicinal chemistry letters (01.08.2021)
Get full text
Journal Article
Identification of aryl sulfonamides as novel and potent inhibitors of Na V 1.5
Sun, Shaoyi, Jia, Qi, Zenova, Alla Y, Lin, Sophia, Hussainkhel, Angela, Mezeyova, Janette, Chang, Elaine, Goodchild, Samuel J, Xie, Zhiwei, Lindgren, Andrea, de Boer, Gina, Kwan, Rainbow, Khakh, Kuldip, Sojo, Luis, Bichler, Paul, Johnson, Jr, J P, Empfield, James R, Cohen, Charles J, Dehnhardt, Christoph M, Dean, Richard
Published in Bioorganic & medicinal chemistry letters (01.08.2021)
Get full text
Published in Bioorganic & medicinal chemistry letters (01.08.2021)
Journal Article
NBI-921352, a first-in-class, Na V 1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats
Johnson, J P, Focken, Thilo, Khakh, Kuldip, Tari, Parisa Karimi, Dube, Celine, Goodchild, Samuel J, Andrez, Jean-Christophe, Bankar, Girish, Bogucki, David, Burford, Kristen, Chang, Elaine, Chowdhury, Sultan, Dean, Richard, de Boer, Gina, Decker, Shannon, Dehnhardt, Christoph, Feng, Mandy, Gong, Wei, Grimwood, Michael, Hasan, Abid, Hussainkhel, Angela, Jia, Qi, Lee, Stephanie, Li, Jenny, Lin, Sophia, Lindgren, Andrea, Lofstrand, Verner, Mezeyova, Janette, Namdari, Rostam, Nelkenbrecher, Karen, Shuart, Noah Gregory, Sojo, Luis, Sun, Shaoyi, Taron, Matthew, Waldbrook, Matthew, Weeratunge, Diana, Wesolowski, Steven, Williams, Aaron, Wilson, Michael, Xie, Zhiwei, Yoo, Rhena, Young, Clint, Zenova, Alla, Zhang, Wei, Cutts, Alison J, Sherrington, Robin P, Pimstone, Simon N, Winquist, Raymond, Cohen, Charles J, Empfield, James R
Published in eLife (02.03.2022)
Get full text
Published in eLife (02.03.2022)
Journal Article
N-Aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamides: KATP Potassium Channel Openers. Modifications on the Western Region
Ohnmacht, Cyrus J, Russell, Keith, Empfield, James R, Frank, Cathy A, Gibson, Keith H, Mayhugh, Daniel R, McLaren, Frances M, Shapiro, Howard S, Brown, Frederick J, Trainor, Diane A, Ceccarelli, Christopher, Lin, Margaret M, Masek, Brian B, Forst, Janet M, Harris, Robert J, Hulsizer, James M, Lewis, Joseph J, Silverman, Stuart M, Smith, Reed W, Warwick, Paul J, Kau, Sen T, Chun, Alexa L, Grant, Thomas L, Howe, Burton B, Li, Jack H, Trivedi, Shephali, Halterman, Tracy J, Yochim, Christopher, Dyroff, Martin C, Neilson, Kathleen L
Published in Journal of medicinal chemistry (14.03.1997)
Published in Journal of medicinal chemistry (14.03.1997)
Get full text
Journal Article